Hanna Martens, PhD
Assistant Professor
Biochemistry and Biophysics
School of Medicine
The Martens lab is interested in the mechanisms of tissue aging with a specific focus on connective tissue compartments that serve as structural pillars of organ architecture.
Show full bio (90 words) Hide full bio
Our work demonstrated a central requirement for the active engagement of cellular mechanotransduction pathways in maintaining youthful organ homeostasis by limiting cellular senescence and inflammatory signaling in mechanically challenged tissue compartments (doi.org/10.1038/s41586-022-04924-6). Building on this concept, we are striving to investigate the role and importance of structural tissue compartments to the maintenance of a youthful tissue state. A special focus is understanding how aging stromal niches impact the plasticity, survival and mitotic potential of resident somatic stem cell populations and progenitor cell pools.
Education & Training
Show all (4) Hide
- PostDoc Mechanobiology University of Padua 07/2023
- Ph.D. Developmental Biology EMBL 02/2016
- M.Sc. Molecular Biotechnology Heidelberg University 11/2011
- B.Sc. Molecular Biotechnology Heidelberg University 08/2009
Publications (14)
Top publication keywords:
MicroRNAsSequence Analysis, RNATretinoinGene Expression ProfilingNucleotidyltransferasesStromal CellsEctodermSingle-Cell AnalysisOptical ImagingCell TrackingEmbryonic Stem CellsOrganogenesisMechanotransduction, CellularMouse Embryonic Stem CellsMesoderm
-
YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING.
Nature 2022 Sladitschek-Martens HL, Guarnieri A, Brumana G, Zanconato F, Battilana G, Xiccato RL, Panciera T, Forcato M, Bicciato S, Guzzardo V, Fassan M, Ulliana L, Gandin A, Tripodo C, Foiani M, Brusatin G, … -
Mechanosignaling in vertebrate development.
Developmental biology 2022 Piccolo S, Sladitschek-Martens HL, Cordenonsi M -
Multi-layered regulation of neuroectoderm differentiation by retinoic acid in a primitive streak-like context.
Stem cell reports 2022 Russo L, Sladitschek HL, Neveu PA -
Editorial: The Role of Epigenetic Modifications in Cancer Progression.
Frontiers in oncology 2021 Fujimura A, Pei H, Zhang H, Sladitschek HL, Chang L -
Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in Glioblastoma.
Nature cancer 2020 Castellan M, Guarnieri A, Fujimura A, Zanconato F, Battilana G, Panciera T, Sladitschek HL, Contessotto P, Citron A, Grilli A, Romano O, Bicciato S, Fassan M, Porcù E, Rosato A, Cordenonsi M, Piccolo …
Show all (9 more) Hide
-
MorphoSeq: Full Single-Cell Transcriptome Dynamics Up to Gastrulation in a Chordate.
Cell 2020 Sladitschek HL, Fiuza UM, Pavlinic D, Benes V, Hufnagel L, Neveu PA -
A gene regulatory network controls the balance between mesendoderm and ectoderm at pluripotency exit.
Molecular systems biology 2019 Sladitschek HL, Neveu PA -
Author Correction: Resonant out-of-phase fluorescence microscopy and remote imaging overcome spectral limitations.
Nature communications 2017 Quérard J, Zhang R, Kelemen Z, Plamont MA, Xie X, Chouket R, Roemgens I, Korepina Y, Albright S, Ipendey E, Volovitch M, Sladitschek HL, Neveu P, Gissot L, Gautier A, Faure JD, Croquette V, Le Saux T,… -
Resonant out-of-phase fluorescence microscopy and remote imaging overcome spectral limitations.
Nature communications 2017 Quérard J, Zhang R, Kelemen Z, Plamont MA, Xie X, Chouket R, Roemgens I, Korepina Y, Albright S, Ipendey E, Volovitch M, Sladitschek HL, Neveu P, Gissot L, Gautier A, Faure JD, Croquette V, Le Saux T,… -
Integrated Experimental and Theoretical Studies of Stem Cells.
Current stem cell reports 2017 Sladitschek HL, Neveu PA -
Dynamic multicolor protein labeling in living cells.
Chemical science 2017 Li C, Plamont MA, Sladitschek HL, Rodrigues V, Aujard I, Neveu P, Le Saux T, Jullien L, Gautier A -
Bidirectional Promoter Engineering for Single Cell MicroRNA Sensors in Embryonic Stem Cells.
PloS one 2016 Sladitschek HL, Neveu PA -
The bimodally expressed microRNA miR-142 gates exit from pluripotency.
Molecular systems biology 2015 Sladitschek HL, Neveu PA -
MXS-Chaining: A Highly Efficient Cloning Platform for Imaging and Flow Cytometry Approaches in Mammalian Systems.
PloS one 2015 Sladitschek HL, Neveu PA