Han Yang, PhD
Postdoctoral Scholar
Human Genetics
School of Medicine

Education & Training

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• PhD Molecular Pathology Peking University 07/2021
• BS Biological Sciences Honors Program China Agricultural University 07/2015

Publications (9)

Top publication keywords:
SOX9 Transcription FactorGenome-Wide Association StudyWnt Signaling PathwayExosomesConnective Tissue Growth FactorNucleic AcidsSignal TransductionCancer-Associated FibroblastsNetrinsImmunity, InnateAdenosine TriphosphateNeoplasmsGene Expression Regulation, NeoplasticTriple Negative Breast NeoplasmsS100 Calcium-Binding Protein A4

• High-throughput PRIME-editing screens identify functional DNA variants in the human genome.
  Molecular cell 2023 Ren X, Yang H, Nierenberg JL, Sun Y, Chen J, Beaman C, Pham T, Nobuhara M, Takagi MA, Narayan V, Li Y, Ziv E, Shen Y
• Functional characterization of Alzheimer's disease genetic variants in microglia.
  Nature genetics 2023 Yang X, Wen J, Yang H, Jones IR, Zhu X, Liu W, Li B, Clelland CD, Luo W, Wong MY, Ren X, Cui X, Song M, Liu H, Chen C, Eng N, Ravichandran M, Sun Y, Lee D, Van Buren E, Jiang MZ, Chan CSY, Ye CJ, …
• Parkinson's Disease Derived Exosomes Aggravate Neuropathology in SNCA*A53T Mice.
  Annals of neurology 2022 Huang Y, Liu Z, Li N, Tian C, Yang H, Huo Y, Li Y, Zhang J, Yu Z
• The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression.
  Science advances 2022 Yang H, Ting X, Geng YH, Xie Y, Nierenberg JL, Huo YF, Zhou YT, Huang Y, Yu YQ, Yu XY, Li XF, Ziv E, Zhang H, Fang WG, Shen Y, Tian XX
• Extracellular ATP promotes angiogenesis and adhesion of TNBC cells to endothelial cells via upregulation of CTGF.
  Cancer science 2022 Zhou YT, Yu YQ, Yang H, Yang H, Huo YF, Huang Y, Tian XX, Fang WG

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• Extracellular ATP promotes breast cancer invasion and chemoresistance via SOX9 signaling.
  Oncogene 2020 Yang H, Geng YH, Wang P, Yang H, Zhou YT, Zhang HQ, He HY, Fang WG, Tian XX
• Dysregulation in nucleic acid-sensing pathway genes is associated with cancer patients' prognosis.
  Cancer science 2020 Yan-Fei H, Han Y, Yan-Ting Z, Hui Y, Yu-Qing Y, Ipsita P, Hui-Ying H, Wei-Gang F, Xin-Xia T
• Extracellular ATP promotes breast cancer invasion and epithelial-mesenchymal transition via hypoxia-inducible factor 2α signaling.
  Cancer science 2019 Yang H, Geng YH, Wang P, Zhou YT, Yang H, Huo YF, Zhang HQ, Li Y, He HY, Tian XX, Fang WG
• Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts.
  Cancer letters 2018 Liu Y, Geng YH, Yang H, Yang H, Zhou YT, Zhang HQ, Tian XX, Fang WG