Hector Huang, PhD
Assistant Professor
Laboratory Medicine
School of Medicine

Education & Training

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• PhD Molecular Cellular Biology University of California Berkeley 06/2011

Publications (13)

Top publication keywords:
OligopeptidesTubulinAutophagyProto-Oncogene Proteins pp60(c-src)Multiple MyelomaAutophagosomesRibosomesProteasome InhibitorsLipid-Linked ProteinsEndoplasmic ReticulumRNA SplicingMyristic AcidDisulfidesActinsSpliceosomes

• ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells.
  The EMBO journal 2022 Kai F, Ou G, Tourdot RW, Stashko C, Gaietta G, Swift MF, Volkmann N, Long AF, Han Y, Huang HH, Northey JJ, Leidal AM, Viasnoff V, Bryant DM, Guo W, Wiita AP, Guo M, Dumont S, Hanein D, Radhakrishnan R…
• GRASP55 restricts early-stage autophagy and regulates spatial organization of the early secretory network.
  Biology open 2021 Liu JY, Lin YT, Leidal AM, Huang HH, Ye J, Wiita AP, Debnath J
• Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma.
  Nature communications 2020 Huang HH, Ferguson ID, Thornton AM, Bastola P, Lam C, Lin YT, Choudhry P, Mariano MC, Marcoulis MD, Teo CF, Malato J, Phojanakong PJ, Martin TG, Wolf JL, Wong SW, Shah N, Hann B, Brooks AN, Wiita AP
• The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles.
  Nature cell biology 2020 Leidal AM, Huang HH, Marsh T, Solvik T, Zhang D, Ye J, Kai F, Goldsmith J, Liu JY, Huang YH, Monkkonen T, Vlahakis A, Huang EJ, Goodarzi H, Yu L, Wiita AP, Debnath J
• Time-Resolved Proteomics Extends Ribosome Profiling-Based Measurements of Protein Synthesis Dynamics.
  Cell systems 2017 Liu TY, Huang HH, Wheeler D, Xu Y, Wells JA, Song YS, Wiita AP

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• Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis.
  Neuron 2016 Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN
• Dynamic Organization of Myristoylated Src in the Live Cell Plasma Membrane.
  The journal of physical chemistry. B 2016 Smith AW, Huang HH, Endres NF, Rhodes C, Groves JT
• Monitoring lipid anchor organization in cell membranes by PIE-FCCS.
  Journal of the American Chemical Society 2012 Triffo SB, Huang HH, Smith AW, Chou ET, Groves JT
• A single-molecule assay to directly identify solvent-accessible disulfide bonds and probe their effect on protein folding.
  Journal of the American Chemical Society 2007 Ainavarapu SR, Wiita AP, Huang HH, Fernandez JM
• ATP ground- and transition states of bacterial enhancer binding AAA+ ATPases support complex formation with their target protein, sigma54.
  Structure (London, England : 1993) 2007 Chen B, Doucleff M, Wemmer DE, De Carlo S, Huang HH, Nogales E, Hoover TR, Kondrashkina E, Guo L, Nixon BT
• Contour length and refolding rate of a small protein controlled by engineered disulfide bonds.
  Biophysical journal 2006 Ainavarapu SR, Brujic J, Huang HH, Wiita AP, Lu H, Li L, Walther KA, Carrion-Vazquez M, Li H, Fernandez JM
• Force-dependent chemical kinetics of disulfide bond reduction observed with single-molecule techniques.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Wiita AP, Ainavarapu SR, Huang HH, Fernandez JM
• Crystal structures of the BtuF periplasmic-binding protein for vitamin B12 suggest a functionally important reduction in protein mobility upon ligand binding.
  The Journal of biological chemistry 2002 Karpowich NK, Huang HH, Smith PC, Hunt JF