Gabriel McKinsey, PhD
Asst Professional Researcher
Pediatrics
School of Medicine

Publications (20)

Top publication keywords:
Cholinergic NeuronsGene Knock-In TechniquesIntegrasesHomeodomain ProteinsTranscription FactorsNeurogenesisGABAergic NeuronsMicrogliaRepressor ProteinsReceptors, Purinergic P2Y12Gene Expression Regulation, DevelopmentalCorpus StriatumInterneuronsEnhancer Elements, GeneticBlood-Brain Barrier

• Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism.
  Neuron 2024 Profaci CP, Harvey SS, Bajc K, Zhang TZ, Jeffrey DA, Zhang AZ, Nemec KM, Davtyan H, O'Brien CA, McKinsey GL, Longworth A, McMullen TP, Capocchi JK, Gonzalez JG, Lawson DA, Arnold TD, Davalos D, …
• A comparative evaluation of the strengths and potential caveats of the microglial inducible CreER mouse models.
  Cell reports 2024 Bedolla AM, McKinsey GL, Ware K, Santander N, Arnold TD, Luo Y
• APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.
  Nature immunology 2023 Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W, Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, Pitts KM, Durao A, Herron S, Shorey H, Cheng Y, Barry JL, Krishnan RK, …
• Radial glia promote microglial development through integrin αVβ8 -TGFβ1 signaling.
  bioRxiv : the preprint server for biology 2023 McKinsey GL, Santander N, Zhang X, Kleemann K, Tran L, Katewa A, Conant K, Barraza M, Waddell K, Lizama C, La Russa M, Koo HJ, Lee H, Mukherjee D, Paidassi H, Anton ES, Atabai K, Sheppard D, Butovsky …
• Finding the right tool: a comprehensive evaluation of microglial inducible cre mouse models.
  bioRxiv : the preprint server for biology 2023 Bedolla A, Mckinsey G, Ware K, Santander N, Arnold T, Luo Y

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• Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Su-Feher L, Rubin AN, Silberberg SN, Catta-Preta R, Lim KJ, Ypsilanti AR, Zdilar I, McGinnis CS, McKinsey GL, Rubino TE, Hawrylycz MJ, Thompson C, Gartner ZJ, Puelles L, Zeng H, Rubenstein JLR, Nord …
• Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier.
  The Journal of clinical investigation 2020 Santander N, Lizama CO, Meky E, McKinsey GL, Jung B, Sheppard D, Betsholtz C, Arnold TD
• A new genetic strategy for targeting microglia in development and disease.
  eLife 2020 McKinsey GL, Lizama CO, Keown-Lang AE, Niu A, Santander N, Larpthaveesarp A, Chee E, Gonzalez FF, Arnold TD
• Functionally Distinct Connectivity of Developmentally Targeted Striosome Neurons.
  Cell reports 2019 McGregor MM, McKinsey GL, Girasole AE, Bair-Marshall CJ, Rubenstein JLR, Nelson AB
• Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons.
  Cell reports 2019 Lindtner S, Catta-Preta R, Tian H, Su-Feher L, Price JD, Dickel DE, Greiner V, Silberberg SN, McKinsey GL, McManus MT, Pennacchio LA, Visel A, Nord AS, Rubenstein JLR
• Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function.
  Cell reports 2019 Pai EL, Vogt D, Clemente-Perez A, McKinsey GL, Cho FS, Hu JS, Wimer M, Paul A, Fazel Darbandi S, Pla R, Nowakowski TJ, Goodrich LV, Paz JT, Rubenstein JLR
• Neural control of sexually dimorphic social behaviors.
  Current opinion in physiology 2018 McKinsey G, Ahmed OM, Shah NM
• Subpallial Enhancer Transgenic Lines: a Data and Tool Resource to Study Transcriptional Regulation of GABAergic Cell Fate.
  Neuron 2016 Silberberg SN, Taher L, Lindtner S, Sandberg M, Nord AS, Vogt D, Mckinsey GL, Hoch R, Pattabiraman K, Zhang D, Ferran JL, Rajkovic A, Golonzhka O, Kim C, Zeng H, Puelles L, Visel A, Rubenstein JLR
• Disruptions in a cluster of computationally identified enhancers near FOXC1 and GMDS may influence brain development.
  Neurogenetics 2015 Haliburton GD, McKinsey GL, Pollard KS
• Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain.
  Neuron 2014 Silbereis JC, Nobuta H, Tsai HH, Heine VM, McKinsey GL, Meijer DH, Howard MA, Petryniak MA, Potter GB, Alberta JA, Baraban SC, Stiles CD, Rubenstein JL, Rowitch DH
• Fezf2 expression identifies a multipotent progenitor for neocortical projection neurons, astrocytes, and oligodendrocytes.
  Neuron 2013 Guo C, Eckler MJ, McKenna WL, McKinsey GL, Rubenstein JL, Chen B
• Many human accelerated regions are developmental enhancers.
  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2013 Capra JA, Erwin GD, McKinsey G, Rubenstein JL, Pollard KS
• A high-resolution enhancer atlas of the developing telencephalon.
  Cell 2013 Visel A, Taher L, Girgis H, May D, Golonzhka O, Hoch RV, McKinsey GL, Pattabiraman K, Silberberg SN, Blow MJ, Hansen DV, Nord AS, Akiyama JA, Holt A, Hosseini R, Phouanenavong S, Plajzer-Frick I, …
• Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.
  Neuron 2013 McKinsey GL, Lindtner S, Trzcinski B, Visel A, Pennacchio LA, Huylebroeck D, Higashi Y, Rubenstein JL
• Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneurons.
  Molecular and cellular neurosciences 2008 Potter GB, Petryniak MA, Shevchenko E, McKinsey GL, Ekker M, Rubenstein JL