Guo Huang, PhD
Associate Professor
Cardiovascular Research Inst
School of Medicine

B.S. Peking University (summa cum laude) Ph.D. Johns Hopkins Medical Institute (Phi Beta Kappa) Postdoc. UT Southwestern Medical Center (Life Sciences Research Foundation Fellow)

Awards

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• Mid-Career Investigator Research Scholarship Award, International Society for Heart Research North American Section, 2023
• Established Investigator Award, American Heart Association, 2022
• Transformational Project Award, American Heart Association, 2020
• Discovery Award, Department of Defense, 2019
• Program for Breakthrough Biomedical Research, UCSF, 2018
• Independence Award, UCSF, 2017
• AFAR Junior Faculty Grant, American Federation for Aging Research, 2016-2018
• AHA Career Beginning Grant-in-aid Award, American Heart Association, 2016-2018
• Basil O'Connor Starter Award, March of Dimes Foundation, 2016-2018
• Academic Senator Award, UCSF, 2015
• Mallinckrodt Young Investigaor Grants, Edward Mallinckrodt Jr. Foundation, 2014-2017
• Program for Breakthrough Biomedical Research, UCSF, 2014-2015
• O'Donnell Foundation Fund, LSRF, 2014
• NIH Pathway to Independence Award (K99/R00), NIH/NHBLI, 2012-2017
• Life Sciences Research Foundation Fellowship, LSRF, 2009-2012

Websites

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• @@GuonHuang on Twitter (twitter.com)
• Current NIH funding (reporter.nih.gov)
• Lab website (cvri.ucsf.edu)
• Twitter (twitter.com)

Grants and Projects

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• Genetic circuitry governing heart growth and repair, NIH/NHLBI, 2022-2027
• Molecular control of cardiac regenerative potential, NIH, 2017-2022
• Retinoic Acid Signaling in Heart Development and Regeneration, NIH/NHBLI, 2014-2018
• Retinoic Acid Signaling in Heart Development and Regeneration, NIH, 2012-2014

Publications (31)

Top publication keywords:
HeartPlanariansThermogenesisTRPC Cation ChannelsE2F2 Transcription FactorPolyploidyCell DedifferentiationRegenerationCell NucleusReceptors, AdrenergicThyroid HormonesMyocytes, CardiacReceptors, GlucocorticoidReceptors, CalcitriolLamin Type B

• Adrenergic-Thyroid Hormone Interactions Drive Postnatal Thermogenesis and Loss of Mammalian Heart Regenerative Capacity.
  Circulation 2021 Payumo AY, Chen X, Hirose K, Chen X, Hoang A, Khyeam S, Yu H, Wang J, Chen Q, Powers N, Chen L, Bigley RB, Lovas J, Hu G, Huang GN
• Lamin B2, Guardian of Cardiomyocyte Nuclear Division.
  Developmental cell 2020 Payumo AY, Huang GN
• Unconventional Functions of Muscles in Planarian Regeneration.
  Developmental cell 2017 Cutie S, Hoang AT, Payumo AY, Huang GN
• C/EBP transcription factors mediate epicardial activation during heart development and injury.
  Science (New York, N.Y.) 2012 Huang GN, Thatcher JE, McAnally J, Kong Y, Qi X, Tan W, DiMaio JM, Amatruda JF, Gerard RD, Hill JA, Bassel-Duby R, Olson EN
• Heart repair by reprogramming non-myocytes with cardiac transcription factors.
  Nature 2012 Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN
• NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.
  Science (New York, N.Y.) 2008 Huang GN, Huso DL, Bouyain S, Tu J, McCorkell KA, May MJ, Zhu Y, Lutz M, Collins S, Dehoff M, Kang S, Whartenby K, Powell J, Leahy D, Worley PF
• STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels.
  Nature cell biology 2006 Huang GN, Zeng W, Kim JY, Yuan JP, Han L, Muallem S, Worley PF

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• Ophthalmic acid is a bloodborne metabolite that contributes to age-induced cardiomyocyte hypertrophy.
  bioRxiv : the preprint server for biology 2024 Mehdipour M, Park S, Wei W, Long JZ, Huang GN
• PD-1-PD-L1 immunomodulatory pathway regulates cardiac regeneration.
  Nature cardiovascular research 2024 Qin J, Huang GN, Moslehi J
• An injury-responsive mmp14b enhancer is required for heart regeneration.
  Science advances 2023 Zlatanova I, Sun F, Wu RS, Chen X, Lau BH, Colombier P, Sinha T, Celona B, Xu SM, Materna SC, Huang GN, Black BL
• Quantitative Three-dimensional Label-free Digital Holographic Imaging of Cardiomyocyte Size, Ploidy, and Cell Division.
  bioRxiv : the preprint server for biology 2023 Park S, Huang H, Ross I, Moreno J, Khyeam S, Simmons J, Huang GN, Payumo AY
• Two decades of heart regeneration research: Cardiomyocyte proliferation and beyond.
  WIREs mechanisms of disease 2023 Huang H, Huang GN, Payumo AY
• Unlocking cardiomyocyte renewal potential for myocardial regeneration therapy.
  Journal of molecular and cellular cardiology 2023 Mehdipour M, Park S, Huang GN
• Visualization of regenerating and repairing hearts.
  Clinical science (London, England : 1979) 2022 Powers N, Huang GN
• Mending a broken heart with novel cardiogenic small molecules.
  Cell regeneration (London, England) 2022 Powers N, Huang GN
• Endocrine Influence on Cardiac Metabolism in Development and Regeneration.
  Endocrinology 2021 Graham N, Huang GN
• Genetic, Epigenetic, and Post-Transcriptional Basis of Divergent Tissue Regenerative Capacities Among Vertebrates.
  Advanced genetics (Hoboken, N.J.) 2021 Khyeam S, Lee S, Huang GN
• Vertebrate cardiac regeneration: evolutionary and developmental perspectives.
  Cell regeneration (London, England) 2021 Cutie S, Huang GN
• Hormonal control of cardiac regenerative potential.
  Endocrine connections 2021 Amram AV, Cutie S, Huang GN
• KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice.
  JCI insight 2020 Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, …
• The coevolutionary process of restaurant CSR in the time of mega disruption.
  International journal of hospitality management 2020 Ou J, Wong IA, Huang GI
• In vitro and in vivo roles of glucocorticoid and vitamin D receptors in the control of neonatal cardiomyocyte proliferative potential.
  Journal of molecular and cellular cardiology 2020 Cutie S, Payumo AY, Lunn D, Huang GN
• Defined factors to reactivate cell cycle activity in adult mouse cardiomyocytes.
  Scientific reports 2019 Judd J, Lovas J, Huang GN
• Evidence for hormonal control of heart regenerative capacity during endothermy acquisition.
  Science (New York, N.Y.) 2019 Hirose K, Payumo AY, Cutie S, Hoang A, Zhang H, Guyot R, Lunn D, Bigley RB, Yu H, Wang J, Smith M, Gillett E, Muroy SE, Schmid T, Wilson E, Field KA, Reeder DM, Maden M, Yartsev MM, Wolfgang MJ, …
• Insights into nuclear dynamics using live-cell imaging approaches.
  Wiley interdisciplinary reviews. Systems biology and medicine 2017 Bigley RB, Payumo AY, Alexander JM, Huang GN
• Isolation, Culture and Transduction of Adult Mouse Cardiomyocytes.
  Journal of visualized experiments : JoVE 2016 Judd J, Lovas J, Huang GN
• Biotinylation of Cell Surface Proteins.
  Bio-protocol 2012 Huang GN
• T Cell Calcium Mobilization Study (Flow Cytometry).
  Bio-protocol 2012 Huang GN
• Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening.
  Neuron 2009 Shim S, Yuan JP, Kim JY, Zeng W, Huang G, Milshteyn A, Kern D, Muallem S, Ming GL, Worley PF
• STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction.
  Molecular cell 2008 Zeng W, Yuan JP, Kim MS, Choi YJ, Huang GN, Worley PF, Muallem S
• STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels.
  Nature cell biology 2007 Yuan JP, Zeng W, Huang GN, Worley PF, Muallem S