Giorgio Lagna, PhD
Assistant Professor
Cardiovascular Research Inst
School of Medicine

Education & Training

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• Postdoctoral Training The Rockefeller University 2000
• PhD University of Rome "La Sapienza" 1997

Publications (37)

Top publication keywords:
Muscle, Smooth, VascularTrans-ActivatorsMyocytes, Smooth MuscleHypertension, PulmonaryBone Morphogenetic Protein Receptors, Type IIBone Morphogenetic Protein 4Bone Morphogenetic ProteinsRibonuclease IIIDNA-Binding ProteinsMicroRNAsTelangiectasia, Hereditary HemorrhagicSignal TransductionOncogene Proteins, FusionMutation, MissenseTransforming Growth Factor beta

• Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response.
  bioRxiv : the preprint server for biology 2023 Prabhakar A, Kumar R, Wadhwa M, Ghatpande P, Zhang J, Zhao Z, Lizama CO, Kharbikar BN, Gräf S, Treacy CM, Morrell NW, Graham BB, Lagna G, Hata A
• Essential role of the amino-terminal region of Drosha for the Microprocessor function.
  iScience 2023 Prabhakar A, Hu S, Tang J, Ghatpande P, Lagna G, Jiang X, Hata A
• How do you mend inactive tumor suppressor mutants? You glue them!
  Cell chemical biology 2021 Hata A, Lagna G
• Control of ribosomal protein synthesis by the Microprocessor complex.
  Science signaling 2021 Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A
• Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia.
  Current opinion in hematology 2019 Hata A, Lagna G

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• Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.
  Communications biology 2018 Vattulainen-Collanus S, Southwood M, Yang XD, Moore S, Ghatpande P, Morrell NW, Lagna G, Hata A
• Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.
  Science signaling 2018 Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A
• Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice.
  Nature communications 2017 Jiang X, Hawkins JS, Lee J, Lizama CO, Bos FL, Zape JP, Ghatpande P, Peng Y, Louie J, Lagna G, Zovein AC, Hata A
• Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome.
  Science signaling 2017 Kashima R, Redmond PL, Ghatpande P, Roy S, Kornberg TB, Hanke T, Knapp S, Lagna G, Hata A
• Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.
  Science signaling 2016 Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A
• Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress.
  The EMBO journal 2013 Chang J, Davis-Dusenbery BN, Kashima R, Jiang X, Marathe N, Sessa R, Louie J, Gu W, Lagna G, Hata A
• Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathway.
  The Journal of biological chemistry 2012 Kang H, Louie J, Weisman A, Sheu-Gruttadauria J, Davis-Dusenbery BN, Lagna G, Hata A
• Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A.
  The Journal of biological chemistry 2012 Wang D, Prakash J, Nguyen P, Davis-Dusenbery BN, Hill NS, Layne MD, Hata A, Lagna G
• Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins.
  The Journal of biological chemistry 2011 Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A
• Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2.
  Molecular and cellular biology 2011 Wu C, So J, Davis-Dusenbery BN, Qi HH, Bloch DB, Shi Y, Lagna G, Hata A
• down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4.
  The Journal of biological chemistry 2011 Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A
• The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway.
  Molecular and cellular biology 2010 Chan MC, Weisman AS, Kang H, Nguyen PH, Hickman T, Mecker SV, Hill NS, Lagna G, Hata A
• Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha.
  Molecular cell 2010 Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A
• Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression.
  The EMBO journal 2009 Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A
• The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular tone.
  The Journal of biological chemistry 2009 Neuman NA, Ma S, Schnitzler GR, Zhu Y, Lagna G, Hata A
• Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype.
  The Journal of biological chemistry 2008 Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A
• SMAD proteins control DROSHA-mediated microRNA maturation.
  Nature 2008 Davis BN, Hilyard AC, Lagna G, Hata A
• Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors.
  The Journal of biological chemistry 2007 Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A
• A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor.
  Molecular and cellular biology 2007 Chan MC, Nguyen PH, Davis BN, Ohoka N, Hayashi H, Du K, Lagna G, Hata A
• BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells.
  American journal of physiology. Lung cellular and molecular physiology 2006 Lagna G, Nguyen PH, Ni W, Hata A
• OAZ regulates bone morphogenetic protein signaling through Smad6 activation.
  The Journal of biological chemistry 2005 Ku M, Howard S, Ni W, Lagna G, Hata A
• OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways.
  Cell 2000 Hata A, Seoane J, Lagna G, Montalvo E, Hemmati-Brivanlou A, Massagué J
• A molecular basis for Smad specificity.
  Developmental dynamics : an official publication of the American Association of Anatomists 1999 Lagna G, Hemmati-Brivanlou A
• Negative regulation of axis formation and Wnt signaling in Xenopus embryos by the F-box/WD40 protein beta TrCP.
  Mechanisms of development 1999 Lagna G, Carnevali F, Marchioni M, Hemmati-Brivanlou A
• Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor.
  Genes & development 1998 Hata A, Lagna G, Massagué J, Hemmati-Brivanlou A
• Use of dominant negative constructs to modulate gene expression.
  Current topics in developmental biology 1998 Lagna G, Hemmati-Brivanlou A
• Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1.
  Development (Cambridge, England) 1997 Wilson PA, Lagna G, Suzuki A, Hemmati-Brivanlou A
• Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4.
  Nature 1997 Hata A, Lo RS, Wotton D, Lagna G, Massagué J
• Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.
  Nature 1996 Lagna G, Hata A, Hemmati-Brivanlou A, Massagué J
• Overlapping transcription by RNA polymerases II and III of the Xenopus TFIIIA gene in somatic cells.
  The Journal of biological chemistry 1994 Martinez E, Lagna G, Roeder RG
• Cloning and characterization of an evolutionarily divergent DNA-binding subunit of mammalian TFIIIC.
  Molecular and cellular biology 1994 Lagna G, Kovelman R, Sukegawa J, Roeder RG
• HrpF, a human sequence-specific DNA-binding protein homologous to XrpFI, a Xenopus laevis oocyte transcription factor.
  Nucleic acids research 1990 Lagna G, Loreni F, Beccari E, Carnevali F