Hakan Cakmak, MD
Associate Professor
Ob/Gyn, Reproductive Sciences
School of Medicine

Dr. Cakmak is board certified in Obstetrics and Gynecology, and is a member of the American Society for Reproductive Medicine and Society of Reproductive Endocrinology and Infertility.

Dr. Cakmak has special interest and clinical expertise in assisted reproduction, fertility preservation, endometriosis, pelvic pain and minimally invasive surgery including laparoscopic/hysteroscopic surgery. He has over 40 publications in leading scientific journals in the fields of infertility, assisted reproduction, fertility preservation, assessment of egg quality, endometriosis and implantation. His current research is focused on the investigation of the regulation of gene expression during egg and early embryo development, and the prevention of toxic effects of cancer treatments on the ovary.

Dr. Cakmak is the recipient of multiple awards for clinical excellence and research including: the American Society for Reproductive Medicine Fertility Preservation Special Interest Group’s Prize Paper Award, Yale University John J. Meehan–Clifford R. Miller Award for academic excellence, Yale University “Resident of Excellence Award” for research, and the The Society of Laparoendoscopic Surgeons’ Outstanding Laparoendoscopic Resident Surgeon Award. In addition, his work on infertility has received two President’s Presenter Awards from the Society for Gynecologic Investigation.

• When is the right time to stop autologous in vitro fertilization treatment in poor responders?
  Fertility and sterility 2022 Cakmak H
• Back-to-back random-start ovarian stimulation prior to chemotherapy to maximize oocyte yield.
  Journal of assisted reproduction and genetics 2019 Wald K, Cakmak H, Mok-Lin E, Cedars M, Rosen M, Letourneau J
• mTOR inhibitor sirolimus negatively impacts in vitro fertilization outcomes.
  Journal of assisted reproduction and genetics 2019 Wald K, Cakmak H, Noel M
• Large Differences in Small RNA Composition Between Human Biofluids.
  Cell reports 2018 Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ
• Author Correction: A novel oocyte maturation trigger using 1500 IU of human chorionic gonadotropin plus 450 IU of follicle-stimulating hormone may decrease ovarian hyperstimulation syndrome across all in vitro fertilization stimulation protocols.
  Journal of assisted reproduction and genetics 2018 Anaya Y, Mata DA, Letourneau J, Cakmak H, Cedars MI, Rosen MP
• A novel oocyte maturation trigger using 1500 IU of human chorionic gonadotropin plus 450 IU of follicle-stimulating hormone may decrease ovarian hyperstimulation syndrome across all in vitro fertilization stimulation protocols.
  Journal of assisted reproduction and genetics 2017 Anaya Y, Mata DA, Letourneau J, Cakmak H, Cedars MI, Rosen MP
• Outcomes from a university-based low-cost in vitro fertilization program providing access to care for a low-resource socioculturally diverse urban community.
  Fertility and sterility 2017 Herndon CN, Anaya Y, Noel M, Cakmak H, Cedars MI
• p38 Mitogen-Activated Protein Kinase is Involved in the Pathogenesis of Endometriosis by Modulating Inflammation, but not Cell Survival.
  Reproductive sciences (Thousand Oaks, Calif.) 2017 Cakmak H, Seval-Celik Y, Arlier S, Guzeloglu-Kayisli O, Schatz F, Arici A, Kayisli UA
• Long-term hormonal contraceptive use is associated with a reversible suppression of antral follicle count and a break from hormonal contraception may improve oocyte yield.
  Journal of assisted reproduction and genetics 2017 Letourneau JM, Cakmak H, Quinn M, Sinha N, I Cedars M, Rosen MP
• Response to ovarian stimulation is not impacted by a breast cancer diagnosis.
  Human reproduction (Oxford, England) 2017 Quinn MM, Cakmak H, Letourneau JM, Cedars MI, Rosen MP
• Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Cakmak H, Franciosi F, Zamah AM, Cedars MI, Conti M
• Random-start ovarian stimulation in patients with cancer.
  Current opinion in obstetrics & gynecology 2015 Cakmak H, Rosen MP
• Bone Marrow-Derived Stem Cell (BMDSC) transplantation improves fertility in a murine model of Asherman's syndrome.
  PloS one 2014 Alawadhi F, Du H, Cakmak H, Taylor HS
• A novel "delayed start" protocol with gonadotropin-releasing hormone antagonist improves outcomes in poor responders.
  Fertility and sterility 2014 Cakmak H, Tran ND, Zamah AM, Cedars MI, Rosen MP
• Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes.
  Nature cell biology 2013 Chen J, Torcia S, Xie F, Lin CJ, Cakmak H, Franciosi F, Horner K, Onodera C, Song JS, Cedars MI, Ramalho-Santos M, Conti M
• Effective method for emergency fertility preservation: random-start controlled ovarian stimulation.
  Fertility and sterility 2013 Cakmak H, Katz A, Cedars MI, Rosen MP
• Ovarian stimulation in cancer patients.
  Fertility and sterility 2013 Cakmak H, Rosen MP
• Metaphase II (MII) oocytes obtained at different time points in the same in vitro fertilization cycle.
  Journal of assisted reproduction and genetics 2012 Cakmak H, Fujimoto VY, Zamah AM, Rosen MP, Tran ND, Cedars MI, Rinaudo PF
• Statins inhibit monocyte chemotactic protein 1 expression in endometriosis.
  Reproductive sciences (Thousand Oaks, Calif.) 2012 Cakmak H, Basar M, Seval-Celik Y, Osteen KG, Duleba AJ, Taylor HS, Lockwood CJ, Arici A
• Uterine dehiscence in early second trimester.
  Obstetrics and gynecology 2011 Zuckerwise LC, Cakmak H, Sfakianaki AK
• Implantation failure: molecular mechanisms and clinical treatment.
  Human reproduction update 2010 Cakmak H, Taylor HS
• Molecular mechanisms of treatment resistance in endometriosis: the role of progesterone-hox gene interactions.
  Seminars in reproductive medicine 2010 Cakmak H, Taylor HS
• Differential regulation of Akt phosphorylation in endometriosis.
  Reproductive biomedicine online 2009 Cinar O, Seval Y, Uz YH, Cakmak H, Ulukus M, Kayisli UA, Arici A
• Immune-endocrine interactions in endometriosis.
  Frontiers in bioscience (Elite edition) 2009 Cakmak H, Guzeloglu-Kayisli O, Kayisli UA, Arici A
• ABO and Rh blood groups distribution in patients with endometriosis.
  Archives of gynecology and obstetrics 2009 Matalliotakis I, Cakmak H, Goumenou A, Sifakis S, Ziogos E, Arici A
• Endometriosis related to family history of malignancies in the Yale series.
  Surgical oncology 2009 Matalliotakis IM, Cakmak H, Krasonikolakis GD, Dermitzaki D, Fragouli Y, Vlastos G, Arici A
• Extracellularly signal-regulated kinase activity in the human endometrium: possible roles in the pathogenesis of endometriosis.
  The Journal of clinical endocrinology and metabolism 2008 Murk W, Atabekoglu CS, Cakmak H, Heper A, Ensari A, Kayisli UA, Arici A
• Impact of body mass index on IVF and ICSI outcome: a retrospective study.
  Reproductive biomedicine online 2008 Matalliotakis I, Cakmak H, Sakkas D, Mahutte N, Koumantakis G, Arici A
• Expression and regulation of c-Jun N-terminal kinase (JNK) in endometrial cells in vivo and in vitro.
  Histochemistry and cell biology 2008 Kizilay G, Cakmak H, Yen CF, Atabekoglu C, Arici A, Kayisli UA
• The familial risk of breast cancer in women with endometriosis from Yale series.
  Surgical oncology 2008 Matalliotakis IM, Cakmak H, Mahutte N, Goumenou AG, Koumantakis G, Arici A
• Familial aggregation of endometriosis in the Yale Series.
  Archives of gynecology and obstetrics 2008 Matalliotakis IM, Arici A, Cakmak H, Goumenou AG, Koumantakis G, Mahutte NG
• Increased rate of endometriosis and spontaneous abortion in an in vitro fertilization program: no correlation with epidemiological factors.
  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2008 Matalliotakis I, Cakmak H, Dermitzaki D, Zervoudis S, Goumenou A, Fragouli Y
• Arguments for a left lateral predisposition of endometrioma.
  Fertility and sterility 2008 Matalliotakis IM, Cakmak H, Koumantakis EE, Margariti A, Neonaki M, Goumenou AG
• Epidemiological characteristics in women with and without endometriosis in the Yale series.
  Archives of gynecology and obstetrics 2007 Matalliotakis IM, Cakmak H, Fragouli YG, Goumenou AG, Mahutte NG, Arici A
• Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility.
  Fertility and sterility 2007 Matalliotakis IM, Cakmak H, Mahutte N, Fragouli Y, Arici A, Sakkas D
• Estradiol increases apoptosis in human coronary artery endothelial cells by up-regulating Fas and Fas ligand expression.
  The Journal of clinical endocrinology and metabolism 2006 Seli E, Guzeloglu-Kayisli O, Cakmak H, Kayisli UA, Selam B, Arici A
• The role of endometrium in endometriosis.
  Journal of the Society for Gynecologic Investigation 2006 Ulukus M, Cakmak H, Arici A
• Increased IL-18 levels in seminal plasma of infertile men with genital tract infections.
  American journal of reproductive immunology (New York, N.Y. : 1989) 2006 Matalliotakis IM, Cakmak H, Fragouli Y, Kourtis A, Arici A, Huszar G
• Estrogen-mediated regulation of p38 mitogen-activated protein kinase in human endometrium.
  The Journal of clinical endocrinology and metabolism 2006 Seval Y, Cakmak H, Kayisli UA, Arici A
• Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window.
  Human reproduction (Oxford, England) 2005 Seli E, Kayisli UA, Cakmak H, Bukulmez O, Bildirici I, Guzeloglu-Kayisli O, Arici A
• Inhibition of chemokines prevents intraperitoneal adhesions in mice.
  Human reproduction (Oxford, England) 2005 Berkkanoglu M, Zhang L, Ulukus M, Cakmak H, Kayisli UA, Kursun S, Arici A
• Progestin suppresses thrombin- and interleukin-1beta-induced interleukin-11 production in term decidual cells: implications for preterm delivery.
  The Journal of clinical endocrinology and metabolism 2005 Cakmak H, Schatz F, Huang ST, Buchwalder L, Rahman M, Arici A, Lockwood CJ