Gilles Rademaker, PhD
Postdoctoral Scholar
Anatomy
School of Medicine

Publications (13)

Top publication keywords:
Membrane ProteinsGene Expression Regulation, NeoplasticAdenocarcinomaCarcinoma, Pancreatic DuctalGlycolysisPancreatic NeoplasmsIronOxidative PhosphorylationProtein BiosynthesisIron-Sulfur ProteinsLipid PeroxidationMuscle ProteinsCalcium-Binding ProteinsMitochondriaIntracellular Membranes

• Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity.
  Nature cell biology 2025 Kovalski JR, Sarioglu G, Subramanyam V, Hernandez G, Rademaker G, Oses-Prieto JA, Slota M, Mohan N, Yiakis K, Liu I, Wen KW, Kim GE, Miglani S, Burlingame AL, Goodarzi H, Perera RM, Ruggero D
• Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.
  bioRxiv : the preprint server for biology 2024 Jain A, Heremans I, Rademaker G, Detomasi TC, Hernandez GA, Zhang J, Gupta S, von Linde T, Lange M, Spacci M, Rohweder P, Anderson D, Citron YR, Olzmann JA, Dawson DW, Craik CS, Bommer G, Perera RM, …
• A multi-subunit autophagic capture complex facilitates degradation of ER stalled MHC-I in pancreatic cancer.
  bioRxiv : the preprint server for biology 2024 Berquez M, Li AL, Luy MA, Venida AC, O'Loughlin T, Rademaker G, Barpanda A, Hu J, Yano J, Wiita A, Gilbert LA, Bruno PM, Perera RM
• Functional screen for mediators of onco-mRNA translation specificity.
  bioRxiv : the preprint server for biology 2024 Kovalski JR, Sarioglu G, Subramanyam V, Hernandez G, Rademaker G, Oses-Prieto JA, Slota M, Mohan N, Yiakis K, Liu I, Wen KW, Kim GE, Miglani S, Burlingame AL, Goodarzi H, Perera RM, Ruggero D
• Correction: Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis.
  Oncogenesis 2023 Rademaker G, Costanza B, Bellier J, Herfs M, Peiffer R, Agirman F, Maloujahmoum N, Habraken Y, Delvenne P, Bellahcène A, Castronovo V, Peulen O

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• Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS-MAPK Pathway Inhibition in Pancreatic Cancer.
  Cancer discovery 2022 Ravichandran M, Hu J, Cai C, Ward NP, Venida A, Foakes C, Kuljanin M, Yang A, Hennessey CJ, Yang Y, Desousa BR, Rademaker G, Staes AAL, Cakir Z, Jain IH, Aguirre AJ, Mancias JD, Shen Y, DeNicola GM, …
• Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells.
  Redox biology 2022 Rademaker G, Boumahd Y, Peiffer R, Anania S, Wissocq T, Liégeois M, Luis G, Sounni NE, Agirman F, Maloujahmoum N, De Tullio P, Thiry M, Bellahcène A, Castronovo V, Peulen O
• Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth.
  Nature cell biology 2021 Gupta S, Yano J, Mercier V, Htwe HH, Shin HR, Rademaker G, Cakir Z, Ituarte T, Wen KW, Kim GE, Zoncu R, Roux A, Dawson DW, Perera RM
• Ferlin Overview: From Membrane to Cancer Biology.
  Cells 2019 Peulen O, Rademaker G, Anania S, Turtoi A, Bellahcène A, Castronovo V
• Myoferlin Contributes to the Metastatic Phenotype of Pancreatic Cancer Cells by Enhancing Their Migratory Capacity through the Control of Oxidative Phosphorylation.
  Cancers 2019 Rademaker G, Costanza B, Anania S, Agirman F, Maloujahmoum N, Di Valentin E, Goval JJ, Bellahcène A, Castronovo V, Peulen O
• Transforming growth factor beta-induced, an extracellular matrix interacting protein, enhances glycolysis and promotes pancreatic cancer cell migration.
  International journal of cancer 2019 Costanza B, Rademaker G, Tiamiou A, De Tullio P, Leenders J, Blomme A, Bellier J, Bianchi E, Turtoi A, Delvenne P, Bellahcène A, Peulen O, Castronovo V
• Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis.
  Oncogenesis 2019 Rademaker G, Costanza B, Bellier J, Herfs M, Peiffer R, Agirman F, Maloujahmoum N, Habraken Y, Delvenne P, Bellahcène A, Castronovo V, Peulen O
• Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness.
  Oncogene 2018 Rademaker G, Hennequière V, Brohée L, Nokin MJ, Lovinfosse P, Durieux F, Gofflot S, Bellier J, Costanza B, Herfs M, Peiffer R, Bettendorff L, Deroanne C, Thiry M, Delvenne P, Hustinx R, Bellahcène A, …