Giovanni Aviles
Staff Research Associate
Pharmaceutical Chemistry
School of Pharmacy

Publications (4)

Top publication keywords:
MitochondriaStress, PhysiologicalPhagocytosisMolecular ChaperonesCytosolMicrogliaPhosphorylationEukaryotic Initiation Factor-2Cryoelectron MicroscopyeIF-2 KinaseMetalloendopeptidasesInduced Pluripotent Stem CellsActivating Transcription Factor 4Clustered Regularly Interspaced Short Palindromic RepeatsMitochondrial Proteins

• DELE1 oligomerization promotes integrated stress response activation.
  Nature structural & molecular biology 2023 Yang J, Baron KR, Pride DE, Schneemann A, Guo X, Chen W, Song AS, Aviles G, Kampmann M, Wiseman RL, Lander GC
• Pharmacologic Activation of a Compensatory Integrated Stress Response Kinase Promotes Mitochondrial Remodeling in PERK-deficient Cells.
  bioRxiv : the preprint server for biology 2023 Perea V, Baron KR, Dolina V, Aviles G, Rosarda JD, Guo X, Kampmann M, Wiseman RL
• A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
  Nature neuroscience 2022 Dräger NM, Sattler SM, Huang CT, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Udeochu JC, Kodama L, Singleton AB, Nalls MA, Ichida J, Ward ME, Faghri F, Gan L, Kampmann M
• Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.
  Nature 2020 Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M