George Carlson, PhD
Adjunct Professor
Institute for Neurodegenerative Diseases
School of Medicine
Grants and Projects
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- Tauopathy in AD and FTD - Molecular Determinants of Phenotypic Diversity, NIH, 2017-2022
- CNS Stem Cells for neurodegenerative disease research, NIH, 2014-2017
- Genetics of Prion Susceptibility in vitro, NIH, 2001-2013
- CNS Stem Cells for Alzheimer's Disease Therapy, NIH, 2004-2006
- 24-Capillary Reveal Mutation Discovery System, NIH, 2003-2004
- Transmissible and Genetic Neurodengenerative Diseases, NIH, 1985-2000
- Transgenic Models for Alzheimers Disease, NIH, 1991-1998
- Minority High School Student Research Apprentice Program, NIH, 1990-1994
- Animal Facility Improvement, NIH, 1992-1993
- Small Instrumentation Grant, NIH, 1992-1993
- Biomedical Research Support Grant, NIH, 1989-1992
- Small Instrumentation Grant, NIH, 1991-1992
- H-2 Associated Natural Resistance, NIH, 1980-1991
- Mitotic Recombination in Mammalian Cells, NIH, 1987-1991
- Small Instrumentation Grant, NIH, 1990-1991
Publications (88)
Top publication keywords:
TauopathiesPrPC Proteinstau ProteinsPrion ProteinsNeuronsPrionsAlzheimer DiseasePrion DiseasesAmyloid beta-PeptidesNeurofibrillary TanglesScrapiePlaque, Amyloidalpha-SynucleinBiotinPrPSc Proteins
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Therapeutic Trial of anle138b in Mouse Models of Genetic Prion Disease.
Journal of virology 2023 Vallabh SM, Zou D, Pitstick R, O'Moore J, Peters J, Silvius D, Kriz J, Jackson WS, Carlson GA, Minikel EV, Cabin DE -
Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.
The Journal of biological chemistry 2023 Griffin TA, Schnier PD, Cleveland EM, Newberry RW, Becker J, Carlson GA -
How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders.
International journal of molecular sciences 2021 Carlson GA, Prusiner SB -
Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components.
Neuron 2021 Lester E, Ooi FK, Bakkar N, Ayers J, Woerman AL, Wheeler J, Bowser R, Carlson GA, Prusiner SB, Parker R -
Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints.
Nucleic acids research 2020 Minikel EV, Zhao HT, Le J, O'Moore J, Pitstick R, Graffam S, Carlson GA, Kavanaugh MP, Kriz J, Kim JB, Ma J, Wille H, Aiken J, McKenzie D, Doh-Ura K, Beck M, O'Keefe R, Stathopoulos J, Caron T, …
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Core transcriptional regulatory circuits in prion diseases.
Molecular brain 2020 Kim TK, Lee I, Cho JH, Canine B, Keller A, Price ND, Hwang D, Carlson G, Hood L -
Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein.
Acta neuropathologica communications 2019 Krejciova Z, Carlson GA, Giles K, Prusiner SB -
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo.
Nature neuroscience 2018 Busche MA, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT -
Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo.
Brain : a journal of neurology 2018 DeVos SL, Corjuc BT, Commins C, Dujardin S, Bannon RN, Corjuc D, Moore BD, Bennett RE, Jorfi M, Gonzales JA, Dooley PM, Roe AD, Pitstick R, Irimia D, Frosch MP, Carlson GA, Hyman BT -
Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2017 Johnson NR, Condello C, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB -
A novel vector for transgenesis in the rat CNS.
Acta neuropathologica communications 2017 Lopez TP, Giles K, Dugger BN, Oehler A, Condello C, Krejciova Z, Castaneda JA, Carlson GA, Prusiner SB -
Neurodegenerative Disease Transmission and Transgenesis in Mice.
Cold Spring Harbor perspectives in biology 2017 Dugger BN, Perl DP, Carlson GA -
Prion Protein and Genetic Susceptibility to Diseases Caused by Its Misfolding.
Progress in molecular biology and translational science 2017 Carlson GA -
Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides.
Circulation research 2017 Park L, Uekawa K, Garcia-Bonilla L, Koizumi K, Murphy M, Pistik R, Younkin L, Younkin S, Zhou P, Carlson G, Anrather J, Iadecola C -
Enhanced Tau Aggregation in the Presence of Amyloid β.
The American journal of pathology 2017 Bennett RE, DeVos SL, Dujardin S, Corjuc B, Gor R, Gonzalez J, Roe AD, Frosch MP, Pitstick R, Carlson GA, Hyman BT -
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.
The American journal of pathology 2017 Nobuhara CK, DeVos SL, Commins C, Wegmann S, Moore BD, Roe AD, Costantino I, Frosch MP, Pitstick R, Carlson GA, Hock C, Nitsch RM, Montrasio F, Grimm J, Cheung AE, Dunah AW, Wittmann M, Bussiere T, … -
Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease.
Synapse (New York, N.Y.) 2017 Pickett EK, Henstridge CM, Allison E, Pitstick R, Pooler A, Wegmann S, Carlson G, Hyman BT, Spires-Jones TL -
High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.
Human molecular genetics 2017 Ament SA, Pearl JR, Grindeland A, St Claire J, Earls JC, Kovalenko M, Gillis T, Mysore J, Gusella JF, Lee JM, Kwak S, Howland D, Lee MY, Baxter D, Scherler K, Wang K, Geman D, Carroll JB, MacDonald ME… -
The familial dysautonomia disease gene IKBKAP is required in the developing and adult mouse central nervous system.
Disease models & mechanisms 2017 Chaverra M, George L, Mergy M, Waller H, Kujawa K, Murnion C, Sharples E, Thorne J, Podgajny N, Grindeland A, Ueki Y, Eiger S, Cusick C, Babcock AM, Carlson GA, Lefcort F -
Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease.
The European journal of neuroscience 2016 Jackson RJ, Rudinskiy N, Herrmann AG, Croft S, Kim JM, Petrova V, Ramos-Rodriguez JJ, Pitstick R, Wegmann S, Garcia-Alloza M, Carlson GA, Hyman BT, Spires-Jones TL -
Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy.
Cell chemical biology 2016 Young ZT, Rauch JN, Assimon VA, Jinwal UK, Ahn M, Li X, Dunyak BM, Ahmad A, Carlson GA, Srinivasan SR, Zuiderweg ER, Dickey CA, Gestwicki JE -
Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.
Annals of neurology 2016 Takeda S, Commins C, DeVos SL, Nobuhara CK, Wegmann S, Roe AD, Costantino I, Fan Z, Nicholls SB, Sherman AE, Trisini Lipsanopoulos AT, Scherzer CR, Carlson GA, Pitstick R, Peskind ER, Raskind MA, Li G… -
Improvement of ENU Mutagenesis Efficiency Using Serial Injection and Mismatch Repair Deficiency Mice.
PloS one 2016 Gallego-Llamas J, Timms AE, Pitstick R, Peters J, Carlson GA, Beier DR -
Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.
Human molecular genetics 2016 Husson H, Moreno S, Smith LA, Smith MM, Russo RJ, Pitstick R, Sergeev M, Ledbetter SR, Bukanov NO, Lane M, Zhang K, Billot K, Carlson G, Shah J, Meijer L, Beier DR, Ibraghimov-Beskrovnaya O -
A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone.
PloS one 2016 Daude N, Lee I, Kim TK, Janus C, Glaves JP, Gapeshina H, Yang J, Sykes BD, Carlson GA, Hood LE, Westaway D -
Brain Aggregates: An Effective In Vitro Cell Culture System Modeling Neurodegenerative Diseases.
Journal of neuropathology and experimental neurology 2016 Ahn M, Kalume F, Pitstick R, Oehler A, Carlson G, DeArmond SJ -
Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity.
The EMBO journal 2015 Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe A, DeVos SL, Nicholls S, Fan Z, Takeda S, Cagsal-Getkin O, William CM, Spires-Jones TL, Pitstick R, Carlson GA, Pooler AM, Hyman BT -
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.
Nature communications 2015 Takeda S, Wegmann S, Cho H, DeVos SL, Commins C, Roe AD, Nicholls SB, Carlson GA, Pitstick R, Nobuhara CK, Costantino I, Frosch MP, Müller DJ, Irimia D, Hyman BT -
Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease.
Acta neuropathologica communications 2015 Pooler AM, Polydoro M, Maury EA, Nicholls SB, Reddy SM, Wegmann S, William C, Saqran L, Cagsal-Getkin O, Pitstick R, Beier DR, Carlson GA, Spires-Jones TL, Hyman BT -
Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice.
Mammalian genome : official journal of the International Mammalian Genome Society 2014 Anderson SR, Lee I, Ebeling C, Stephenson DA, Schweitzer KM, Baxter D, Moon TM, LaPierre S, Jaques B, Silvius D, Wegner M, Hood LE, Carlson G, Gunn TM -
A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice.
Lipids in health and disease 2014 Helmering J, Juan T, Li CM, Chhoa M, Baron W, Gyuris T, Richards WG, Turk JR, Lawrence J, Cosgrove PA, Busby J, Kim KW, Kaufman SA, Cummings C, Carlson G, Véniant MM, Lloyd DJ -
Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy.
Stroke 2014 Park L, Koizumi K, El Jamal S, Zhou P, Previti ML, Van Nostrand WE, Carlson G, Iadecola C -
Development of a novel cellular model of Alzheimer's disease utilizing neurosphere cultures derived from B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J embryonic mouse brain.
SpringerPlus 2014 Ghate PS, Sidhar H, Carlson GA, Giri RK -
Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs.
The Journal of cell biology 2014 Rouvinski A, Karniely S, Kounin M, Moussa S, Goldberg MD, Warburg G, Lyakhovetsky R, Papy-Garcia D, Kutzsche J, Korth C, Carlson GA, Godsave SF, Peters PJ, Luhr K, Kristensson K, Taraboulos A -
Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy.
Neuroscience letters 2014 Spires-Jones TL, Friedman T, Pitstick R, Polydoro M, Roe A, Carlson GA, Hyman BT -
Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology.
The Journal of comparative neurology 2013 Pooler AM, Polydoro M, Wegmann SK, Pitstick R, Kay KR, Sanchez L, Carlson GA, Gomez-Isla T, Albers MW, Spires-Jones TL, Hyman BT -
Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.
Neuropharmacology 2013 Graham DL, Gray AJ, Joyce JA, Yu D, O'Moore J, Carlson GA, Shearman MS, Dellovade TL, Hering H -
Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model.
Acta neuropathologica 2013 Polydoro M, Dzhala VI, Pooler AM, Nicholls SB, McKinney AP, Sanchez L, Pitstick R, Carlson GA, Staley KJ, Spires-Jones TL, Hyman BT -
Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.
PloS one 2013 Kopeikina KJ, Wegmann S, Pitstick R, Carlson GA, Bacskai BJ, Betensky RA, Hyman BT, Spires-Jones TL -
Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons.
Proceedings of the National Academy of Sciences of the United States of America 2013 George L, Chaverra M, Wolfe L, Thorne J, Close-Davis M, Eibs A, Riojas V, Grindeland A, Orr M, Carlson GA, Lefcort F -
Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400.
FEBS letters 2013 Cameron A, Giacomozzi B, Joyce J, Gray A, Graham D, Ousson S, Neny M, Beher D, Carlson G, O'Moore J, Shearman M, Hering H -
Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Polydoro M, de Calignon A, Suárez-Calvet M, Sanchez L, Kay KR, Nicholls SB, Roe AD, Pitstick R, Carlson GA, Gómez-Isla T, Spires-Jones TL, Hyman BT -
RML prions act through Mahogunin and Attractin-independent pathways.
Prion 2013 Gunn TM, Carlson GA -
Synaptic alterations in the rTg4510 mouse model of tauopathy.
The Journal of comparative neurology 2013 Kopeikina KJ, Polydoro M, Tai HC, Yaeger E, Carlson GA, Pitstick R, Hyman BT, Spires-Jones TL -
Innate immunity receptor CD36 promotes cerebral amyloid angiopathy.
Proceedings of the National Academy of Sciences of the United States of America 2013 Park L, Zhou J, Zhou P, Pistick R, El Jamal S, Younkin L, Pierce J, Arreguin A, Anrather J, Younkin SG, Carlson GA, McEwen BS, Iadecola C -
Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease.
PloS one 2013 Silvius D, Pitstick R, Ahn M, Meishery D, Oehler A, Barsh GS, DeArmond SJ, Carlson GA, Gunn TM -
Brain and circulating levels of Aβ1-40 differentially contribute to vasomotor dysfunction in the mouse brain.
Stroke 2012 Park L, Zhou P, Koizumi K, El Jamal S, Previti ML, Van Nostrand WE, Carlson G, Iadecola C -
Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau.
PloS one 2012 Orr ME, Pitstick R, Canine B, Ashe KH, Carlson GA -
LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation.
Journal of molecular biology 2012 Ehsani S, Salehzadeh A, Huo H, Reginold W, Pocanschi CL, Ren H, Wang H, So K, Sato C, Mehrabian M, Strome R, Trimble WS, Hazrati LN, Rogaeva E, Westaway D, Carlson GA, Schmitt-Ulms G -
Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrP(C)-deficiency.
Proceedings of the National Academy of Sciences of the United States of America 2012 Daude N, Wohlgemuth S, Brown R, Pitstick R, Gapeshina H, Yang J, Carlson GA, Westaway D -
A brain aggregate model gives new insights into the pathobiology and treatment of prion diseases.
Journal of neuropathology and experimental neurology 2012 Bajsarowicz K, Ahn M, Ackerman L, Dearmond BN, Carlson G, DeArmond SJ -
Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia.
Frontiers in pharmacology 2012 Spires-Jones TL, Fox LM, Rozkalne A, Pitstick R, Carlson GA, Kazantsev AG -
Propagation of tau pathology in a model of early Alzheimer's disease.
Neuron 2012 de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT -
Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.
PLoS pathogens 2011 Westaway D, Genovesi S, Daude N, Brown R, Lau A, Lee I, Mays CE, Coomaraswamy J, Canine B, Pitstick R, Herbst A, Yang J, Ko KW, Schmitt-Ulms G, Dearmond SJ, McKenzie D, Hood L, Carlson GA -
Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain.
The American journal of pathology 2011 Kopeikina KJ, Carlson GA, Pitstick R, Ludvigson AE, Peters A, Luebke JI, Koffie RM, Frosch MP, Hyman BT, Spires-Jones TL -
The effect of HIV protease inhibitors on amyloid-β peptide degradation and synthesis in human cells and Alzheimer's disease animal model.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2011 Lan X, Kiyota T, Hanamsagar R, Huang Y, Andrews S, Peng H, Zheng JC, Swindells S, Carlson GA, Ikezu T -
Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model.
Journal of neuropathology and experimental neurology 2011 Fox LM, William CM, Adamowicz DH, Pitstick R, Carlson GA, Spires-Jones TL, Hyman BT -
Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta.
Proceedings of the National Academy of Sciences of the United States of America 2011 Park L, Wang G, Zhou P, Zhou J, Pitstick R, Previti ML, Younkin L, Younkin SG, Van Nostrand WE, Cho S, Anrather J, Carlson GA, Iadecola C -
Principal network analysis: identification of subnetworks representing major dynamics using gene expression data.
Bioinformatics (Oxford, England) 2010 Kim Y, Kim TK, Kim Y, Yoo J, You S, Lee I, Carlson G, Hood L, Choi S, Hwang D -
Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration.
Neuron 2010 Hoover BR, Reed MN, Su J, Penrod RD, Kotilinek LA, Grant MK, Pitstick R, Carlson GA, Lanier LM, Yuan LL, Ashe KH, Liao D -
Generation of antisera to purified prions in lipid rafts.
Prion 2010 Hnasko R, Serban AV, Carlson G, Prusiner SB, Stanker LH -
Caspase activation precedes and leads to tangles.
Nature 2010 de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Hyman BT -
Systems biology and the discovery of diagnostic biomarkers.
Disease markers 2010 Wang K, Lee I, Carlson G, Hood L, Galas D -
Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones.
PLoS pathogens 2009 Watts JC, Huo H, Bai Y, Ehsani S, Jeon AH, Won AH, Shi T, Daude N, Lau A, Young R, Xu L, Carlson GA, Williams D, Westaway D, Schmitt-Ulms G -
The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases.
Database : the journal of biological databases and curation 2009 Gehlenborg N, Hwang D, Lee IY, Yoo H, Baxter D, Petritis B, Pitstick R, Marzolf B, Dearmond SJ, Carlson GA, Hood L -
New variants in the Enpp1 and Ptpn6 genes cause low BMD, crystal-related arthropathy, and vascular calcification.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009 Babij P, Roudier M, Graves T, Han CY, Chhoa M, Li CM, Juan T, Morony S, Grisanti M, Li X, Yu L, Dwyer D, Lloyd DJ, Bass MB, Richards WG, Ebeling C, Amato J, Carlson G -
Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy.
Journal of neuropathology and experimental neurology 2009 de Calignon A, Spires-Jones TL, Pitstick R, Carlson GA, Hyman BT -
A systems approach to prion disease.
Molecular systems biology 2009 Hwang D, Lee IY, Yoo H, Gehlenborg N, Cho JH, Petritis B, Baxter D, Pitstick R, Young R, Spicer D, Price ND, Hohmann JG, Dearmond SJ, Carlson GA, Hood LE -
Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice.
Journal of lipid research 2008 Juan T, Véniant MM, Helmering J, Babij P, Baker DM, Damore MA, Bass MB, Gyuris T, Chhoa M, Li CM, Ebeling C, Amato J, Carlson GA, Lloyd DJ -
Genes contributing to prion pathogenesis.
The Journal of general virology 2008 Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz… -
Cholesterol transporter ATP-binding cassette A1 (ABCA1) is elevated in prion disease and affects PrPC and PrPSc concentrations in cultured cells.
The Journal of general virology 2008 Kumar R, McClain D, Young R, Carlson GA -
In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT -
Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein.
Proceedings of the National Academy of Sciences of the United States of America 2008 Park L, Zhou P, Pitstick R, Capone C, Anrather J, Norris EH, Younkin L, Younkin S, Carlson G, McEwen BS, Iadecola C -
The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.
The EMBO journal 2007 Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson GA, Mount HT, Schmitt-Ulms G, Westaway D -
Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation.
The American journal of pathology 2006 Murakami T, Paitel E, Kawarabayashi T, Ikeda M, Chishti MA, Janus C, Matsubara E, Sasaki A, Kawarai T, Phinney AL, Harigaya Y, Horne P, Egashira N, Mishima K, Hanna A, Yang J, Iwasaki K, Takahashi M, … -
Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy.
The American journal of pathology 2006 Spires TL, Orne JD, SantaCruz K, Pitstick R, Carlson GA, Ashe KH, Hyman BT -
Prion infection of mouse neurospheres.
Proceedings of the National Academy of Sciences of the United States of America 2006 Giri RK, Young R, Pitstick R, DeArmond SJ, Prusiner SB, Carlson GA -
Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Ramsden M, Kotilinek L, Forster C, Paulson J, McGowan E, SantaCruz K, Guimaraes A, Yue M, Lewis J, Carlson G, Hutton M, Ashe KH -
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Proceedings of the National Academy of Sciences of the United States of America 2005 Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-… -
NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Park L, Anrather J, Zhou P, Frys K, Pitstick R, Younkin S, Carlson GA, Iadecola C -
Implementing large-scale ENU mutagenesis screens in North America.
Genetica 2004 Clark AT, Goldowitz D, Takahashi JS, Vitaterna MH, Siepka SM, Peters LL, Frankel WN, Carlson GA, Rossant J, Nadeau JH, Justice MJ -
Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression.
Human molecular genetics 2004 Krezowski J, Knudson D, Ebeling C, Pitstick R, Giri RK, Schenk D, Westaway D, Younkin L, Younkin SG, Ashe KH, Carlson GA -
Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.
Journal of neurochemistry 2004 Li F, Calingasan NY, Yu F, Mauck WM, Toidze M, Almeida CG, Takahashi RH, Carlson GA, Flint Beal M, Lin MT, Gouras GK -
Abeta-induced vascular oxidative stress and attenuation of functional hyperemia in mouse somatosensory cortex.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2004 Park L, Anrather J, Forster C, Kazama K, Carlson GA, Iadecola C -
In vivo reduction of amyloid-beta by a mutant copper transporter.
Proceedings of the National Academy of Sciences of the United States of America 2003 Phinney AL, Drisaldi B, Schmidt SD, Lugowski S, Coronado V, Liang Y, Horne P, Yang J, Sekoulidis J, Coomaraswamy J, Chishti MA, Cox DW, Mathews PM, Nixon RA, Carlson GA, St George-Hyslop P, Westaway D -
A welcoming environment for amyloid plaques.
Nature neuroscience 2003 Carlson GA -
Postexposure prophylaxis against transmissible spongiform encephalopathies: CpG oligodeoxynucleotides in mice.
Lancet (London, England) 2002 Carlson GA -
The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, Carlson GA, Younkin SG, Ashe KH