Heather Huddleston, MD
Professor
Ob/Gyn, Reproductive Sciences
School of Medicine

She also has expertise in techniques for diagnosing and treating complex uterine causes of infertility, including hysteroscopy, in which a thin, lighted tube is inserted into the vagina to allow examination of the cervix and interior of the uterus.

As director of the UCSF PCOS Clinic and research program, Huddleston oversees multiple research projects focused on improving medical understanding of PCOS. She also conducts research on recurrent pregnancy loss and treatment approaches for uterine factor infertility (abnormalities of the uterus that interfere with pregnancy). She has spoken on her findings all over the country, and her research has been widely published in scientific journals.

Huddleston earned her medical degree at Harvard Medical School. She completed a residency in obstetrics and gynecology, followed by a fellowship in reproductive endocrinology and infertility, at Brigham and Women's Hospital and Massachusetts General Hospital.

Huddleston is a member of the American Society for Reproductive Medicine and American College of Obstetricians and Gynecologists.

• Improved Clinical Outcomes With Dynamic, Force-Controlled, Gap-Balancing in Posterior-Stabilized Total Knee Arthroplasty.
  The Journal of arthroplasty 2024 Valtanen RS, Seligson M, Huddleston HG, Angibaud L, Huddleston JI
• Productivity loss due to polycystic ovary syndrome and its relationship to race, mental health and healthcare delivery indices.
  F&S reports 2024 Huddleston HG, Milani A, Blank R
• Associations of Polycystic Ovary Syndrome With Indicators of Brain Health at Midlife in the CARDIA Cohort.
  Neurology 2024 Huddleston HG, Jaswa EG, Casaletto KB, Neuhaus J, Kim C, Wellons M, Launer LJ, Yaffe K
• Vigorous vs. moderate exercise to improve glucose metabolism in inactive women with polycystic ovary syndrome and insulin resistance: a pilot randomized controlled trial of two home-based exercise routines.
  F&S reports 2023 Wang A, Noel M, Christ JP, Corley J, Lenhart N, Cedars MI, Huddleston H
• Platelet-rich plasma infusion as an adjunct treatment for persistent thin lining in frozen embryo transfer cycles: first US experience report.
  Journal of assisted reproduction and genetics 2023 Aghajanova L, Zhang A, Lathi RB, Huddleston HG
• Association between social media use for medical information during pregnancy and likelihood of vaccination against COVID-19.
  AJOG global reports 2023 Jaswa EG, Lindquist KJ, Hariton E, Aliaga KE, Cedars MI, Huddleston HG
• Decision regret among women considering planned oocyte cryopreservation: a prospective cohort study.
  Journal of assisted reproduction and genetics 2023 Jaswa EG, Pasch LA, McGough A, Wong R, Corley J, Cedars MI, Huddleston HG
• Women's Reproductive Milestones and Cardiovascular Disease Risk: A Review of Reports and Opportunities From the CARDIA Study.
  Journal of the American Heart Association 2023 Kim C, Catov J, Schreiner PJ, Appiah D, Wellons MF, Siscovick D, Calderon-Margalit R, Huddleston H, Ebong IA, Lewis CE
• Endophenotypic correlates of cognitive function in reproductive-age individuals with polycystic ovary syndrome.
  F&S reports 2022 Huddleston HG, Casaletto KB, Jaswa EG, Rasgon NL, Maki PP, Cedars MI, Pasch L
• Learning from Online Video Education (LOVE) improves confidence in fertility treatments: a randomized controlled trial.
  NPJ digital medicine 2022 Adeleye A, Cruz K, Cedars MI, Pasch L, Huddleston H
• Polycystic ovary syndrome is associated with nonalcoholic steatohepatitis in women of reproductive age.
  Hepatology communications 2022 Maldonado SS, Grab J, Wang CW, Huddleston H, Cedars M, Sarkar M
• Early pregnancy anxiety during the COVID-19 pandemic: preliminary findings from the UCSF ASPIRE study.
  BMC pregnancy and childbirth 2022 Morris JR, Jaswa E, Kaing A, Hariton E, Andrusier M, Aliaga K, Davis M, Cedars MI, Huddleston HG
• Decision regret after failed autologous in vitro fertilization in women ≥42 years of age.
  Fertility and sterility 2022 Huang D, Jaswa E, Ransohoff A, Boscardin WJ, Pasch L, Cedars M, Huddleston H
• Diagnosis and Treatment of Polycystic Ovary Syndrome.
  JAMA 2022 Huddleston HG, Dokras A
• COVID-19 vaccination patterns and attitudes among American pregnant individuals.
  American journal of obstetrics & gynecology MFM 2021 Huddleston HG, Jaswa EG, Lindquist KJ, Kaing A, Morris JR, Hariton E, Corley J, Hoskin E, Gaw SL, Cedars MI
• Autologous platelet-rich plasma treatment for moderate-severe Asherman syndrome: the first experience.
  Journal of assisted reproduction and genetics 2021 Aghajanova L, Sundaram V, Kao CN, Letourneau JM, Manvelyan E, Cedars MI, Huddleston HG
• Association of obstructive sleep apnea risk with depression and anxiety symptoms in women with polycystic ovary syndrome.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2021 Zhou X, Jaswa E, Pasch L, Shinkai K, Cedars MI, Huddleston HG
• Predictors of adequate physical activity within a multiethnic polycystic ovary syndrome patient population: a cross-sectional assessment.
  BMC women's health 2021 Huang D, Jaswa E, Kao CN, Quinn M, Cedars M, Huddleston H
• Let there be light: does circadian rhythm disruption cause polycystic ovary syndrome?
  Fertility and sterility 2021 Zhou X, Huddleston H
• Sexual dysfunction in polycystic ovary syndrome: a complex entity that may find improvement with the simplest of solutions.
  Fertility and sterility 2021 Huddleston HG
• Increased Body Mass Index Is Associated With A Nondilutional Reduction in Antimüllerian Hormone.
  The Journal of clinical endocrinology and metabolism 2020 Jaswa EG, Rios JS, Cedars MI, Santoro NF, Pavone MEG, Legro RS, Huddleston HG
• Comparison of metabolic syndrome elements in White and Asian women with polycystic ovary syndrome: results of a regional, American cross-sectional study.
  F&S reports 2020 Chahal N, Quinn M, Jaswa EA, Kao CN, Cedars MI, Huddleston HG
• Highly elevated level of antimüllerian hormone associated with preterm delivery in polycystic ovary syndrome patients who underwent ovulation induction.
  Fertility and sterility 2020 Kaing A, Jaswa EA, Diamond MP, Legro RS, Cedars MI, Huddleston HG
• Differences in perceived stress during ovarian stimulation between women with infertility and those pursing oocyte cryopreservation.
  Fertility and sterility 2020 Adeleye A, Cruz K, Pasch L, Huddleston H
• Obesity and depression are risk factors for future eating disorder-related attitudes and behaviors in women with polycystic ovary syndrome.
  Fertility and sterility 2020 Greenwood EA, Pasch LA, Cedars MI, Huddleston HG
• Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index.
  The Journal of clinical endocrinology and metabolism 2020 Rios JS, Greenwood EA, Pavone MEG, Cedars MI, Legro RS, Diamond MP, Santoro N, Sun F, Robinson RD, Christman G, Zhang H, Huddleston HG
• Polycystic ovary syndrome (PCOS) is associated with NASH severity and advanced fibrosis.
  Liver international : official journal of the International Association for the Study of the Liver 2019 Sarkar M, Terrault N, Chan W, Cedars MI, Huddleston HG, Duwaerts CC, Balitzer D, Gill RM
• Insulin resistance in polycystic ovary syndrome: concept versus cutoff.
  Fertility and sterility 2019 Greenwood EA, Huddleston HG
• Depression Over the Lifespan in a Population-Based Cohort of Women With Polycystic Ovary Syndrome: Longitudinal Analysis.
  The Journal of clinical endocrinology and metabolism 2019 Greenwood EA, Yaffe K, Wellons MF, Cedars MI, Huddleston HG
• Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee.
  The Journal of clinical endocrinology and metabolism 2019 Carmina E, Azziz R, Bergfeld W, Escobar-Morreale HF, Futterweit W, Huddleston H, Lobo R, Olsen E
• Interpregnancy interval and singleton pregnancy outcomes after frozen embryo transfer.
  Fertility and sterility 2019 Quinn MM, Rosen MP, Allen IE, Huddleston HG, Cedars MI, Fujimoto VY
• Improved diagnostic performance for the diagnosis of polycystic ovary syndrome using age-stratified criteria.
  Fertility and sterility 2019 Ahmad AK, Quinn M, Kao CN, Greenwood E, Cedars MI, Huddleston HG
• Clinical course of depression symptoms and predictors of enduring depression risk in women with polycystic ovary syndrome: Results of a longitudinal study.
  Fertility and sterility 2018 Greenwood EA, Pasch LA, Shinkai K, Cedars MI, Huddleston HG
• Speak up! Equipping women with polycystic ovary syndrome to have high quality encounters with their providers.
  Fertility and sterility 2018 Greenwood EA, Huddleston HG
• Decreased clinical pregnancy and live birth rates after short interval from delivery to subsequent assisted reproductive treatment cycle.
  Human reproduction (Oxford, England) 2018 Quinn MM, Rosen MP, Allen IE, Huddleston HG, Cedars MI, Fujimoto VY
• Interpregnancy Interval and Singleton Live Birth Outcomes From In Vitro Fertilization.
  Obstetrics and gynecology 2018 Quinn MM, Rosen MP, Huddleston HG, Cedars MI, Fujimoto VY
• Association among depression, symptom experience, and quality of life in polycystic ovary syndrome.
  American journal of obstetrics and gynecology 2018 Greenwood EA, Pasch LA, Cedars MI, Legro RS, Huddleston HG, Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicin
• Insulin resistance is associated with depression risk in polycystic ovary syndrome.
  Fertility and sterility 2018 Greenwood EA, Pasch LA, Cedars MI, Legro RS, Eisenberg E, Huddleston HG, Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicin
• To freeze or not to freeze: decision regret and satisfaction following elective oocyte cryopreservation.
  Fertility and sterility 2018 Greenwood EA, Pasch LA, Hastie J, Cedars MI, Huddleston HG
• Continuum of polycystic ovary syndrome physiology.
  Fertility and sterility 2018 Huddleston HG
• The Association of Hispanic Ethnicity with Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome.
  Current opinion in gynecology and obstetrics 2018 Sarkar M, Terrault N, Duwaerts CC, Tien P, Cedars MI, Huddleston H
• Platelet-rich plasma in the management of Asherman syndrome: case report.
  Journal of assisted reproduction and genetics 2018 Aghajanova L, Cedars MI, Huddleston HG
• Differential rate in decline in ovarian reserve markers in women with polycystic ovary syndrome compared with control subjects: results of a longitudinal study.
  Fertility and sterility 2018 Ahmad AK, Kao CN, Quinn M, Lenhart N, Rosen M, Cedars MI, Huddleston H
• In vitro evidence that platelet-rich plasma stimulates cellular processes involved in endometrial regeneration.
  Journal of assisted reproduction and genetics 2018 Aghajanova L, Houshdaran S, Balayan S, Manvelyan E, Irwin JC, Huddleston HG, Giudice LC
• Antimüllerian hormone levels and antral follicle counts are not reduced compared with community controls in patients with rigorously defined unexplained infertility.
  Fertility and sterility 2017 Greenwood EA, Cedars MI, Santoro N, Eisenberg E, Kao CN, Haisenleder DJ, Diamond MP, Huddleston HG, National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human De
• Women with polycystic ovary syndrome demonstrate worsening markers of cardiovascular risk over the short-term despite declining hyperandrogenaemia: Results of a longitudinal study with community controls.
  Clinical endocrinology 2017 Huddleston HG, Quinn MM, Kao CN, Lenhart N, Rosen MP, Cedars MI
• Age-stratified thresholds of anti-Müllerian hormone improve prediction of polycystic ovary syndrome over a population-based threshold.
  Clinical endocrinology 2017 Quinn MM, Kao CN, Ahmad AK, Haisenleder DJ, Santoro N, Eisenberg E, Legro RS, Cedars MI, Huddleston HG, NIH/NICHD Reproductive Medicine Network
• Rotterdam criteria-based diagnostic subtype is not a strong predictor of cutaneous phenotype in patients with polycystic ovary syndrome: A cross-sectional study.
  Journal of the American Academy of Dermatology 2017 Schmidt TH, Okhovat JP, Khanijow K, Huddleston H, Cedars M, Pasch L, Wang ET, Lee J, Shinkai K
• Transvaginal Obliteration of a Complex Uterine Arteriovenous Fistula Using Ethylene Vinyl Alcohol Copolymer.
  Journal of vascular and interventional radiology : JVIR 2017 Lehrman ED, Heller M, Poder L, Kerlan R, Huddleston HG, Kohi MP
• Ovarian morphology is associated with insulin resistance in women with polycystic ovary syndrome: a cross sectional study.
  Fertility research and practice 2017 Reid SP, Kao CN, Pasch L, Shinkai K, Cedars MI, Huddleston HG
• A higher prevalence of endometriosis among Asian women does not contribute to poorer IVF outcomes.
  Journal of assisted reproduction and genetics 2017 Yamamoto A, Johnstone EB, Bloom MS, Huddleston HG, Fujimoto VY
• Association of ethnicity, Fitzpatrick skin type, and hirsutism: A retrospective cross-sectional study of women with polycystic ovarian syndrome.
  International journal of women's dermatology 2017 Afifi L, Saeed L, Pasch LA, Huddleston HG, Cedars MI, Zane LT, Shinkai K
• Raising threshold for diagnosis of polycystic ovary syndrome excludes population of patients with metabolic risk.
  Fertility and sterility 2016 Quinn MM, Kao CN, Ahmad A, Lenhart N, Shinkai K, Cedars MI, Huddleston HG
• Clinician vs Self-ratings of Hirsutism in Patients With Polycystic Ovarian Syndrome: Associations With Quality of Life and Depression.
  JAMA dermatology 2016 Pasch L, He SY, Huddleston H, Cedars MI, Beshay A, Zane LT, Shinkai K
• Cutaneous Findings and Systemic Associations in Women With Polycystic Ovary Syndrome.
  JAMA dermatology 2016 Schmidt TH, Khanijow K, Cedars MI, Huddleston H, Pasch L, Wang ET, Lee J, Zane LT, Shinkai K
• Vigorous exercise is associated with superior metabolic profiles in polycystic ovary syndrome independent of total exercise expenditure.
  Fertility and sterility 2015 Greenwood EA, Noel MW, Kao CN, Shinkai K, Pasch LA, Cedars MI, Huddleston HG
• Putative role for insulin resistance in depression risk in polycystic ovary syndrome.
  Fertility and sterility 2015 Greenwood EA, Pasch LA, Shinkai K, Cedars MI, Huddleston HG
• Does Intraoperative Fluoroscopy Optimize Limb Length and the Precision of Acetabular Positioning in Primary THA?
  Orthopedics 2015 Leucht P, Huddleston HG, Bellino MJ, Huddleston JI
• Polycystic Ovary Syndrome: Special Diagnostic and Therapeutic Considerations for Children.
  Pediatric dermatology 2015 Kamangar F, Okhovat JP, Schmidt T, Beshay A, Pasch L, Cedars MI, Huddleston H, Shinkai K
• Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro.
  Human reproduction (Oxford, England) 2015 Piltonen TT, Chen JC, Khatun M, Kangasniemi M, Liakka A, Spitzer T, Tran N, Huddleston H, Irwin JC, Giudice LC
• Prevalence of androgenic alopecia in patients with polycystic ovary syndrome and characterization of associated clinical and biochemical features.
  Fertility and sterility 2014 Quinn M, Shinkai K, Pasch L, Kuzmich L, Cedars M, Huddleston H
• Oocyte donors' comprehension as assessed by the EDICT (Egg Donor Informed Consent Tool).
  Fertility and sterility 2013 Skillern AA, Cedars MI, Huddleston HG
• Biomarkers of ovarian reserve in women with polycystic ovary syndrome.
  Seminars in reproductive medicine 2013 Huddleston HG
• Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential.
  The Journal of clinical endocrinology and metabolism 2013 Piltonen TT, Chen J, Erikson DW, Spitzer TL, Barragan F, Rabban JT, Huddleston H, Irwin JC, Giudice LC
• Phenotypic comparison of Caucasian and Asian women with polycystic ovary syndrome: a cross-sectional study.
  Fertility and sterility 2013 Wang ET, Kao CN, Shinkai K, Pasch L, Cedars MI, Huddleston HG
• Egg Donor Informed Consent Tool (EDICT): development and validation of a new informed consent tool for oocyte donors.
  Fertility and sterility 2013 Skillern A, Cedars M, Huddleston H
• Cost-effectiveness of cytogenetic evaluation of products of conception in the patient with a second pregnancy loss.
  Fertility and sterility 2012 Foyouzi N, Cedars MI, Huddleston HG
• MI TKA: a risk factor for early revision surgery.
  The journal of knee surgery 2012 Mayle RE, Graw BP, Huddleston HG, Woolson ST, Goodman SB, Huddleston JI
• Age-related differences in the reproductive and metabolic implications of polycystic ovarian syndrome: findings in an obese, United States population.
  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2012 Johnstone EB, Davis G, Zane LT, Cedars MI, Huddleston HG
• Advanced age and comorbidity increase the risk for adverse events after revision total hip arthroplasty.
  The Journal of arthroplasty 2012 Koenig K, Huddleston JI, Huddleston H, Maloney WJ, Goodman SB
• Correlations of follicular fluid oxidative stress biomarkers and enzyme activities with embryo morphology parameters during in vitro fertilization.
  Fertility and sterility 2011 Fujimoto VY, Bloom MS, Huddleston HG, Shelley WB, Ocque AJ, Browne RW
• Ethnic variation in estradiol metabolism in reproductive age Asian and white women treated with transdermal estradiol.
  Fertility and sterility 2011 Huddleston HG, Rosen MP, Gibson M, Cedars MI, Fujimoto VY
• Asian ethnicity and fecundability in women with spontaneous conceptions.
  Fertility and sterility 2011 Wang ET, Fujimoto VY, Yeaton-Massey AJ, Vittinghoff E, Caughey AB, Huddleston HG
• Asian immigrants to the United States are less likely to donate cryopreserved embryos for research use.
  Fertility and sterility 2011 Sharma H, Johnstone EB, Gates E, Sohn SH, Huddleston HG, Fujimoto VY
• Physical activity in women with polycystic ovary syndrome: prevalence, predictors, and positive health associations.
  American journal of obstetrics and gynecology 2011 Lamb JD, Johnstone EB, Rousseau JA, Jones CL, Pasch LA, Cedars MI, Huddleston HG
• Minimal incision surgery as a risk factor for early failure of total hip arthroplasty.
  Clinical orthopaedics and related research 2010 Graw BP, Woolson ST, Huddleston HG, Goodman SB, Huddleston JI
• Racial and ethnic disparities in reproductive endocrinology and infertility.
  American journal of obstetrics and gynecology 2010 Huddleston HG, Cedars MI, Sohn SH, Giudice LC, Fujimoto VY
• Health disparities: definitions and measurements.
  American journal of obstetrics and gynecology 2010 Dehlendorf C, Bryant AS, Huddleston HG, Jacoby VL, Fujimoto VY
• Asian ethnicity in anonymous oocyte donors is associated with increased estradiol levels but comparable recipient pregnancy rates compared with Caucasians.
  Fertility and sterility 2010 Huddleston HG, Rosen MP, Lamb JD, Modan A, Cedars MI, Fujimoto VY
• Follicular fluid high density lipoprotein-associated micronutrient levels are associated with embryo fragmentation during IVF.
  Journal of assisted reproduction and genetics 2009 Browne RW, Bloom MS, Shelly WB, Ocque AJ, Huddleston HG, Fujimoto VY
• Asian ethnicity is associated with decreased pregnancy rates following intrauterine insemination.
  Reproductive biomedicine online 2009 Lamb JD, Huddleston HG, Purcell KJ, Modan A, Farsani TT, Dingeldein MA, Vittinghoff E, Fujimoto VY
• Fertilization rate is an independent predictor of implantation rate.
  Fertility and sterility 2009 Rosen MP, Shen S, Rinaudo PF, Huddleston HG, McCulloch CE, Cedars MI
• hMG increases the yield of mature oocytes and excellent-quality embryos in patients with a previous cycle having a high incidence of oocyte immaturity.
  Fertility and sterility 2009 Huddleston HG, Jackson KV, Doyle JO, Racowsky C
• Distributions of high-density lipoprotein particle components in human follicular fluid and sera and their associations with embryo morphology parameters during IVF.
  Human reproduction (Oxford, England) 2008 Browne RW, Shelly WB, Bloom MS, Ocque AJ, Sandler JR, Huddleston HG, Fujimoto VY
• Coasting vs. cryopreservation of all embryos for prevention of ovarian hyperstimulation syndrome in in vitro fertilization.
  Fertility and sterility 2007 Huddleston HG, Racowsky C, Jackson KV, Fox JH, Ginsburg ES
• Clinical applications of microarray technology: creatine kinase B is an up-regulated gene in epithelial ovarian cancer and shows promise as a serum marker.
  Gynecologic oncology 2005 Huddleston HG, Wong KK, Welch WR, Berkowitz RS, Mok SC
• Immune interactions at the maternal-fetal interface: a focus on antigen presentation.
  American journal of reproductive immunology (New York, N.Y. : 1989) 2004 Huddleston H, Schust DJ