Henry Vanbrocklin, PhD
Professor
Radiology
School of Medicine

Louis in 1990, and he completed a two-year postdoctoral program at the University of Illinois, Urbana in 1992. He maintains an active radiotracer research program in addition to providing tracers for collaborative basic science and translational clinical research. His research interests include short-lived radioisotope production to the creation of fluorine-18 and carcbon-11 labeling chemistry strategies for new radiotracer preparations and applications.

Dr. VanBrocklin is one of the core faculty for the Master's in Biomedical Imaging (MSBI) program and a member of the MSBI executive committee.

Dr. VanBrocklin was awarded the Alexander Hollaender Distinguished Postdoctoral Fellowship from the U.S. Department of Energy for developing positron-labeled estrogens, progestins, and androgens for tumor imaging. He has 70 published research articles.

Expertise: Radiopharmaceutical

Specialty: Short-lived radioisotope production to the creation of fluorine-18 and carbon-11 labeling chemistry strategies for new radiotracer preparations and applications, development of positron-labeled estrogens, progestin’s, androgens for tumor imaging

Professional Interests: Developing radiopharmaceutical probes for PET and SPECT imaging applications including tracers for blood flow measurement, receptor-targeted tracers for prostate, pancreatic and breast cancer, and neurological imaging agents for neuroinflammation and excititory amino acid transport. Education and Training:

• Doctor of Philosophy: Washington University, St. Louis - Radiopharmaceutical Chemistry
• Postdoctoral Fellow: University of Illinois, Urbana

• Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19.
  medRxiv : the preprint server for health sciences 2023 Peluso MJ, Ryder D, Flavell R, Wang Y, Levi J, LaFranchi BH, Deveau TM, Buck AM, Munter SE, Asare KA, Aslam M, Koch W, Szabo G, Hoh R, Deswal M, Rodriguez A, Buitrago M, Tai V, Shrestha U, Lu S, …
• Evaluation of 134Ce/134La as a PET Imaging Theranostic Pair for 225Ac α-Radiotherapeutics.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2023 Bobba KN, Bidkar AP, Meher N, Fong C, Wadhwa A, Dhrona S, Sorlin A, Bidlingmaier S, Shuere B, He J, Wilson DM, Liu B, Seo Y, VanBrocklin HF, Flavell RR
• Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Bidkar AP, Wang S, Bobba KN, Chan E, Bidlingmaier S, Egusa EA, Peter R, Ali U, Meher N, Wadhwa A, Dhrona S, Dasari C, Beckford-Vera D, Su Y, Tang R, Zhang L, He J, Wilson DM, Aggarwal R, VanBrocklin …
• A feasibility study for quantitative assessment of cerebrovascular malformations using flutriciclamide ([18F]GE-180) PET/MRI.
  Frontiers in medicine 2023 Kim SJW, Lupo JM, Chen Y, Pampaloni MH, VanBrocklin HF, Narvid J, Kim H, Seo Y
• Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism.
  Cell metabolism 2023 Midha AD, Zhou Y, Queliconi BB, Barrios AM, Haribowo AG, Chew BTL, Fong COY, Blecha JE, VanBrocklin H, Seo Y, Jain IH
• PSMA-Targeted Nanotheranostics for Imaging and Radiotherapy of Prostate Cancer.
  Pharmaceuticals (Basel, Switzerland) 2023 Meher N, VanBrocklin HF, Wilson DM, Flavell RR
• Prostate-Specific Membrane Antigen Targeted Deep Tumor Penetration of Polymer Nanocarriers.
  ACS applied materials & interfaces 2022 Meher N, Ashley GW, Bidkar AP, Dhrona S, Fong C, Fontaine SD, Beckford Vera DR, Wilson DM, Seo Y, Santi DV, VanBrocklin HF, Flavell RR
• Biodistribution of a Mitochondrial Metabolic Tracer, [18F]F-AraG, in Healthy Volunteers.
  Molecular imaging 2022 Levi J, Duan H, Yaghoubi S, Packiasamy J, Huynh L, Lam T, Shaikh F, Behera D, Song H, Blecha J, Jivan S, Seo Y, VanBrocklin HF
• Imaging joint infections using D-methyl-11C-methionine PET/MRI: initial experience in humans.
  European journal of nuclear medicine and molecular imaging 2022 Polvoy I, Seo Y, Parker M, Stewart M, Siddiqua K, Manacsa HS, Ravanfar V, Blecha J, Hope TA, Vanbrocklin H, Flavell RR, Barry J, Hansen E, Villanueva-Meyer JE, Engel J, Rosenberg OS, Wilson DM, …
• Evaluating Radioactive Analogs of Doxorubicin to Quantify ChemoFilter Binding and Whole-Body Positron Emission Tomography/Magnetic Resonance Imaging for Drug Biodistribution.
  Journal of vascular and interventional radiology : JVIR 2022 Kumar P, Yee C, Blecha JE, Hayes TR, Kilbride BF, Stillson C, Losey AD, Mastria E, Jordan CD, Huynh TL, Moore T, Wilson MW, VanBrocklin HF, Hetts SW
• First-in-human immunoPET imaging of HIV-1 infection using 89Zr-labeled VRC01 broadly neutralizing antibody.
  Nature communications 2022 Beckford-Vera DR, Flavell RR, Seo Y, Martinez-Ortiz E, Aslam M, Thanh C, Fehrman E, Pardons M, Kumar S, Deitchman AN, Ravanfar V, Schulte B, Wu IK, Pan T, Reeves JD, Nixon CC, Iyer NS, Torres L, …
• Proceedings: PET Drugs-A Workshop on Inspections Management and Regulatory Considerations.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2022 Bunning S, Ignace C, Mattmuller S, Schwarz SW, Scott PJH, VanBrocklin HF, Zigler SS, Coalition of Drug Manufacturers
• Synthesis and Preliminary Biological Assessment of Carborane-Loaded Theranostic Nanoparticles to Target Prostate-Specific Membrane Antigen.
  ACS applied materials & interfaces 2021 Meher N, Seo K, Wang S, Bidkar AP, Fogarty M, Dhrona S, Huang X, Tang R, Blaha C, Evans MJ, Raleigh DR, Jun YW, VanBrocklin HF, Desai TA, Wilson DM, Ozawa T, Flavell RR
• Longitudinal Imaging of T Cells and Inflammatory Demyelination in a Preclinical Model of Multiple Sclerosis Using 18F-FAraG PET and MRI.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2021 Guglielmetti C, Levi J, Huynh TL, Tiret B, Blecha J, Tang R, VanBrocklin H, Chaumeil MM
• Biological Distribution and Metabolic Profiles of Carbon-11 and Fluorine-18 Tracers of VX- and Sarin-Analogs in Sprague-Dawley Rats.
  Chemical research in toxicology 2020 Hayes TR, Chao CK, Blecha JE, Huynh TL, Zinn KR, Thompson CM, Gerdes JM, VanBrocklin HF
• Total-Body PET Imaging in Infectious Diseases.
  PET clinics 2020 Henrich TJ, Jones T, Beckford-Vera D, Price PM, VanBrocklin HF
• Positron Emission Tomography Imaging of Functional Transforming Growth Factor β (TGFβ) Activity and Benefit of TGFβ Inhibition in Irradiated Intracranial Tumors.
  International journal of radiation oncology, biology, physics 2020 Gonzalez-Junca A, Reiners O, Borrero-Garcia LD, Beckford-Vera D, Lazar AA, Chou W, Braunstein S, VanBrocklin H, Franc BL, Barcellos-Hoff MH
• The Synthesis and Structural Requirements for Measuring Glucocorticoid Receptor Expression In Vivo with (±)-11C-YJH08 PET.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2020 Huang Y, Zhao N, Wang YH, Truillet C, Wei J, Parker MFL, Blecha JE, Drake CR, VanBrocklin HF, Garrido-Ruiz D, Jacobson MP, Aggarwal R, Behr SC, Flavell RR, Wilson DM, Seo Y, Evans MJ
• An Analysis of Isoclonal Antibody Formats Suggests a Role for Measuring PD-L1 with Low Molecular Weight PET Radiotracers.
  Molecular imaging and biology 2020 Wei J, Wang YH, Lee CY, Truillet C, Oh DY, Xu Y, Ruggero D, Flavell RR, VanBrocklin HF, Seo Y, Craik CS, Fong L, Wang CI, Evans MJ
• Positron emission tomography evaluation of oxime countermeasures in live rats using the tracer O-(2-[18 F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate [18 F]-VXS.
  Annals of the New York Academy of Sciences 2020 Hayes TR, Blecha JE, Chao CK, Huynh TL, VanBrocklin HF, Zinn KR, Taylor PW, Gerdes JM, Thompson CM
• 124I-MIBG PET/CT to Monitor Metastatic Disease in Children with Relapsed Neuroblastoma.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2020 Aboian MS, Huang SY, Hernandez-Pampaloni M, Hawkins RA, VanBrocklin HF, Huh Y, Vo KT, Gustafson WC, Matthay KK, Seo Y
• A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography.
  ACS chemical biology 2020 Huang Y, Zhao N, Wang YH, Truillet C, Wei J, Blecha JE, VanBrocklin HF, Seo Y, Sayeed M, Feldman BJ, Aggarwal R, Behr SC, Shao H, Wilson DM, Villanueva-Meyer JE, Gestwicki JE, Evans MJ
• Arabinofuranose-derived positron-emission tomography radiotracers for detection of pathogenic microorganisms.
  Journal of labelled compounds & radiopharmaceuticals 2020 Kalita M, Parker MFL, Luu JM, Stewart MN, Blecha JE, VanBrocklin HF, Evans MJ, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM
• PET/CT Imaging of Human TNFα Using [89Zr]Certolizumab Pegol in a Transgenic Preclinical Model of Rheumatoid Arthritis.
  Molecular imaging and biology 2020 Beckford-Vera DR, Gonzalez-Junca A, Janneck JS, Huynh TL, Blecha JE, Seo Y, Li X, VanBrocklin HF, Franc BL
• High Enantiomeric Excess In-Loop Synthesis of d-[methyl-11C]Methionine for Use as a Diagnostic Positron Emission Tomography Radiotracer in Bacterial Infection.
  ACS infectious diseases 2019 Stewart MN, Parker MFL, Jivan S, Luu JM, Huynh TL, Schulte B, Seo Y, Blecha JE, Villanueva-Meyer JE, Flavell RR, VanBrocklin HF, Ohliger MA, Rosenberg O, Wilson DM
• PET Imaging of the EPR Effect in Tumor Xenografts Using Small 15 nm Diameter Polyethylene Glycols Labeled with Zirconium-89.
  Molecular cancer therapeutics 2019 Beckford Vera DR, Fontaine SD, VanBrocklin HF, Hearn BR, Reid R, Ashley GW, Santi DV
• Seeing Is Believing: Nuclear Imaging of HIV Persistence.
  Frontiers in immunology 2019 Henrich TJ, Hsue PY, VanBrocklin H
• Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy.
  Molecular pharmaceutics 2019 Wang S, Blaha C, Santos R, Huynh T, Hayes TR, Beckford-Vera DR, Blecha JE, Hong AS, Fogarty M, Hope TA, Raleigh DR, Wilson DM, Evans MJ, VanBrocklin HF, Ozawa T, Flavell RR
• Divergent synthesis of organophosphate [11C]VX- and [11C]Sarin-surrogates from a common set of starting materials.
  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2019 Hayes TR, Blecha JE, Thompson CM, Gerdes JM, VanBrocklin HF
• Imaging of Activated T Cells as an Early Predictor of Immune Response to Anti-PD-1 Therapy.
  Cancer research 2019 Levi J, Lam T, Goth SR, Yaghoubi S, Bates J, Ren G, Jivan S, Huynh TL, Blecha JE, Khattri R, Schmidt KF, Jennings D, VanBrocklin H
• Positron emission tomography studies of organophosphate chemical threats and oxime countermeasures.
  Neurobiology of disease 2019 Thompson CM, Gerdes JM, VanBrocklin HF
• Enzymatically Catalyzed Radiofluorination of Biomolecules.
  Methods in molecular biology (Clifton, N.J.) 2019 Drake CR, Evans MJ, VanBrocklin HF
• Phase I Study of CTT1057, an 18F-Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate-Specific Membrane Antigen in Prostate Cancer.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2018 Behr SC, Aggarwal R, VanBrocklin HF, Flavell RR, Gao K, Small EJ, Blecha J, Jivan S, Hope TA, Simko JP, Kurhanewicz J, Noworolski SM, Korn NJ, De Los Santos R, Cooperberg MR, Carroll PR, Nguyen HG, …
• Radiosynthesis of O-(1-[18 F]fluoropropan-2-yl)-O-(4-nitrophenyl)methylphosphonate: A novel PET tracer surrogate of sarin.
  Journal of labelled compounds & radiopharmaceuticals 2018 Hayes TR, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF
• A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors.
  Molecular cancer therapeutics 2018 Chamberlain CE, German MS, Yang K, Wang J, VanBrocklin H, Regan M, Shokat KM, Ducker GS, Kim GE, Hann B, Donner DB, Warren RS, Venook AP, Bergsland EK, Lee D, Wang Y, Nakakura EK
• Radiosynthesis, ex Vivo Biodistribution, and in Vivo Positron Emission Tomography Imaging Evaluations of [11C]2-Pyridinealdoxime Methiodide ([11C]2-PAM): A First-In-Class Antidote Tracer for Organophosphate Intoxication.
  ACS chemical neuroscience 2018 Neumann KD, Blecha JE, Hayes TR, Huynh T, Chao CK, Guilloteau N, Zinn KR, VanBrocklin HF, Thompson CM, Gerdes JM
• Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI.
  Chemical communications (Cambridge, England) 2018 Taglang C, Korenchan DE, von Morze C, Yu J, Najac C, Wang S, Blecha JE, Subramaniam S, Bok R, VanBrocklin HF, Vigneron DB, Ronen SM, Sriram R, Kurhanewicz J, Wilson DM, Flavell RR
• Quantification of 89 Zr-Iron oxide nanoparticle biodistribution using PET-MR and ultrashort TE sequences.
  Journal of magnetic resonance imaging : JMRI 2018 Jordan CD, Han M, Kondapavulur S, Vera DB, Neumann KD, Moore T, Stillson C, Krug R, Behr S, Seo Y, VanBrocklin HF, Larson PEZ, Wilson M, Martin AJ, Hetts SW
• [11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism.
  ACS infectious diseases 2018 Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha J, Carroll V, Taglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK, Neumann KD, Wilson DM
• Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers.
  Scientific reports 2017 Neumann KD, Villanueva-Meyer JE, Mutch CA, Flavell RR, Blecha JE, Kwak T, Sriram R, VanBrocklin HF, Rosenberg OS, Ohliger MA, Wilson DM
• A PET Imaging Strategy to Visualize Activated T Cells in Acute Graft-versus-Host Disease Elicited by Allogenic Hematopoietic Cell Transplant.
  Cancer research 2017 Ronald JA, Kim BS, Gowrishankar G, Namavari M, Alam IS, D'Souza A, Nishikii H, Chuang HY, Ilovich O, Lin CF, Reeves R, Shuhendler A, Hoehne A, Chan CT, Baker J, Yaghoubi SS, VanBrocklin HF, Hawkins R,…
• An improved radiosynthesis of O-(2-[18 F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate: A first-in-class cholinesterase PET tracer.
  Journal of labelled compounds & radiopharmaceuticals 2017 Neumann KD, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF
• An updated synthesis of [11 C]carfentanil for positron emission tomography (PET) imaging of the μ-opioid receptor.
  Journal of labelled compounds & radiopharmaceuticals 2017 Blecha JE, Henderson BD, Hockley BG, VanBrocklin HF, Zubieta JK, DaSilva AF, Kilbourn MR, Koeppe RA, Scott PJH, Shao X
• Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging.
  The Analyst 2017 Korenchan DE, Taglang C, von Morze C, Blecha JE, Gordon JW, Sriram R, Larson PEZ, Vigneron DB, VanBrocklin HF, Kurhanewicz J, Wilson DM, Flavell RR
• 11C-L-methyl methionine dynamic PET/CT of skeletal muscle: response to protein supplementation compared to L-[ring 13C6] phenylalanine infusion with serial muscle biopsy.
  Annals of nuclear medicine 2017 Arentson-Lantz EJ, Saeed IH, Frassetto LA, Masharani U, Harnish RJ, Seo Y, VanBrocklin HF, Hawkins RA, Mari-Aparici C, Pampaloni MH, Slater J, Paddon-Jones D, Lang TF
• In Vivo PET Imaging of the Activated Immune Environment in a Small Animal Model of Inflammatory Arthritis.
  Molecular imaging 2017 Franc BL, Goth S, MacKenzie J, Li X, Blecha J, Lam T, Jivan S, Hawkins RA, VanBrocklin H
• Optimization of an endovascular magnetic filter for maximized capture of magnetic nanoparticles.
  Biomedical microdevices 2016 Kondapavulur S, Cote AM, Neumann KD, Jordan CD, McCoy D, Mabray MC, Liu D, Sze CH, Gautam A, VanBrocklin HF, Wilson M, Hetts SW
• Structure-Activity Relationship of (18)F-Labeled Phosphoramidate Peptidomimetic Prostate-Specific Membrane Antigen (PSMA)-Targeted Inhibitor Analogues for PET Imaging of Prostate Cancer.
  Journal of medicinal chemistry 2016 Dannoon S, Ganguly T, Cahaya H, Geruntho JJ, Galliher MS, Beyer SK, Choy CJ, Hopkins MR, Regan M, Blecha JE, Skultetyova L, Drake CR, Jivan S, Barinka C, Jones EF, Berkman CE, VanBrocklin HF
• [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice.
  Molecular imaging and biology 2016 Li L, Che L, Wang C, Blecha JE, Li X, VanBrocklin HF, Calvisi DF, Puchowicz M, Chen X, Seo Y
• Ictal lack of binding to brain parenchyma suggests integrity of the blood-brain barrier for 11C-dihydroergotamine during glyceryl trinitrate-induced migraine.
  Brain : a journal of neurology 2016 Schankin CJ, Maniyar FH, Seo Y, Kori S, Eller M, Chou DE, Blecha J, Murphy ST, Hawkins RA, Sprenger T, VanBrocklin HF, Goadsby PJ
• Site-Specific Radiofluorination of Biomolecules with 8-[(18)F]-Fluorooctanoic Acid Catalyzed by Lipoic Acid Ligase.
  ACS chemical biology 2016 Drake CR, Sevillano N, Truillet C, Craik CS, VanBrocklin HF, Evans MJ
• [(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography.
  Chemical communications (Cambridge, England) 2016 Carroll VN, Truillet C, Shen B, Flavell RR, Shao X, Evans MJ, VanBrocklin HF, Scott PJ, Chin FT, Wilson DM
• Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging.
  Chemical communications (Cambridge, England) 2016 Korenchan DE, Flavell RR, Baligand C, Sriram R, Neumann K, Sukumar S, VanBrocklin H, Vigneron DB, Wilson DM, Kurhanewicz J
• Caged [(18)F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography.
  Bioconjugate chemistry 2015 Flavell RR, Truillet C, Regan MK, Ganguly T, Blecha JE, Kurhanewicz J, VanBrocklin HF, Keshari KR, Chang CJ, Evans MJ, Wilson DM
• Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography.
  Nature communications 2015 Page MJ, Lourenço AL, David T, LeBeau AM, Cattaruzza F, Castro HC, VanBrocklin HF, Coughlin SR, Craik CS
• Simultaneous (68)Ga-DOTA-TOC PET/MRI with gadoxetate disodium in patients with neuroendocrine tumor.
  Abdominal imaging 2015 Hope TA, Pampaloni MH, Nakakura E, VanBrocklin H, Slater J, Jivan S, Aparici CM, Yee J, Bergsland E
• Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor.
  The Prostate 2015 Keshari KR, Wilson DM, Van Criekinge M, Sriram R, Koelsch BL, Wang ZJ, VanBrocklin HF, Peehl DM, O'Brien T, Sampath D, Carano RA, Kurhanewicz J
• A high-affinity [(18)F]-labeled phosphoramidate peptidomimetic PSMA-targeted inhibitor for PET imaging of prostate cancer.
  Nuclear medicine and biology 2015 Ganguly T, Dannoon S, Hopkins MR, Murphy S, Cahaya H, Blecha JE, Jivan S, Drake CR, Barinka C, Jones EF, VanBrocklin HF, Berkman CE
• Somatostatin imaging of neuroendocrine-differentiated prostate cancer.
  Clinical nuclear medicine 2015 Hope TA, Aggarwal R, Simko JP, VanBrocklin HF, Ryan CJ
• Synthesis and evaluation of constrained phosphoramidate inhibitors of prostate-specific membrane antigen.
  Bioorganic & medicinal chemistry letters 2015 Ley CR, Beattie NR, Dannoon S, Regan M, VanBrocklin H, Berkman CE
• Imaging active urokinase plasminogen activator in prostate cancer.
  Cancer research 2015 LeBeau AM, Sevillano N, Markham K, Winter MB, Murphy ST, Hostetter DR, West J, Lowman H, Craik CS, VanBrocklin HF
• A boronate-caged [¹⁸F]FLT probe for hydrogen peroxide detection using positron emission tomography.
  Journal of the American Chemical Society 2014 Carroll V, Michel BW, Blecha J, VanBrocklin H, Keshari K, Wilson D, Chang CJ
• Regulatory Requirements for PET Drug Production.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2014 Schwarz SW, Dick D, VanBrocklin HF, Hoffman JM
• A novel fluorine-18 β-fluoroethoxy organophosphate positron emission tomography imaging tracer targeted to central nervous system acetylcholinesterase.
  ACS chemical neuroscience 2014 James SL, Ahmed SK, Murphy S, Braden MR, Belabassi Y, VanBrocklin HF, Thompson CM, Gerdes JM
• Imaging the urokinase plasminongen activator receptor in preclinical breast cancer models of acquired drug resistance.
  Theranostics 2014 LeBeau AM, Sevillano N, King ML, Duriseti S, Murphy ST, Craik CS, Murphy LL, VanBrocklin HF
• Photons across medicine: relating optical and nuclear imaging.
  Biomedical optics express 2013 Nordstrom R, Cherry S, Azhdarinia A, Sevick-Muraca E, Vanbrocklin H
• Hyperpolarized [1-13C]dehydroascorbate MR spectroscopy in a murine model of prostate cancer: comparison with 18F-FDG PET.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013 Keshari KR, Sai V, Wang ZJ, Vanbrocklin HF, Kurhanewicz J, Wilson DM
• Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer.
  Cancer research 2013 LeBeau AM, Duriseti S, Murphy ST, Pepin F, Hann B, Gray JW, VanBrocklin HF, Craik CS
• Imaging a functional tumorigenic biomarker in the transformed epithelium.
  Proceedings of the National Academy of Sciences of the United States of America 2012 LeBeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, VanBrocklin HF, Craik CS
• Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model.
  Molecular imaging and biology 2012 Seo Y, Gustafson WC, Dannoon SF, Nekritz EA, Lee CL, Murphy ST, VanBrocklin HF, Hernandez-Pampaloni M, Haas-Kogan DA, Weiss WA, Matthay KK
• Approach to assessing myocardial perfusion in rats using static [13N]-ammonia images and a small-animal PET.
  Molecular imaging and biology 2012 Vaquero JJ, Gao DW, García-Villaba C, Bacharach S, Vanbrocklin H, Fang Q, Desco M, Lee R, Dae M
• In memoriam: Michael John Welch, Ph.D 1939-2012.
  Molecular imaging and biology 2012 McCarthy TJ, Vanbrocklin HF
• The Q43L mutant of neuregulin 2β is a pan-ErbB receptor antagonist.
  The Biochemical journal 2012 Wilson KJ, Mill CP, Gallo RM, Cameron EM, VanBrocklin H, Settleman J, Riese DJ
• Accepting the torch.
  Molecular imaging 2012 VanBrocklin H
• Myocardial uptake of 7'-(Z)-[(123)I]iodorotenone during vasodilator stress in dogs with critical coronary stenoses.
  Circulation. Cardiovascular imaging 2011 Broisat A, Ruiz M, Goodman NC, Hanrahan SM, Reutter BW, Brennan KM, Janabi M, Schaefer S, Watson DD, Beller GA, VanBrocklin HF, Glover DK
• FDA cGMP requirements for PET drugs.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011 Norenberg JP, Schwarz S, VanBrocklin H
• Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas.
  Cancer research 2011 Iyer AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF, Broaddus VC, Liu B, He J
• Metabolic stability of 6,7-dialkoxy-4-(2-, 3- and 4-[18F]fluoroanilino)quinazolines, potential EGFR imaging probes.
  Bioorganic & medicinal chemistry 2011 Vasdev N, Dorff PN, O'Neil JP, Chin FT, Hanrahan S, VanBrocklin HF
• Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2011 More SS, Itsara M, Yang X, Geier EG, Tadano MK, Seo Y, Vanbrocklin HF, Weiss WA, Mueller S, Haas-Kogan DA, Dubois SG, Matthay KK, Giacomini KM
• The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma.
  Biomaterials 2011 Iyer AK, Su Y, Feng J, Lan X, Zhu X, Liu Y, Gao D, Seo Y, Vanbrocklin HF, Courtney Broaddus V, Liu B, He J
• CGMP for PET drugs: important steps to take now.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010 Vanbrocklin H, Schwarz S
• Radiolabeled small molecule protein kinase inhibitors for imaging with PET or SPECT.
  Molecules (Basel, Switzerland) 2010 Hicks JW, VanBrocklin HF, Wilson AA, Houle S, Vasdev N
• Radiation dose estimation using preclinical imaging with 124I-metaiodobenzylguanidine (MIBG) PET.
  Medical physics 2010 Lee CL, Wahnishe H, Sayre GA, Cho HM, Kim HJ, Hernandez-Pampaloni M, Hawkins RA, Dannoon SF, VanBrocklin HF, Itsara M, Weiss WA, Yang X, Haas-Kogan DA, Matthay KK, Seo Y
• Targeted in vivo extracellular matrix formation promotes neovascularization in a rodent model of myocardial infarction.
  PloS one 2010 Mihardja SS, Gao D, Sievers RE, Fang Q, Feng J, Wang J, Vanbrocklin HF, Larrick JW, Huang M, Dae M, Lee RJ
• Design of targeted cardiovascular molecular imaging probes.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010 Anderson CJ, Bulte JW, Chen K, Chen X, Khaw BA, Shokeen M, Wooley KL, VanBrocklin HF
• Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single-chain antibody fragment.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010 He J, Wang Y, Feng J, Zhu X, Lan X, Iyer AK, Zhang N, Seo Y, VanBrocklin HF, Liu B
• Assessment of an 18F-labeled phosphoramidate peptidomimetic as a new prostate-specific membrane antigen-targeted imaging agent for prostate cancer.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009 Lapi SE, Wahnishe H, Pham D, Wu LY, Nedrow-Byers JR, Liu T, Vejdani K, VanBrocklin HF, Berkman CE, Jones EF
• Safety and tolerability of putaminal AADC gene therapy for Parkinson disease.
  Neurology 2009 Christine CW, Starr PA, Larson PS, Eberling JL, Jagust WJ, Hawkins RA, VanBrocklin HF, Wright JF, Bankiewicz KS, Aminoff MJ
• Introduction to special issue.
  Molecular imaging 2009 VanBrocklin HF
• Development of an optimized activatable MMP-14 targeted SPECT imaging probe.
  Bioorganic & medicinal chemistry 2008 Watkins GA, Jones EF, Scott Shell M, VanBrocklin HF, Pan MH, Hanrahan SM, Feng JJ, He J, Sounni NE, Dill KA, Contag CH, Coussens LM, Franc BL
• Advancing molecular imaging from the laboratory to everyday practice.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008 VanBrocklin HF
• Bruce H. Hasegawa, PhD, 1951-2008.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008 Jones EF, Gould RG, VanBrocklin HF
• Session 2: strategies for fast-track technological development and regulatory issues.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008 VanBrocklin H
• Molecular imaging update: advances in MI of the brain.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2007 VanBrocklin H, Herscovitch P
• Mitochondrial avid radioprobes. Preparation and evaluation of 7'(Z)-[125I]iodorotenone and 7'(Z)-[125I]iodorotenol.
  Nuclear medicine and biology 2006 VanBrocklin HF, Hanrahan SM, Enas JD, Nandanan E, O'Neil JP
• Anilinodialkoxyquinazolines: screening epidermal growth factor receptor tyrosine kinase inhibitors for potential tumor imaging probes.
  Journal of medicinal chemistry 2005 VanBrocklin HF, Lim JK, Coffing SL, Hom DL, Negash K, Ono MY, Gilmore JL, Bryant I, Riese DJ
• A new precursor for the preparation of 6-[18F]Fluoro-L-m-tyrosine ([18F]FMT): efficient synthesis and comparison of radiolabeling.
  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2004 VanBrocklin HF, Blagoev M, Hoepping A, O'Neil JP, Klose M, Schubiger PA, Ametamey S
• Kinetic analysis of 18F-fluorodihydrorotenone as a deposited myocardial flow tracer: comparison to 201Tl.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004 Marshall RC, Powers-Risius P, Reutter BW, O'Neil JP, La Belle M, Huesman RH, VanBrocklin HF
• Exemption of radiopharmaceuticals from <797>.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004 Hung JC, VanBrocklin HF
• No effect of age and estrogen on aromatic L- amino acid decarboxylase activity in rhesus monkey brain.
  Neurobiology of aging 2002 Eberling JL, Roberts JA, Taylor SE, VanBrocklin HF, O'Neil JP, Nordahl TE
• Assessment of cancer-associated biomarkers by positron emission tomography: advances and challenges.
  Disease markers 2002 Collier TL, Lecomte R, McCarthy TJ, Meikle S, Ruth TJ, Scopinaro F, Signore A, VanBrocklin H, van De Wiele C, Waterhouse RN
• A novel MPTP primate model of Parkinson's disease: neurochemical and clinical changes.
  Brain research 1998 Eberling JL, Jagust WJ, Taylor S, Bringas J, Pivirotto P, VanBrocklin HF, Bankiewicz KS
• An in vivo microdialysis study of striatal 6-[18F]fluoro-L-m-tyrosine metabolism.
  Neurochemical research 1998 Jordan S, Bankiewicz KS, Eberling JL, VanBrocklin HF, O'Neil JP, Jagust WJ
• PET studies of functional compensation in a primate model of Parkinson's disease.
  Neuroreport 1997 Eberling JL, Bankiewicz KS, Jordan S, VanBrocklin HF, Jagust WJ
• 6-[18F]fluoro-L-m-tyrosine: metabolism, positron emission tomography kinetics, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lesions in primates.
  Brain research 1997 Jordan S, Eberling JL, Bankiewicz KS, Rosenberg D, Coxson PG, VanBrocklin HF, O'Neil JP, Emborg ME, Jagust WJ
• Iodine-123-5-iodo-6-nitroquipazine: SPECT radiotracer to image the serotonin transporter.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1996 Jagust WJ, Eberling JL, Biegon A, Taylor SE, VanBrocklin HF, Jordan S, Hanrahan SM, Roberts JA, Brennan KM, Mathis CA
• PET studies of cerebral glucose metabolism in conscious rhesus macaques.
  Neurobiology of aging 1995 Eberling JL, Roberts JA, De Manincor DJ, Brennan KM, Hanrahan SM, Vanbrocklin HF, Roos MS, Jagust WJ
• Synthesis and tissue biodistribution of [omega-11C]palmitic acid. A novel PET imaging agent for cardiac fatty acid metabolism.
  Journal of medicinal chemistry 1994 Buckman BO, VanBrocklin HF, Dence CS, Bergmann SR, Welch MJ, Katzenellenbogen JA
• The synthesis of 7 alpha-methyl-substituted estrogens labeled with fluorine-18: potential breast tumor imaging agents.
  Steroids 1994 VanBrocklin HF, Liu A, Welch MJ, O'Neil JP, Katzenellenbogen JA
• In vivo imaging of the 5-hydroxytryptamine reuptake site in primate brain using single photon emission computed tomography and [123I]5-iodo-6-nitroquipazine.
  European journal of pharmacology 1993 Jagust WJ, Eberling JL, Roberts JA, Brennan KM, Hanrahan SM, VanBrocklin H, Enas JD, Biegon A, Mathis CA
• Titration of the in vivo uptake of 16 alpha-[18F]fluoroestradiol by target tissues in the rat: competition by tamoxifen, and implications for quantitating estrogen receptors in vivo and the use of animal models in receptor-binding radiopharmaceutical development.
  Nuclear medicine and biology 1993 Katzenellenbogen JA, Mathias CJ, VanBrocklin HF, Brodack JW, Welch MJ
• 16 beta-([18F]fluoro)estrogens: systematic investigation of a new series of fluorine-18-labeled estrogens as potential imaging agents for estrogen-receptor-positive breast tumors.
  Journal of medicinal chemistry 1993 VanBrocklin HF, Carlson KE, Katzenellenbogen JA, Welch MJ
• Fluorine-18-labeled progestin ketals: synthesis and target tissue uptake selectivity of potential imaging agents for receptor-positive breast tumors.
  Journal of medicinal chemistry 1993 Kochanny MJ, VanBrocklin HF, Kym PR, Carlson KE, O'Neil JP, Bonasera TA, Welch MJ, Katzenellenbogen JA
• 16 beta-[18F]fluoromoxestrol: a potent, metabolically stable positron emission tomography imaging agent for estrogen receptor positive human breast tumors.
  Life sciences 1993 VanBrocklin HF, Rocque PA, Lee HV, Carlson KE, Katzenellenbogen JA, Welch MJ
• Synthesis, radiolabeling and tissue distribution of 11 beta-fluoroalkyl- and 11 beta-fluoroalkoxy-substituted estrogens: target tissue uptake selectivity and defluorination of a homologous series of fluorine-18-labeled estrogens.
  Nuclear medicine and biology 1993 French AN, Napolitano E, VanBrocklin HF, Hanson RN, Welch MJ, Katzenellenbogen JA
• Fluorine-substituted corticosteroids: synthesis and evaluation as potential receptor-based imaging agents for positron emission tomography of the brain.
  International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1992 Pomper MG, Kochanny MJ, Thieme AM, Carlson KE, VanBrocklin HF, Mathias CJ, Welch MJ, Katzenellenbogen JA
• Preparation and evaluation of 17-ethynyl-substituted 16 alpha-[18F]fluoroestradiols: selective receptor-based PET imaging agents.
  International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1992 VanBrocklin HF, Pomper MG, Carlson KE, Welch MJ, Katzenellenbogen JA
• 20-[18F]fluoromibolerone, a positron-emitting radiotracer for androgen receptors: synthesis and tissue distribution studies.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1991 Liu AJ, Katzenellenbogen JA, VanBrocklin HF, Mathias CJ, Welch MJ
• 11 beta-methoxy-, 11 beta-ethyl- and 17 alpha-ethynyl-substituted 16 alpha-fluoroestradiols: receptor-based imaging agents with enhanced uptake efficiency and selectivity.
  Journal of medicinal chemistry 1990 Pomper MG, VanBrocklin H, Thieme AM, Thomas RD, Kiesewetter DO, Carlson KE, Mathias CJ, Welch MJ, Katzenellenbogen JA
• Synthesis and tissue distribution of fluorine-18 labeled trifluorohexadecanoic acids. Considerations in the development of metabolically blocked myocardial imaging agents.
  Bioconjugate chemistry 1990 Pochapsky SS, VanBrocklin HF, Welch MJ, Katzenellenbogen JA
• Binding of 16 alpha-[18F]fluoro-17 beta-estradiol to alphafetoprotein in Sprague-Dawley female rats affects blood levels.
  International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1990 VanBrocklin HF, Brodack JW, Mathias CJ, Welch MJ, Katzenellenbogen JA, Keenan JF, Mizejewski GJ