Gregory Craven, PhD
Postdoctoral Scholar
Cellular Molecular Pharmacology
School of Medicine

Publications (13)

Top publication keywords:
LigandsProtein Kinase InhibitorsCyclin-Dependent Kinase 2Multiple Endocrine Neoplasia Type 2aPhosphotransferasesProtein Sorting SignalsAcrylamideSmall Molecule LibrariesHigh-Throughput Screening AssaysFluorescent DyesSulfonamidesDrug DiscoveryCysteineAlkynesLysine

• Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes.
  Nature chemistry 2023 Chen Y, Craven GB, Kamber RA, Cuesta A, Zhersh S, Moroz YS, Bassik MC, Taunton J
• Signal peptide mimicry primes Sec61 for client-selective inhibition.
  Nature chemical biology 2023 Rehan S, Tranter D, Sharp PP, Craven GB, Lowe E, Anderl JL, Muchamuel T, Abrishami V, Kuivanen S, Wenzell NA, Jennings A, Kalyanaraman C, Strandin T, Javanainen M, Vapalahti O, Jacobson MP, McMinn D, …
• Unexpected structures formed by the kinase RET C634R mutant extracellular domain suggest potential oncogenic mechanisms in MEN2A.
  The Journal of biological chemistry 2022 Liu Y, De Castro Ribeiro O, Haapanen O, Craven GB, Sharma V, Muench SP, Goldman A
• Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease.
  Acta pharmaceutica Sinica. B 2022 Qin B, Craven GB, Hou P, Chesti J, Lu X, Child ES, Morgan RML, Niu W, Zhao L, Armstrong A, Mann DJ, Cui S
• Reversible lysine-targeted probes reveal residence time-based kinase selectivity.
  Nature chemical biology 2022 Yang T, Cuesta A, Wan X, Craven GB, Hirakawa B, Khamphavong P, May JR, Kath JC, Lapek JD, Niessen S, Burlingame AL, Carelli JD, Taunton J

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• Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
  RSC medicinal chemistry 2021 Jamshidiha M, Lanyon-Hogg T, Sutherell CL, Craven GB, Tersa M, De Vita E, Brustur D, Pérez-Dorado I, Hassan S, Petracca R, Morgan RM, Sanz-Hernández M, Norman JC, Armstrong A, Mann DJ, Cota E, Tate EW
• Synthesis and Configurational Assignment of Vinyl Sulfoximines and Sulfonimidamides.
  The Journal of organic chemistry 2021 Craven GB, Briggs EL, Zammit CM, McDermott A, Greed S, Affron DP, Leinfellner C, Cudmore HR, Tweedy RR, Luisi R, Bull JA, Armstrong A
• Quantitative Irreversible Tethering (qIT) for Target-directed Covalent Fragment Screening.
  Bio-protocol 2020 Craven GB, Armstrong A, Mann DJ
• Multiparameter Kinetic Analysis for Covalent Fragment Optimization by Using Quantitative Irreversible Tethering (qIT).
  Chembiochem : a European journal of chemical biology 2020 Craven GB, Affron DP, Kösel T, Wong TLM, Jukes ZH, Liu CT, Morgan RML, Armstrong A, Mann DJ
• Vinyl sulfonamide synthesis for irreversible tethering via a novel α-selenoether protection strategy.
  MedChemComm 2018 Craven GB, Affron DP, Raymond PN, Mann DJ, Armstrong A
• High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.
  Angewandte Chemie (International ed. in English) 2018 Craven GB, Affron DP, Allen CE, Matthies S, Greener JG, Morgan RML, Tate EW, Armstrong A, Mann DJ
• Intramolecular hydride transfer onto arynes: redox-neutral and transition metal-free C(sp3)-H functionalization of amines.
  Chemical science 2018 Idiris FIM, Majesté CE, Craven GB, Jones CR
• Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity.
  Nature communications 2016 Alguel Y, Amillis S, Leung J, Lambrinidis G, Capaldi S, Scull NJ, Craven G, Iwata S, Armstrong A, Mikros E, Diallinas G, Cameron AD, Byrne B