Hayarpi Torosyan
Postdoctoral Scholar
Cardiovascular Research Inst
School of Medicine

Publications (16)

Top publication keywords:
Lipid BilayersProtein MultimerizationSterolsCatalytic DomainEnzyme ActivationCytoskeletal ProteinsProto-Oncogene Proteins p21(ras)beta-Lactamase InhibitorsExcipientsClass I Phosphatidylinositol 3-Kinasesbeta-LactamasesColloids14-3-3 ProteinsEnzyme InhibitorsDrug Compounding

• Structures of the PI3Kα/KRas complex on lipid bilayers reveal molecular mechanisms of PI3Kα activation.
  Molecular cell 2026 Torosyan H, Paul MD, Meyer BG, Maker A, Jura N, Verba KA
• Structures of the PI3Kα/KRas complex on lipid bilayers reveal the molecular mechanism of PI3Kα activation.
  bioRxiv : the preprint server for biology 2025 Torosyan H, Paul MD, Maker A, Meyer BG, Jura N, Verba KA
• Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3.
  Nature communications 2023 Torosyan H, Paul MD, Forget A, Lo M, Diwanji D, Pawlowski K, Krogan NJ, Jura N, Verba KA
• CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids.
  Nature communications 2022 Lo M, Sharir A, Paul MD, Torosyan H, Agnew C, Li A, Neben C, Marangoni P, Xu L, Raleigh DR, Jura N, Klein OD
• Piquing our interest: Insights into the role of PEAK3 in signaling and disease.
  Science signaling 2022 Paul MD, Torosyan H, Jura N

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• Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma.
  The Journal of clinical investigation 2021 Jin N, Keam B, Cho J, Lee MJ, Kim HR, Torosyan H, Jura N, Ng PK, Mills GB, Li H, Zeng Y, Barbash Z, Tarcic G, Kang H, Bauman JE, Kim MO, VanLandingham NK, Swaney DL, Krogan NJ, Johnson DE, Grandis JR
• Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding.
  ACS chemical biology 2020 Newberry RW, Arhar T, Costello J, Hartoularos GC, Maxwell AM, Naing ZZC, Pittman M, Reddy NR, Schwarz DMC, Wassarman DR, Wu TS, Barrero D, Caggiano C, Catching A, Cavazos TB, Estes LS, Faust B, Fink …
• The activities of drug inactive ingredients on biological targets.
  Science (New York, N.Y.) 2020 Pottel J, Armstrong D, Zou L, Fekete A, Huang XP, Torosyan H, Bednarczyk D, Whitebread S, Bhhatarai B, Liang G, Jin H, Ghaemi SN, Slocum S, Lukacs KV, Irwin JJ, Berg EL, Giacomini KM, Roth BL, …
• Protein Stability Effects in Aggregate-Based Enzyme Inhibition.
  Journal of medicinal chemistry 2019 Torosyan H, Shoichet BK
• Triggered Release Enhances the Cytotoxicity of Stable Colloidal Drug Aggregates.
  ACS chemical biology 2019 Donders EN, Ganesh AN, Torosyan H, Lak P, Shoichet BK, Shoichet MS
• Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Korczynska M, Clark MJ, Valant C, Xu J, Moo EV, Albold S, Weiss DR, Torosyan H, Huang W, Kruse AC, Lyda BR, May LT, Baltos JA, Sexton PM, Kobilka BK, Christopoulos A, Shoichet BK, Sunahara RK
• Internal Structure and Preferential Protein Binding of Colloidal Aggregates.
  ACS chemical biology 2016 Duan D, Torosyan H, Elnatan D, McLaughlin CK, Logie J, Shoichet MS, Agard DA, Shoichet BK
• Structure-based approach for identification of novel phenylboronic acids as serine-β-lactamase inhibitors.
  Journal of computer-aided molecular design 2016 Sgrignani J, De Luca F, Torosyan H, Docquier JD, Duan D, Novati B, Prati F, Colombo G, Grazioso G
• Identification of Novel Smoothened Ligands Using Structure-Based Docking.
  PloS one 2016 Lacroix C, Fish I, Torosyan H, Parathaman P, Irwin JJ, Shoichet BK, Angers S
• Stable Colloidal Drug Aggregates Catch and Release Active Enzymes.
  ACS chemical biology 2016 McLaughlin CK, Duan D, Ganesh AN, Torosyan H, Shoichet BK, Shoichet MS
• An Aggregation Advisor for Ligand Discovery.
  Journal of medicinal chemistry 2015 Irwin JJ, Duan D, Torosyan H, Doak AK, Ziebart KT, Sterling T, Tumanian G, Shoichet BK