Girish Vyas, PhD
Professor Emeritus
Laboratory Medicine
School of Medicine
girish.vyas@ucsf.edu 415-514-7963
Girish N. Vyas, Ph.D. (Univ. of Bombay, 1965), F.R.C.Path. (London, 2012), completed a postdoctoral fellowship at Case-WRU in Cleveland, Ohio in 1967. Then he joined UCSF School of Medicine as a Lecturer in Hematology and Immunology Unit of the Department of Medicine. He moved to Department of Laboratory Medicine as an Assistant Professor and served as Director of Blood Bank at UCSF Medical Center from 1969-89.
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During his sabbatical leave in 1972-73 he worked as a visiting scientist at Weizmann Institute in Israel and Walter and Eliza Hall Institute in Australia. In 1980 he got an American Fulbright Senior Scholar Award to work with Pierre Tiollais on molecular biology of HBV at the Pasteur Institute, Paris. During his four decades of faculty service at UCSF he trained 18 graduate and 46 postdoctoral scholars. His seminal contributions to our current knowledge about IgA deficiency and anaphylactic transfusion reactions, HBsAg structure, HBV vaccine and immune globulins in perinatal prevention of mother to child transmission of infection, screening and elimination of transfusion-transmitted HBV, HCV, HIV to enhance transfusion safety, and sustained commitment to immune prevention of HIV/AIDS. These contributions earned him the honor as a "Pioneer and Pathfinder in Transfusion Medicine" in 2008. He has edited 12 books and monographs and published 225 original papers. He has served on several committees of NAS-NRC, NIH, CDC, FDA, WHO, AABB, ASH, and UNDP and as the Editor-in-Chief of Biological. Currently he is an Emeritus Professor of Laboratory Medicine at UCSF and full-time CEO of TheraBiol, Inc., a start-up biotech company launched in 2012 for R&D of antibodies for prevention and treatment of persistent infections, HIV being the first target.
Awards
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- American Fulbright Visiting Scholar, Pasteur Institute, Paris, 1980
- Jean Julliard Prize, International Society of Blood Transfusion, 1969
Education & Training
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- F.R.C.Path. Virology, Immunology, Transfusion Medicine Royal College of Pathologists 2012
- Ph.D. Pathology, G.S. Medical College University of Bombay 1965
Interests
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- thinking and working to fulfil unmet medical needs
- Reading
Grants and Projects
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- General Clinical Research Center, NIH, 1974-2009
- In Vitro Inactivation of Viruses in Blood Components, NIH, 1994-2000
- Development of Screening Tests for Htlv-iii, NIH/NHLBI, 1986-1995
- Effectiveness of Htlv-iii Antibody Screening, NIH/NHLBI, 1986-1995
- Removal/inactivation of Viruses in Blood, NIH, 1988-1992
- Transfusion-related Viral Infections and Immune Response, NIH, 1986-1991
Publications (36)
Top publication keywords:
Virus CultivationHepatitis BTransfusion ReactionBlood SafetyVirionHepatitis B virusBlood Group AntigensHIV Envelope Protein gp120Infectious Disease Transmission, VerticalPlasmaBlood-Borne PathogensHepatitis B VaccinesBlood Component TransfusionHIV Envelope Protein gp41Blood Transfusion
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Fifty years of advancing biologicals and beyond.
Biologicals : journal of the International Association of Biological Standardization 2023 Gupta R, Elwyn G, Vyas G, Thorpe R, Baylor N -
Eradicating hepatitis B virus: The critical role of preventing perinatal transmission.
Biologicals : journal of the International Association of Biological Standardization 2017 Stevens CE, Toy P, Kamili S, Taylor PE, Tong MJ, Xia GL, Vyas GN -
Remembering James W. Mosley, MD (1929-2015), and his legacy in transfusion safety.
Transfusion 2016 Busch MP, Vyas GN -
Possible transmission of human immunodeficiency virus-1 infection from an elite controller to a patient who progressed to acquired immunodeficiency syndrome: a case report.
Journal of medical case reports 2012 Killian MS, Vyas GN, Mehta R, Young K, Ebrahim O -
Adverse effects of plasma transfusion.
Transfusion 2012 Pandey S, Vyas GN
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The life and legacy of Alfred M. Prince, M. D. (1928-2011).
Biologicals : journal of the International Association of Biological Standardization 2012 Vyas GN, Grady GF -
Derivation of non-infectious envelope proteins from virions isolated from plasma negative for HIV antibodies.
Biologicals : journal of the International Association of Biological Standardization 2011 Vyas GN, Stoddart CA, Killian MS, Brennan TV, Goldberg T, Ziman A, Bryson Y -
Pooled peripheral blood mononuclear cells provide an optimized cellular substrate for human immunodeficiency virus Type 1 isolation during acute infection.
Transfusion 2010 Lai-Hipp C, Goldberg T, Scott E, Ziman A, Vyas G -
Unconventional journals: research ramifications.
Science (New York, N.Y.) 2010 Vyas GN -
Transfusion medicine and safety.
Biologicals : journal of the International Association of Biological Standardization 2009 Dodd R, Kurt Roth W, Ashford P, Dax EM, Vyas G -
Preparation and use of therapeutic antibodies primarily of human origin.
Biologicals : journal of the International Association of Biological Standardization 2008 Stiehm ER, Keller MA, Vyas GN -
Participating in the evolution of transfusion medicine from a dispensary into a discipline.
Transfusion medicine reviews 2008 Vyas GN -
A hollow-fiber bioreactor for expanding HIV-1 in human lymphocytes used in preparing an inactivated vaccine candidate.
Biologicals : journal of the International Association of Biological Standardization 2007 Leong M, Babbitt W, Vyas G -
Blood-transmitted prions and variant Creutzfeldt-Jakob disease.
Biologicals : journal of the International Association of Biological Standardization 2007 Grady GF, Vyas GN -
Hepatitis B immune globulin preparations and use in liver transplantation.
Clinics in liver disease 2003 Terrault NA, Vyas G -
Hepatitis B virus in non-hepatocytes.
Lancet (London, England) 1983 Blum HE, Vyas GN -
Partial amino acid sequence of two major component polypeptides of hepatitis B surface antigen.
Proceedings of the National Academy of Sciences of the United States of America 1977 Peterson DL, Roberts IM, Vyas GN -
Biochemical characterization of hepatitis B surface antigen in relation to serologic activity.
Journal of biological standardization 1976 Rao KR, Vyas GN -
T-cell dependence of immune response to hepatitis B antigen in mice.
Nature 1975 Roberts IM, Bernard CC, Vyas GN, Mackay IR -
Hepatitis B surface antigen (HBs Ag): tryptophan content and biological activity.
The Journal of general virology 1974 Rao KR, Vyas GN -
Structure and activity of hepatitis B antigen (HBAg). 2. Amino acid composition of an active subunit of HBAg.
Microbios 1974 Rao KR, Vyas GN -
Structure and activity of hepatitis B antigen (HBAg). 1. Studies on some conformational aspects and chemical modification of hepatitis B antigen.
Microbios 1974 Rao KR, Vyas GN -
Hepatitis B antigen activity in protein subunits produced by sonicaation.
Nature: New biology 1973 Rao KR, Vyas GN -
Australia antigen (hepatitis B antigen): a conformational antigen dependent on disulfide bonds.
Science (New York, N.Y.) 1972 Vyas GN, Rao KR, Ibrahim AB -
Study of a French family with a new variant of blood group A: A lae .
American journal of human genetics 1972 Schuh V, Vyas GN, Fudenberg HH -
Passive haemagglutination test for anti-rhinovirus antibodies.
Nature: New biology 1971 Faulk WP, Vyas GN, Phillips CA, Fudenberg HH, Chism K -
Intrauterine isoimmunization caused by maternal IgA crossing the placenta.
Nature 1970 Vyas GN, Levin AS, Fudenberg HH -
Am(1), the first genetic marker of human immunoglobulin A.
Proceedings of the National Academy of Sciences of the United States of America 1969 Vyas GN, Fudenberg HH -
Human antibodies to human IgA globulins.
Immunochemistry 1968 Fudenberg HH, Gold ER, Vyas GN, Mackenzie MR -
A new rapid method for genetic typing of human immunoglobulins.
Journal of immunology (Baltimore, Md. : 1950) 1968 Vyas GN, Fudenberg HH, Pretty HM, Gold ER -
Hemagglutinating substances in plant seeds.
Journal of postgraduate medicine 1967 Sathe MS, Vyas GN, Bhatia HM, Purandare NM -
RED CELL, PLASMA AND BLOOD VOLUME MEASURED BY RADIOCHROMIUM LABELLED CELLS AND HAEMATOCRIT IN INDIANS BELONGING TO LOW AND HIGH SOCIO-ECONOMIC GROUPS.
The Indian journal of medical research 1965 VYAS GN, SATHE MS, PURANDARE NM, SATOSKAR RS -
Suppression of gene A in two cases of anti-H (Bombay bloods) in a family from South Canara.
The Journal of the Association of Physicians of India 1962 VYAS GN, PANDIT HM, PURANDARE NM -
Study of blood groups, abnormal hemoglobins and other genetical characters in some tribes of Gujarat.
American journal of physical anthropology 1962 Vyas GN, Bhatia HM, Sukumaran PK, Balkrishnan V, Sanghvi LD -
Study of blood groups and other genetical characters in six Gujarati endogamous groups in Western India.
Annals of human genetics 1958 VYAS GN, BHATIA HM, BANKER DD, PURANDARE NM -
Chalkones from quinacetophenone monomethyl ether.
Current science 1950 VYAS GN, SHAH NM