Guoxun Zhang, PhD
Postdoctoral Scholar
Pharmaceutical Chemistry
School of Pharmacy

Education & Training

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• PhD AI ehnaced microscopy Department of Automation, Tsinghua University 2024
• Bachelor MRI Department of Engineering Physics, Tsinghua University 2019
• Department of Materials Science and Engineering, Tsinghua University 2016

Interests

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• Robotic high-throughput imaging
• Foundation AI models for medicine
• AI enhanced microscopy

Publications (13)

Top publication keywords:
PhotonsTomographySignal-To-Noise RatioOptics and PhotonicsAction PotentialsPolymerase Chain ReactionZebrafishImage Processing, Computer-AssistedNucleic AcidsMicroscopy, FluorescenceDictyosteliumCalciumAlgorithmsImage EnhancementMicroscopy, Confocal

• Bio-friendly long-term subcellular dynamic recording by self-supervised image enhancement microscopy.
  Nature methods 2023 Zhang G, Li X, Zhang Y, Han X, Li X, Yu J, Liu B, Wu J, Yu L, Dai Q
• Rapid detection of neurons in widefield calcium imaging datasets after training with synthetic data.
  Nature methods 2023 Zhang Y, Zhang G, Han X, Wu J, Li Z, Li X, Xiao G, Xie H, Fang L, Dai Q
• Reinforcing neuron extraction and spike inference in calcium imaging using deep self-supervised denoising.
  Nature methods 2021 Li X, Zhang G, Wu J, Zhang Y, Zhao Z, Lin X, Qiao H, Xie H, Wang H, Fang L, Dai Q
• Unsupervised content-preserving transformation for optical microscopy.
  Light, science & applications 2021 Li X, Zhang G, Qiao H, Bao F, Deng Y, Wu J, He Y, Yun J, Lin X, Xie H, Wang H, Dai Q
• A Generative Lung CT Foundation Model Facilitating Disease Diagnosis and Medical Imaging
  medRxiv 2025 Zebin Gao†, Guoxun Zhang†, Hengrui Liang†, Jiaxin Liu, Liangdi Ma, Tianyun Wang, YuJia Chen, Yuchen Guo‡, Jianxing He‡, Feng Xu‡ & Qionghai Dai‡

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• Self-supervised denoising for medical imaging enhancement
  BMEMat 2025 Guoxun Zhang, Yuanyuan Wei, Ho-Pui Ho
• Dark-based optical sectioning assists background removal in fluorescence microscopy.
  Nature methods 2025 Cao R, Li Y, Zhou Y, Li M, Lin F, Wang W, Zhang G, Wang G, Jin B, Ren W, Sun Y, Zhao Z, Zhang W, Sun J, Hou Y, Xu X, Hu J, Shi W, Fu S, Liang Q, Lu Y, Li C, Zhao Y, Li Y, Kuang D, Wu J, Fei P, Qu J, …
• Accurate and Generalist Nuclei Acid Quantification Leveraging the Zero‐Shot Segment Anything Model
  Advanced science 2024 Yuanyuan Wei, Shanhang Luo, Changran Xu, Yingqi Fu, Yi Zhang, Fuyang Qu, Guoxun Zhang, Yi-Ping Ho, Ho-Pui Ho‡, Wu Yuan
• SAM-dPCR: Accurate and Generalist Nuclei Acid Quantification Leveraging the Zero-Shot Segment Anything Model.
  Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Wei Y, Luo S, Xu C, Fu Y, Zhang Y, Qu F, Zhang G, Ho YP, Ho HP, Yuan W
• High-speed in toto 3D imaging with isotropic resolution by scanning light-field tomography
  Optica 2024 Yifan Chen†, Jiamin Wu†, Bo Xiong, Zhi Lu, Yuduo Guo, Yi Zhang, Jiaqi Fan, Guihua Xiao, Guoxun Zhang, Xiaopeng Li, Xukang Wang, Zhifeng Zhao, and Qionghai Dai
• Multifocal fluorescence video-rate imaging of centimetre-wide arbitrarily shaped brain surfaces at micrometric resolution.
  Nature biomedical engineering 2023 Xie H, Han X, Xiao G, Xu H, Zhang Y, Zhang G, Li Q, He J, Zhu D, Yu X, Dai Q
• Real-time denoising enables high-sensitivity fluorescence time-lapse imaging beyond the shot-noise limit.
  Nature biotechnology 2022 Li X, Li Y, Zhou Y, Wu J, Zhao Z, Fan J, Deng F, Wu Z, Xiao G, He J, Zhang Y, Zhang G, Hu X, Chen X, Zhang Y, Qiao H, Xie H, Li Y, Wang H, Fang L, Dai Q
• Iterative tomography with digital adaptive optics permits hour-long intravital observation of 3D subcellular dynamics at millisecond scale.
  Cell 2021 Wu J, Lu Z, Jiang D, Guo Y, Qiao H, Zhang Y, Zhu T, Cai Y, Zhang X, Zhanghao K, Xie H, Yan T, Zhang G, Li X, Jiang Z, Lin X, Fang L, Zhou B, Xi P, Fan J, Yu L, Dai Q