Harish Vasudevan, MD, PhD
Assistant Professor
Radiation Oncology
School of Medicine

I am a physician scientist in the Departments of Radiation Oncology and Neurological Surgery. My clinical expertise is providing radiotherapy for children and adults with nervous system cancers. My scientific focus is understanding oncogenic growth factor signaling through receptor tyrosine kinases and the Ras signaling pathway with an emphasis on neurofibromatosis and nervous system tumors to identify better treatments for patients.

Education & Training

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• Radiation Oncology UCSF 2022
• Internal Medicine California Pacific Medical Center 2018
• MD, PhD Medicine, Neuroscience Mount Sinai School of Medicine 2017
• B.S. Biology California Institute of Technology 2009

Websites

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• Vasudevan Laboratory (vasudevanlab.ucsf.edu)

Grants and Projects

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• Dissecting Ras GAP Specificity in the Peripheral Nervous System, Department of Defense, 2024-2027
• Francis Collins Scholar, Neurofibromatosis Therapeutic Acceleration Program, 2022-2025
• Too much of a GAP: full length NF1 reconstitution in neurofibroma and MPNST, Children's Tumor Foundation, 2023-2024

Publications (52)

Top publication keywords:
Receptor Protein-Tyrosine KinasesNeurofibromin 1Peripheral Nervous System NeoplasmsNeurofibromatosis 2MelanomaNeurilemmomaNeural CrestNeurofibromatosis 1Brain NeoplasmsMeningiomaNasopharyngeal NeoplasmsGenetic HeterogeneityMeningeal NeoplasmsSchwann CellsNeurofibromatoses

• Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance.
  Nature communications 2024 Vasudevan HN, Payne E, Delley CL, John Liu S, Mirchia K, Sale MJ, Lastella S, Nunez MS, Lucas CG, Eaton CD, Casey-Clyde T, Magill ST, Chen WC, Braunstein SE, Perry A, Jacques L, Reddy AT, Pekmezci M, …
• Molecular Features of Resected Melanoma Brain Metastases, Clinical Outcomes, and Responses to Immunotherapy.
  JAMA network open 2023 Vasudevan HN, Delley C, Chen WC, Mirchia K, Pan S, Shukla P, Aabedi AA, Nguyen MP, Morshed RA, Young JS, Boreta L, Fogh SE, Nakamura JL, Theodosopoulos PV, Phillips J, Hervey-Jumper SL, Daras M, Pike …
• Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer.
  Neurosurgery 2021 Vasudevan HN, Lucas CG, Villanueva-Meyer JE, Theodosopoulos PV, Raleigh DR
• Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival.
  Neuro-oncology advances 2020 Lucas CG, Vasudevan HN, Chen WC, Magill ST, Braunstein SE, Jacques L, Dahiya S, Rodriguez FJ, Horvai AE, Perry A, Pekmezci M, Raleigh DR
• Comprehensive Molecular Profiling Identifies FOXM1 as a Key Transcription Factor for Meningioma Proliferation.
  Cell reports 2018 Vasudevan HN, Braunstein SE, Phillips JJ, Pekmezci M, Tomlin BA, Wu A, Reis GF, Magill ST, Zhang J, Feng FY, Nicholaides T, Chang SM, Sneed PK, McDermott MW, Berger MS, Perry A, Raleigh DR
• SRF regulates craniofacial development through selective recruitment of MRTF cofactors by PDGF signaling.
  Developmental cell 2014 Vasudevan HN, Soriano P

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• MerlinS13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features.
  Nature communications 2024 Eaton CD, Avalos L, Liu SJ, Chen Z, Zakimi N, Casey-Clyde T, Bisignano P, Lucas CG, Stevenson E, Choudhury A, Vasudevan HN, Magill ST, Young JS, Krogan NJ, Villanueva-Meyer JE, Swaney DL, Raleigh DR
• In Reply to the Letter to the Editor Regarding "Mutational Status and Clinical Outcomes Following Systemic Therapy with or without Focal Radiation for Resected Melanoma Brain Metastases".
  World neurosurgery 2024 Vasudevan H, Braunstein S
• Correction to: Past, Present, and Future Therapeutic Strategies for NF‑1‑Associated Tumors.
  Current oncology reports 2024 Na B, Shah SR, Vasudevan HN
• Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest.
  bioRxiv : the preprint server for biology 2024 Casey-Clyde T, Liu SJ, Serrano JAC, Teng C, Jang YG, Vasudevan HN, Bush JO, Raleigh DR
• Demographic and clinical characteristics of patients with metastatic breast cancer and leptomeningeal disease: a single center retrospective cohort study.
  Breast cancer research and treatment 2024 Huppert LA, Fisch S, Tsopurashvili E, Somepalle SS, Salans M, Vasudevan HN, Jo Chien A, Majure M, Rugo HS, Balassanian R, Boreta L, Melisko ME
• Spatial genomic, biochemical and cellular mechanisms underlying meningioma heterogeneity and evolution.
  Nature genetics 2024 Lucas CG, Mirchia K, Seo K, Najem H, Chen WC, Zakimi N, Foster K, Eaton CD, Cady MA, Choudhury A, Liu SJ, Phillips JJ, Magill ST, Horbinski CM, Solomon DA, Perry A, Vasudevan HN, Heimberger AB, …
• Past, Present, and Future Therapeutic Strategies for NF-1-Associated Tumors.
  Current oncology reports 2024 Na B, Shah SR, Vasudevan HN
• Targeted DNA Sequencing of Cutaneous Melanoma Identifies Prognostic and Predictive Alterations.
  Cancers 2024 Haugh AM, Osorio RC, Francois RA, Tawil ME, Tsai KK, Tetzlaff M, Daud A, Vasudevan HN
• Adverse radiation effect versus tumor progression following stereotactic radiosurgery for brain metastases: Implications of radiologic uncertainty.
  Journal of neuro-oncology 2024 Salans M, Ni L, Morin O, Ziemer B, Capaldi DPI, Raleigh DR, Vasudevan HN, Chew J, Nakamura J, Sneed PK, Boreta L, Villanueva-Meyer JE, Theodosopoulos P, Braunstein S
• Epigenetic reprogramming shapes the cellular landscape of schwannoma.
  Nature communications 2024 Liu SJ, Casey-Clyde T, Cho NW, Swinderman J, Pekmezci M, Dougherty MC, Foster K, Chen WC, Villanueva-Meyer JE, Swaney DL, Vasudevan HN, Choudhury A, Pak J, Breshears JD, Lang UE, Eaton CD, Hiam-Galvez…
• Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses.
  Nature medicine 2023 Chen WC, Choudhury A, Youngblood MW, Polley MC, Lucas CG, Mirchia K, Maas SLN, Suwala AK, Won M, Bayley JC, Harmanci AS, Harmanci AO, Klisch TJ, Nguyen MP, Vasudevan HN, McCortney K, Yu TJ, Bhave V, …
• Genomic analysis and clinical correlations of non-small cell lung cancer brain metastasis.
  Nature communications 2023 Skakodub A, Walch H, Tringale KR, Eichholz J, Imber BS, Vasudevan HN, Li BT, Moss NS, Hei Yu KK, Mueller BA, Powell S, Razavi P, Yu HA, Reis-Filho JS, Gomez D, Schultz N, Pike LRG
• Genomic alterations associated with postoperative nodular leptomeningeal disease after resection of brain metastases.
  Journal of neurosurgery 2023 Morshed RA, Cummins DD, Nguyen MP, Saggi S, Vasudevan HN, Braunstein SE, Goldschmidt E, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Daras M, Hervey-Jumper SL, Aghi MK
• Spatial genomic, biochemical, and cellular mechanisms drive meningioma heterogeneity and evolution.
  Research square 2023 Lucas CH, Mirchia K, Seo K, Najem H, Chen W, Zakimi N, Choudhury A, Liu SJ, Phillips J, Magill S, Horbinski C, Solomon D, Perry A, Vasudevan H, Heimberger A, Raleigh D
• Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses.
  Research square 2023 Raleigh D, Chen W, Choudhury A, Youngblood M, Polley MY, Lucas CH, Mirchia K, Maas S, Suwala A, Won M, Bayley J, Harmanci A, Harmanci A, Klisch T, Nguyen M, Vasudevan H, McCortney K, Yu T, Bhave V, …
• MerlinS13 phosphorylation controls meningioma Wnt signaling and magnetic resonance imaging features.
  Research square 2023 Eaton C, Avalos L, Liu SJ, Casey-Clyde T, Bisignano P, Lucas CH, Stevenson E, Choudhury A, Vasudevan H, Magill S, Krogan N, Villanueva-Meyer J, Swaney D, Raleigh D
• Mutational Status and Clinical Outcomes Following Systemic Therapy with or without Focal Radiation for Resected Melanoma Brain Metastases.
  World neurosurgery 2022 Vasudevan HN, Susko MS, Ma L, Nakamura JL, Raleigh DR, Boreta L, Fogh S, Theodosopoulos PV, McDermott MW, Tsai KK, Sneed PK, Braunstein SE
• Miat and interacting protein Metadherin maintain a stem-like niche to promote medulloblastoma tumorigenesis and treatment resistance.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Peng KL, Vasudevan HN, Lockney DT, Baum R, Hendrickson RC, Raleigh DR, Schmitt AM
• Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1.
  Acta neuropathologica 2022 Lucas CG, Sloan EA, Gupta R, Wu J, Pratt D, Vasudevan HN, Ravindranathan A, Barreto J, Williams EA, Shai A, Whipple NS, Bruggers CS, Maher O, Nabors B, Rodriguez M, Samuel D, Brown M, Carmichael J, Lu…
• Intratumor and informatic heterogeneity influence meningioma molecular classification.
  Acta neuropathologica 2022 Vasudevan HN, Choudhury A, Hilz S, Villanueva-Meyer JE, Chen WC, Lucas CG, Braunstein SE, Oberheim Bush NA, Butowski N, Pekmezci M, McDermott MW, Perry A, Solomon DA, Magill ST, Raleigh DR
• Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities.
  Nature genetics 2022 Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA, Seo K, Lucas CG, Casey-Clyde TJ, Vasudevan HN, Liu SJ, Villanueva-Meyer JE, Lam TC, Pu JK, Li LF, Leung GK, Swaney DL, Zhang MY, Chan JW,…
• A molecularly integrated grade for meningioma.
  Neuro-oncology 2022 Driver J, Hoffman SE, Tavakol S, Woodward E, Maury EA, Bhave V, Greenwald NF, Nassiri F, Aldape K, Zadeh G, Choudhury A, Vasudevan HN, Magill ST, Raleigh DR, Abedalthagafi M, Aizer AA, Alexander BM, …
• Resection with intraoperative cesium-131 brachytherapy as salvage therapy for recurrent brain tumors.
  Journal of neurosurgery 2022 Chen WC, Lafreniere M, Phuong C, Liu SJ, Baal JD, Lometti M, Morin O, Ziemer B, Vasudevan HN, Lucas CG, Hervey-Jumper SL, Theodosopoulos PV, Magill ST, Fogh S, Nakamura JL, Boreta L, Sneed PK, …
• Should Sentinel Lymph Node Biopsy Status Guide Adjuvant Radiation Therapy in Patients With Merkel Cell Carcinoma?
  Advances in radiation oncology 2021 Ahmad TR, Vasudevan HN, Lazar AA, Chan JW, George JR, Alvarado MD, Yu SS, Daud A, Yom SS
• Accurate Bulk Quantitation of Droplet Digital Polymerase Chain Reaction.
  Analytical chemistry 2021 Sun C, Liu L, Vasudevan HN, Chang KC, Abate AR
• Risk Stratification for Imminent Risk of Death at the Time of Palliative Radiotherapy Consultation.
  JAMA network open 2021 Wu SY, Yee E, Vasudevan HN, Fogh SE, Boreta L, Braunstein SE, Hong JC
• Nasopharyngeal Carcinoma and Its Association with Epstein-Barr Virus.
  Hematology/oncology clinics of North America 2021 Vasudevan HN, Yom SS
• Letter: Patterns of Intermediate- and High-Risk Meningioma Recurrence After Treatment With Postoperative External Beam Radiotherapy.
  Neurosurgery 2021 Susko MS, Chen WC, Vasudevan HN, Magill ST, Lucas CG, Oberheim Bush NA, Solomon DA, Theodosopoulos PV, McDermott MW, Villanueva-Meyer JE, Boreta L, Nakamura JL, Sneed PK, Braunstein SE, Raleigh DR
• Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia.
  Nature communications 2021 Demaree B, Delley CL, Vasudevan HN, Peretz CAC, Ruff D, Smith CC, Abate AR
• Accurate bulk quantitation of droplet digital PCR.
  bioRxiv : the preprint server for biology 2021 Sun C, Liu L, Vasudevan HN, Chang KC, Abate AR
• Digital droplet PCR accurately quantifies SARS-CoV-2 viral load from crude lysate without nucleic acid purification.
  Scientific reports 2021 Vasudevan HN, Xu P, Servellita V, Miller S, Liu L, Gopez A, Chiu CY, Abate AR
• A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection.
  Neurosurgery 2020 Chen WC, Vasudevan HN, Choudhury A, Pekmezci M, Lucas CG, Phillips J, Magill ST, Susko MS, Braunstein SE, Oberheim Bush NA, Boreta L, Nakamura JL, Villanueva-Meyer JE, Sneed PK, Perry A, McDermott MW,…
• Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.
  Nature communications 2020 Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, …
• Digital droplet PCR accurately quantifies SARS-CoV-2 viral load from crude lysate without nucleic acid purification.
  medRxiv : the preprint server for health sciences 2020 Vasudevan H, Xu P, Servellita V, Miller S, Liu L, Gopez A, Chiu CY, Abate AR
• The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies.
  Cancer discovery 2020 Prager BC, Vasudevan HN, Dixit D, Bernatchez JA, Wu Q, Wallace LC, Bhargava S, Lee D, King BH, Morton AR, Gimple RC, Pekmezci M, Zhu Z, Siqueira-Neto JL, Wang X, Xie Q, Chen C, Barnett GH, Vogelbaum …
• Combining Systemic Therapy With Radiation: Head and Neck Cancer Treatments in an Era of Targeted Agents and Immunotherapy.
  Journal of the National Comprehensive Cancer Network : JNCCN 2020 Vasudevan HN, Yom SS
• DNA methylation profiling demonstrates superior diagnostic classification to RNA-sequencing in a case of metastatic meningioma.
  Acta neuropathologica communications 2020 Vasudevan HN, Castro MRH, Lee JC, Villanueva-Meyer JE, Bush NAO, McDermott MW, Solomon DA, Perry A, Magill ST, Raleigh DR
• Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma.
  Cell reports 2020 Liu SJ, Magill ST, Vasudevan HN, Hilz S, Villanueva-Meyer JE, Lastella S, Daggubati V, Spatz J, Choudhury A, Orr BA, Demaree B, Seo K, Ferris SP, Abate AR, Oberheim Bush NA, Bollen AW, McDermott MW, …
• Integrated models incorporating radiologic and radiomic features predict meningioma grade, local failure, and overall survival.
  Neuro-oncology advances 2019 Morin O, Chen WC, Nassiri F, Susko M, Magill ST, Vasudevan HN, Wu A, Vallières M, Gennatas ED, Valdes G, Pekmezci M, Alcaide-Leon P, Choudhury A, Interian Y, Mortezavi S, Turgutlu K, Bush NAO, Solberg…
• Histopathological features predictive of local control of atypical meningioma after surgery and adjuvant radiotherapy.
  Journal of neurosurgery 2018 Chen WC, Magill ST, Wu A, Vasudevan HN, Morin O, Aghi MK, Theodosopoulos PV, Perry A, McDermott MW, Sneed PK, Braunstein SE, Raleigh DR
• Presenting Symptoms and Prognostic Factors for Symptomatic Outcomes Following Resection of Meningioma.
  World neurosurgery 2017 Wu A, Garcia MA, Magill ST, Chen W, Vasudevan HN, Perry A, Theodosopoulos PV, McDermott MW, Braunstein SE, Raleigh DR
• Management of Chordoma and Chondrosarcoma with Fractionated Stereotactic Radiotherapy.
  Frontiers in surgery 2017 Vasudevan HN, Raleigh DR, Johnson J, Garsa AA, Theodosopoulos PV, Aghi MK, Ames C, McDermott MW, Barani IJ, Braunstein SE
• A Thousand and One Receptor Tyrosine Kinases: Wherein the Specificity?
  Current topics in developmental biology 2016 Vasudevan HN, Soriano P
• Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways.
  eLife 2015 Vasudevan HN, Mazot P, He F, Soriano P
• The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling.
  Developmental biology 2013 Lewis AE, Vasudevan HN, O'Neill AK, Soriano P, Bush JO
• Detection of viral ribonucleic acid and histologic analysis of inflamed synovium in Ross River virus infection.
  Arthritis and rheumatism 2000 Soden M, Vasudevan H, Roberts B, Coelen R, Hamlin G, Vasudevan S, La Brooy J