Hamish Mehaffey, PhD
Associate Specialist
Howard Hughes Medical Instit
School of Medicine

Publications (24)

Top publication keywords:
Shaw Potassium ChannelsPyramidal CellsNonlinear DynamicsPurkinje CellsElectric OrganAction PotentialsDendritesElectric FishBasal GangliaElectric StimulationVocalization, AnimalShal Potassium ChannelsModels, NeurologicalCalcium Channels, T-TypeLateral Line System

• Dynamic top-down biasing implements rapid adaptive changes to individual movements.
  eLife 2023 Tian LY, Warren TL, Mehaffey WH, Brainard MS
• Naturalistic stimulation drives opposing heterosynaptic plasticity at two inputs to songbird cortex.
  Nature neuroscience 2015 Mehaffey WH, Doupe AJ
• The Cav3-Kv4 complex acts as a calcium sensor to maintain inhibitory charge transfer during extracellular calcium fluctuations.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Anderson D, Engbers JD, Heath NC, Bartoletti TM, Mehaffey WH, Zamponi GW, Turner RW
• Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Engbers JD, Anderson D, Asmara H, Rehak R, Mehaffey WH, Hameed S, McKay BE, Kruskic M, Zamponi GW, Turner RW
• Distinct roles for I(T) and I(H) in controlling the frequency and timing of rebound spike responses.
  The Journal of physiology 2011 Engbers JD, Anderson D, Tadayonnejad R, Mehaffey WH, Molineux ML, Turner RW

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• Rebound discharge in deep cerebellar nuclear neurons in vitro.
  Cerebellum (London, England) 2010 Tadayonnejad R, Anderson D, Molineux ML, Mehaffey WH, Jayasuriya K, Turner RW
• Regulation of the KV4.2 complex by CaV3.1 calcium channels.
  Channels (Austin, Tex.) 2010 Anderson D, Rehak R, Hameed S, Mehaffey WH, Zamponi GW, Turner RW
• Regulation of neuronal activity by Cav3-Kv4 channel signaling complexes.
  Nature neuroscience 2010 Anderson D, Mehaffey WH, Iftinca M, Rehak R, Engbers JD, Hameed S, Zamponi GW, Turner RW
• Reliability of triggering postinhibitory rebound bursts in deep cerebellar neurons.
  Channels (Austin, Tex.) 2009 Tadayonnejad R, Mehaffey WH, Anderson D, Turner RW
• Ionic and neuromodulatory regulation of burst discharge controls frequency tuning.
  Journal of physiology, Paris 2008 Mehaffey WH, Ellis LD, Krahe R, Dunn RJ, Chacron MJ
• Regulation of somatic firing dynamics by backpropagating dendritic spikes.
  Journal of physiology, Paris 2008 Mehaffey WH, Fernandez FR, Doiron B, Turner RW
• Ionic factors governing rebound burst phenotype in rat deep cerebellar neurons.
  Journal of neurophysiology 2008 Molineux ML, Mehaffey WH, Tadayonnejad R, Anderson D, Tennent AF, Turner RW
• Intrinsic frequency tuning in ELL pyramidal cells varies across electrosensory maps.
  Journal of neurophysiology 2008 Mehaffey WH, Maler L, Turner RW
• SK channels provide a novel mechanism for the control of frequency tuning in electrosensory neurons.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Ellis LD, Mehaffey WH, Harvey-Girard E, Turner RW, Maler L, Dunn RJ
• Regulation of burst dynamics improves differential encoding of stimulus frequency by spike train segregation.
  Journal of neurophysiology 2007 Mehaffey WH, Fernandez FR, Maler L, Turner RW
• Climbing fiber discharge regulates cerebellar functions by controlling the intrinsic characteristics of purkinje cell output.
  Journal of neurophysiology 2007 McKay BE, Engbers JD, Mehaffey WH, Gordon GR, Molineux ML, Bains JS, Turner RW
• Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Molineux ML, McRory JE, McKay BE, Hamid J, Mehaffey WH, Rehak R, Snutch TP, Zamponi GW, Turner RW
• Distribution and function of potassium channels in the electrosensory lateral line lobe of weakly electric apteronotid fish.
  Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 2006 Mehaffey WH, Fernandez FR, Rashid AJ, Dunn RJ, Turner RW
• A-type and T-type currents interact to produce a novel spike latency-voltage relationship in cerebellar stellate cells.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Molineux ML, Fernandez FR, Mehaffey WH, Turner RW
• Deterministic multiplicative gain control with active dendrites.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Mehaffey WH, Doiron B, Maler L, Turner RW
• Dendritic Na+ current inactivation can increase cell excitability by delaying a somatic depolarizing afterpotential.
  Journal of neurophysiology 2005 Fernandez FR, Mehaffey WH, Turner RW
• Kv1 K+ channels control Purkinje cell output to facilitate postsynaptic rebound discharge in deep cerebellar neurons.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 McKay BE, Molineux ML, Mehaffey WH, Turner RW
• High-threshold K+ current increases gain by offsetting a frequency-dependent increase in low-threshold K+ current.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Fernandez FR, Mehaffey WH, Molineux ML, Turner RW
• Releasing the peri-neuronal net to patch-clamp neurons in adult CNS.
  Pflugers Archiv : European journal of physiology 2004 Morales E, Fernandez FR, Sinclair S, Molineux ML, Mehaffey WH, Turner RW