Grant Dorsey, MD, MPH, PhD
Professor
Medicine
School of Medicine
Overview: Our malaria research group has been active for over 20 years, bringing together a diverse group of UCSF faculty members from the Departments of Medicine, Pediatrics, Clinical Pharmacology, Obstetrics, Gynecology & Reproductive Sciences, and Bioengineering & Therapeutic Sciences.
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Areas of interest include clinical trials for the treatment and prevention of malaria, antimalarial drug resistance, antimalarial drug discovery, pharmacokinetics and pharmacodynamics of antimalarial drugs, malaria in pregnancy, molecular epidemiology, sero-epidemiology, naturally acquired immunity to malaria, and public health surveillance. Laboratory work is performed at a number of laboratories at SFGH. A majority of our fieldwork is conducted in Uganda with the Infectious Diseases Research Collaboration (http://idrc-uganda.org/) and collaborators from Makerere University. We have a large field site in Eastern Uganda that includes several study clinics, a data center, an insectary, and a research lab with capacity to culture parasites and perform basic immunology, histopathology, and molecular biology studies. We also have a health facility based network at 68 sites around the country. We also have research projects at other international sites including Burkina Faso, several countries in Southern Africa, and countries in Southeast Asia. We have active collaborations with several international and domestic institutions including the London School of Tropical Medicine and Hygiene, Liverpool School of Tropical Medicine, Radboud Institute for Health Sciences, Stanford University, University of Washington, University of Pennsylvania, Johns Hopkins School of Public Health, Harvard School of Public Health, and Brown University. Training and capacity building is a major focus of our group. We have mentored many medical students, graduate students, residents, and post-doctoral fellows, many of whom have gone on to successful careers in malaria research at UCSF or other institutions including Southwestern Medical Center, Yale University, Stanford University, and the London School of Tropical Medicine and Hygiene. We place a strong emphasis on providing opportunities for fieldwork and partnering U.S. based trainees with scientist from malaria endemic countries. Many of our trainees have been awarded mentored research career development awards including NIH F31 grants for doctoral students and K series grants for post-doctoral and Infectious Diseases fellows.
Subcategories
1) Clinical trials. Our group has a long history of conducting clinical trials, including dozens of antimalarial drug efficacy studies and evaluations of antimalarial drugs for the prevention of malaria in children and pregnant women. Currently funded studies include a randomized controlled trail comparing different regimens for the prevention of malaria and improvement of birth outcomes in pregnant women, evaluating the impact of chemoprevention in young children and the development of antimalarial immunity, and a large cluster randomized trial comparing long lasting bednets with different formulations of insecticides. These trials offer the opportunity to work on all aspects of trial design, implementation, and analysis as well as the opportunity for secondary data analysis and complementary translational studies.
2) Drug mechanisms, resistance and pharmacology. At UCSF we are engaged in antimalarial drug discovery, characterization of mechanisms of action of novel antimalarial compounds, characterization of the genotypes and phenotypes of malaria parasites with varied sensitivity to established and novel antimalarials, and evaluation of the pharmacokinetics and pharmacodynamics of antimalarial drugs. Working with collaborating groups in Uganda and Burkina Faso, we are maintaining surveillance for markers of antimalarial drug resistance, characterizing in vitro antimalarial drug resistance, and performing translational studies to better understand the interplay of antimalarial activity, drug resistance, parasite fitness, and drug pharmacokinetics. These studies offer opportunities to work in a range of translational research areas, from basic research at UCSF to translational studies in Africa.
3) Molecular Epidemiology. The large and diverse genomes of malaria parasites provide a tool to track infections within hosts, through populations, and between regions over time. Our team builds laboratory and analytical tools to extract this information and applies them with innovative field studies to understand details of transmission epidemiology that are difficult or impossible to measure accurately with traditional methods. These studies allow us to provide actionable data for public health and answer fundamental questions regarding the transmission biology and epidemiology of malaria. Projects are located at numerous sites in Africa.
4) Immunology. Immunity to malaria is a complex phenotype, requiring integration of numerous streams of data including molecular and immunologic analysis of the parasite and host. We work on novel ways to more accurately measure various manifestations of clinical immunity and study the relationships between infection and various aspects of the host response including humoral immunity, cellular immunity, and comprehensive systems immunology projects. Novel ways of using antibodies for precisely determining prior exposure are also being evaluated for public health surveillance. Our group has also made significant progress in elucidating the immunopathogenesis of human malaria, including definition of regulatory and effector cell populations that are associated with immunity. Currently funded studies investigate how the natural acquisition of antimalarial immunity is altered by chemopreventive interventions, how immunogenetic factors influence susceptibility to malaria, and how fetal T cells respond to pathogen-derived antigens encountered in utero. These studies leverage large and well-characterized human biospecimen banks and provide numerous opportunities for add-on studies to investigate the host immune response to malaria and co-pathogens.
5) Epidemiology and Surveillance. Our group has pioneered longitudinal studies of malaria in cohorts living in settings with varying transmission intensity and population level control interventions. These studies have greatly improved our understanding of malaria epidemiology, clinical measures of immunity, and the impact of various environmental and vector control strategies. In addition, these studies have generated an immense bio-specimen repository and has been used complementary basic science and translational research project. Over the past 15 years we have also developed a health facility-based malaria surveillance network in collaboration with the Uganda Ministry of Health. This network currently collects individual level electronic data from all patients presenting to the outpatient departments at numerous sites around Uganda.
Education & Training
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- Diversity, Equity, and Inclusion Champion Training University of California 2019
- PhD Epidemiology University of California Berkeley 2004
- Fellowship Infecious Diseases University of California San Francisco 2002
- MPH Epidemiology University of California Berkeley 1997
- Residency Internal Medicine University of California San Francisco 1996
- MD Medicine Southwestern Medical Center 1993
- BA Microbiology University of Texas 1989
Interests
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- Surveillance
- Indoor residual spraying of insecticide
- Insecticide treated bednets
- Antimalarial drug resistance
- Chemoprevention
- Naturally acquired immunity to malaria
- Insecticide resistance
- Epidemiology
- Malaria
- HIV/malaria interactions
Grants and Projects
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- Enhancing immunity to malaria in young children with effective chemoprevention, NIH, 2021-2026
- Malaria across borders: Measuring imported infections and contributions to local transmission in Uganda and Zimbabwe, NIH, 2021-2026
- Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies in Uganda, NIH, 2007-2025
- Pharmacological insights into antimalarial exposure, clinical outcomes, and drug resistance in Africa, NIH, 2015-2025
- Optimal chemopreventive regimens to prevent malaria and improve birth outcomes in Uganda, NIH, 2020-2025
- Training in malaria surveillance, epidemiology and implementation science research to strengthen malaria policy and control in Uganda, NIH, 2017-2023
- Biology of Infectious Diseases Training Program, NIH, 2000-2022
- Novel Strategies to Prevent Malaria and Improve Maternal-Child Health in Africa, NIH/NICHD, 2008-2018
- Program for Resistance, Immunology, Surveillance & Modeling of Malaria in Uganda, NIH, 2010-2017
- Research Activities in Support of Malaria Prevention and Control in Uganda (PMI), NIH, 2011-2016
- Supporting the Implementation of Malaria Prevention and Control Strategies and Re, NIH, 2008-2013
- Global Malaria Prevention and Control, NIH, 2005-2008
- Clinical and Molecular Studies of Drug-Resistant Malaria, NIH, 1999-2006
Publications (316)
Top publication keywords:
AntimalarialsArtemisininsParasitemiaMalaria, FalciparumInsecticide-Treated BednetsPregnancy Complications, ParasiticQuinolinesMalariaMosquito ControlInsecticidesSulfadoxineEthanolaminesPyrimethaminePlasmodium falciparumUganda
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Piperaquine-Induced QTc Prolongation Decreases With Repeated Monthly Dihydroartemisinin-Piperaquine Dosing in Pregnant Ugandan Women.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2022 Hughes E, Wallender E, Kajubi R, Jagannathan P, Ochieng T, Kakuru A, Kamya MR, Clark TD, Rosenthal PJ, Dorsey G, Aweeka F, Savic RM -
Targeted newborn metabolomics: prediction of gestational age from cord blood.
Journal of perinatology : official journal of the California Perinatal Association 2022 Jasper EA, Oltman SP, Rogers EE, Dagle JM, Murray JC, Kamya M, Kakuru A, Kajubi R, Ochieng T, Adrama H, Okitwi M, Olwoch P, Jagannathan P, Clark TD, Dorsey G, Ruel T, Jelliffe-Pawlowski LL, Ryckman KK -
Gender difference in the incidence of malaria diagnosed at public health facilities in Uganda.
Malaria journal 2022 Okiring J, Epstein A, Namuganga JF, Kamya EV, Nabende I, Nassali M, Sserwanga A, Gonahasa S, Muwema M, Kiwuwa SM, Staedke SG, Kamya MR, Nankabirwa JI, Briggs J, Jagannathan P, Dorsey G -
A quasi-experimental study estimating the impact of long-lasting insecticidal nets with and without piperonyl butoxide on pregnancy outcomes.
Malaria journal 2022 Roh ME, Oundo B, Dorsey G, Shiboski S, Gosling R, Glymour MM, Staedke SG, Bennett A, Sturrock H, Mpimbaza A -
Impact of COVID-19 on routine malaria indicators in rural Uganda: an interrupted time series analysis.
Malaria journal 2021 Namuganga JF, Briggs J, Roh ME, Okiring J, Kisambira Y, Sserwanga A, Kapisi JA, Arinaitwe E, Ebong C, Ssewanyana I, Maiteki-Ssebuguzi C, Kamya MR, Staedke SG, Dorsey G, Nankabirwa JI
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Marked reduction in antibiotic usage following intensive malaria control in a cohort of Ugandan children.
BMC medicine 2021 Krezanoski PJ, Roh ME, Rek J, Nankabirwa JI, Arinaitwe E, Staedke SG, Nayiga S, Hsiang MS, Smith D, Kamya M, Dorsey G -
Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children.
Nature communications 2021 Wallender E, Ali AM, Hughes E, Kakuru A, Jagannathan P, Muhindo MK, Opira B, Whalen M, Huang L, Duvalsaint M, Legac J, Kamya MR, Dorsey G, Aweeka F, Rosenthal PJ, Savic RM -
Age-Related Changes in Malaria Clinical Phenotypes During Infancy Are Modified by Sickle Cell Trait.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021 Zehner N, Adrama H, Kakuru A, Andra T, Kajubi R, Conrad M, Nankya F, Clark TD, Kamya M, Rodriguez-Barraquer I, Dorsey G, Jagannathan P -
Associations between environmental covariates and temporal changes in malaria incidence in high transmission settings of Uganda: a distributed lag nonlinear analysis.
BMC public health 2021 Okiring J, Routledge I, Epstein A, Namuganga JF, Kamya EV, Obeng-Amoako GO, Sebuguzi CM, Rutazaana D, Kalyango JN, Kamya MR, Dorsey G, Wesonga R, Kiwuwa SM, Nankabirwa JI -
Impact of COVID-19 on routine malaria indicators in Uganda: An interrupted time series analysis.
Research square 2021 Namuganga JF, Briggs J, Roh ME, Okiring J, Kisambira Y, Sserwanga A, Kapisi JA, Arinaitwe E, Ebong C, Ssewanyana I, Greenhouse B, Maiteki-Ssebuguzi C, Kamya MR, Staedke SG, Dorsey G, Nankabirwa JI -
Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With Higher Plasmodium falciparum Parasite Prevalence.
The Journal of infectious diseases 2021 Digitale JC, Callaway PC, Martin M, Nelson G, Viard M, Rek J, Arinaitwe E, Dorsey G, Kamya M, Carrington M, Rodriguez-Barraquer I, Feeney ME -
Effectiveness of in-service training plus the collaborative improvement strategy on the quality of routine malaria surveillance data: results of a pilot study in Kayunga District, Uganda.
Malaria journal 2021 Westercamp N, Staedke SG, Maiteki-Sebuguzi C, Ndyabakira A, Okiring JM, Kigozi SP, Dorsey G, Broughton E, Hutchinson E, Massoud MR, Rowe AK -
Sources of persistent malaria transmission in a setting with effective malaria control in eastern Uganda: a longitudinal, observational cohort study.
The Lancet. Infectious diseases 2021 Andolina C, Rek JC, Briggs J, Okoth J, Musiime A, Ramjith J, Teyssier N, Conrad M, Nankabirwa JI, Lanke K, Rodriguez-Barraquer I, Meerstein-Kessel L, Arinaitwe E, Olwoch P, Rosenthal PJ, Kamya MR, … -
Assessment of the accuracy of malaria microscopy in private health facilities in Entebbe Municipality, Uganda: a cross-sectional study.
Malaria journal 2021 Mutabazi T, Arinaitwe E, Ndyabakira A, Sendaula E, Kakeeto A, Okimat P, Orishaba P, Katongole SP, Mpimbaza A, Byakika-Kibwika P, Karamagi C, Kalyango JN, Kamya MR, Dorsey G, Nankabirwa JI -
The impact of stopping and starting indoor residual spraying on malaria burden in Uganda.
Nature communications 2021 Namuganga JF, Epstein A, Nankabirwa JI, Mpimbaza A, Kiggundu M, Sserwanga A, Kapisi J, Arinaitwe E, Gonahasa S, Opigo J, Ebong C, Staedke SG, Shililu J, Okia M, Rutazaana D, Maiteki-Sebuguzi C, Belay … -
Changing Prevalence of Potential Mediators of Aminoquinoline, Antifolate, and Artemisinin Resistance Across Uganda.
The Journal of infectious diseases 2021 Asua V, Conrad MD, Aydemir O, Duvalsaint M, Legac J, Duarte E, Tumwebaze P, Chin DM, Cooper RA, Yeka A, Kamya MR, Dorsey G, Nsobya SL, Bailey J, Rosenthal PJ -
HLA Alleles B*53:01 and C*06:02 Are Associated With Higher Risk of P. falciparum Parasitemia in a Cohort in Uganda.
Frontiers in immunology 2021 Digitale JC, Callaway PC, Martin M, Nelson G, Viard M, Rek J, Arinaitwe E, Dorsey G, Kamya M, Carrington M, Rodriguez-Barraquer I, Feeney ME -
Impact of seasonality and malaria control interventions on Anopheles density and species composition from three areas of Uganda with differing malaria endemicity.
Malaria journal 2021 Mawejje HD, Kilama M, Kigozi SP, Musiime AK, Kamya M, Lines J, Lindsay SW, Smith D, Dorsey G, Donnelly MJ, Staedke SG -
Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity.
Malaria journal 2021 Tukwasibwe S, Traherne JA, Chazara O, Jayaraman J, Trowsdale J, Moffett A, Jiang W, Nankabirwa JI, Rek J, Arinaitwe E, Nsobya SL, Atuheirwe M, Frank M, Godwin A, Jagannathan P, Cose S, Kamya MR, … -
Gestational age dating using newborn metabolic screening: A validation study in Busia, Uganda.
Journal of global health 2021 Oltman SP, Jasper EA, Kajubi R, Ochieng T, Kakuru A, Adrama H, Okitwi M, Olwoch P, Kamya M, Bedell B, McCarthy M, Dagle J, Jagannathan P, Clark TD, Dorsey G, Rand L, Ruel T, Rogers EE, Ryckman KK, … -
Within-household clustering of genetically related Plasmodium falciparum infections in a moderate transmission area of Uganda.
Malaria journal 2021 Briggs J, Kuchta A, Murphy M, Tessema S, Arinaitwe E, Rek J, Chen A, Nankabirwa JI, Drakeley C, Smith D, Bousema T, Kamya M, Rodriguez-Barraquer I, Staedke S, Dorsey G, Rosenthal PJ, Greenhouse B -
Impact of a Rapid Decline in Malaria Transmission on Antimalarial IgG Subclasses and Avidity.
Frontiers in immunology 2021 Ssewanyana I, Rek J, Rodriguez I, Wu L, Arinaitwe E, Nankabirwa JI, Beeson JG, Mayanja-Kizza H, Rosenthal PJ, Dorsey G, Kamya MR, Drakeley C, Greenhouse B, Tetteh KKA -
Relationships between test positivity rate, total laboratory confirmed cases of malaria, and malaria incidence in high burden settings of Uganda: an ecological analysis.
Malaria journal 2021 Okiring J, Epstein A, Namuganga JF, Kamya V, Sserwanga A, Kapisi J, Ebong C, Kigozi SP, Mpimbaza A, Wanzira H, Briggs J, Kamya MR, Nankabirwa JI, Dorsey G -
Exposure to pesticides in utero impacts the fetal immune system and response to vaccination in infancy.
Nature communications 2021 Prahl M, Odorizzi P, Gingrich D, Muhindo M, McIntyre T, Budker R, Jagannathan P, Farrington L, Nalubega M, Nankya F, Sikyomu E, Musinguzi K, Naluwu K, Auma A, Kakuru A, Kamya MR, Dorsey G, Aweeka F, … -
Deletions of pfhrp2 and pfhrp3 genes were uncommon in rapid diagnostic test-negative Plasmodium falciparum isolates from Uganda.
Malaria journal 2021 Nsobya SL, Walakira A, Namirembe E, Kiggundu M, Nankabirwa JI, Ruhamyankaka E, Arinaitwe E, Conrad MD, Kamya MR, Dorsey G, Rosenthal PJ -
Infant sex modifies associations between placental malaria and risk of malaria in infancy.
Malaria journal 2020 Kakuru A, Roh ME, Kajubi R, Ochieng T, Ategeka J, Ochokoru H, Nakalembe M, Clark TD, Ruel T, Staedke SG, Chandramohan D, Havlir DV, Kamya MR, Dorsey G, Jagannathan P -
Non-adherence to long-lasting insecticide treated bednet use following successful malaria control in Tororo, Uganda.
PloS one 2020 Rek J, Musiime A, Zedi M, Otto G, Kyagamba P, Asiimwe Rwatooro J, Arinaitwe E, Nankabirwa J, Staedke SG, Drakeley C, Rosenthal PJ, Kamya M, Dorsey G, Krezanoski PJ -
Estimating malaria incidence from routine health facility-based surveillance data in Uganda.
Malaria journal 2020 Epstein A, Namuganga JF, Kamya EV, Nankabirwa JI, Bhatt S, Rodriguez-Barraquer I, Staedke SG, Kamya MR, Dorsey G, Greenhouse B -
Associations between Malaria-Preventive Regimens and Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Ugandan Pregnant Women.
Antimicrobial agents and chemotherapy 2020 Nayebare P, Asua V, Conrad MD, Kajubi R, Kakuru A, Nankabirwa JI, Muhanguzi D, Dorsey G, Kamya MR, Nsobya S, Rosenthal PJ -
Piperaquine Exposure Is Altered by Pregnancy, HIV, and Nutritional Status in Ugandan Women.
Antimicrobial agents and chemotherapy 2020 Hughes E, Imperial M, Wallender E, Kajubi R, Huang L, Jagannathan P, Zhang N, Kakuru A, Natureeba P, Mwima MW, Muhindo M, Mwebaza N, Clark TD, Opira B, Nakalembe M, Havlir D, Kamya M, Rosenthal PJ, … -
Association between recent overnight travel and use of long-lasting insecticidal nets in rural Uganda: a prospective cohort study in Tororo.
Malaria journal 2020 Arinaitwe E, Nankabirwa JI, Krezanoski P, Rek J, Kamya V, Epstein A, Rosenthal PJ, Drakeley C, Kamya MR, Dorsey G, Staedke SG -
Increased malaria parasitaemia among adults living with HIV who have discontinued cotrimoxazole prophylaxis in Kitgum district, Uganda.
PloS one 2020 Orishaba P, Kalyango JN, Byakika-Kibwika P, Arinaitwe E, Wandera B, Katairo T, Muzeyi W, Nansikombi HT, Nakato A, Mutabazi T, Kamya MR, Dorsey G, Nankabirwa JI -
Cost-effectiveness of intermittent preventive treatment with dihydroartemisinin-piperaquine for malaria during pregnancy: an analysis using efficacy results from Uganda and Kenya, and pooled data.
The Lancet. Global health 2020 Fernandes S, Were V, Gutman J, Dorsey G, Kakuru A, Desai M, Kariuki S, Kamya MR, Ter Kuile FO, Hanson K -
Sex-based differences in clearance of chronic Plasmodium falciparum infection.
eLife 2020 Briggs J, Teyssier N, Nankabirwa JI, Rek J, Jagannathan P, Arinaitwe E, Bousema T, Drakeley C, Murray M, Crawford E, Hathaway N, Staedke SG, Smith D, Rosenthal PJ, Kamya M, Dorsey G, Rodriguez-… -
Estimating the optimal interval between rounds of indoor residual spraying of insecticide using malaria incidence data from cohort studies.
PloS one 2020 Mugenyi L, Nankabirwa JI, Arinaitwe E, Rek J, Hens N, Kamya M, Dorsey G -
Opsonized antigen activates Vδ2+ T cells via CD16/FCγRIIIa in individuals with chronic malaria exposure.
PLoS pathogens 2020 Farrington LA, Callaway PC, Vance HM, Baskevitch K, Lutz E, Warrier L, McIntyre TI, Budker R, Jagannathan P, Nankya F, Musinguzi K, Nalubega M, Sikyomu E, Naluwu K, Arinaitwe E, Dorsey G, Kamya MR, … -
Generation of a malaria negative Ugandan birth weight standard for the diagnosis of small for gestational age.
PloS one 2020 Zakama AK, Weekes T, Kajubi R, Kakuru A, Ategeka J, Kamya M, Muhindo MK, Havlir D, Jagannathan P, Dorsey G, Gaw SL -
Malaria Diagnosed in an Urban Setting Strongly Associated with Recent Overnight Travel: A Case-Control Study from Kampala, Uganda.
The American journal of tropical medicine and hygiene 2020 Arinaitwe E, Mpimbaza A, Nankabirwa JI, Kamya V, Asiimwe A, Kuule JK, Kamya MR, Drakeley C, Dorsey G, Rosenthal PJ, Staedke SG -
Malaria Transmission, Infection, and Disease following Sustained Indoor Residual Spraying of Insecticide in Tororo, Uganda.
The American journal of tropical medicine and hygiene 2020 Nankabirwa JI, Arinaitwe E, Rek J, Kilama M, Kizza T, Staedke SG, Rosenthal PJ, Rodriguez-Barraquer I, Briggs J, Greenhouse B, Bousema T, Drakeley C, Roos DS, Tomko SS, Smith DL, Kamya MR, Dorsey G -
Impact of intermittent preventive treatment of malaria in pregnancy with dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine on the incidence of malaria in infancy: a randomized controlled trial.
BMC medicine 2020 Kakuru A, Jagannathan P, Kajubi R, Ochieng T, Ochokoru H, Nakalembe M, Clark TD, Ruel T, Staedke SG, Chandramohan D, Havlir DV, Kamya MR, Dorsey G -
Gravidity-dependent associations between interferon response and birth weight in placental malaria.
Malaria journal 2020 Quanquin NM, Barres LG, Aliyari SR, Day NT, Gerami H, Fisher SJ, Kakuru A, Kamya MR, Havlir DV, Feeney M, Dorsey G, Cheng G, Gaw SL -
Relationships Between Measures of Malaria at Delivery and Adverse Birth Outcomes in a High-Transmission Area of Uganda.
The Journal of infectious diseases 2020 Ategeka J, Kakuru A, Kajubi R, Wasswa R, Ochokoru H, Arinaitwe E, Yeka A, Jagannathan P, Kamya MR, Muehlenbachs A, Chico RM, Dorsey G -
The age-specific incidence of hospitalized paediatric malaria in Uganda.
BMC infectious diseases 2020 Mpimbaza A, Walemwa R, Kapisi J, Sserwanga A, Namuganga JF, Kisambira Y, Tagoola A, Nanteza JF, Rutazaana D, Staedke SG, Dorsey G, Opigo J, Kamau A, Snow RW -
Overall, anti-malarial, and non-malarial effect of intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine on birthweight: a mediation analysis.
The Lancet. Global health 2020 Roh ME, Kuile FOT, Rerolle F, Glymour MM, Shiboski S, Gosling R, Gutman J, Kakuru A, Desai M, Kajubi R, L'Ianziva A, Kamya MR, Dorsey G, Chico RM -
The impact of gravidity, symptomatology and timing of infection on placental malaria.
Malaria journal 2020 Tran EE, Cheeks ML, Kakuru A, Muhindo MK, Natureeba P, Nakalembe M, Ategeka J, Nayebare P, Kamya M, Havlir D, Feeney ME, Dorsey G, Gaw SL -
Identification and characterization of immature Anopheles and culicines (Diptera: Culicidae) at three sites of varying malaria transmission intensities in Uganda.
Malaria journal 2020 Musiime AK, Smith DL, Kilama M, Geoffrey O, Kyagamba P, Rek J, Conrad MD, Nankabirwa JI, Arinaitwe E, Akol AM, Kamya MR, Dorsey G, Staedke SG, Drakeley C, Lindsay SW -
Determination of piperaquine concentration in human plasma and the correlation of capillary versus venous plasma concentrations.
PloS one 2020 Mwebaza N, Cheah V, Forsman C, Kajubi R, Marzan F, Wallender E, Dorsey G, Rosenthal PJ, Aweeka F, Huang L -
The Impact of Control Interventions on Malaria Burden in Young Children in a Historically High-Transmission District of Uganda: A Pooled Analysis of Cohort Studies from 2007 to 2018.
The American journal of tropical medicine and hygiene 2020 Kamya MR, Kakuru A, Muhindo M, Arinaitwe E, Nankabirwa JI, Rek J, Bigira V, Kapisi J, Wanzira H, Achan J, Natureeba P, Gasasira A, Havlir D, Jagannathan P, Rosenthal PJ, Rodriguez-Barraquer I, Dorsey … -
Effect of long-lasting insecticidal nets with and without piperonyl butoxide on malaria indicators in Uganda (LLINEUP): a pragmatic, cluster-randomised trial embedded in a national LLIN distribution campaign.
Lancet (London, England) 2020 Staedke SG, Gonahasa S, Dorsey G, Kamya MR, Maiteki-Sebuguzi C, Lynd A, Katureebe A, Kyohere M, Mutungi P, Kigozi SP, Opigo J, Hemingway J, Donnelly MJ -
Practical Implications of a Relationship between Health Management Information System and Community Cohort-Based Malaria Incidence Rates.
The American journal of tropical medicine and hygiene 2020 Kigozi SP, Giorgi E, Mpimbaza A, Kigozi RN, Bousema T, Arinaitwe E, Nankabirwa JI, Sebuguzi CM, Kamya MR, Staedke SG, Dorsey G, Pullan RL -
Rapid shifts in the age-specific burden of malaria following successful control interventions in four regions of Uganda.
Malaria journal 2020 Kigozi SP, Kigozi RN, Epstein A, Mpimbaza A, Sserwanga A, Yeka A, Nankabirwa JI, Halliday K, Pullan RL, Rutazaana D, Sebuguzi CM, Opigo J, Kamya MR, Staedke SG, Dorsey G, Greenhouse B, Rodriguez-… -
Active Case Finding for Malaria: A 3-Year National Evaluation of Optimal Approaches to Detect Infections and Hotspots Through Reactive Case Detection in the Low-transmission Setting of Eswatini.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2020 Hsiang MS, Ntshalintshali N, Kang Dufour MS, Dlamini N, Nhlabathi N, Vilakati S, Malambe C, Zulu Z, Maphalala G, Novotny J, Murphy M, Schwartz A, Sturrock H, Gosling R, Dorsey G, Kunene S, Greenhouse … -
Factors affecting the electrocardiographic QT interval in malaria: A systematic review and meta-analysis of individual patient data.
PLoS medicine 2020 Chan XHS, Win YN, Haeusler IL, Tan JY, Loganathan S, Saralamba S, Chan SKS, Ashley EA, Barnes KI, Baiden R, Bassi PU, Djimde A, Dorsey G, Duparc S, Hanboonkunupakarn B, Ter Kuile FO, Lacerda MVG, Nasa… -
The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data.
BMC medicine 2020 Bretscher MT, Dahal P, Griffin J, Stepniewska K, Bassat Q, Baudin E, D'Alessandro U, Djimde AA, Dorsey G, Espié E, Fofana B, González R, Juma E, Karema C, Lasry E, Lell B, Lima N, Menéndez C, Mombo-… -
Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study.
Malaria journal 2020 Kakande E, Greenhouse B, Bajunirwe F, Drakeley C, Nankabirwa JI, Walakira A, Nsobya SL, Katureebe A, Rek J, Arinaitwe E, Rosenthal PJ, Kamya MR, Dorsey G, Rodriguez-Barraquer I -
The Impact of Multiple Rounds of Indoor Residual Spraying on Malaria Incidence and Hemoglobin Levels in a High-Transmission Setting.
The Journal of infectious diseases 2020 Zinszer K, Charland K, Vahey S, Jahagirdar D, Rek JC, Arinaitwe E, Nankabirwa J, Morrison K, Sadoine ML, Tutt-Guérette MA, Staedke SG, Kamya MR, Greenhouse B, Rodriguez-Barraquer I, Dorsey G -
Impact of vector control interventions on malaria transmission intensity, outdoor vector biting rates and Anopheles mosquito species composition in Tororo, Uganda.
Malaria journal 2019 Musiime AK, Smith DL, Kilama M, Rek J, Arinaitwe E, Nankabirwa JI, Kamya MR, Conrad MD, Dorsey G, Akol AM, Staedke SG, Lindsay SW, Egonyu JP -
ClinEpiDB: an open-access clinical epidemiology database resource encouraging online exploration of complex studies.
Gates open research 2019 Ruhamyankaka E, Brunk BP, Dorsey G, Harb OS, Helb DA, Judkins J, Kissinger JC, Lindsay B, Roos DS, San EJ, Stoeckert CJ, Zheng J, Tomko SS -
Intermittent preventive treatment of malaria delivered to primary schoolchildren provided effective individual protection in Jinja, Uganda: secondary outcomes of a cluster-randomized trial (START-IPT).
Malaria journal 2019 Rehman AM, Maiteki-Sebuguzi C, Gonahasa S, Okiring J, Kigozi SP, Chandler CIR, Drakeley C, Dorsey G, Kamya MR, Staedke SG -
Impact of Plasmodium falciparum malaria and intermittent preventive treatment of malaria in pregnancy on the risk of malaria in infants: a systematic review.
Malaria journal 2019 Kakuru A, Staedke SG, Dorsey G, Rogerson S, Chandramohan D -
Pareto rules for malaria super-spreaders and super-spreading.
Nature communications 2019 Cooper L, Kang SY, Bisanzio D, Maxwell K, Rodriguez-Barraquer I, Greenhouse B, Drakeley C, Arinaitwe E, G Staedke S, Gething PW, Eckhoff P, Reiner RC, Hay SI, Dorsey G, Kamya MR, Lindsay SW, Grenfell … -
Is that a real oocyst? Insectary establishment and identification of Plasmodium falciparum oocysts in midguts of Anopheles mosquitoes fed on infected human blood in Tororo, Uganda.
Malaria journal 2019 Musiime AK, Okoth J, Conrad M, Ayo D, Onyige I, Rek J, Nankabirwa JI, Arinaitwe E, Kamya MR, Dorsey G, van Gemert GJ, Staedke SG, Drakeley C, Bousema T, Andolina C -
How Are Insecticide-Treated Bednets Used in Ugandan Households? A Comprehensive Characterization of Bednet Adherence Using a Remote Monitor.
The American journal of tropical medicine and hygiene 2019 Krezanoski PJ, Santorino D, Agaba A, Dorsey G, Bangsberg DR, Carroll RW -
Reduced Exposure to Piperaquine, Compared to Adults, in Young Children Receiving Dihydroartemisinin-Piperaquine as Malaria Chemoprevention.
Clinical pharmacology and therapeutics 2019 Whalen ME, Kajubi R, Chamankhah N, Huang L, Orukan F, Wallender E, Kamya MR, Dorsey G, Jagannathan P, Rosenthal PJ, Mwebaza N, Aweeka FT -
Intermittent preventive treatment with dihydroartemisinin-piperaquine and risk of malaria following cessation in young Ugandan children: a double-blind, randomised, controlled trial.
The Lancet. Infectious diseases 2019 Muhindo MK, Jagannathan P, Kakuru A, Opira B, Olwoch P, Okiring J, Nalugo N, Clark TD, Ruel T, Charlebois E, Feeney ME, Havlir DV, Dorsey G, Kamya MR -
Impact of Microscopic and Submicroscopic Parasitemia During Pregnancy on Placental Malaria in a High-Transmission Setting in Uganda.
The Journal of infectious diseases 2019 Briggs J, Ategeka J, Kajubi R, Ochieng T, Kakuru A, Ssemanda C, Wasswa R, Jagannathan P, Greenhouse B, Rodriguez-Barraquer I, Kamya M, Dorsey G -
LLIN Evaluation in Uganda Project (LLINEUP): factors associated with childhood parasitaemia and anaemia 3 years after a national long-lasting insecticidal net distribution campaign: a cross-sectional survey.
Malaria journal 2019 Rugnao S, Gonahasa S, Maiteki-Sebuguzi C, Opigo J, Yeka A, Katureebe A, Kyohere M, Lynd A, Hemingway J, Donnelly MJ, Dorsey G, Kamya MR, Staedke SG -
LLIN Evaluation in Uganda Project (LLINEUP) - Impact of long-lasting insecticidal nets with, and without, piperonyl butoxide on malaria indicators in Uganda: study protocol for a cluster-randomised trial.
Trials 2019 Staedke SG, Kamya MR, Dorsey G, Maiteki-Sebuguzi C, Gonahasa S, Yeka A, Lynd A, Opigo J, Hemingway J, Donnelly MJ -
Systemic inflammation is associated with malaria and preterm birth in women living with HIV on antiretrovirals and co-trimoxazole.
Scientific reports 2019 McDonald CR, Weckman AM, Conroy AL, Olwoch P, Natureeba P, Kamya MR, Havlir DV, Dorsey G, Kain KC -
Household and maternal risk factors for malaria in pregnancy in a highly endemic area of Uganda: a prospective cohort study.
Malaria journal 2019 Okiring J, Olwoch P, Kakuru A, Okou J, Ochokoru H, Ochieng TA, Kajubi R, Kamya MR, Dorsey G, Tusting LS -
The prevalence of histologic acute chorioamnionitis among HIV infected pregnant women in Uganda and its association with adverse birth outcomes.
PloS one 2019 Ategeka J, Wasswa R, Olwoch P, Kakuru A, Natureeba P, Muehlenbachs A, Kamya MR, Dorsey G, Rizzuto G -
Monthly sulfadoxine-pyrimethamine versus dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a double-blind, randomised, controlled, superiority trial.
Lancet (London, England) 2019 Kajubi R, Ochieng T, Kakuru A, Jagannathan P, Nakalembe M, Ruel T, Opira B, Ochokoru H, Ategeka J, Nayebare P, Clark TD, Havlir DV, Kamya MR, Dorsey G -
Persistent Parasitemia Despite Dramatic Reduction in Malaria Incidence After 3 Rounds of Indoor Residual Spraying in Tororo, Uganda.
The Journal of infectious diseases 2019 Nankabirwa JI, Briggs J, Rek J, Arinaitwe E, Nayebare P, Katrak S, Staedke SG, Rosenthal PJ, Rodriguez-Barraquer I, Kamya MR, Dorsey G, Greenhouse B -
LLIN Evaluation in Uganda Project (LLINEUP): a cross-sectional survey of species diversity and insecticide resistance in 48 districts of Uganda.
Parasites & vectors 2019 Lynd A, Gonahasa S, Staedke SG, Oruni A, Maiteki-Sebuguzi C, Dorsey G, Opigo J, Yeka A, Katureebe A, Kyohere M, Hemingway J, Kamya MR, Donnelly MJ -
Case Report: Birth Outcome and Neurodevelopment in Placental Malaria Discordant Twins.
The American journal of tropical medicine and hygiene 2019 Conroy AL, Bangirana P, Muhindo MK, Kakuru A, Jagannathan P, Opoka RO, Liechty EA, Nakalembe M, Kamya MR, Dorsey G, John CC -
Changing Molecular Markers of Antimalarial Drug Sensitivity across Uganda.
Antimicrobial agents and chemotherapy 2019 Asua V, Vinden J, Conrad MD, Legac J, Kigozi SP, Kamya MR, Dorsey G, Nsobya SL, Rosenthal PJ -
Modeling Prevention of Malaria and Selection of Drug Resistance with Different Dosing Schedules of Dihydroartemisinin-Piperaquine Preventive Therapy during Pregnancy in Uganda.
Antimicrobial agents and chemotherapy 2019 Wallender E, Zhang N, Conrad M, Kakuru A, Muhindo M, Tumwebaze P, Kajubi R, Mota D, Legac J, Jagannathan P, Havlir D, Kamya M, Dorsey G, Aweeka F, Rosenthal PJ, Savic RM -
Association Between Recent Overnight Travel and Risk of Malaria: A Prospective Cohort Study at 3 Sites in Uganda.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2019 Arinaitwe E, Dorsey G, Nankabirwa JI, Kigozi SP, Katureebe A, Kakande E, Rek J, Rosenthal PJ, Drakeley C, Kamya MR, Staedke SG -
Heterogeneous exposure and hotspots for malaria vectors at three study sites in Uganda.
Gates open research 2018 Kang SY, Battle KE, Gibson HS, Cooper LV, Maxwell K, Kamya M, Lindsay SW, Dorsey G, Greenhouse B, Rodriguez-Barraquer I, Reiner RCJ, Smith DL, Bisanzio D -
LLIN Evaluation in Uganda Project (LLINEUP): factors associated with ownership and use of long-lasting insecticidal nets in Uganda: a cross-sectional survey of 48 districts.
Malaria journal 2018 Gonahasa S, Maiteki-Sebuguzi C, Rugnao S, Dorsey G, Opigo J, Yeka A, Katureebe A, Kyohere M, Lynd A, Hemingway J, Donnelly M, Kamya MR, Staedke SG -
In utero priming of highly functional effector T cell responses to human malaria.
Science translational medicine 2018 Odorizzi PM, Jagannathan P, McIntyre TI, Budker R, Prahl M, Auma A, Burt TD, Nankya F, Nalubega M, Sikyomu E, Musinguzi K, Naluwu K, Kakuru A, Dorsey G, Kamya MR, Feeney ME -
Intermittent Preventive Treatment for Malaria in Pregnancy: Optimization of Target Concentrations of Dihydroartemisinin-Piperaquine.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018 Savic RM, Jagannathan P, Kajubi R, Huang L, Zhang N, Were M, Kakuru A, Muhindo MK, Mwebaza N, Wallender E, Clark TD, Opira B, Kamya M, Havlir DV, Rosenthal PJ, Dorsey G, Aweeka FT -
Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure.
eLife 2018 Rodriguez-Barraquer I, Arinaitwe E, Jagannathan P, Kamya MR, Rosenthal PJ, Rek J, Dorsey G, Nankabirwa J, Staedke SG, Kilama M, Drakeley C, Ssewanyana I, Smith DL, Greenhouse B -
Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial.
PLoS medicine 2018 Jagannathan P, Kakuru A, Okiring J, Muhindo MK, Natureeba P, Nakalembe M, Opira B, Olwoch P, Nankya F, Ssewanyana I, Tetteh K, Drakeley C, Beeson J, Reiling L, Clark TD, Rodriguez-Barraquer I, … -
Assessment of community-level effects of intermittent preventive treatment for malaria in schoolchildren in Jinja, Uganda (START-IPT trial): a cluster-randomised trial.
The Lancet. Global health 2018 Staedke SG, Maiteki-Sebuguzi C, Rehman AM, Kigozi SP, Gonahasa S, Okiring J, Lindsay SW, Kamya MR, Chandler CIR, Dorsey G, Drakeley C -
Predicting Optimal Dihydroartemisinin-Piperaquine Regimens to Prevent Malaria During Pregnancy for Human Immunodeficiency Virus-Infected Women Receiving Efavirenz.
The Journal of infectious diseases 2018 Wallender E, Vucicevic K, Jagannathan P, Huang L, Natureeba P, Kakuru A, Muhindo M, Nakalembe M, Havlir D, Kamya M, Aweeka F, Dorsey G, Rosenthal PJ, Savic RM -
Rapid improvements to rural Ugandan housing and their association with malaria from intense to reduced transmission: a cohort study.
The Lancet. Planetary health 2018 Rek JC, Alegana V, Arinaitwe E, Cameron E, Kamya MR, Katureebe A, Lindsay SW, Kilama M, Staedke SG, Todd J, Dorsey G, Tusting LS -
Clinical consequences of submicroscopic malaria parasitaemia in Uganda.
Malaria journal 2018 Katrak S, Nayebare P, Rek J, Arinaitwe E, Nankabirwa JI, Kamya M, Dorsey G, Rosenthal PJ, Greenhouse B -
Estradiol Levels Are Altered in Human Immunodeficiency Virus-Infected Pregnant Women Randomized to Efavirenz-Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018 McDonald CR, Conroy AL, Gamble JL, Papp E, Hawkes M, Olwoch P, Natureeba P, Kamya M, Silverman M, Cohan D, Koss CA, Dorsey G, Kain KC, Serghides L -
Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa.
BMC medicine 2018 Taylor WR, Naw HK, Maitland K, Williams TN, Kapulu M, D'Alessandro U, Berkley JA, Bejon P, Okebe J, Achan J, Amambua AN, Affara M, Nwakanma D, van Geertruyden JP, Mavoko M, Lutumba P, Matangila J, … -
Both inflammatory and regulatory cytokine responses to malaria are blunted with increasing age in highly exposed children.
Malaria journal 2017 Farrington L, Vance H, Rek J, Prahl M, Jagannathan P, Katureebe A, Arinaitwe E, Kamya MR, Dorsey G, Feeney ME -
Protective Effect of Indoor Residual Spraying of Insecticide on Preterm Birth Among Pregnant Women With HIV Infection in Uganda: A Secondary Data Analysis.
The Journal of infectious diseases 2017 Roh ME, Shiboski S, Natureeba P, Kakuru A, Muhindo M, Ochieng T, Plenty A, Koss CA, Clark TD, Awori P, Nakalambe M, Cohan D, Jagannathan P, Gosling R, Havlir DV, Kamya MR, Dorsey G -
Impact of Intermittent Preventive Treatment During Pregnancy on Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Uganda.
The Journal of infectious diseases 2017 Conrad MD, Mota D, Foster M, Tukwasibwe S, Legac J, Tumwebaze P, Whalen M, Kakuru A, Nayebare P, Wallender E, Havlir DV, Jagannathan P, Huang L, Aweeka F, Kamya MR, Dorsey G, Rosenthal PJ -
Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges.
Malaria journal 2017 Dahal P, Simpson JA, Dorsey G, Guérin PJ, Price RN, Stepniewska K -
The Development of Plasmodium falciparum-Specific IL10 CD4 T Cells and Protection from Malaria in Children in an Area of High Malaria Transmission.
Frontiers in immunology 2017 Boyle MJ, Jagannathan P, Bowen K, McIntyre TI, Vance HM, Farrington LA, Schwartz A, Nankya F, Naluwu K, Wamala S, Sikyomu E, Rek J, Greenhouse B, Arinaitwe E, Dorsey G, Kamya MR, Feeney ME -
Altered angiogenesis as a common mechanism underlying preterm birth, small for gestational age, and stillbirth in women living with HIV.
American journal of obstetrics and gynecology 2017 Conroy AL, McDonald CR, Gamble JL, Olwoch P, Natureeba P, Cohan D, Kamya MR, Havlir DV, Dorsey G, Kain KC -
Comparative Prevalence of Plasmodium falciparum Resistance-Associated Genetic Polymorphisms in Parasites Infecting Humans and Mosquitoes in Uganda.
The American journal of tropical medicine and hygiene 2017 Conrad MD, Mota D, Musiime A, Kilama M, Rek J, Kamya M, Dorsey G, Rosenthal PJ -
Performance of Loop-Mediated Isothermal Amplification for the Identification of Submicroscopic Plasmodium falciparum Infection in Uganda.
The American journal of tropical medicine and hygiene 2017 Katrak S, Murphy M, Nayebare P, Rek J, Smith M, Arinaitwe E, Nankabirwa JI, Kamya M, Dorsey G, Rosenthal PJ, Greenhouse B -
Relationships between infection with Plasmodium falciparum during pregnancy, measures of placental malaria, and adverse birth outcomes.
Malaria journal 2017 Kapisi J, Kakuru A, Jagannathan P, Muhindo MK, Natureeba P, Awori P, Nakalembe M, Ssekitoleko R, Olwoch P, Ategeka J, Nayebare P, Clark TD, Rizzuto G, Muehlenbachs A, Havlir DV, Kamya MR, Dorsey G, … -
Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2017 Walakira A, Tukwasibwe S, Kiggundu M, Verra F, Kakeeto P, Ruhamyankaka E, Drakeley C, Dorsey G, Kamya MR, Nsobya SL, Rosenthal PJ -
Population genomics of virulence genes of Plasmodium falciparum in clinical isolates from Uganda.
Scientific reports 2017 Ruybal-Pesántez S, Tiedje KE, Tonkin-Hill G, Rask TS, Kamya MR, Greenhouse B, Dorsey G, Duffy MF, Day KP -
Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure.
Scientific reports 2017 Jagannathan P, Lutwama F, Boyle MJ, Nankya F, Farrington LA, McIntyre TI, Bowen K, Naluwu K, Nalubega M, Musinguzi K, Sikyomu E, Budker R, Katureebe A, Rek J, Greenhouse B, Dorsey G, Kamya MR, Feeney … -
Resurgence of Malaria Following Discontinuation of Indoor Residual Spraying of Insecticide in an Area of Uganda With Previously High-Transmission Intensity.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017 Raouf S, Mpimbaza A, Kigozi R, Sserwanga A, Rubahika D, Katamba H, Lindsay SW, Kapella BK, Belay KA, Kamya MR, Staedke SG, Dorsey G -
Intermittent Preventive Treatment With Dihydroartemisinin-Piperaquine for the Prevention of Malaria Among HIV-Infected Pregnant Women.
The Journal of infectious diseases 2017 Natureeba P, Kakuru A, Muhindo M, Ochieng T, Ategeka J, Koss CA, Plenty A, Charlebois ED, Clark TD, Nzarubara B, Nakalembe M, Cohan D, Rizzuto G, Muehlenbachs A, Ruel T, Jagannathan P, Havlir DV, … -
Haemoglobin changes and risk of anaemia following treatment for uncomplicated falciparum malaria in sub-Saharan Africa.
BMC infectious diseases 2017 Zwang J, D'Alessandro U, Ndiaye JL, Djimdé AA, Dorsey G, Mårtensson AA, Karema C, Olliaro PL -
Antiretroviral Therapy With Efavirenz Accentuates Pregnancy-Associated Reduction of Dihydroartemisinin-Piperaquine Exposure During Malaria Chemoprevention.
Clinical pharmacology and therapeutics 2017 Kajubi R, Huang L, Jagannathan P, Chamankhah N, Were M, Ruel T, Koss CA, Kakuru A, Mwebaza N, Kamya M, Havlir D, Dorsey G, Rosenthal PJ, Aweeka FT -
Low-Quality Housing Is Associated With Increased Risk of Malaria Infection: A National Population-Based Study From the Low Transmission Setting of Swaziland.
Open forum infectious diseases 2017 Dlamini N, Hsiang MS, Ntshalintshali N, Pindolia D, Allen R, Nhlabathi N, Novotny J, Kang Dufour MS, Midekisa A, Gosling R, LeMenach A, Cohen J, Dorsey G, Greenhouse B, Kunene S -
Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda.
Malaria journal 2017 Tukwasibwe S, Tumwebaze P, Conrad M, Arinaitwe E, Kamya MR, Dorsey G, Nsobya SL, Greenhouse B, Rosenthal PJ -
The impact of an intervention to introduce malaria rapid diagnostic tests on fever case management in a high transmission setting in Uganda: A mixed-methods cluster-randomized trial (PRIME).
PloS one 2017 Chandler CI, Webb EL, Maiteki-Sebuguzi C, Nayiga S, Nabirye C, DiLiberto DD, Ssemmondo E, Dorsey G, Kamya MR, Staedke SG -
Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda.
The Journal of infectious diseases 2017 Tumwebaze P, Tukwasibwe S, Taylor A, Conrad M, Ruhamyankaka E, Asua V, Walakira A, Nankabirwa J, Yeka A, Staedke SG, Greenhouse B, Nsobya SL, Kamya MR, Dorsey G, Rosenthal PJ -
Sex Disparity in Cord Blood FoxP3+ CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero.
Open forum infectious diseases 2017 Prahl M, Jagannathan P, McIntyre TI, Auma A, Wamala S, Nalubega M, Musinguzi K, Naluwu K, Sikyoma E, Budker R, Odorizzi P, Kakuru A, Havlir DV, Kamya MR, Dorsey G, Feeney ME -
Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda.
Malaria journal 2017 Ssewanyana I, Arinaitwe E, Nankabirwa JI, Yeka A, Sullivan R, Kamya MR, Rosenthal PJ, Dorsey G, Mayanja-Kizza H, Drakeley C, Greenhouse B, Tetteh KK -
THE REAL McCOIL: A method for the concurrent estimation of the complexity of infection and SNP allele frequency for malaria parasites.
PLoS computational biology 2017 Chang HH, Worby CJ, Yeka A, Nankabirwa J, Kamya MR, Staedke SG, Dorsey G, Murphy M, Neafsey DE, Jeffreys AE, Hubbart C, Rockett KA, Amato R, Kwiatkowski DP, Buckee CO, Greenhouse B -
Spatio-temporal analysis of malaria vector density from baseline through intervention in a high transmission setting.
Parasites & vectors 2016 Alegana VA, Kigozi SP, Nankabirwa J, Arinaitwe E, Kigozi R, Mawejje H, Kilama M, Ruktanonchai NW, Ruktanonchai CW, Drakeley C, Lindsay SW, Greenhouse B, Kamya MR, Smith DL, Atkinson PM, Dorsey G, … -
Safety, tolerability, and efficacy of repeated doses of dihydroartemisinin-piperaquine for prevention and treatment of malaria: a systematic review and meta-analysis.
The Lancet. Infectious diseases 2016 Gutman J, Kovacs S, Dorsey G, Stergachis A, Ter Kuile FO -
Measures of Malaria Burden after Long-Lasting Insecticidal Net Distribution and Indoor Residual Spraying at Three Sites in Uganda: A Prospective Observational Study.
PLoS medicine 2016 Katureebe A, Zinszer K, Arinaitwe E, Rek J, Kakande E, Charland K, Kigozi R, Kilama M, Nankabirwa J, Yeka A, Mawejje H, Mpimbaza A, Katamba H, Donnelly MJ, Rosenthal PJ, Drakeley C, Lindsay SW, … -
Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine Exert Inverse Selective Pressure on Plasmodium Falciparum Drug Sensitivity-Associated Haplotypes in Uganda.
Open forum infectious diseases 2016 Taylor AR, Flegg JA, Holmes CC, Guérin PJ, Sibley CH, Conrad MD, Dorsey G, Rosenthal PJ -
Malaria burden in a birth cohort of HIV-exposed uninfected Ugandan infants living in a high malaria transmission setting.
Malaria journal 2016 Kakuru A, Natureeba P, Muhindo MK, Clark TD, Havlir DV, Cohan D, Dorsey G, Kamya MR, Ruel T -
Timing of in utero malaria exposure influences fetal CD4 T cell regulatory versus effector differentiation.
Malaria journal 2016 Prahl M, Jagannathan P, McIntyre TI, Auma A, Farrington L, Wamala S, Nalubega M, Musinguzi K, Naluwu K, Sikyoma E, Budker R, Vance H, Odorizzi P, Nayebare P, Ategeka J, Kakuru A, Havlir DV, Kamya MR, … -
Intermittent Preventive Treatment with Dihydroartemisinin-Piperaquine in Ugandan Schoolchildren Selects for Plasmodium falciparum Transporter Polymorphisms That Modify Drug Sensitivity.
Antimicrobial agents and chemotherapy 2016 Nankabirwa JI, Conrad MD, Legac J, Tukwasibwe S, Tumwebaze P, Wandera B, Brooker SJ, Staedke SG, Kamya MR, Nsobya SL, Dorsey G, Rosenthal PJ -
Characterizing microscopic and submicroscopic malaria parasitaemia at three sites with varied transmission intensity in Uganda.
Malaria journal 2016 Rek J, Katrak S, Obasi H, Nayebare P, Katureebe A, Kakande E, Arinaitwe E, Nankabirwa JI, Jagannathan P, Drakeley C, Staedke SG, Smith DL, Bousema T, Kamya M, Rosenthal PJ, Dorsey G, Greenhouse B -
A Novel Model of Asymptomatic Plasmodium Parasitemia That Recapitulates Elements of the Human Immune Response to Chronic Infection.
PloS one 2016 Fontana MF, Baccarella A, Craft JF, Boyle MJ, McIntyre TI, Wood MD, Thorn KS, Anidi C, Bayat A, Chung MR, Hamburger R, Kim CY, Pearman E, Pham J, Tang JJ, Boon L, Kamya MR, Dorsey G, Feeney ME, Kim CC -
Reductions in malaria in pregnancy and adverse birth outcomes following indoor residual spraying of insecticide in Uganda.
Malaria journal 2016 Muhindo MK, Kakuru A, Natureeba P, Awori P, Olwoch P, Ategeka J, Nayebare P, Clark TD, Muehlenbachs A, Roh M, Mpeka B, Greenhouse B, Havlir DV, Kamya MR, Dorsey G, Jagannathan P -
Why is malaria associated with poverty? Findings from a cohort study in rural Uganda.
Infectious diseases of poverty 2016 Tusting LS, Rek J, Arinaitwe E, Staedke SG, Kamya MR, Cano J, Bottomley C, Johnston D, Dorsey G, Lindsay SW, Lines J -
Quantifying Heterogeneous Malaria Exposure and Clinical Protection in a Cohort of Ugandan Children.
The Journal of infectious diseases 2016 Rodriguez-Barraquer I, Arinaitwe E, Jagannathan P, Boyle MJ, Tappero J, Muhindo M, Kamya MR, Dorsey G, Drakeley C, Ssewanyana I, Smith DL, Greenhouse B -
The Impact of an Intervention to Improve Malaria Care in Public Health Centers on Health Indicators of Children in Tororo, Uganda (PRIME): A Cluster-Randomized Trial.
The American journal of tropical medicine and hygiene 2016 Staedke SG, Maiteki-Sebuguzi C, DiLiberto DD, Webb EL, Mugenyi L, Mbabazi E, Gonahasa S, Kigozi SP, Willey BA, Dorsey G, Kamya MR, Chandler CIR -
Tuberculosis Infection in Early Childhood and the Association with HIV-exposure in HIV-uninfected Children in Rural Uganda.
The Pediatric infectious disease journal 2016 Marquez C, Chamie G, Achan J, Luetkemeyer AF, Kyohere M, Okiring J, Dorsey G, Kamya MR, Charlebois ED, Havlir DV -
Malaria illness mediated by anaemia lessens cognitive development in younger Ugandan children.
Malaria journal 2016 Boivin MJ, Sikorskii A, Familiar-Lopez I, Ruiseñor-Escudero H, Muhindo M, Kapisi J, Bigira V, Bass JK, Opoka RO, Nakasujja N, Kamya M, Dorsey G -
Effective Antimalarial Chemoprevention in Childhood Enhances the Quality of CD4+ T Cells and Limits Their Production of Immunoregulatory Interleukin 10.
The Journal of infectious diseases 2016 Jagannathan P, Bowen K, Nankya F, McIntyre TI, Auma A, Wamala S, Sikyomu E, Naluwu K, Nalubega M, Boyle MJ, Farrington LA, Bigira V, Kapisi J, Aweeka F, Greenhouse B, Kamya M, Dorsey G, Feeney ME -
Erratum to: B cell sub-types following acute malaria and associations with clinical immunity.
Malaria journal 2016 Sullivan RT, Ssewanyana I, Wamala S, Nankya F, Jagannathan P, Tappero JW, Mayanja-Kizza H, Muhindo MK, Arinaitwe E, Kamya M, Dorsey G, Feeney ME, Riley EM, Drakeley CJ, Greenhouse B -
Dihydroartemisinin-Piperaquine for the Prevention of Malaria in Pregnancy.
The New England journal of medicine 2016 Kakuru A, Jagannathan P, Muhindo MK, Natureeba P, Awori P, Nakalembe M, Opira B, Olwoch P, Ategeka J, Nayebare P, Clark TD, Feeney ME, Charlebois ED, Rizzuto G, Muehlenbachs A, Havlir DV, Kamya MR, … -
B cell sub-types following acute malaria and associations with clinical immunity.
Malaria journal 2016 Sullivan RT, Ssewanyana I, Wamala S, Nankya F, Jagannathan P, Tappero JW, Mayanja-Kizza H, Muhindo MK, Arinaitwe E, Kamya M, Dorsey G, Feeney ME, Riley EM, Drakeley CJ, Greenhouse B, Sullivan R -
Community-wide Prevalence of Malaria Parasitemia in HIV-Infected and Uninfected Populations in a High-Transmission Setting in Uganda.
The Journal of infectious diseases 2016 Katrak S, Day N, Ssemmondo E, Kwarisiima D, Midekisa A, Greenhouse B, Kamya M, Havlir D, Dorsey G -
Measuring Socioeconomic Inequalities in Relation to Malaria Risk: A Comparison of Metrics in Rural Uganda.
The American journal of tropical medicine and hygiene 2016 Tusting LS, Rek JC, Arinaitwe E, Staedke SG, Kamya MR, Bottomley C, Johnston D, Lines J, Dorsey G, Lindsay SW -
Estimating malaria parasite prevalence from community surveys in Uganda: a comparison of microscopy, rapid diagnostic tests and polymerase chain reaction.
Malaria journal 2015 Nankabirwa JI, Yeka A, Arinaitwe E, Kigozi R, Drakeley C, Kamya MR, Greenhouse B, Rosenthal PJ, Dorsey G, Staedke SG -
Frequent Malaria Drives Progressive Vδ2 T-Cell Loss, Dysfunction, and CD16 Up-regulation During Early Childhood.
The Journal of infectious diseases 2015 Farrington LA, Jagannathan P, McIntyre TI, Vance HM, Bowen K, Boyle MJ, Nankya F, Wamala S, Auma A, Nalubega M, Sikyomu E, Naluwu K, Bigira V, Kapisi J, Dorsey G, Kamya MR, Feeney ME -
Artesunate/Amodiaquine Versus Artemether/Lumefantrine for the Treatment of Uncomplicated Malaria in Uganda: A Randomized Trial.
The Journal of infectious diseases 2015 Yeka A, Kigozi R, Conrad MD, Lugemwa M, Okui P, Katureebe C, Belay K, Kapella BK, Chang MA, Kamya MR, Staedke SG, Dorsey G, Rosenthal PJ -
Associations between urbanicity and malaria at local scales in Uganda.
Malaria journal 2015 Kigozi SP, Pindolia DK, Smith DL, Arinaitwe E, Katureebe A, Kilama M, Nankabirwa J, Lindsay SW, Staedke SG, Dorsey G, Kamya MR, Tatem AJ -
Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children.
Malaria journal 2015 Sundell K, Jagannathan P, Huang L, Bigira V, Kapisi J, Kakuru MM, Savic R, Kamya MR, Dorsey G, Aweeka F -
Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data.
BMC medicine 2015 WWARN Artemisinin based Combination Therapy (ACT) Africa Baseline Study Group, Dahal P, d'Alessandro U, Dorsey G, Guerin PJ, Nsanzabana C, Price RN, Sibley CH, Stepniewska K, Talisuna AO -
Anti-malarial prescription practices among children admitted to six public hospitals in Uganda from 2011 to 2013.
Malaria journal 2015 Sserwanga A, Sears D, Kapella BK, Kigozi R, Rubahika D, Staedke SG, Kamya M, Yoon SS, Chang MA, Dorsey G, Mpimbaza A -
Malaria Epidemiology and Control Within the International Centers of Excellence for Malaria Research.
The American journal of tropical medicine and hygiene 2015 Moss WJ, Dorsey G, Mueller I, Laufer MK, Krogstad DJ, Vinetz JM, Guzman M, Rosas-Aguirre AM, Herrera S, Arevalo-Herrera M, Chery L, Kumar A, Mohapatra PK, Ramanathapuram L, Srivastava HC, Cui L, Zhou … -
Admission Risk Score to Predict Inpatient Pediatric Mortality at Four Public Hospitals in Uganda.
PloS one 2015 Mpimbaza A, Sears D, Sserwanga A, Kigozi R, Rubahika D, Nadler A, Yeka A, Dorsey G -
Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities.
Proceedings of the National Academy of Sciences of the United States of America 2015 Helb DA, Tetteh KK, Felgner PL, Skinner J, Hubbard A, Arinaitwe E, Mayanja-Kizza H, Ssewanyana I, Kamya MR, Beeson JG, Tappero J, Smith DL, Crompton PD, Rosenthal PJ, Dorsey G, Drakeley CJ, Greenhouse… -
Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria.
PLoS pathogens 2015 Boyle MJ, Jagannathan P, Farrington LA, Eccles-James I, Wamala S, McIntyre TI, Vance HM, Bowen K, Nankya F, Auma A, Nalubega M, Sikyomu E, Naluwu K, Rek J, Katureebe A, Bigira V, Kapisi J, Tappero J, … -
Forecasting malaria in a highly endemic country using environmental and clinical predictors.
Malaria journal 2015 Zinszer K, Kigozi R, Charland K, Dorsey G, Brewer TF, Brownstein JS, Kamya MR, Buckeridge DL -
The evidence for improving housing to reduce malaria: a systematic review and meta-analysis.
Malaria journal 2015 Tusting LS, Ippolito MM, Willey BA, Kleinschmidt I, Dorsey G, Gosling RD, Lindsay SW -
FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure.
PLoS pathogens 2015 Sullivan RT, Kim CC, Fontana MF, Feeney ME, Jagannathan P, Boyle MJ, Drakeley CJ, Ssewanyana I, Nankya F, Mayanja-Kizza H, Dorsey G, Greenhouse B -
Quality of inpatient pediatric case management for four leading causes of child mortality at six government-run Ugandan hospitals.
PloS one 2015 Sears D, Mpimbaza A, Kigozi R, Sserwanga A, Chang MA, Kapella BK, Yoon S, Kamya MR, Dorsey G, Ruel T -
Poor housing construction associated with increased malaria incidence in a cohort of young Ugandan children.
The American journal of tropical medicine and hygiene 2015 Snyman K, Mwangwa F, Bigira V, Kapisi J, Clark TD, Osterbauer B, Greenhouse B, Sturrock H, Gosling R, Liu J, Dorsey G -
The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data.
BMC medicine 2015 WorldWide Antimalarial Resistance Network (WWARN) AS-AQ Study Group, Adjuik MA, Allan R, Anvikar AR, Ashley EA, Ba MS, Barennes H, Barnes KI, Bassat Q, Baudin E, Björkman A, Bompart F, Bonnet M, … -
Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control.
The American journal of tropical medicine and hygiene 2015 Kamya MR, Arinaitwe E, Wanzira H, Katureebe A, Barusya C, Kigozi SP, Kilama M, Tatem AJ, Rosenthal PJ, Drakeley C, Lindsay SW, Staedke SG, Smith DL, Greenhouse B, Dorsey G -
Factors associated with malaria parasitemia, anemia and serological responses in a spectrum of epidemiological settings in Uganda.
PloS one 2015 Yeka A, Nankabirwa J, Mpimbaza A, Kigozi R, Arinaitwe E, Drakeley C, Greenhouse B, Kamya MR, Dorsey G, Staedke SG -
Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children.
Antimicrobial agents and chemotherapy 2015 Tumwebaze P, Conrad MD, Walakira A, LeClair N, Byaruhanga O, Nakazibwe C, Kozak B, Bloome J, Okiring J, Kakuru A, Bigira V, Kapisi J, Legac J, Gut J, Cooper RA, Kamya MR, Havlir DV, Dorsey G, … -
The Effect of Storage and Extraction Methods on Amplification of Plasmodium falciparum DNA from Dried Blood Spots.
The American journal of tropical medicine and hygiene 2015 Schwartz A, Baidjoe A, Rosenthal PJ, Dorsey G, Bousema T, Greenhouse B -
The effect of malnutrition on the pharmacokinetics and virologic outcomes of lopinavir, efavirenz and nevirapine in food insecure HIV-infected children in Tororo, Uganda.
The Pediatric infectious disease journal 2015 Bartelink IH, Savic RM, Dorsey G, Ruel T, Gingrich D, Scherpbier HJ, Capparelli E, Jullien V, Young SL, Achan J, Plenty A, Charlebois E, Kamya M, Havlir D, Aweeka F -
Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria in the setting of three different chemopreventive regimens.
Malaria journal 2015 Kapisi J, Bigira V, Clark T, Kinara S, Mwangwa F, Achan J, Kamya M, Soremekun S, Dorsey G -
Effector Phenotype of Plasmodium falciparum-Specific CD4+ T Cells Is Influenced by Both Age and Transmission Intensity in Naturally Exposed Populations.
The Journal of infectious diseases 2015 Boyle MJ, Jagannathan P, Bowen K, McIntyre TI, Vance HM, Farrington LA, Greenhouse B, Nankya F, Rek J, Katureebe A, Arinaitwe E, Dorsey G, Kamya MR, Feeney ME -
Mind the gap: house structure and the risk of malaria in Uganda.
PloS one 2015 Wanzirah H, Tusting LS, Arinaitwe E, Katureebe A, Maxwell K, Rek J, Bottomley C, Staedke SG, Kamya M, Dorsey G, Lindsay SW -
IFNγ Responses to Pre-erythrocytic and Blood-stage Malaria Antigens Exhibit Differential Associations With Past Exposure and Subsequent Protection.
The Journal of infectious diseases 2014 Jagannathan P, Nankya F, Stoyanov C, Eccles-James I, Sikyomu E, Naluwu K, Wamala S, Nalubega M, Briggs J, Bowen K, Bigira V, Kapisi J, Kamya MR, Dorsey G, Feeney ME -
Protective efficacy of prolonged co-trimoxazole prophylaxis in HIV-exposed children up to age 4 years for the prevention of malaria in Uganda: a randomised controlled open-label trial.
The Lancet. Global health 2014 Homsy J, Dorsey G, Arinaitwe E, Wanzira H, Kakuru A, Bigira V, Muhindo M, Kamya MR, Sandison TG, Tappero JW -
Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial.
AIDS (London, England) 2014 Kamya MR, Kapisi J, Bigira V, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Kakuru A, Aweeka FT, Huang L, Jagannathan P, Achan J, Havlir DV, Rosenthal PJ, Dorsey G -
Comparison of routine health management information system versus enhanced inpatient malaria surveillance for estimating the burden of malaria among children admitted to four hospitals in Uganda.
The American journal of tropical medicine and hygiene 2014 Mpimbaza A, Miles M, Sserwanga A, Kigozi R, Wanzira H, Rubahika D, Nasr S, Kapella BK, Yoon SS, Chang M, Yeka A, Staedke SG, Kamya MR, Dorsey G -
Household food insecurity, maternal nutritional status, and infant feeding practices among HIV-infected Ugandan women receiving combination antiretroviral therapy.
Maternal and child health journal 2014 Young SL, Plenty AH, Luwedde FA, Natamba BK, Natureeba P, Achan J, Mwesigwa J, Ruel TD, Ades V, Osterbauer B, Clark TD, Dorsey G, Charlebois ED, Kamya M, Havlir DV, Cohan DL -
Assessing the quality of tuberculosis evaluation for children with prolonged cough presenting to routine community health care settings in rural Uganda.
PloS one 2014 Marquez C, Davis JL, Katamba A, Haguma P, Ochom E, Ayakaka I, Chamie G, Dorsey G, Kamya MR, Charlebois E, Havlir DV, Cattamanchi A -
Loss and dysfunction of Vδ2⁺ γδ T cells are associated with clinical tolerance to malaria.
Science translational medicine 2014 Jagannathan P, Kim CC, Greenhouse B, Nankya F, Bowen K, Eccles-James I, Muhindo MK, Arinaitwe E, Tappero JW, Kamya MR, Dorsey G, Feeney ME -
Increased morbidity in early childhood among HIV-exposed uninfected children in Uganda is associated with breastfeeding duration.
Journal of tropical pediatrics 2014 Marquez C, Okiring J, Chamie G, Ruel TD, Achan J, Kakuru A, Kamya MR, Charlebois ED, Havlir DV, Dorsey G -
Polymorphisms in K13 and falcipain-2 associated with artemisinin resistance are not prevalent in Plasmodium falciparum isolated from Ugandan children.
PloS one 2014 Conrad MD, Bigira V, Kapisi J, Muhindo M, Kamya MR, Havlir DV, Dorsey G, Rosenthal PJ -
Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial.
PLoS medicine 2014 Bigira V, Kapisi J, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Osterbauer B, Aweeka FT, Huang L, Achan J, Havlir DV, Rosenthal PJ, Kamya MR, Dorsey G -
Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine.
The American journal of tropical medicine and hygiene 2014 Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C, Moriera C, Price RN, Mårtensson A, Rosenthal PJ, Dorsey G, Sutherland CJ, Guérin P, Davis TME, Ménard D, Adam I, Ademowo G, Arze C, … -
Lopinavir/ritonavir-based antiretroviral treatment (ART) versus efavirenz-based ART for the prevention of malaria among HIV-infected pregnant women.
The Journal of infectious diseases 2014 Natureeba P, Ades V, Luwedde F, Mwesigwa J, Plenty A, Okong P, Charlebois ED, Clark TD, Nzarubara B, Havlir DV, Achan J, Kamya MR, Cohan D, Dorsey G -
Long-lasting insecticide-treated bed net ownership and use among children under five years of age following a targeted distribution in central Uganda.
Malaria journal 2014 Wanzira H, Yeka A, Kigozi R, Rubahika D, Nasr S, Sserwanga A, Kamya M, Filler S, Dorsey G, Steinhardt L -
Longitudinal outcomes in a cohort of Ugandan children randomized to artemether-lumefantrine versus dihydroartemisinin-piperaquine for the treatment of malaria.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2014 Wanzira H, Kakuru A, Arinaitwe E, Bigira V, Muhindo MK, Conrad M, Rosenthal PJ, Kamya MR, Tappero JW, Dorsey G -
Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda.
The American journal of tropical medicine and hygiene 2014 Mbogo GW, Nankoberanyi S, Tukwasibwe S, Baliraine FN, Nsobya SL, Conrad MD, Arinaitwe E, Kamya M, Tappero J, Staedke SG, Dorsey G, Greenhouse B, Rosenthal PJ -
Artemisinin-based combination therapies are efficacious and safe for treatment of uncomplicated malaria in HIV-infected Ugandan children.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2014 Kakuru A, Achan J, Muhindo MK, Ikilezi G, Arinaitwe E, Mwangwa F, Ruel T, Clark TD, Charlebois E, Rosenthal PJ, Havlir D, Kamya MR, Tappero JW, Dorsey G -
Virologic and immunologic outcomes of HIV-infected Ugandan children randomized to lopinavir/ritonavir or nonnucleoside reverse transcriptase inhibitor therapy.
Journal of acquired immune deficiency syndromes (1999) 2014 Ruel TD, Kakuru A, Ikilezi G, Mwangwa F, Dorsey G, Rosenthal PJ, Charlebois E, Havlir D, Kamya M, Achan J -
Plasmodium falciparum clearance in clinical studies of artesunate-amodiaquine and comparator treatments in sub-Saharan Africa, 1999-2009.
Malaria journal 2014 Zwang J, Dorsey G, Mårtensson A, d'Alessandro U, Ndiaye JL, Karema C, Djimde A, Brasseur P, Sirima SB, Olliaro P -
Estimating the annual entomological inoculation rate for Plasmodium falciparum transmitted by Anopheles gambiae s.l. using three sampling methods in three sites in Uganda.
Malaria journal 2014 Kilama M, Smith DL, Hutchinson R, Kigozi R, Yeka A, Lavoy G, Kamya MR, Staedke SG, Donnelly MJ, Drakeley C, Greenhouse B, Dorsey G, Lindsay SW -
Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections.
Malaria journal 2014 Taylor AR, Flegg JA, Nsobya SL, Yeka A, Kamya MR, Rosenthal PJ, Dorsey G, Sibley CH, Guerin PJ, Holmes CC -
Impact of intermittent preventive treatment with dihydroartemisinin-piperaquine on malaria in Ugandan schoolchildren: a randomized, placebo-controlled trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2014 Nankabirwa JI, Wandera B, Amuge P, Kiwanuka N, Dorsey G, Rosenthal PJ, Brooker SJ, Staedke SG, Kamya MR -
Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children.
The Journal of infectious diseases 2014 Conrad MD, LeClair N, Arinaitwe E, Wanzira H, Kakuru A, Bigira V, Muhindo M, Kamya MR, Tappero JW, Greenhouse B, Dorsey G, Rosenthal PJ -
Early parasite clearance following artemisinin-based combination therapy among Ugandan children with uncomplicated Plasmodium falciparum malaria.
Malaria journal 2014 Muhindo MK, Kakuru A, Jagannathan P, Talisuna A, Osilo E, Orukan F, Arinaitwe E, Tappero JW, Kaharuza F, Kamya MR, Dorsey G -
Determining health-care facility catchment areas in Uganda using data on malaria-related visits.
Bulletin of the World Health Organization 2014 Zinszer K, Charland K, Kigozi R, Dorsey G, Kamya MR, Buckeridge DL -
IFNγ/IL-10 co-producing cells dominate the CD4 response to malaria in highly exposed children.
PLoS pathogens 2014 Jagannathan P, Eccles-James I, Bowen K, Nankya F, Auma A, Wamala S, Ebusu C, Muhindo MK, Arinaitwe E, Briggs J, Greenhouse B, Tappero JW, Kamya MR, Dorsey G, Feeney ME -
Determination of the antimalarial drug piperaquine in small volume pediatric plasma samples by LC-MS/MS.
Bioanalysis 2014 Kjellin LL, Dorsey G, Rosenthal PJ, Aweeka F, Huang L -
The PRIME trial protocol: evaluating the impact of an intervention implemented in public health centres on management of malaria and health outcomes of children using a cluster-randomised design in Tororo, Uganda.
Implementation science : IS 2013 Staedke SG, Chandler CI, DiLiberto D, Maiteki-Sebuguzi C, Nankya F, Webb E, Dorsey G, Kamya MR -
Intermittent preventive therapy with sulfadoxine-pyrimethamine for malaria in pregnancy: a cross-sectional study from Tororo, Uganda.
PloS one 2013 Arinaitwe E, Ades V, Walakira A, Ninsiima B, Mugagga O, Patil TS, Schwartz A, Kamya MR, Nasr S, Chang M, Filler S, Dorsey G -
Anti-malarial prescription practices among outpatients with laboratory-confirmed malaria in the setting of a health facility-based sentinel site surveillance system in Uganda.
Malaria journal 2013 Sears D, Kigozi R, Mpimbaza A, Kakeeto S, Sserwanga A, Staedke SG, Chang M, Kapella BK, Rubahika D, Kamya MR, Dorsey G -
An artesunate-containing antimalarial treatment regimen did not suppress cytomegalovirus viremia.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2013 Gantt S, Huang ML, Magaret A, Bunts L, Selke S, Wald A, Rosenthal PJ, Dorsey G, Casper C -
The effect of indoor residual spraying on malaria and anemia in a high-transmission area of northern Uganda.
The American journal of tropical medicine and hygiene 2013 Steinhardt LC, Yeka A, Nasr S, Wiegand RE, Rubahika D, Sserwanga A, Wanzira H, Lavoy G, Kamya M, Dorsey G, Filler S -
The effects of ACT treatment and TS prophylaxis on Plasmodium falciparum gametocytemia in a cohort of young Ugandan children.
The American journal of tropical medicine and hygiene 2013 Kakuru A, Jagannathan P, Arinaitwe E, Wanzira H, Muhindo M, Bigira V, Osilo E, Homsy J, Kamya MR, Tappero JW, Dorsey G -
Prevalence of asymptomatic parasitemia and gametocytemia among HIV-infected Ugandan children randomized to receive different antiretroviral therapies.
The American journal of tropical medicine and hygiene 2013 Ikilezi G, Achan J, Kakuru A, Ruel T, Charlebois E, Clark TD, Rosenthal PJ, Havlir D, Kamya MR, Dorsey G -
Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda.
Malaria journal 2012 Jagannathan P, Muhindo MK, Kakuru A, Arinaitwe E, Greenhouse B, Tappero J, Rosenthal PJ, Kaharuza F, Kamya MR, Dorsey G -
Factors associated with malaria parasitaemia, malnutrition, and anaemia among HIV-exposed and unexposed Ugandan infants: a cross-sectional survey.
Malaria journal 2012 Osterbauer B, Kapisi J, Bigira V, Mwangwa F, Kinara S, Kamya MR, Dorsey G -
Associations between antibodies to a panel of Plasmodium falciparum specific antigens and response to sub-optimal antimalarial therapy in Kampala, Uganda.
PloS one 2012 Keh CE, Jha AR, Nzarubara B, Lanar DE, Dutta S, Theisen M, Rosenthal PJ, Dorsey G, Nixon DF, Greenhouse B -
Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children.
The New England journal of medicine 2012 Achan J, Kakuru A, Ikilezi G, Ruel T, Clark TD, Nsanzabana C, Charlebois E, Aweeka F, Dorsey G, Rosenthal PJ, Havlir D, Kamya MR -
Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteers.
Journal of acquired immune deficiency syndromes (1999) 2012 Huang L, Parikh S, Rosenthal PJ, Lizak P, Marzan F, Dorsey G, Havlir D, Aweeka FT -
Indoor residual spraying of insecticide and malaria morbidity in a high transmission intensity area of Uganda.
PloS one 2012 Kigozi R, Baxi SM, Gasasira A, Sserwanga A, Kakeeto S, Nasr S, Rubahika D, Dissanayake G, Kamya MR, Filler S, Dorsey G -
Clinical tolerability of artesunate-amodiaquine versus comparator treatments for uncomplicated falciparum malaria: an individual-patient analysis of eight randomized controlled trials in sub-Saharan Africa.
Malaria journal 2012 Zwang J, Dorsey G, Djimdé A, Karema C, Mårtensson A, Ndiaye JL, Sirima SB, Olliaro P -
Health facility-based malaria surveillance: the effects of age, area of residence and diagnostics on test positivity rates.
Malaria journal 2012 Francis D, Gasasira A, Kigozi R, Kigozi S, Nasr S, Kamya MR, Dorsey G -
The association between malnutrition and the incidence of malaria among young HIV-infected and -uninfected Ugandan children: a prospective study.
Malaria journal 2012 Arinaitwe E, Gasasira A, Verret W, Homsy J, Wanzira H, Kakuru A, Sandison TG, Young S, Tappero JW, Kamya MR, Dorsey G -
Improved clinical and laboratory skills after team-based, malaria case management training of health care professionals in Uganda.
Malaria journal 2012 Namagembe A, Ssekabira U, Weaver MR, Blum N, Burnett S, Dorsey G, Sebuyira LM, Ojaku A, Schneider G, Willis K, Yeka A -
Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait.
Blood 2012 Gong L, Maiteki-Sebuguzi C, Rosenthal PJ, Hubbard AE, Drakeley CJ, Dorsey G, Greenhouse B -
Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012 Ruel TD, Boivin MJ, Boal HE, Bangirana P, Charlebois E, Havlir DV, Rosenthal PJ, Dorsey G, Achan J, Akello C, Kamya MR, Wong JK -
Comparing changes in haematologic parameters occurring in patients included in randomized controlled trials of artesunate-amodiaquine vs single and combination treatments of uncomplicated falciparum in sub-Saharan Africa.
Malaria journal 2012 Zwang J, Ndiaye JL, Djimdé A, Dorsey G, Mårtensson A, Karema C, Olliaro P -
Surveillance for malaria elimination in Swaziland: a national cross-sectional study using pooled PCR and serology.
PloS one 2012 Hsiang MS, Hwang J, Kunene S, Drakeley C, Kandula D, Novotny J, Parizo J, Jensen T, Tong M, Kemere J, Dlamini S, Moonen B, Angov E, Dutta S, Ockenhouse C, Dorsey G, Greenhouse B -
The effect of HIV on malaria in the context of the current standard of care for HIV-infected populations in Africa.
Future virology 2012 Kamya MR, Byakika-Kibwika P, Gasasira AF, Havlir D, Rosenthal PJ, Dorsey G, Achan J -
The seroprevalence of Helicobacter pylori and its relationship to malaria in Ugandan children.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2011 Gupta V, Perez-Perez GI, Dorsey G, Rosenthal PJ, Blaser MJ -
Hematologic parameters in pediatric uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa.
The American journal of tropical medicine and hygiene 2011 Olliaro P, Djimdé A, Dorsey G, Karema C, Mårtensson A, Ndiaye JL, Sirima SB, Vaillant M, Zwang J -
Virologic suppression in nevirapine-exposed HIV-infected infants initiating antiretroviral therapy in rural Uganda.
Journal of tropical pediatrics 2011 Kay J, Wanzira H, Sandison T, Kakuru A, Bigira V, Kamya M, Homsy J, Tappero JW, Havlir D, Dorsey G, Ruel T -
Malaria in Uganda: challenges to control on the long road to elimination. II. The path forward.
Acta tropica 2011 Talisuna A, Adibaku S, Dorsey G, Kamya MR, Rosenthal PJ -
Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemic.
The Journal of infectious diseases 2011 Greenhouse B, Ho B, Hubbard A, Njama-Meya D, Narum DL, Lanar DE, Dutta S, Rosenthal PJ, Dorsey G, John CC -
Evaluation of a comprehensive refresher training program in malaria microscopy covering four districts of Uganda.
The American journal of tropical medicine and hygiene 2011 Kiggundu M, Nsobya SL, Kamya MR, Filler S, Nasr S, Dorsey G, Yeka A -
Protective efficacy of co-trimoxazole prophylaxis against malaria in HIV exposed children in rural Uganda: a randomised clinical trial.
BMJ (Clinical research ed.) 2011 Sandison TG, Homsy J, Arinaitwe E, Wanzira H, Kakuru A, Bigira V, Kalamya J, Vora N, Kublin J, Kamya MR, Dorsey G, Tappero JW -
Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts.
Acta tropica 2011 Yeka A, Gasasira A, Mpimbaza A, Achan J, Nankabirwa J, Nsobya S, Staedke SG, Donnelly MJ, Wabwire-Mangen F, Talisuna A, Dorsey G, Kamya MR, Rosenthal PJ -
Evaluating tuberculosis case detection via real-time monitoring of tuberculosis diagnostic services.
American journal of respiratory and critical care medicine 2011 Davis J, Katamba A, Vasquez J, Crawford E, Sserwanga A, Kakeeto S, Kizito F, Dorsey G, den Boon S, Vittinghoff E, Huang L, Adatu F, Kamya MR, Hopewell PC, Cattamanchi A -
Effect of nutritional status on response to treatment with artemisinin-based combination therapy in young Ugandan children with malaria.
Antimicrobial agents and chemotherapy 2011 Verret WJ, Arinaitwe E, Wanzira H, Bigira V, Kakuru A, Kamya M, Tappero JW, Sandison T, Dorsey G -
Likely health outcomes for untreated acute febrile illness in the tropics in decision and economic models; a Delphi survey.
PloS one 2011 Lubell Y, Staedke SG, Greenwood BM, Kamya MR, Molyneux M, Newton PN, Reyburn H, Snow RW, D'Alessandro U, English M, Day N, Kremsner P, Dondorp A, Mbacham W, Dorsey G, Owusu-Agyei S, Maitland K, … -
Standardised versus actual white cell counts in estimating thick film parasitaemia in African children under five.
Tropical medicine & international health : TM & IH 2011 Olliaro P, Djimdé A, Karema C, Mårtensson A, Ndiaye JL, Sirima SB, Dorsey G, Zwang J -
Improved malaria case management through the implementation of a health facility-based sentinel site surveillance system in Uganda.
PloS one 2011 Sserwanga A, Harris JC, Kigozi R, Menon M, Bukirwa H, Gasasira A, Kakeeto S, Kizito F, Quinto E, Rubahika D, Nasr S, Filler S, Kamya MR, Dorsey G -
Early virologic failure and the development of antiretroviral drug resistance mutations in HIV-infected Ugandan children.
Journal of acquired immune deficiency syndromes (1999) 2011 Ruel TD, Kamya MR, Li P, Pasutti W, Charlebois ED, Liegler T, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK, Achan J -
Short-term risk of HIV disease progression and death in Ugandan children not eligible for antiretroviral therapy.
Journal of acquired immune deficiency syndromes (1999) 2010 Charlebois ED, Ruel TD, Gasasira AF, Achan J, Kateera F, Akello C, Cao H, Dorsey G, Rosenthal PJ, Ssewanyana I, Kamya MR, Havlir DV -
Efficacy, safety, and tolerability of three regimens for prevention of malaria: a randomized, placebo-controlled trial in Ugandan schoolchildren.
PloS one 2010 Nankabirwa J, Cundill B, Clarke S, Kabatereine N, Rosenthal PJ, Dorsey G, Brooker S, Staedke SG -
Breastfeeding and the risk of malaria in children born to HIV-infected and uninfected mothers in rural Uganda.
Journal of acquired immune deficiency syndromes (1999) 2010 Vora N, Homsy J, Kakuru A, Arinaitwe E, Wanzira H, Sandison TG, Bigira V, Kamya MR, Tappero JW, Dorsey G -
Increased risk of early vomiting among infants and young children treated with dihydroartemisinin-piperaquine compared with artemether-lumefantrine for uncomplicated malaria.
The American journal of tropical medicine and hygiene 2010 Creek D, Bigira V, Arinaitwe E, Wanzira H, Kakuru A, Tappero J, Kamya MR, Dorsey G, Sandison TG -
Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypes.
Journal of virological methods 2010 Li P, Ruel T, Fujimoto K, Hatano H, Yukl S, Eller LA, Liegler T, Kamya M, Gassasira A, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK -
PCR-based pooling of dried blood spots for detection of malaria parasites: optimization and application to a cohort of Ugandan children.
Journal of clinical microbiology 2010 Hsiang MS, Lin M, Dokomajilar C, Kemere J, Pilcher CD, Dorsey G, Greenhouse B -
Acute HIV-1 infection is highly prevalent in Ugandan adults with suspected malaria.
AIDS (London, England) 2010 Bebell LM, Pilcher CD, Dorsey G, Havlir D, Kamya MR, Busch MP, Dunn Williams J, Nugent CT, Bentsen C, Rosenthal PJ, Charlebois ED -
Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children.
PloS one 2010 Clark TD, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Greenhouse B, Staedke SG, Kamya MR, Dorsey G, Rosenthal PJ -
Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance.
Malaria journal 2010 Gasasira AF, Kamya MR, Ochong EO, Vora N, Achan J, Charlebois E, Ruel T, Kateera F, Meya DN, Havlir D, Rosenthal PJ, Dorsey G -
Plasmodium falciparum dihydrofolate reductase and dihyropteroate synthase mutations and the use of trimethoprim-sulfamethoxazole prophylaxis among persons infected with human immunodeficiency virus.
The American journal of tropical medicine and hygiene 2010 Malamba S, Sandison T, Lule J, Reingold A, Walker J, Dorsey G, Mermin J -
In vivo parasitological measures of artemisinin susceptibility.
The Journal of infectious diseases 2010 Stepniewska K, Ashley E, Lee SJ, Anstey N, Barnes KI, Binh TQ, D'Alessandro U, Day NP, de Vries PJ, Dorsey G, Guthmann JP, Mayxay M, Newton PN, Olliaro P, Osorio L, Price RN, Rowland M, Smithuis F, … -
Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda.
Malaria journal 2010 Gupta V, Dorsey G, Hubbard AE, Rosenthal PJ, Greenhouse B -
Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009 Arinaitwe E, Sandison TG, Wanzira H, Kakuru A, Homsy J, Kalamya J, Kamya MR, Vora N, Greenhouse B, Rosenthal PJ, Tappero J, Dorsey G -
Safety and tolerability of artemether-lumefantrine versus dihydroartemisinin-piperaquine for malaria in young HIV-infected and uninfected children.
Malaria journal 2009 Katrak S, Gasasira A, Arinaitwe E, Kakuru A, Wanzira H, Bigira V, Sandison TG, Homsy J, Tappero JW, Kamya MR, Dorsey G -
Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda.
Malaria journal 2009 Newman PM, Wanzira H, Tumwine G, Arinaitwe E, Waldman S, Achan J, Havlir D, Rosenthal PJ, Dorsey G, Clark TD, Cohan D -
Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda.
Antimicrobial agents and chemotherapy 2009 Mwesigwa J, Parikh S, McGee B, German P, Drysdale T, Kalyango JN, Clark TD, Dorsey G, Lindegardh N, Annerberg A, Rosenthal PJ, Kamya MR, Aweeka F -
Assessing the impact of indoor residual spraying on malaria morbidity using a sentinel site surveillance system in Western Uganda.
The American journal of tropical medicine and hygiene 2009 Bukirwa H, Yau V, Kigozi R, Filler S, Quick L, Lugemwa M, Dissanayake G, Kamya M, Wabwire-Mangen F, Dorsey G -
Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children.
Malaria journal 2009 Jensen TP, Bukirwa H, Njama-Meya D, Francis D, Kamya MR, Rosenthal PJ, Dorsey G -
Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis.
Malaria journal 2009 Zwang J, Olliaro P, Barennes H, Bonnet M, Brasseur P, Bukirwa H, Cohuet S, D'Alessandro U, Djimdé A, Karema C, Guthmann JP, Hamour S, Ndiaye JL, Mårtensson A, Rwagacondo C, Sagara I, Same-Ekobo A, … -
Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission.
The Journal of infectious diseases 2009 Butler LM, Dorsey G, Hladik W, Rosenthal PJ, Brander C, Neilands TB, Mbisa G, Whitby D, Kiepiela P, Mosam A, Mzolo S, Dollard SC, Martin JN -
Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers.
Journal of acquired immune deficiency syndromes (1999) 2009 German P, Parikh S, Lawrence J, Dorsey G, Rosenthal PJ, Havlir D, Charlebois E, Hanpithakpong W, Lindegardh N, Aweeka FT -
Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: a prospective multi-centre individual patient data analysis.
PloS one 2009 Zwang J, Ashley EA, Karema C, D'Alessandro U, Smithuis F, Dorsey G, Janssens B, Mayxay M, Newton P, Singhasivanon P, Stepniewska K, White NJ, Nosten F -
Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial.
BMJ (Clinical research ed.) 2009 Achan J, Tibenderana JK, Kyabayinze D, Wabwire Mangen F, Kamya MR, Dorsey G, D'Alessandro U, Rosenthal PJ, Talisuna AO -
Interaction of malaria and HIV in Africa.
BMJ (Clinical research ed.) 2009 Reithinger R, Kamya MR, Whitty CJ, Dorsey G, Vermund SH -
The effect of varying analytical methods on estimates of anti-malarial clinical efficacy.
Malaria journal 2009 Verret WJ, Dorsey G, Nosten F, Price RN -
Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial.
Lancet (London, England) 2009 Staedke SG, Mwebaza N, Kamya MR, Clark TD, Dorsey G, Rosenthal PJ, Whitty CJ -
Antimalarial therapies in children from Papua New Guinea.
The New England journal of medicine 2009 Price RN, Dorsey G, Nosten F -
Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistance.
The Journal of infectious diseases 2009 Greenhouse B, Slater M, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Clark TD, Staedke SG, Kamya MR, Hubbard A, Rosenthal PJ, Dorsey G -
The Distribution and Immune Profile of T Cell Subsets in HIV-Infected Children from Uganda.
AIDS research and human retroviruses 2009 Ssewanyana I, Baker CA, Ruel T, Bousheri S, Kamya M, Dorsey G, Rosenthal PJ, Charlebois E, Havlir D, Cao H -
Improved malaria case management after integrated team-based training of health care workers in Uganda.
The American journal of tropical medicine and hygiene 2008 Ssekabira U, Bukirwa H, Hopkins H, Namagembe A, Weaver MR, Sebuyira LM, Quick L, Staedke S, Yeka A, Kiggundu M, Schneider G, McAdam K, Wabwire-Mangen F, Dorsey G -
Complexity of Plasmodium falciparum clinical samples from Uganda during short-term culture.
The Journal of infectious diseases 2008 Nsobya SL, Kiggundu M, Joloba M, Dorsey G, Rosenthal PJ -
Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children.
Malaria journal 2008 Ashley EA, Pinoges L, Turyakira E, Dorsey G, Checchi F, Bukirwa H, van den Broek I, Zongo I, Urruta PP, van Herp M, Balkan S, Taylor WR, Olliaro P, Guthmann JP -
The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria.
Malaria journal 2008 Lee SJ, Stepniewska K, Anstey N, Ashley E, Barnes K, Binh TQ, D'Alessandro U, Day NP, de Vries PJ, Dorsey G, Guthmann JP, Mayxay M, Newton P, Nosten F, Olliaro P, Osario L, Pinoges L, Price R, Rowland… -
Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda.
The Journal of infectious diseases 2008 Clark TD, Greenhouse B, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Staedke SG, Seto E, Kamya MR, Rosenthal PJ, Dorsey G -
Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda.
PloS one 2008 Yeka A, Dorsey G, Kamya MR, Talisuna A, Lugemwa M, Rwakimari JB, Staedke SG, Rosenthal PJ, Wabwire-Mangen F, Bukirwa H -
Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda.
Malaria journal 2008 Staedke SG, Jagannathan P, Yeka A, Bukirwa H, Banek K, Maiteki-Sebuguzi C, Clark TD, Nzarubara B, Njama-Meya D, Mpimbaza A, Rosenthal PJ, Kamya MR, Wabwire-Mangen F, Dorsey G, Talisuna AO -
Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children.
Malaria journal 2008 Maiteki-Sebuguzi C, Jagannathan P, Yau VM, Clark TD, Njama-Meya D, Nzarubara B, Talisuna AO, Kamya MR, Rosenthal PJ, Dorsey G, Staedke SG -
HIV RNA suppression among HIV-infected Ugandan children with measles.
Journal of acquired immune deficiency syndromes (1999) 2008 Ruel TD, Achan J, Gasasira AF, Charlebois ED, Mehbratu T, Rosenthal PJ, Dorsey G, Kamya MR, Kekitiinwa A, Wong J, Havlir DV -
Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum.
Antimicrobial agents and chemotherapy 2008 Mehlotra RK, Mattera G, Bockarie MJ, Maguire JD, Baird JK, Sharma YD, Alifrangis M, Dorsey G, Rosenthal PJ, Fryauff DJ, Kazura JW, Stoneking M, Zimmerman PA -
High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008 Gasasira AF, Kamya MR, Achan J, Mebrahtu T, Kalyango JN, Ruel T, Charlebois E, Staedke SG, Kekitiinwa A, Rosenthal PJ, Havlir D, Dorsey G -
Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda.
The Journal of infectious diseases 2008 Hopkins H, Bebell L, Kambale W, Dokomajilar C, Rosenthal PJ, Dorsey G -
HIV-1 infection in patients referred for malaria blood smears at government health clinics in Uganda.
Journal of acquired immune deficiency syndromes (1999) 2007 Bebell LM, Gasasira A, Kiggundu M, Dokomajilar C, Kamya MR, Charlebois ED, Havlir D, Rosenthal PJ, Dorsey G -
Pattern of malaria-specific T-cell responses in a cohort of Ugandan children.
Journal of tropical pediatrics 2007 Ssewanyana I, Pietras C, Baker CA, Nghania F, Jones NG, Rosenthal PJ, Dorsey G, Cao H -
Profile of T cell immune responses in HIV-infected children from Uganda.
The Journal of infectious diseases 2007 Ssewanyana I, Elrefaei M, Dorsey G, Ruel T, Jones NG, Gasasira A, Kamya M, Nakiwala J, Achan J, Charlebois E, Havlir D, Cao H -
Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007 Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Séré Y, Rosenthal PJ, Ouédraogo JB -
Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children.
AIDS (London, England) 2007 Kamya MR, Gasasira AF, Achan J, Mebrahtu T, Ruel T, Kekitiinwa A, Charlebois ED, Rosenthal PJ, Havlir D, Dorsey G -
World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs.
Malaria journal 2007 Price RN, Dorsey G, Ashley EA, Barnes KI, Baird JK, d'Alessandro U, Guerin PJ, Laufer MK, Naidoo I, Nosten F, Olliaro P, Plowe CV, Ringwald P, Sibley CH, Stepniewska K, White NJ -
Efficacy studies of malaria treatments in Africa: efficient estimation with missing indicators of failure.
Statistical methods in medical research 2007 Machekano RN, Dorsey G, Hubbard A -
Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials.
Antimicrobial agents and chemotherapy 2007 Greenhouse B, Dokomajilar C, Hubbard A, Rosenthal PJ, Dorsey G -
Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda.
Antimicrobial agents and chemotherapy 2007 Nsobya SL, Dokomajilar C, Joloba M, Dorsey G, Rosenthal PJ -
Comparison of HRP2- and pLDH-based rapid diagnostic tests for malaria with longitudinal follow-up in Kampala, Uganda.
The American journal of tropical medicine and hygiene 2007 Hopkins H, Kambale W, Kamya MR, Staedke SG, Dorsey G, Rosenthal PJ -
Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial.
JAMA 2007 Dorsey G, Staedke S, Clark TD, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Dokomajilar C, Kamya MR, Rosenthal PJ -
Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial.
PLoS clinical trials 2007 Kamya MR, Yeka A, Bukirwa H, Lugemwa M, Rwakimari JB, Staedke SG, Talisuna AO, Greenhouse B, Nosten F, Rosenthal PJ, Wabwire-Mangen F, Dorsey G -
Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007 German P, Greenhouse B, Coates C, Dorsey G, Rosenthal PJ, Charlebois E, Lindegardh N, Havlir D, Aweeka FT -
Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial.
Lancet (London, England) 2007 Zongo I, Dorsey G, Rouamba N, Tinto H, Dokomajilar C, Guiguemde RT, Rosenthal PJ, Ouedraogo JB -
Treatment of malaria restricted to laboratory-confirmed cases: a prospective cohort study in Ugandan children.
Malaria journal 2007 Njama-Meya D, Clark TD, Nzarubara B, Staedke S, Kamya MR, Dorsey G -
The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005.
Malaria journal 2006 Collins WJ, Greenhouse B, Rosenthal PJ, Dorsey G -
Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infections.
The American journal of tropical medicine and hygiene 2006 Greenhouse B, Myrick A, Dokomajilar C, Woo JM, Carlson EJ, Rosenthal PJ, Dorsey G -
Effect of cotrimoxazole prophylaxis taken by human immunodeficiency virus (HIV)-infected persons on the selection of sulfadoxine-pyrimethamine-resistant malaria parasites among HIV-uninfected household members.
The American journal of tropical medicine and hygiene 2006 Malamba SS, Mermin J, Reingold A, Lule JR, Downing R, Ransom R, Kigozi A, Hunt BM, Hubbard A, Rosenthal PJ, Dorsey G -
False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malaria.
Journal of clinical microbiology 2006 Gasasira AF, Dorsey G, Kamya MR, Havlir D, Kiggundu M, Rosenthal PJ, Charlebois ED -
Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso.
The American journal of tropical medicine and hygiene 2006 Dokomajilar C, Lankoande ZM, Dorsey G, Zongo I, Ouedraogo JB, Rosenthal PJ -
Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic review.
Tropical medicine & international health : TM & IH 2006 Hwang J, Bitarakwate E, Pai M, Reingold A, Rosenthal PJ, Dorsey G -
Prevention and treatment strategies used for the community management of childhood fever in Kampala, Uganda.
The American journal of tropical medicine and hygiene 2006 Kemble SK, Davis JC, Nalugwa T, Njama-Meya D, Hopkins H, Dorsey G, Staedke SG -
Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda.
PLoS clinical trials 2006 Bukirwa H, Yeka A, Kamya MR, Talisuna A, Banek K, Bakyaita N, Rwakimari JB, Rosenthal PJ, Wabwire-Mangen F, Dorsey G, Staedke SG -
Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic.
Antimicrobial agents and chemotherapy 2006 Dokomajilar C, Nsobya SL, Greenhouse B, Rosenthal PJ, Dorsey G -
Short report: Dynamics of Plasmodium falciparum malaria after sub-optimal therapy in Uganda.
The American journal of tropical medicine and hygiene 2006 Myrick A, Leemann E, Dokomajilar C, Hopkins H, Dorsey G, Kamya MR, Rosenthal PJ -
Longitudinal study of urban malaria in a cohort of Ugandan children: description of study site, census and recruitment.
Malaria journal 2006 Davis JC, Clark TD, Kemble SK, Talemwa N, Njama-Meya D, Staedke SG, Dorsey G -
Complexity of Plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda.
The Journal of infectious diseases 2006 Lee SA, Yeka A, Nsobya SL, Dokomajilar C, Rosenthal PJ, Talisuna A, Dorsey G -
Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance.
The Journal of infectious diseases 2006 Francis D, Nsobya SL, Talisuna A, Yeka A, Kamya MR, Machekano R, Dokomajilar C, Rosenthal PJ, Dorsey G -
CD4 T cell activation as a predictor for treatment failure in Ugandans with Plasmodium falciparum malaria.
The American journal of tropical medicine and hygiene 2006 Eggena MP, Hopkins H, Barugahare B, Okello M, Ssali F, Mugyenyi P, Rosenthal PJ, Cao H, Dorsey G -
Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study.
The Journal of infectious diseases 2005 Kamya MR, Gasasira AF, Yeka A, Bakyaita N, Nsobya SL, Francis D, Rosenthal PJ, Dorsey G, Havlir D -
Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso.
The American journal of tropical medicine and hygiene 2005 Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Lankoande M, Ouedraogo JB, Rosenthal PJ -
Distinguishing recrudescences from new infections in antimalarial clinical trials: major impact of interpretation of genotyping results on estimates of drug efficacy.
The American journal of tropical medicine and hygiene 2005 Slater M, Kiggundu M, Dokomajilar C, Kamya MR, Bakyaita N, Talisuna A, Rosenthal PJ, Dorsey G -
Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda.
PLoS medicine 2005 Yeka A, Banek K, Bakyaita N, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya SL, Kilian A, Slater M, Reingold A, Rosenthal PJ, Wabwire-Mangen F, Dorsey G -
Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda.
The American journal of tropical medicine and hygiene 2005 Bakyaita N, Dorsey G, Yeka A, Banek K, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya S, Kilian A, Reingold A, Rosenthal PJ, Wabwire-Mangen F -
Host polymorphisms and the incidence of malaria in Ugandan children.
The American journal of tropical medicine and hygiene 2004 Parikh S, Dorsey G, Rosenthal PJ -
Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda.
The American journal of tropical medicine and hygiene 2004 Dorsey G, Dokomajilar C, Kiggundu M, Staedke SG, Kamya MR, Rosenthal PJ -
Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial.
Lancet (London, England) 2004 Staedke SG, Mpimbaza A, Kamya MR, Nzarubara BK, Dorsey G, Rosenthal PJ -
The impact of age, temperature, and parasite density on treatment outcomes from antimalarial clinical trials in Kampala, Uganda.
The American journal of tropical medicine and hygiene 2004 Dorsey G, Gasasira AF, Machekano R, Kamya MR, Staedke SG, Hubbard A -
Asymptomatic parasitaemia as a risk factor for symptomatic malaria in a cohort of Ugandan children.
Tropical medicine & international health : TM & IH 2004 Njama-Meya D, Kamya MR, Dorsey G -
Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children.
The Journal of infectious diseases 2004 Nsobya SL, Parikh S, Kironde F, Lubega G, Kamya MR, Rosenthal PJ, Dorsey G -
Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, Uganda.
Tropical medicine & international health : TM & IH 2004 Staedke SG, Sendagire H, Lamola S, Kamya MR, Dorsey G, Rosenthal PJ -
Prevention of increasing rates of treatment failure by combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the sequential treatment of malaria.
The Journal of infectious diseases 2003 Dorsey G, Vlahos J, Kamya MR, Staedke SG, Rosenthal PJ -
Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children.
The American journal of tropical medicine and hygiene 2003 Staedke SG, Nottingham EW, Cox J, Kamya MR, Rosenthal PJ, Dorsey G -
Validation of a simplified method for using molecular markers to predict sulfadoxine-pyrimethamine treatment failure in African children with falciparum malaria.
The American journal of tropical medicine and hygiene 2003 Kyabayinze D, Cattamanchi A, Kamya MR, Rosenthal PJ, Dorsey G -
Urban malaria: primary caregivers' knowledge, attitudes, practices and predictors of malaria incidence in a cohort of Ugandan children.
Tropical medicine & international health : TM & IH 2003 Njama D, Dorsey G, Guwatudde D, Kigonya K, Greenhouse B, Musisi S, Kamya MR -
Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda.
The American journal of tropical medicine and hygiene 2003 Gasasira AF, Dorsey G, Nzarubara B, Staedke SG, Nassali A, Rosenthal PJ, Kamya MR -
Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp.
The American journal of tropical medicine and hygiene 2003 Cattamanchi A, Kyabayinze D, Hubbard A, Rosenthal PJ, Dorsey G -
Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial.
Lancet (London, England) 2002 Dorsey G, Njama D, Kamya MR, Cattamanchi A, Kyabayinze D, Staedke SG, Gasasira A, Rosenthal PJ -
Amodiaquine, sulfadoxine/pyrimethamine, and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomised trial.
Lancet (London, England) 2001 Staedke SG, Kamya MR, Dorsey G, Gasasira A, Ndeezi G, Charlebois ED, Rosenthal PJ -
Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr-1 genes and clinical response to chloroquine in Kampala, Uganda.
The Journal of infectious diseases 2001 Dorsey G, Kamya MR, Singh A, Rosenthal PJ -
The comparative efficacy of chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in Kampala, Uganda.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2001 Kamya MR, Dorsey G, Gasasira A, Ndeezi G, Babirye JN, Staedke SG, Rosenthal PJ -
Difficulties in the prevention, diagnosis, and treatment of imported malaria.
Archives of internal medicine 2000 Dorsey G, Gandhi M, Oyugi JH, Rosenthal PJ -
A heterogeneous outbreak of Enterobacter cloacae and Serratia marcescens infections in a surgical intensive care unit.
Infection control and hospital epidemiology 2000 Dorsey G, Borneo HT, Sun SJ, Wells J, Steele L, Howland K, Perdreau-Remington F, Bangsberg DR -
Predictors of chloroquine treatment failure in children and adults with falciparum malaria in Kampala, Uganda.
The American journal of tropical medicine and hygiene 2000 Dorsey G, Kamya MR, Ndeezi G, Babirye JN, Phares CR, Olson JE, Katabira ET, Rosenthal PJ