Gregory Allen, MD, PhD
Assistant Professor
Medicine
School of Medicine
Greg Allen, MD/PhD is a physician-scientist specializing in designing and translating next-generation immune cell therapies for solid tumors. He cares for patients with lung cancer at the Hellen Diller Cancer Center and runs a research laboratory at the Parker Institute for Cancer Immunotherapy.
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The Allen Lab is focused on developing and applying advanced synthetic biology tools to dissect the fundamental design principles of the immune system. We use synthetic receptors, cytokines, and secondary messengers to generate novel alternatively engineered tumor-immune eco-systems, which we then interrogate with high-dimensional tools. From this ground-up systems biology perspective we are attempting to rationally design engineered cells to tackle the most challenging diseases we face in the clinic.
Awards
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- K08 Scholar, NIH - NCI, 2021
- Fellow, Jane Coffin Childs Memorial Fund, 2017-2020
- Geoffrey D. Parfitt Award for Excellence in Research, Carnegie Mellon, 2004
- Alumni Award, Carnegie Mellon, 2001
Education & Training
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- Fellowship Oncology UCSF 06/2018
- Residency Medicine Johns Hopkins Hospital 06/2015
- MD/PHD Biochemistry, Medicine Stanford Medical School 06/2013
- BS Chemical Engineering Carnegie Mellon University 06/2004
Websites
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- Allen Lab Website (allen-lab.org)
Videos
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- Video (youtube.com)
Grants and Projects
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Publications (13)
Top publication keywords:
Cell EngineeringCell ShapeT-LymphocytesReceptors, NotchCell MovementInterleukin-2CichlidsModels, BiologicalImmunotherapy, AdoptivePharynxCorneal KeratocytesElectricityCuesNeoplasmsPulmonary Ventilation
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Synthetic cytokine circuits that drive T cells into immune-excluded tumors.
Science (New York, N.Y.) 2022 Allen GM, Frankel NW, Reddy NR, Bhargava HK, Yoshida MA, Stark SR, Purl M, Lee J, Yee JL, Yu W, Li AW, Garcia KC, El-Samad H, Roybal KT, Spitzer MH, Lim WA -
Rethinking cancer targeting strategies in the era of smart cell therapeutics.
Nature reviews. Cancer 2022 Allen GM, Lim WA -
Precise T cell recognition programs designed by transcriptionally linking multiple receptors.
Science (New York, N.Y.) 2020 Williams JZ, Allen GM, Shah D, Sterin IS, Kim KH, Garcia VP, Shavey GE, Yu W, Puig-Saus C, Tsoi J, Ribas A, Roybal KT, Lim WA -
Discriminatory Power of Combinatorial Antigen Recognition in Cancer T Cell Therapies.
Cell systems 2020 Dannenfelser R, Allen GM, VanderSluis B, Koegel AK, Levinson S, Stark SR, Yao V, Tadych A, Troyanskaya OG, Lim WA -
An immune-based tool platform for in vivo cell clearance.
Life science alliance 2023 Zhang J, Tsukui T, Wu X, Brito A, Trumble JM, Caraballo JC, Allen GM, Zavala-Solorio J, Zhang C, Paw J, Lim WA, Geng J, Kutskova Y, Freund A, Kolumam G, Sheppard D, Cohen RL
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Changes in older adults' life space during lung cancer treatment: A mixed methods cohort study.
Journal of the American Geriatrics Society 2021 Wong ML, Shi Y, Smith AK, Miaskowski C, Boscardin WJ, Cohen HJ, Lam V, Mazor M, Metzger L, Presley CJ, Williams GR, Loh KP, Ursem CJ, Friedlander TW, Blakely CM, Gubens MA, Allen G, Shumay D, Walter … -
Cell Mechanics at the Rear Act to Steer the Direction of Cell Migration.
Cell systems 2020 Allen GM, Lee KC, Barnhart EL, Tsuchida MA, Wilson CA, Gutierrez E, Groisman A, Theriot JA, Mogilner A -
Balance between cell-substrate adhesion and myosin contraction determines the frequency of motility initiation in fish keratocytes.
Proceedings of the National Academy of Sciences of the United States of America 2015 Barnhart E, Lee KC, Allen GM, Theriot JA, Mogilner A -
Electrophoresis of cellular membrane components creates the directional cue guiding keratocyte galvanotaxis.
Current biology : CB 2013 Allen GM, Mogilner A, Theriot JA -
Myosin II contributes to cell-scale actin network treadmilling through network disassembly.
Nature 2010 Wilson CA, Tsuchida MA, Allen GM, Barnhart EL, Applegate KT, Yam PT, Ji L, Keren K, Danuser G, Theriot JA -
Bipedal locomotion in crawling cells.
Biophysical journal 2010 Barnhart EL, Allen GM, Jülicher F, Theriot JA -
Mechanism of shape determination in motile cells.
Nature 2008 Keren K, Pincus Z, Allen GM, Barnhart EL, Marriott G, Mogilner A, Theriot JA -
Computational simulations of airflow in an in vitro model of the pediatric upper airways.
Journal of biomechanical engineering 2004 Allen GM, Shortall BP, Gemci T, Corcoran TE, Chigier NA