Gabriel Loeb, MD, PhD
Assistant Professor
Medicine
School of Medicine
Gabriel Loeb, MD, PhD is a physician-scientist whose research and patient-care focuses on genetic kidney diseases.
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The Loeb laboratory uses genetics to understand the mechanisms underlying common and rare forms of kidney disease. Our research focuses on two major areas: 1) using human common genetic variation to identify cellular and molecular drivers of chronic kidney disease and 2) identifying the molecular mediators of Autosomal Dominant Polycystic Kidney Disease. The Loeb laboratory integrates human genetics, novel kidney disease models, and genomics to reveal essential regulators of kidney health and enable new therapies for people suffering from kidney disease.
In the UCSF Nephrology Faculty Practice, Dr. Loeb specializes in the care of individuals with familial and genetic forms of kidney disease.
Education & Training
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- Fellowship Nephrology UCSF 2021
- Residency Internal Medicine Brigham and Women's Hospital/Harvard Medical School 2018
- MD Medicine Cornell 2015
- PhD Immunology Cornell/Rockefeller/Sloan Kettering 2015
- BS Biology Stanford University 2005
Grants and Projects
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- , UCSF School of Medicine, 2021-2026
Publications (11)
Top publication keywords:
Nucleotide MotifsArgonaute ProteinsAtlases as TopicSingle-Cell AnalysisTranscriptomeOrgan SpecificityChemical FractionationMuromegalovirusSuppressor of Cytokine Signaling ProteinsCellsB-LymphocytesSaltsMicroRNAsRNA Splicing3' Untranslated Regions
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ADPKD-Causing Missense Variants in Polycystin-1 Disrupt Cell Surface Localization or Polycystin Channel Function.
bioRxiv : the preprint server for biology 2023 Ha K, Loeb GB, Park M, Pinedo A, Park CH, Brandes N, Ritu F, Ye CJ, Reiter JF, Delling M -
Multiomics characterization of cell type repertoires for urine liquid biopsies.
bioRxiv : the preprint server for biology 2023 Vorperian SK, DeFelice BC, Buonomo JA, Chinchinian HJ, Gray IJ, Yan J, Mach KE, La V, Lee TJ, Liao JC, Lafayette R, Loeb GB, Bertozzi CR, Quake SR -
The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans.
Science (New York, N.Y.) 2022 Tabula Sapiens Consortium*, Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, Yosef N, Bulthaup B, Brown P, Harper W, Hemenez M, Ponnusamy R, Salehi A, Sanagavarapu BA, Spallino E, … -
The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types.
Nature immunology 2018 Hsin JP, Lu Y, Loeb GB, Leslie CS, Rudensky AY -
Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155.
Proceedings of the National Academy of Sciences of the United States of America 2013 Zawislak CL, Beaulieu AM, Loeb GB, Karo J, Canner D, Bezman NA, Lanier LL, Rudensky AY, Sun JC
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Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting.
Molecular cell 2012 Loeb GB, Khan AA, Canner D, Hiatt JB, Shendure J, Darnell RB, Leslie CS, Rudensky AY -
Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion.
The Journal of biological chemistry 2009 Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT -
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein.
Immunity 2009 Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K, Rudensky AY -
Genome-wide profiling of salt fractions maps physical properties of chromatin.
Genome research 2008 Henikoff S, Henikoff JG, Sakai A, Loeb GB, Ahmad K -
Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America 2008 Cuellar TL, Davis TH, Nelson PT, Loeb GB, Harfe BD, Ullian E, McManus MT -
Unintentional miRNA ablation is a risk factor in gene knockout studies: a short report.
PLoS genetics 2008 Osokine I, Hsu R, Loeb GB, McManus MT