Gabby Joseph, PhD
Specialist
Radiology
School of Medicine

In addition to studying knee osteoarthritis, she has performed MR imaging of the intervertebral disc to investigate early markers of disc degeneration and back pain.

Dr. Joseph has received two NIH grants (F31 and F32), has over than 70 peer-reviewed articles published in the high-ranking journals, and serves as a reviewer for 14 scientific journals. She has mentored 30 researchers including medical students, residents, and fellows, providing guidance on study design, statistical analysis, and manuscript writing.

Expertise: Musculoskeletal Imaging

Specialty: Magnetic Resonance Imaging

Professional Interests: Osteoarthritis, cartilage degeneration, intervertebral disc degeneration, quantitative imaging, statistical programming and analysis, predictive modeling, machine learning, technical writing

• Natural history of new horizontal meniscal tears in individuals at risk for and with mild to moderate osteoarthritis: data from osteoarthritis initiative.
  European radiology 2020 Posadzy M, Joseph GB, McCulloch CE, Nevitt MC, Lynch JA, Lane NE, Link TM
• Meniscal Root Tears and Extrusion Are Significantly Associated with the Development of Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative.
  Cartilage 2020 Foreman SC, Liu Y, Nevitt MC, Neumann J, Joseph GB, Lane NE, McCulloch CE, Link TM
• Association of blood pressure with knee cartilage composition and structural knee abnormalities: data from the osteoarthritis initiative.
  Skeletal radiology 2020 Ashmeik W, Joseph GB, Nevitt MC, Lane NE, McCulloch CE, Link TM
• Secondary aneurysmal bone cysts and associated primary lesions: imaging features of 49 cases.
  Clinical imaging 2020 Gutierrez LB, Link TM, Horvai AE, Joseph GB, O'Donnell RJ, Motamedi D
• Diagnostic Performance of CT-Guided Bone Biopsies in Patients with Suspected Osteomyelitis of the Appendicular and Axial Skeleton with a Focus on Clinical and Technical Factors Associated with Positive Microbiology Culture Results.
  Journal of vascular and interventional radiology : JVIR 2020 Schirò S, Foreman SC, Bucknor M, Chin CT, Joseph GB, Link TM
• Chondrocalcinosis is associated with increased knee joint degeneration over 4 years: data from the Osteoarthritis Initiative.
  Osteoarthritis and cartilage 2019 Foreman SC, Gersing AS, von Schacky CE, Joseph GB, Neumann J, Lane NE, McCulloch CE, Nevitt MC, Link TM
• Patients with Type 2 Diabetes Exhibit a More Mineralized Deep Cartilage Layer Compared with Nondiabetic Controls: A Pilot Study.
  Cartilage 2019 Foreman SC, Ashmeik W, Baal JD, Han M, Bahroos E, von Schacky CE, Carl M, Krug R, Joseph GB, Link TM
• Cartilage degeneration post-meniscectomy performed for degenerative disease versus trauma: data from the Osteoarthritis Initiative.
  Skeletal radiology 2019 Neumann J, Kern K, Sun D, Foreman SC, Joseph GB, Gersing AS, Nevitt MC, McCulloch CE, Quitzke A, Link TM
• Longitudinal MRI structural findings observed in accelerated knee osteoarthritis: data from the Osteoarthritis Initiative.
  Skeletal radiology 2019 Foreman SC, Neumann J, Joseph GB, Nevitt MC, McCulloch CE, Lane NE, Link TM
• Is treated HIV infection associated with knee cartilage degeneration and structural changes? A longitudinal study using data from the osteoarthritis initiative.
  BMC musculoskeletal disorders 2019 Liu Y, Foreman SC, Joseph GB, Neumann J, Tien PC, Li X, Lane NE, Nevitt MC, McCulloch CE, Link TM
• Factors Associated with Osteoid Osteoma Recurrence after CT-Guided Radiofrequency Ablation.
  Journal of vascular and interventional radiology : JVIR 2019 Baal JD, Pai JS, Chen WC, Joseph GB, O'Donnell RJ, Link TM
• Weight loss regimen in obese and overweight individuals is associated with reduced cartilage degeneration: 96-month data from the Osteoarthritis Initiative.
  Osteoarthritis and cartilage 2019 Gersing AS, Schwaiger BJ, Nevitt MC, Zarnowski J, Joseph GB, Feuerriegel G, Jungmann PM, Guimaraes JB, Facchetti L, McCulloch CE, Link TM
• Spatial distribution and temporal progression of T2 relaxation time values in knee cartilage prior to the onset of cartilage lesions - data from the Osteoarthritis Initiative (OAI).
  Osteoarthritis and cartilage 2019 Kretzschmar M, Nevitt MC, Schwaiger BJ, Joseph GB, McCulloch CE, Link TM
• Central osteophytes develop in cartilage with abnormal structure and composition: data from the Osteoarthritis Initiative cohort.
  Skeletal radiology 2019 Kretzschmar M, Heilmeier U, Foreman SC, Joseph GB, McCulloch CE, Nevitt MC, Link TM
• Associations between vertebral body fat fraction and intervertebral disc biochemical composition as assessed by quantitative MRI.
  Journal of magnetic resonance imaging : JMRI 2019 Krug R, Joseph GB, Han M, Fields A, Cheung J, Mundada M, Bailey J, Rochette A, Ballatori A, McCulloch CE, McCormick Z, O'Neill C, Link TM, Lotz J
• Introduction of an MR-based semi-quantitative score for assessing partial meniscectomy and relation to knee joint degenerative disease: data from the Osteoarthritis Initiative.
  European radiology 2019 Sun D, Neumann J, Joseph GB, Foreman S, Nevitt MC, McCulloch CE, Li X, Link TM
• Diabetics show accelerated progression of knee cartilage and meniscal lesions: data from the osteoarthritis initiative.
  Skeletal radiology 2018 Neumann J, Guimaraes JB, Heilmeier U, Joseph GB, Nevitt MC, McCulloch CE, Link TM
• Validation of scoring hip osteoarthritis with MRI (SHOMRI) scores using hip arthroscopy as a standard of reference.
  European radiology 2018 Neumann J, Zhang AL, Schwaiger BJ, Samaan MA, Souza R, Foreman SC, Joseph GB, Grace T, Majumdar S, Link TM
• Baseline knee joint effusion and medial femoral bone marrow edema, in addition to MRI-based T2 relaxation time and texture measurements of knee cartilage, can help predict incident total knee arthroplasty 4-7 years later: data from the Osteoarthritis Initiative.
  Skeletal radiology 2018 Heilmeier U, Wamba JM, Joseph GB, Darakananda K, Callan J, Neumann J, Link TM
• Associations between molecular biomarkers and MR-based cartilage composition and knee joint morphology: data from the Osteoarthritis Initiative.
  Osteoarthritis and cartilage 2018 Joseph GB, Nevitt MC, McCulloch CE, Neumann J, Lynch JA, Heilmeier U, Lane NE, Link TM
• Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative.
  Osteoarthritis and cartilage 2018 Neumann J, Hofmann FC, Heilmeier U, Ashmeik W, Tang K, Gersing AS, Schwaiger BJ, Nevitt MC, Joseph GB, Lane NE, McCulloch CE, Link TM
• Longitudinal changes in MR T1ρ/T2 signal of meniscus and its association with cartilage T1p/T2 in ACL-injured patients.
  Osteoarthritis and cartilage 2018 Knox J, Pedoia V, Wang A, Tanaka M, Joseph GB, Neumann J, Link TM, Li X, Ma CB
• Tool for osteoarthritis risk prediction (TOARP) over 8 years using baseline clinical data, X-ray, and MRI: Data from the osteoarthritis initiative.
  Journal of magnetic resonance imaging : JMRI 2017 Joseph GB, McCulloch CE, Nevitt MC, Neumann J, Gersing AS, Kretzschmar M, Schwaiger BJ, Lynch JA, Heilmeier U, Lane NE, Link TM
• Association of weight change with progression of meniscal intrasubstance degeneration over 48 months: Data from the Osteoarthritis Initiative.
  European radiology 2017 Guimaraes JB, Nevitt MC, McCulloch CE, Schwaiger BJ, Gersing AS, Facchetti L, Bucknor MD, Chanchek N, Liu F, Joseph GB, Link TM
• Conservatively treated knee injury is associated with knee cartilage matrix degeneration measured with MRI-based T2 relaxation times: data from the osteoarthritis initiative.
  Skeletal radiology 2017 Hofmann FC, Neumann J, Heilmeier U, Joseph GB, Nevitt MC, McCulloch CE, Link TM
• Association of diabetes mellitus and biochemical knee cartilage composition assessed by T2 relaxation time measurements: Data from the osteoarthritis initiative.
  Journal of magnetic resonance imaging : JMRI 2017 Chanchek N, Gersing AS, Schwaiger BJ, Nevitt MC, Neumann J, Joseph GB, Lane NE, Zarnowski J, Hofmann FC, Heilmeier U, McCulloch CE, Link TM
• Is Weight Loss Associated with Less Progression of Changes in Knee Articular Cartilage among Obese and Overweight Patients as Assessed with MR Imaging over 48 Months? Data from the Osteoarthritis Initiative.
  Radiology 2017 Gersing AS, Schwaiger BJ, Nevitt MC, Joseph GB, Chanchek N, Guimaraes JB, Mbapte Wamba J, Facchetti L, McCulloch CE, Link TM
• Medial femur T2 Z-scores predict the probability of knee structural worsening over 4-8 years: Data from the osteoarthritis initiative.
  Journal of magnetic resonance imaging : JMRI 2017 Joseph GB, McCulloch CE, Nevitt MC, Gersing AS, Schwaiger BJ, Kretzschmar M, Heilmeier U, Link TM
• Evaluation of Chondrocalcinosis and Associated Knee Joint Degeneration Using MR Imaging: Data from the Osteoarthritis Initiative.
  European radiology 2016 Gersing AS, Schwaiger BJ, Heilmeier U, Joseph GB, Facchetti L, Kretzschmar M, Lynch JA, McCulloch CE, Nevitt MC, Steinbach LS, Link TM
• Role of thigh muscle cross-sectional area and strength in progression of knee cartilage degeneration over 48 months - data from the Osteoarthritis Initiative.
  Osteoarthritis and cartilage 2016 Goldman LH, Tang K, Facchetti L, Heilmeier U, Joseph GB, Nevitt MC, McCulloch CE, Souza RB, Link TM
• Cortical bone laminar analysis reveals increased midcortical and periosteal porosity in type 2 diabetic postmenopausal women with history of fragility fractures compared to fracture-free diabetics.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2016 Heilmeier U, Cheng K, Pasco C, Parrish R, Nirody J, Patsch JM, Zhang CA, Joseph GB, Burghardt AJ, Schwartz AV, Link TM, Kazakia G
• Longitudinal analysis of cartilage T2 relaxation times and joint degeneration in African American and Caucasian American women over an observation period of 6 years - data from the Osteoarthritis Initiative.
  Osteoarthritis and cartilage 2016 Kretzschmar M, Heilmeier U, Yu A, Joseph GB, Liu F, Solka M, McCulloch CE, Nevitt MC, Link TM
• MRI findings associated with development of incident knee pain over 48 months: data from the osteoarthritis initiative.
  Skeletal radiology 2016 Joseph GB, Hou SW, Nardo L, Heilmeier U, Nevitt MC, McCulloch CE, Link TM
• Progression of cartilage degeneration and clinical symptoms in obese and overweight individuals is dependent on the amount of weight loss: 48-month data from the Osteoarthritis Initiative.
  Osteoarthritis and cartilage 2016 Gersing AS, Solka M, Joseph GB, Schwaiger BJ, Heilmeier U, Feuerriegel G, Nevitt MC, McCulloch CE, Link TM
• Do persons with asymmetric hip pain or radiographic hip OA have worse pain and structure outcomes in the knee opposite the more affected hip? Data from the Osteoarthritis Initiative.
  Osteoarthritis and cartilage 2015 Joseph GB, Hilton JF, Jungmann PM, Lynch JA, Lane NE, Liu F, McCulloch CE, Tolstykh I, Link TM, Nevitt MC
• Subchondral insufficiency fractures of the femoral head: associated imaging findings and predictors of clinical progression.
  European radiology 2015 Hackney LA, Lee MH, Joseph GB, Vail TP, Link TM
• Association of Physical Activity Measured by Accelerometer, Knee Joint Abnormalities, and Cartilage T2 Measurements Obtained From 3T Magnetic Resonance Imaging: Data From the Osteoarthritis Initiative.
  Arthritis care & research 2015 Kretzschmar M, Lin W, Nardo L, Joseph GB, Dunlop DD, Heilmeier U, Nevitt MC, Alizai H, McCulloch CE, Lynch JA, Link TM
• Racial differences in biochemical knee cartilage composition between African-American and Caucasian-American women with 3 T MR-based T2 relaxation time measurements--data from the Osteoarthritis Initiative.
  Osteoarthritis and cartilage 2015 Yu A, Heilmeier U, Kretzschmar M, Joseph GB, Liu F, Liebl H, McCulloch CE, Nevitt MC, Lane NE, Link TM
• Metal artefact suppression at 3 T MRI: comparison of MAVRIC-SL with conventional fast spin echo sequences in patients with Hip joint arthroplasty.
  European radiology 2015 Kretzschmar M, Nardo L, Han MM, Heilmeier U, Sam C, Joseph GB, Koch KM, Krug R, Link TM
• A reference database of cartilage 3 T MRI T2 values in knees without diagnostic evidence of cartilage degeneration: data from the osteoarthritis initiative.
  Osteoarthritis and cartilage 2015 Joseph GB, McCulloch CE, Nevitt MC, Heilmeier U, Nardo L, Lynch JA, Liu F, Baum T, Link TM
• Volumetric femoral BMD, bone geometry, and serum sclerostin levels differ between type 2 diabetic postmenopausal women with and without fragility fractures.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2015 Heilmeier U, Carpenter DR, Patsch JM, Harnish R, Joseph GB, Burghardt AJ, Baum T, Schwartz AV, Lang TF, Link TM
• Association of cartilage degeneration with four year weight gain--3T MRI data from the Osteoarthritis Initiative.
  Osteoarthritis and cartilage 2015 Bucknor MD, Nardo L, Joseph GB, Alizai H, Srikhum W, Nevitt MC, Lynch JA, McCulloch CE, Link TM
• MR imaging characteristics and clinical symptoms related to displaced meniscal flap tears.
  Skeletal radiology 2014 Lance V, Heilmeier UR, Joseph GB, Steinbach L, Ma B, Link TM
• Weight loss over 48 months is associated with reduced progression of cartilage T2 relaxation time values: data from the osteoarthritis initiative.
  Journal of magnetic resonance imaging : JMRI 2014 Serebrakian AT, Poulos T, Liebl H, Joseph GB, Lai A, Nevitt MC, Lynch JA, McCulloch CE, Link TM
• Cartilage lesion score: comparison of a quantitative assessment score with established semiquantitative MR scoring systems.
  Radiology 2014 Alizai H, Virayavanich W, Joseph GB, Nardo L, Liu F, Liebl H, Nevitt MC, Lynch JA, McCulloch CE, Link TM
• Association of metabolic risk factors with cartilage degradation assessed by T2 relaxation time at the knee: data from the osteoarthritis initiative.
  Arthritis care & research 2013 Jungmann PM, Kraus MS, Alizai H, Nardo L, Baum T, Nevitt MC, McCulloch CE, Joseph GB, Lynch JA, Link TM
• T(2) relaxation time measurements are limited in monitoring progression, once advanced cartilage defects at the knee occur: longitudinal data from the osteoarthritis initiative.
  Journal of magnetic resonance imaging : JMRI 2013 Jungmann PM, Kraus MS, Nardo L, Liebl H, Alizai H, Joseph GB, Liu F, Lynch J, McCulloch CE, Nevitt MC, Link TM
• Cartilage and meniscal T2 relaxation time as non-invasive biomarker for knee osteoarthritis and cartilage repair procedures.
  Osteoarthritis and cartilage 2013 Baum T, Joseph GB, Karampinos DC, Jungmann PM, Link TM, Bauer JS
• Physical activity in relation to knee cartilage T2 progression measured with 3 T MRI over a period of 4 years: data from the Osteoarthritis Initiative.
  Osteoarthritis and cartilage 2013 Lin W, Alizai H, Joseph GB, Srikhum W, Nevitt MC, Lynch JA, McCulloch CE, Link TM
• Regional variations in MR relaxation of hip joint cartilage in subjects with and without femoralacetabular impingement.
  Magnetic resonance imaging 2013 Subburaj K, Valentinitsch A, Dillon AB, Joseph GB, Li X, Link TM, Vail TP, Majumdar S
• Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 Patsch JM, Burghardt AJ, Yap SP, Baum T, Schwartz AV, Joseph GB, Link TM
• Correlation of magnetic resonance imaging-based knee cartilage T2 measurements and focal knee lesions with body mass index: thirty-six-month followup data from a longitudinal, observational multicenter study.
  Arthritis care & research 2013 Baum T, Joseph GB, Nardo L, Virayavanich W, Arulanandan A, Alizai H, Carballido-Gamio J, Nevitt MC, Lynch J, McCulloch CE, Link TM
• T₁ρ and T₂ relaxation times predict progression of knee osteoarthritis.
  Osteoarthritis and cartilage 2012 Prasad AP, Nardo L, Schooler J, Joseph GB, Link TM
• Baseline mean and heterogeneity of MR cartilage T2 are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3 years--data from the Osteoarthritis Initiative.
  Osteoarthritis and cartilage 2012 Joseph GB, Baum T, Alizai H, Carballido-Gamio J, Nardo L, Virayavanich W, Lynch JA, Nevitt MC, McCulloch CE, Majumdar S, Link TM
• Comparison of clinical semi-quantitative assessment of muscle fat infiltration with quantitative assessment using chemical shift-based water/fat separation in MR studies of the calf of post-menopausal women.
  European radiology 2012 Alizai H, Nardo L, Karampinos DC, Joseph GB, Yap SP, Baum T, Krug R, Majumdar S, Link TM
• Association of magnetic resonance imaging-based knee cartilage T2 measurements and focal knee lesions with knee pain: data from the Osteoarthritis Initiative.
  Arthritis care & research 2012 Baum T, Joseph GB, Arulanandan A, Nardo L, Virayavanich W, Carballido-Gamio J, Nevitt MC, Lynch J, McCulloch CE, Link TM
• In vivo intervertebral disc characterization using magnetic resonance spectroscopy and T1ρ imaging: association with discography and Oswestry Disability Index and Short Form-36 Health Survey.
  Spine 2012 Zuo J, Joseph GB, Li X, Link TM, Hu SS, Berven SH, Kurhanewitz J, Majumdar S
• Changes in knee cartilage T2 values over 24 months in subjects with and without risk factors for knee osteoarthritis and their association with focal knee lesions at baseline: data from the osteoarthritis initiative.
  Journal of magnetic resonance imaging : JMRI 2011 Baum T, Stehling C, Joseph GB, Carballido-Gamio J, Schwaiger BJ, Müller-Höcker C, Nevitt MC, Lynch J, McCulloch CE, Link TM
• Texture analysis of cartilage T2 maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR T2 compared to normal controls--data from the osteoarthritis initiative.
  Arthritis research & therapy 2011 Joseph GB, Baum T, Carballido-Gamio J, Nardo L, Virayavanich W, Alizai H, Lynch JA, McCulloch CE, Majumdar S, Link TM
• Knee cartilage T2 characteristics and evolution in relation to morphologic abnormalities detected at 3-T MR imaging: a longitudinal study of the normal control cohort from the Osteoarthritis Initiative.
  Radiology 2011 Pan J, Pialat JB, Joseph T, Kuo D, Joseph GB, Nevitt MC, Link TM
• A novel fast knee cartilage segmentation technique for T2 measurements at MR imaging--data from the Osteoarthritis Initiative.
  Osteoarthritis and cartilage 2011 Stehling C, Baum T, Mueller-Hoecker C, Liebl H, Carballido-Gamio J, Joseph GB, Majumdar S, Link TM
• Longitudinal analysis of MRI T2 knee cartilage laminar organization in a subset of patients from the osteoarthritis initiative: a texture approach.
  Magnetic resonance in medicine 2010 Carballido-Gamio J, Joseph GB, Lynch JA, Link TM, Majumdar S
• In vivo 3.0-tesla magnetic resonance T1rho and T2 relaxation mapping in subjects with intervertebral disc degeneration and clinical symptoms.
  Magnetic resonance in medicine 2010 Blumenkrantz G, Zuo J, Li X, Kornak J, Link TM, Majumdar S
• Longitudinal analysis of MRI T(2) knee cartilage laminar organization in a subset of patients from the osteoarthritis initiative.
  Magnetic resonance in medicine 2010 Carballido-Gamio J, Blumenkrantz G, Lynch JA, Link TM, Majumdar S
• Spatial analysis of magnetic resonance T1rho and T2 relaxation times improves classification between subjects with and without osteoarthritis.
  Medical physics 2009 Carballido-Gamio J, Stahl R, Blumenkrantz G, Romero A, Majumdar S, Link TM
• Spatial distribution and relationship of T1rho and T2 relaxation times in knee cartilage with osteoarthritis.
  Magnetic resonance in medicine 2009 Li X, Pai A, Blumenkrantz G, Carballido-Gamio J, Link T, Ma B, Ries M, Majumdar S
• The feasibility of characterizing the spatial distribution of cartilage T(2) using texture analysis.
  Osteoarthritis and cartilage 2008 Blumenkrantz G, Stahl R, Carballido-Gamio J, Zhao S, Lu Y, Munoz T, Hellio Le Graverand-Gastineau MP, Jain SK, Link TM, Majumdar S
• MRI-derived T2 relaxation times and cartilage morphometry of the tibio-femoral joint in subjects with and without osteoarthritis during a 1-year follow-up.
  Osteoarthritis and cartilage 2007 Stahl R, Blumenkrantz G, Carballido-Gamio J, Zhao S, Munoz T, Hellio Le Graverand-Gastineau MP, Li X, Majumdar S, Link TM
• Quantitative magnetic resonance imaging of articular cartilage in osteoarthritis.
  European cells & materials 2007 Blumenkrantz G, Majumdar S
• In vivo T(1rho) and T(2) mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI.
  Osteoarthritis and cartilage 2007 Li X, Benjamin Ma C, Link TM, Castillo DD, Blumenkrantz G, Lozano J, Carballido-Gamio J, Ries M, Majumdar S
• MR imaging and early cartilage degeneration and strategies for monitoring regeneration.
  Journal of musculoskeletal & neuronal interactions 2006 Majumdar S, Li X, Blumenkrantz G, Saldanha K, Ma CB, Kim H, Lozano J, Link T
• A feasibility study of in vivo T1rho imaging of the intervertebral disc.
  Magnetic resonance imaging 2006 Blumenkrantz G, Li X, Han ET, Newitt DC, Crane JC, Link TM, Majumdar S
• MR imaging findings in the follow-up of patients with different stages of knee osteoarthritis and the correlation with clinical symptoms.
  European radiology 2005 Phan CM, Link TM, Blumenkrantz G, Dunn TC, Ries MD, Steinbach LS, Majumdar S
• Magnetic resonance imaging of in vivo kinematics after total knee arthroplasty.
  Journal of magnetic resonance imaging : JMRI 2005 Lee KY, Slavinsky JP, Ries MD, Blumenkrantz G, Majumdar S
• A pilot, two-year longitudinal study of the interrelationship between trabecular bone and articular cartilage in the osteoarthritic knee.
  Osteoarthritis and cartilage 2004 Blumenkrantz G, Lindsey CT, Dunn TC, Jin H, Ries MD, Link TM, Steinbach LS, Majumdar S