Gary Jarvis, PhD
Professor
Laboratory Medicine
School of Medicine

Education & Training

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• Ph.D. Microbiology University of California 1985
• B.S. Medical Microbiology University of Wisconsin 1978

Grants and Projects

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• Contraception development research center to advance a novel intravaginal ring as a non-hormonal multipurpose prevention technology, NIH, 2021-2026
• Targeting of LOS for Treatment of Antibiotic-Resistant Neisseria gonorrhoeae, Department of Veterans Affairs, 2022-2026
• Survival of Neisseria gonorrhoeae after primary human neutrophil challenge, NIH, 2012-2022
• Interaction of LOS and Innate Immunity in Neisseria Infection, NIH, 2011-2020
• Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
• Southeastern Sexually Transmitted Infections Cooperative, NIH, 2009-2014
• Bacterial STI and Innate Immunity in HIV Susceptibility, NIH, 2005-2012
• A Meningococcal LOS Vaccine, NIH, 2002-2012
• TLR4 Agonists as Neuroprotectants in Traumatic Brain Injury, VA/DOD Neurological Center for Excellence, 2008-2010
• Immunology of Bacterial Pneumonia in Htlv-ii Infection, NIH, 2000-2004
• Efficacy of Galectin-3C in Mouse Model of Metastatic Breast Cancer, DOD Breast Cancer Research Program, 1998-2000
• Mechanism of Iga1 Initiated Bacterial Lysis, NIH, 1995-1999

Publications (68)

Top publication keywords:
NeisseriaGonorrheaTumor Necrosis Factor-alphaCampylobacterMonocytesLipopolysaccharidesMeningococcal InfectionsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationLipid ANeisseria meningitidisNeisseria gonorrhoeaeCell-Penetrating PeptidesBacterial Outer Membrane ProteinsNeisseria meningitidis, Serogroup BMeningitis, Meningococcal

• Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation.
  mBio 2024 Cardenas AJ, Thomas KS, Broden MW, Ferraro NJ, Pires MM, John CM, Jarvis GA, Criss AK
• Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation.
  bioRxiv : the preprint server for biology 2024 Cardenas AJ, Thomas KS, Broden MW, Ferraro NJ, John CM, Pires MM, Jarvis GA, Criss AK
• Comparison of lipooligosaccharides from human challenge strains of Neisseria gonorrhoeae.
  Frontiers in microbiology 2023 John CM, Phillips NJ, Cardenas AJ, Criss AK, Jarvis GA
• Novel small molecules that increase the susceptibility of Neisseria gonorrhoeae to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase.
  The Journal of antimicrobial chemotherapy 2022 Mullally C, Stubbs KA, Thai VC, Anandan A, Bartley S, Scanlon MJ, Jarvis GA, John CM, Lim KYL, Sullivan CM, Sarkar-Tyson M, Vrielink A, Kahler CM
• Predominant phosphorylation patterns in Neisseria meningitidis lipid A determined by top-down MS/MS.
  Journal of lipid research 2020 John CM, Phillips NJ, Jarvis GA

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• Cationic cell-penetrating peptide is bactericidal against Neisseria gonorrhoeae.
  The Journal of antimicrobial chemotherapy 2019 John CM, Li M, Feng D, Jarvis GA
• Treatment of human challenge and MDR strains of Neisseria gonorrhoeae with LpxC inhibitors.
  The Journal of antimicrobial chemotherapy 2018 John CM, Feng D, Jarvis GA
• Novel Campylobacter concisus lipooligosaccharide is a determinant of inflammatory potential and virulence.
  Journal of lipid research 2018 Brunner K, John CM, Phillips NJ, Alber DG, Gemmell MR, Hansen R, Nielsen HL, Hold GL, Bajaj-Elliott M, Jarvis GA
• Innate immune response to lipooligosaccharide: pivotal regulator of the pathobiology of invasive Neisseria meningitidis infections.
  Pathogens and disease 2017 John CM, Phillips NJ, Stein DC, Jarvis GA
• Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Anandan A, Evans GL, Condic-Jurkic K, O'Mara ML, John CM, Phillips NJ, Jarvis GA, Wills SS, Stubbs KA, Moraes I, Kahler CM, Vrielink A
• Analysis of Bacterial Lipooligosaccharides by MALDI-TOF MS with Traveling Wave Ion Mobility.
  Journal of the American Society for Mass Spectrometry 2016 Phillips NJ, John CM, Jarvis GA
• Arginine- and Polyamine-Induced Lactic Acid Resistance in Neisseria gonorrhoeae.
  PloS one 2016 Gong Z, Tang MM, Wu X, Phillips N, Galkowski D, Jarvis GA, Fan H
• Lipooligosaccharide Structures of Invasive and Carrier Isolates of Neisseria meningitidis Are Correlated with Pathogenicity and Carriage.
  The Journal of biological chemistry 2015 John CM, Phillips NJ, Din R, Liu M, Rosenqvist E, Høiby EA, Stein DC, Jarvis GA
• Induction of endotoxin tolerance by pathogenic Neisseria is correlated with the inflammatory potential of lipooligosaccharides and regulated by microRNA-146a.
  Journal of immunology (Baltimore, Md. : 1950) 2014 Liu M, John CM, Jarvis GA
• Campylobacter jejuni lipooligosaccharide sialylation, phosphorylation, and amide/ester linkage modifications fine-tune human Toll-like receptor 4 activation.
  The Journal of biological chemistry 2013 Stephenson HN, John CM, Naz N, Gundogdu O, Dorrell N, Wren BW, Jarvis GA, Bajaj-Elliott M
• Post-injury conditioning with lipopolysaccharide or lipooligosaccharide reduces inflammation in the brain.
  Journal of neuroimmunology 2013 Bingham D, John CM, Levin J, Panter SS, Jarvis GA
• Lack of lipid A pyrophosphorylation and functional lptA reduces inflammation by Neisseria commensals.
  Infection and immunity 2012 John CM, Liu M, Phillips NJ, Yang Z, Funk CR, Zimmerman LI, Griffiss JM, Stein DC, Jarvis GA
• The association between body mass index and severe biliary infections: a multivariate analysis.
  American journal of surgery 2012 Stewart L, Griffiss JM, Jarvis GA, Way LW
• Secretory leukocyte protease inhibitor binds to Neisseria gonorrhoeae outer membrane opacity protein and is bactericidal.
  American journal of reproductive immunology (New York, N.Y. : 1989) 2012 Cooper MD, Roberts MH, Barauskas OL, Jarvis GA
• Modulation of HIV transmission by Neisseria gonorrhoeae: molecular and immunological aspects.
  Current HIV research 2012 Jarvis GA, Chang TL
• Neisseria gonorrhoeae selectively suppresses the development of Th1 and Th2 cells, and enhances Th17 cell responses, through TGF-β-dependent mechanisms.
  Mucosal immunology 2012 Liu Y, Islam EA, Jarvis GA, Gray-Owen SD, Russell MW
• Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure.
  The Journal of biological chemistry 2011 Cheng H, Yang Z, Estabrook MM, John CM, Jarvis GA, McLaughlin S, Griffiss JM
• Post-injury treatment with lipopolysaccharide or lipooligosaccharide protects rat neuronal and glial cell cultures.
  Brain research bulletin 2011 Bingham D, John CM, Panter SS, Jarvis GA
• Phosphoryl moieties of lipid A from Neisseria meningitidis and N. gonorrhoeae lipooligosaccharides play an important role in activation of both MyD88- and TRIF-dependent TLR4-MD-2 signaling pathways.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Liu M, John CM, Jarvis GA
• Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Ding J, Rapista A, Teleshova N, Mosoyan G, Jarvis GA, Klotman ME, Chang TL
• Natural phosphoryl and acyl variants of lipid A from Neisseria meningitidis strain 89I differentially induce tumor necrosis factor-alpha in human monocytes.
  The Journal of biological chemistry 2009 John CM, Liu M, Jarvis GA
• Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Duncan JA, Gao X, Huang MT, O'Connor BP, Thomas CE, Willingham SB, Bergstralh DT, Jarvis GA, Sparling PF, Ting JP
• Profiles of structural heterogeneity in native lipooligosaccharides of Neisseria and cytokine induction.
  Journal of lipid research 2008 John CM, Liu M, Jarvis GA
• Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Klotman ME, Rapista A, Teleshova N, Micsenyi A, Jarvis GA, Lu W, Porter E, Chang TL
• TREM-2 binds to lipooligosaccharides of Neisseria gonorrhoeae and is expressed on reproductive tract epithelial cells.
  Mucosal immunology 2008 Quan DN, Cooper MD, Potter JL, Roberts MH, Cheng H, Jarvis GA
• Elderly patients have more severe biliary infections: influence of complement-killing and induction of TNFalpha production.
  Surgery 2007 Stewart L, Grifiss JM, Jarvis GA, Way LW
• Bacteria entombed in the center of cholesterol gallstones induce fewer infectious manifestations than bacteria in the matrix of pigment stones.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2007 Stewart L, Griffiss JM, Jarvis GA, Way LW
• Gallstones containing bacteria are biofilms: bacterial slime production and ability to form pigment solids determines infection severity and bacteremia.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2007 Stewart L, Griffiss JM, Jarvis GA, Way LW
• Affinity-purified human immunoglobulin G that binds a lacto-N-neotetraose-dependent lipooligosaccharide structure is bactericidal for serogroup B Neisseria meningitidis.
  Infection and immunity 2006 Estabrook MM, Jarvis GA, McLeod Griffiss J
• Biliary bacterial factors determine the path of gallstone formation.
  American journal of surgery 2006 Stewart L, Grifiss JM, Jarvis GA, Way LW
• Gonococcal lipooligosaccharide suppresses HIV infection in human primary macrophages through induction of innate immunity.
  The Journal of infectious diseases 2006 Liu X, Mosoian A, Li-Yun Chang T, Zerhouni-Layachi B, Snyder A, Jarvis GA, Klotman ME
• Binding of the Streptococcus gordonii surface glycoproteins GspB and Hsa to specific carbohydrate structures on platelet membrane glycoprotein Ibalpha.
  Molecular microbiology 2005 Takamatsu D, Bensing BA, Cheng H, Jarvis GA, Siboo IR, López JA, Griffiss JM, Sullam PM
• Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action.
  Antimicrobial agents and chemotherapy 2005 Scordi-Bello IA, Mosoian A, He C, Chen Y, Cheng Y, Jarvis GA, Keller MJ, Hogarty K, Waller DP, Profy AT, Herold BC, Klotman ME
• Human T lymphotropic virus type II infection and humoral responses to pneumococcal polysaccharide and tetanus toxoid vaccines.
  The Journal of infectious diseases 2005 Jarvis GA, Janoff EN, Cheng H, Devita D, Fasching C, McCulloch CE, Murphy EL
• Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread.
  Antimicrobial agents and chemotherapy 2004 Cheshenko N, Keller MJ, MasCasullo V, Jarvis GA, Cheng H, John M, Li JH, Hogarty K, Anderson RA, Waller DP, Zaneveld LJ, Profy AT, Klotman ME, Herold BC
• Mannose-binding lectin binds to two major outer membrane proteins, opacity protein and porin, of Neisseria meningitidis.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Estabrook MM, Jack DL, Klein NJ, Jarvis GA
• Activation of toll-like receptor 2 (TLR2) and TLR4/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strains.
  Infection and immunity 2003 Pridmore AC, Jarvis GA, John CM, Jack DL, Dower SK, Read RC
• Truncated galectin-3 inhibits tumor growth and metastasis in orthotopic nude mouse model of human breast cancer.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2003 John CM, Leffler H, Kahl-Knutsson B, Svensson I, Jarvis GA
• Cholangitis: bacterial virulence factors that facilitate cholangiovenous reflux and tumor necrosis factor-alpha production.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2003 Stewart L, Oesterle AL, Grifiss JM, Jarvis GA, Way LW
• Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected.
  Cellular microbiology 2002 John CM, Jarvis GA, Swanson KV, Leffler H, Cooper MD, Huflejt ME, Griffiss JM
• Gram-negative bacteria killed by complement are associated with more severe biliary infections and produce more tumor necrosis factor-alpha in sera.
  Surgery 2002 Stewart L, Oesterle AL, Griffiss JM, Jarvis GA, Aagaard B, Way LW
• Functional activities and immunoglobulin variable regions of human and murine monoclonal antibodies specific for the P1.7 PorA protein loop of Neisseria meningitidis.
  Infection and immunity 2000 Wang J, Jarvis GA, Achtman M, Rosenqvist E, Michaelsen TE, Aase A, Griffiss JM
• Invasion of human mucosal epithelial cells by Neisseria gonorrhoeae upregulates expression of intercellular adhesion molecule 1 (ICAM-1).
  Infection and immunity 1999 Jarvis GA, Li J, Swanson KV
• Acquired resistance of Escherichia coli to complement lysis by binding of glycophosphoinositol-anchored protectin (CD59).
  Infection and immunity 1998 Rautemaa R, Jarvis GA, Marnila P, Meri S
• Sialylation of Neisseria meningitidis lipooligosaccharide inhibits serum bactericidal activity by masking lacto-N-neotetraose.
  Infection and immunity 1997 Estabrook MM, Griffiss JM, Jarvis GA
• Expression and function of the complement membrane attack complex inhibitor protectin (CD59) in human prostate cancer.
  International journal of cancer 1997 Jarvis GA, Li J, Hakulinen J, Brady KA, Nordling S, Dahiya R, Meri S
• Bacterial enzymes can add galactose alpha 1,3 to human erythrocytes and creates a senescence-associated epitope.
  Infection and immunity 1996 Hamadeh RM, Jarvis GA, Zhou P, Cotleur AC, Griffiss JM
• Anti-Gal binds to pili of Neisseria meningitidis: the immunoglobulin A isotype blocks complement-mediated killing.
  Infection and immunity 1995 Hamadeh RM, Estabrook MM, Zhou P, Jarvis GA, Griffiss JM
• Recognition and control of neisserial infection by antibody and complement.
  Trends in microbiology 1995 Jarvis GA
• Analysis of C3 deposition and degradation on Neisseria meningitidis and Neisseria gonorrhoeae.
  Infection and immunity 1994 Jarvis GA
• Detection and some properties of the sialyltransferase implicated in the sialylation of lipopolysaccharide of Neisseria gonorrhoeae.
  Microbial pathogenesis 1993 Mandrell RE, Smith H, Jarvis GA, Griffiss JM, Cole JA
• Human natural anti-Gal IgG regulates alternative complement pathway activation on bacterial surfaces.
  The Journal of clinical investigation 1992 Hamadeh RM, Jarvis GA, Galili U, Mandrell RE, Zhou P, Griffiss JM
• Human IgA1 blockade of IgG-initiated lysis of Neisseria meningitidis is a function of antigen-binding fragment binding to the polysaccharide capsule.
  Journal of immunology (Baltimore, Md. : 1950) 1991 Jarvis GA, Griffiss JM
• Lysis of Neisseria gonorrhoeae initiated by binding of normal human IgM to a hexosamine-containing lipooligosaccharide epitope(s) is augmented by strain-specific, properdin-binding-dependent alternative complement pathway activation.
  Journal of immunology (Baltimore, Md. : 1950) 1991 Griffiss JM, Jarvis GA, O'Brien JP, Eads MM, Schneider H
• Localization of host immunoglobulin G to the surface of Pneumocystis carinii.
  Infection and immunity 1990 Blumenfeld W, Mandrell RE, Jarvis GA, Griffiss JM
• Human IgA1 initiates complement-mediated killing of Neisseria meningitidis.
  Journal of immunology (Baltimore, Md. : 1950) 1989 Jarvis GA, Griffiss JM
• Role of immunoglobulin G in platelet aggregation by viridans group streptococci.
  Infection and immunity 1988 Sullam PM, Jarvis GA, Valone FH
• Lipooligosaccharides: the principal glycolipids of the neisserial outer membrane.
  Reviews of infectious diseases 1988 Griffiss JM, Schneider H, Mandrell RE, Yamasaki R, Jarvis GA, Kim JJ, Gibson BW, Hamadeh R, Apicella MA
• Phenotypic variation in epitope expression of the Neisseria gonorrhoeae lipooligosaccharide.
  Infection and immunity 1987 Apicella MA, Shero M, Jarvis GA, Griffiss JM, Mandrell RE, Schneider H
• Interaction of serum IgA with complement components: the molecular basis of IgA blockade.
  Advances in experimental medicine and biology 1987 Griffiss JM, Jarvis GA
• Sialic acid of group B Neisseria meningitidis regulates alternative complement pathway activation.
  Infection and immunity 1987 Jarvis GA, Vedros NA
• The immunochemistry of neisserial LOS.
  Antonie van Leeuwenhoek 1987 Griffiss JM, Schneider H, Mandrell RE, Jarvis GA, Kim JJ, Gibson B, Apicella MA
• Elaboration of a 3.6-kilodalton lipooligosaccharide, antibody against which is absent from human sera, is associated with serum resistance of Neisseria gonorrhoeae.
  Infection and immunity 1985 Schneider H, Griffiss JM, Mandrell RE, Jarvis GA