Franciscus Kuypers, PhD
Professional Researcher
Pediatrics
School of Medicine

My laboratory serves as a central laboratory for the analysis of blood components in translational research studies in hemoglobinopathies, as part of the reference laboratory for hemoglobinopathies in California. Starting 1/1/2021, the RBC lab was integrated in the hematology division at UCSF and continues to provide support for several NIH and industry sponsored research studies and clinical trials. Work with the mechanical engineering department at UC Berkeley has provided novel technology to characterize individual cells in heterogeneous populations. The establishment of the first sibling cord blood program in the US, translated into the invention of a novel and highly efficient way to collect cord blood and subsequent studies that established the human term placenta as a rich source of hematopoietic and multipotent stem cells.

RBC lab The RBC lab at UCSF builds on a decades long experience defining blood physiology in basic, translational and clinical studies. Our highly experienced staff partners with academia and industry to evaluate approaches aimed to improve the quality of life of patients with abnormalities in blood and blood cell physiology. The RBC lab provide detailed assessment of -Hematology blood cell characteristics -Plasma factors including hemostasis and inflammatory determinants -RBC Oxygen affinity assessment -Hemoglobin and globin HPLC -Microcalorimetric protein-protein interactions -Flowcytometry and Image Flowcytometry -Ektacytometric RBC deformability

• Dual Role of ACBD6 in the Acylation Remodeling of Lipids and Proteins.
  Biomolecules 2022 Soupene E, Kuypers FA
• The effects of glutamine supplementation on markers of apoptosis and autophagy in sickle cell disease peripheral blood mononuclear cells.
  Complementary therapies in medicine 2022 Walter PB, Hohman LS, Rokeby A, Lum JJ, Hagar R, Lavrisha L, Saulys A, Kuypers FA, Vichinsky E, Morris CR
• P1495: ETAVOPIVAT TREATMENT FOR UP TO 12 WEEKS IN PATIENTS WITH SICKLE CELL DISEASE IS WELL TOLERATED AND IMPROVES RED BLOOD CELL HEALTH.
  HemaSphere 2022 S. Saraf, R. C. Brown, R. W. Hagar, M. Idowu, I. Osunkwo, T. A. Kalfa, F. A. Kuypers, J. Geib, P. Schroeder, E. Wu, P. Kelly, M. J. Telen
• Hyperinflammation, apoptosis, and organ damage.
  Experimental biology and medicine (Maywood, N.J.) 2022 Kuypers FA
• Correction: Requirement of the acyl-CoA carrier ACBD6 in myristoylation of proteins: Activation by ligand binding and protein interaction.
  PloS one 2022 Soupene E, Schatz UA, Rudnik-Schöneborn S, Kuypers FA
• The ektacytometric elongation Index (EI) of erythrocytes, validation of a prognostic, rheological biomarker for patients with sickle cell disease.
  European journal of haematology 2022 Franck P, Buijs P, Meenhuis A, Dane M, Postma C, Spaans A, Gijsbertha N, Kuypers FA, Hudig C, Kerkhoffs JL
• Implications for the metabolic fate of oral glutamine supplementation within plasma and erythrocytes of patients with sickle cell disease: A pharmacokinetics study.
  Complementary therapies in medicine 2022 Morris CR, Kuypers FA, Hagar R, Larkin S, Lavrisha L, Saulys A, Vichinsky EP, Suh JH
• Etavopivat, an Allosteric Activator of Pyruvate Kinase-R, Improves Sickle RBC Functional Health and Survival and Reduces Systemic Markers of Inflammation and Hypercoagulability in Patients with Sickle Cell Disease: An Analysis of Exploratory Studies in a Phase 1 Study.
  Blood 2021 Theodosia A. Kalfa, Marilyn J. Telen, Santosh L. Saraf, R. Clark Clark Brown, Katie Giger Seu, Sandra K. Larkin, Maria D. Ribadeneira, Patricia Schroeder, Eric Wu, Patrick Kelly, Frans A. Kuypers
• The Effect of Voxelotor on Exercise Capacity of Youths with Sickle Cell Anemia.
  Blood 2021 Vivian Phan, Laura Caldarera, Ana Lucia Cortez, Kari Wheeler, Sandra K. Larkin, Sangah Nancy Park, Robin Yates Dulman, Noravy Briere, Angela Lewis, Frans A. Kuypers, Jared Hershenson, Elizabeth Yang
• Novel, de novo, beta-globin variant with decreased oxygen affinity (HBB:c.317T>A, "Hemoglobin St. George") in a healthy child with low oxygen saturations and anemia.
  American journal of hematology 2021 Meznarich JA, Rets A, Agarwal AM, Christensen RD, Reading NS, Kuypers FA, Prchal JT
• Common host variation drives malaria parasite fitness in healthy human red cells.
  eLife 2021 Ebel ER, Kuypers FA, Lin C, Petrov DA, Egan ES
• Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C).
  Experimental biology and medicine (Maywood, N.J.) 2021 Kuypers FA, Rostad CA, Anderson EJ, Chahroudi A, Jaggi P, Wrammert J, Mantus G, Basu R, Harris F, Hanberry B, Camacho-Gonzalez A, Manoranjithan S, Vos M, Brown LA, Morris CR
• Time to rethink haemoglobin threshold guidelines in sickle cell disease.
  British journal of haematology 2021 Ballas SK, Kuypers FA, Gordeuk VR, Hankins JS, Thompson AA, Vichinsky E
• Stress and corticotropin releasing factor (CRF) promote necrotizing enterocolitis in a formula-fed neonatal rat model.
  PloS one 2021 Bell RL, Withers GS, Kuypers FA, Stehr W, Bhargava A
• Differential Acetone Extraction of Total and Hemoprotein-Unbound Heme to Quantify Heme Binding Capacity of Plasma in Patients with Sickle Cell Disease: The Role of Heme Scavengers.
  Blood 2020 Madhav Vissa, Eric Soupene, Sandra K. Larkin, Lynne D. Neumayr, Elliott P. Vichinsky, Frans A. Kuypers
• FT-4202, an Allosteric Activator of Pyruvate Kinase-R, Demonstrates Proof of Mechanism and Proof of Concept after a Single Dose and after Multiple Daily Doses in a Phase 1 Study of Patients with Sickle Cell Disease.
  Blood 2020 R. Clark Brown, Kimberly Cruz, Theodosia A. Kalfa, Frans A. Kuypers, Santosh L. Saraf, Jeremie H. Estepp, Luke R. Smart, Punam Malik, Mark Lerman, Renae Mayer, Maria D. Ribadeneira, Sanjeev Forsyth, …
• Requirement of the acyl-CoA carrier ACBD6 in myristoylation of proteins: Activation by ligand binding and protein interaction.
  PloS one 2020 Soupene E, Schatz UA, Rudnik-Schöneborn S, Kuypers FA
• The diversity of ACBD proteins - From lipid binding to protein modulators and organelle tethers.
  Biochimica et biophysica acta. Molecular cell research 2020 Islinger M, Costello JL, Kors S, Soupene E, Levine TP, Kuypers FA, Schrader M
• Phase 1 Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of FT-4202, an Allosteric Activator of Pyruvate Kinase-R, in Healthy and Sickle Cell Disease Subjects.
  Blood 2019 Theodosia A. Kalfa, Frans A Kuypers, Marilyn J. Telen, Punam Malik, Diamantis G. Konstantinidis, Jeremy H. Estepp, Hyon J. Kim, Santosh L. Saraf, Lindsey Wilson, Maria D Ribadeneira, Sanjeev Forsyth, …
• Vincristine-induced anemia in hereditary spherocytosis.
  Experimental biology and medicine (Maywood, N.J.) 2019 Michlitsch J, Larkin S, Vichinsky E, Kuypers FA
• Image-Based Flow Cytometry and Angle-Resolved Light Scattering to Define the Sickling Process.
  Cytometry. Part A : the journal of the International Society for Analytical Cytology 2019 Goktas P, Sukharevsky IO, Larkin S, Kuypers FA, Yalcin O, Altintas A
• ACBD6 protein controls acyl chain availability and specificity of the N-myristoylation modification of proteins.
  Journal of lipid research 2019 Soupene E, Kuypers FA
• Hereditary elliptocytosis: Variable clinical severity caused by 3 variants in the α-spectrin gene.
  International journal of laboratory hematology 2018 Franck P, Postma C, Spaans A, Veuger M, de Kort G, Hudig C, Wijermans P, Kuypers F
• Phosphatidylserine decarboxylase CT699, lysophospholipid acyltransferase CT775, and acyl-ACP synthase CT776 provide membrane lipid diversity to Chlamydia trachomatis.
  Scientific reports 2017 Soupene E, Kuypers FA
• Erythrocytes from hereditary xerocytosis patients heterozygous for KCNN4 V282M exhibit increased spontaneous Gardos channel-like activity inhibited by senicapoc.
  American journal of hematology 2017 Rivera A, Vandorpe DH, Shmukler BE, Gallagher DR, Fikry CC, Kuypers FA, Brugnara C, Snyder LM, Alper SL
• Featured Article: Depletion of HDL3 high density lipoprotein and altered functionality of HDL2 in blood from sickle cell patients.
  Experimental biology and medicine (Maywood, N.J.) 2017 Soupene E, Larkin SK, Kuypers FA
• Simvastatin reduces vaso-occlusive pain in sickle cell anaemia: a pilot efficacy trial.
  British journal of haematology 2017 Hoppe C, Jacob E, Styles L, Kuypers F, Larkin S, Vichinsky E
• Interim Results from a Phase 1/2 Clinical Study of Lentiglobin Gene Therapy for Severe Sickle Cell Disease.
  Blood 2016 Julie Kanter, Mark C. Walters, Matthew M. Hsieh, Lakshmanan Krishnamurti, Janet Kwiatkowski, Rammurti T Kamble, Christof von Kalle, Frans A. Kuypers, Marina Cavazzana, Philippe Leboulch, Marcelyne …
• Targeting tumor hypoxia with the epigenetic anticancer agent, RRx-001: a superagonist of nitric oxide generation.
  Medical oncology (Northwood, London, England) 2016 Fens MH, Cabrales P, Scicinski J, Larkin SK, Suh JH, Kuypers FA, Oronsky N, Lybeck M, Oronsky A, Oronsky B
• Featured Article: Alterations of lecithin cholesterol acyltransferase activity and apolipoprotein A-I functionality in human sickle blood.
  Experimental biology and medicine (Maywood, N.J.) 2016 Soupene E, Borja MS, Borda M, Larkin SK, Kuypers FA
• A look inside the mechanistic black box: Are red blood cells the critical effectors of RRx-001 cytotoxicity?
  Medical oncology (Northwood, London, England) 2016 Cabrales P, Scicinski J, Reid T, Kuypers F, Larkin S, Fens M, Oronsky A, Oronsky B
• Initial Results from Study Hgb-206: A Phase 1 Study Evaluating Gene Therapy By Transplantation of Autologous CD34+ Stem Cells Transduced Ex Vivo with the Lentiglobin BB305 Lentiviral Vector in Subjects with Severe Sickle Cell Disease.
  Blood 2015 Julie Kanter, Mark C. Walters, Matthew Hsieh, Alexis A. Thompson, Lakshmanan Krishnamurti, Janet Kwiatkowski, Rammurti T Kamble, Christof von Kalle, Frans A. Kuypers, Marina Cavazzana, Philippe …
• Outcomes of Gene Therapy for Severe Sickle Disease and Beta-Thalassemia Major Via Transplantation of Autologous Hematopoietic Stem Cells Transduced Ex Vivo with a Lentiviral Beta AT87Q-Globin Vector.
  Blood 2015 Marina Cavazzana, Jean-Antoine Ribeil, Emmanuel Payen, Felipe Suarez, Yves Beuzard, Fabien Touzot, Resy Cavallesco, Francois Lefrere, Stany Chretien, Philippe Bourget, Fabrice Monpoux, Corinne …
• Simvastatin Reduces Frequency of Vaso-Occlusive Pain in Sickle Cell Disease: A Pilot Efficacy Trial.
  Blood 2015 Carolyn C. Hoppe, Eufemia Jacob, Frans A. Kuypers, Lori Styles
• Sub-population analysis of deformability distribution in heterogeneous red blood cell population.
  Biomedical microdevices 2015 Lee DW, Doh I, Kuypers FA, Cho YH
• Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA.
  Journal of lipid research 2015 Soupene E, Kao J, Cheng DH, Wang D, Greninger AL, Knudsen GM, DeRisi JL, Kuypers FA
• Ligand binding to the ACBD6 protein regulates the acyl-CoA transferase reactions in membranes.
  Journal of lipid research 2015 Soupene E, Kuypers FA
• From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria.
  Malaria journal 2015 Yalcin O, Oronsky B, Carvalho LJ, Kuypers FA, Scicinski J, Cabrales P
• Dysregulated arginine metabolism and cardiopulmonary dysfunction in patients with thalassaemia.
  British journal of haematology 2015 Morris CR, Kim HY, Klings ES, Wood J, Porter JB, Trachtenberg F, Sweeters N, Olivieri NF, Kwiatkowski JL, Virzi L, Hassell K, Taher A, Neufeld EJ, Thompson AA, Larkin S, Suh JH, Vichinsky EP, Kuypers …
• Inability to maintain GSH pool in G6PD-deficient red cells causes futile AMPK activation and irreversible metabolic disturbance.
  Antioxidants & redox signaling 2015 Tang HY, Ho HY, Wu PR, Chen SH, Kuypers FA, Cheng ML, Chiu DT
• Remodeling of host phosphatidylcholine by Chlamydia acyltransferase is regulated by acyl-CoA binding protein ACBD6 associated with lipid droplets.
  MicrobiologyOpen 2015 Soupene E, Wang D, Kuypers FA
• Pan-Selectin Antagonist Rivipansel (GMI-1070) Reduces Soluble E-Selectin Levels While Improving Clinical Outcomes in SCD Vaso-Occlusive Crisis.
  Blood 2014 Ted Wun, Marilyn J. Telen, Lakshmanan Krishnamurti, Timothy L. McCavit, Laura M DeCastro, Henry Flanner, Frans A. Kuypers, Sandra K. Larkin, Seungshin Rhee, John L. Magnani, Helen M. Thackray
• Microparticles as biomarkers of osteonecrosis of the hip in sickle cell disease.
  British journal of haematology 2014 Marsh A, Schiffelers R, Kuypers F, Larkin S, Gildengorin G, van Solinge W, Hoppe C
• The capacity of red blood cells to reduce nitrite determines nitric oxide generation under hypoxic conditions.
  PloS one 2014 Fens MH, Larkin SK, Oronsky B, Scicinski J, Morris CR, Kuypers FA
• Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia.
  PloS one 2014 Wun T, Styles L, DeCastro L, Telen MJ, Kuypers F, Cheung A, Kramer W, Flanner H, Rhee S, Magnani JL, Thackray H
• Elevated tricuspid regurgitant jet velocity in subgroups of thalassemia patients: insight into pathophysiology and the effect of splenectomy.
  Annals of hematology 2014 Singer ST, Kuypers F, Fineman J, Gildengorin G, Larkin S, Sweeters N, Rosenfeld H, Kurio G, Higa A, Jeng M, Huang J, Vichinsky EP
• Thiol/redox metabolomic profiling implicates GSH dysregulation in early experimental graft versus host disease (GVHD).
  PloS one 2014 Suh JH, Kanathezhath B, Shenvi S, Guo H, Zhou A, Tiwana A, Kuypers F, Ames BN, Walters MC
• Hemoglobin s polymerization and red cell membrane changes.
  Hematology/oncology clinics of North America 2014 Kuypers FA
• Citrate Synthase Activity Is Increased In Children With Sickle Cell Disease (SCD) On Hydroxyurea (HU) Therapy.
  Blood 2013 Claudia R. Morris, Cornelia Latronica, Frans A Kuypers, Howard Rosenfeld, Sandra K Larkin, Stephanie Doniger, Elliott Vichinsky, Sruti Shiva
• Microparticles As Biomarkers Of Osteonecrosis Of The Hip In Sickle Cell Disease.
  Blood 2013 Anne M Marsh, Raymond Schiffelers, Ginny Gildengorin, Frans A Kuypers, Carolyn Hoppe
• RBC deformability and amino acid concentrations after hypo-osmotic challenge may reflect chronic cell hydration status in healthy young men.
  Physiological reports 2013 Stookey JD, Klein A, Hamer J, Chi C, Higa A, Ng V, Arieff A, Kuypers FA, Larkin S, Perrier E, Lang F
• Corticotropin-releasing factor promotes necrotizing enterocolitis in formula fed neonatal rats.
  Journal of the American College of Surgeons 2013 Robert L. Bell, Aditi Bhargava, Min Liao, Ginger Withers, Frans Kuypers, Wolfgang Stehr
• A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes.
  Haematologica 2013 Morris CR, Kuypers FA, Lavrisha L, Ansari M, Sweeters N, Stewart M, Gildengorin G, Neumayr L, Vichinsky EP
• Sildenafil therapy in thalassemia patients with Doppler-defined risk of pulmonary hypertension.
  Haematologica 2013 Morris CR, Kim HY, Wood J, Porter JB, Klings ES, Trachtenberg FL, Sweeters N, Olivieri NF, Kwiatkowski JL, Virzi L, Singer ST, Taher A, Neufeld EJ, Thompson AA, Sachdev V, Larkin S, Suh JH, Kuypers FA…
• Flow-lysometry for cytoplasmic analysis of single cells in large populations.
  Micro & Nano Letters 2013 Won Chul Lee, Albert P. Pisano, Young-Ho Cho, Frans A. Kuypers
• Cardiopulmonary and Laboratory Profiling of Patients with Thalassemia At Risk for Pulmonary Hypertension: Report From the Thalassemia Clinical Research Network.
  Blood 2012 Claudia R. Morris, Hae-Young Kim, John C Wood, Felicia Trachtenberg, Elizabeth S Klings, John B. Porter, Nancy Sweeters, Nancy F Olivieri, Janet L. Kwiatkowski, Sylvia Titi Singer, Ali T Taher, Ellis …
• Pan-Selectin Antagonist GMI-1070 Affects Biomarkers of Adhesion, Activation and the Coagulation Cascade in Sickle Cell Adults At Steady State.
  Blood 2012 John L. Magnani, Frans A Kuypers, John T. Patton, Sandra K Larkin, Lori Styles, Laura M DeCastro, Marilyn J. Telen, Ted Wun, Helen Thackray
• Sildenafil Therapy in Patients with Thalassemia and an Elevated Tricuspid Regurgitant Jet Velocity (TRV) On Doppler Echocardiography At Risk for Pulmonary Hypertension: Report From the Thalassemia Clinical Research Network.
  Blood 2012 Claudia R. Morris, Hae-Young Kim, John C Wood, Felicia Trachtenberg, Elizabeth S Klings, John B. Porter, Nancy Sweeters, Nancy F Olivieri, Janet L. Kwiatkowski, Sylvia Titi Singer, Ali T Taher, Ellis …
• Treatment with a Novel Dinitroazetidine, Abdnaz, Improves Nitrite Reductase Activity of Sickle Red Blood Cells.
  Blood 2012 Marcel H.A.M. Fens, Sandra K Larkin, William L Fitch, Jan Scicinski, Bryan Oronsky, Frans A Kuypers
• Tricuspid Regurgitant Jet Velocity (TRV), Biomarkers of Hemolysis, and Impact of Oxygen Therapy in Children with Sickle Cell Disease (SCD) and Vaso-Occlusive Pain Episodes (VOE).
  Blood 2012 Cornelia Latronica, Frans A Kuypers, Howard Rosenfeld, Sandra K Larkin, Stephanie Doniger, Elliott Vichinsky, Claudia R. Morris
• Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium.
  PloS one 2012 Smith S, Witkowski A, Moghul A, Yoshinaga Y, Nefedov M, de Jong P, Feng D, Fong L, Tu Y, Hu Y, Young SG, Pham T, Cheung C, Katzman SM, Brand MD, Quinlan CL, Fens M, Kuypers F, Misquitta S, Griffey SM,…
• Phosphatidylcholine formation by LPCAT1 is regulated by Ca(2+) and the redox status of the cell.
  BMC biochemistry 2012 Soupene E, Kuypers FA
• Eukaryotic protein recruitment into the Chlamydia inclusion: implications for survival and growth.
  PloS one 2012 Soupene E, Rothschild J, Kuypers FA, Dean D
• Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential.
  Stem cells translational medicine 2012 Nazarov I, Lee JW, Soupene E, Etemad S, Knapik D, Green W, Bashkirova E, Fang X, Matthay MA, Kuypers FA, Serikov VB
• Deformation measurement of individual cells in large populations using a single-cell microchamber array chip.
  Applied physics letters 2012 Doh I, Lee WC, Cho YH, Pisano AP, Kuypers FA
• Changes in cell hydration and amino acid efflux related to chronically higher water intake in healthy young men.
  The FASEB Journal 2012 Jodi Stookey, Alexis Klein, Janice Hamer, Christine Chi, Annie Higa, Vivian Ng, Frans Kuypers, Florian Lang
• Research in athletes with sickle cell trait: just do it.
  Journal of applied physiology (Bethesda, Md. : 1985) 2012 Kuypers FA, Marsh AM
• Systemic and Hepatic Thiol Redox Dysregulation in Graft Versus Host Disease.
  Transplantation and Cellular Therapy 2012 B. Kanathezhath, S. Shenvi, A. Johl, R. Manmohan, M.K. Bhandhal, D. Oh, A. Zhou, F.A. Kuypers, M.C. Walters, B.N. Ames, J. Suh
• A transgenic mouse model expressing exclusively human hemoglobin E: indications of a mild oxidative stress.
  Blood cells, molecules & diseases 2012 Chen Q, Fabry ME, Rybicki AC, Suzuka SM, Balazs TC, Etzion Z, de Jong K, Akoto EK, Canterino JE, Kaul DK, Kuypers FA, Lefer D, Bouhassira EE, Hirsch RE
• A Family with Hereditary Elliptocytosis: Variable Clinical Severity Caused by Three Mutations in the a-Spectrin Gene,.
  Blood 2011 Paul Hubert Frans Franck, Cobie Postma, Marjan Veuger, Pierre Wijermans, Frans A Kuypers
• Effect of Short-Term Simvastatin Treatment on Endothelial Adhesion Molecules in Sickle Cell Disease: A Pilot Study.
  Blood 2011 Carolyn Hoppe, Frans A Kuypers, Sandra K Larkin, Robert Hagar, Elliott Vichinsky, Lori A Styles
• NO or No NO, Increased Reduction of Nitrite to Nitric Oxide by Modified Red Blood Cells.
  Blood 2011 Marcel H.A.M. Fens, Sandra K Larkin, Claudia R. Morris, Bill Fitch, Jan Scicinski, Bryan Oronsky, Frans A Kuypers
• Phosphatidylserine Exposure in Hemoglobinopathies.
  Transmembrane Dynamics of Lipids 2011 Frans A. Kuypers, Eric Soupene
• Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S.
  American journal of physiology. Cell physiology 2011 Stewart AK, Shmukler BE, Vandorpe DH, Rivera A, Heneghan JF, Li X, Hsu A, Karpatkin M, O'Neill AF, Bauer DE, Heeney MM, John K, Kuypers FA, Gallagher PG, Lux SE, Brugnara C, Westhoff CM, Alper SL
• Tapered oral dexamethasone for the acute chest syndrome of sickle cell disease.
  British journal of haematology 2011 Quinn CT, Stuart MJ, Kesler K, Ataga KI, Wang WC, Styles L, Smith-Whitley K, Wun T, Raj A, Hsu LL, Krishnan S, Kuypers FA, Setty Y, Rhee S, Key NS, Buchanan GR, Investigators of the Comprehensive …
• A pilot study of subcutaneous decitabine in β-thalassemia intermedia.
  Blood 2011 Olivieri NF, Saunthararajah Y, Thayalasuthan V, Kwiatkowski J, Ware RE, Kuypers FA, Kim HY, Trachtenberg FL, Vichinsky EP, Thalassemia Clinical Research Network
• A pilot study of the short-term use of simvastatin in sickle cell disease: effects on markers of vascular dysfunction.
  British journal of haematology 2011 Hoppe C, Kuypers F, Larkin S, Hagar W, Vichinsky E, Styles L
• Improved engraftment with minimal graft-versus-host disease after major histocompatibility complex-mismatched cord blood transplantation with photochemically treated donor lymphocytes.
  Experimental biology and medicine (Maywood, N.J.) 2011 Kanathezhath B, Mizokami M, Stanislaus S, Hounshell C, Neumayr L, Guo H, Hearst JE, Walters MC, Kuypers FA
• Augmented Regulatory T Cell Response After Photochemical Treatment Alleviates Acute Graft-Versus Host Disease and Improves Survival.
  Transplantation and Cellular Therapy 2011 B. Kanathezhath, S. Stanislaus, J. Kaplan, S. Larkin, F. Kuypers, M. Walters
• Inhibition Of Scramblase-1 Attenuates Endothelial Fluid Loss During Ischemia Reperfusion Injury.
  Journal of Surgical Research 2011 A. Strumwasser, E. Cureton, M. Cripps, E. Miraflor, L. Yeung, B. Curran, J. Sadjadi, S. Larkin, F. Kuypers, G. Victorino
• Augmented Regulatory T Cell Response After Photochemical Treatment Alleviates Acute Graft-Versus-Host Disease and Improves Survival.
  Blood 2010 Bindu Kanathezhath, Sandra K Larkin, Julika Kaplan, Mark C. Walters, Frans Kuypers
• Effects of Selectin Antagonist GMI-1070 on the Activation State of Leukocytes In Sickle Cell Patients Not In Crisis.
  Blood 2010 Scott I Simon, Shannon Chase, Sandra K Larkin, Frans Kuypers, Lori Styles, Ted Wun, Helen Thackray, John L Magnani
• Metabolic Fate of Oral Glutamine Supplementation within Plasma and Erythrocytes of Patients with Sickle Cell Disease: Preliminary Pharmacokinetics Results.
  Blood 2010 Claudia R. Morris, Frans Kuypers, Robert W Hagar, Michael Ansari, Sandra K Larkin, Lisa Lavrisha, Meghan Wardlaw, Alicia Zhou, Elliott Vichinsky, Jung H Suh
• The Effect of Thalassemia and Other RBC Hemolytic Disorders and Splenectomy on the Frequency of Pulmonary Hypertension.
  Blood 2010 Sylvia T Singer, Frans Kuypers, Jeffrey Fineman, Sandra K Larkin, Michael Jeng, Cynthia Harmon, Nancy Sweeters, Ann Higa, Elliott Vichinsky
• Estimation of red blood cell volume fraction from overall permittivity measurements.
  International Journal of Engineering Science 2010 T.I. Zohdi, F.A. Kuypers, W.C. Lee
• Large-scale arrays of picolitre chambers for single-cell analysis of large cell populations.
  Lab on a chip 2010 Lee WC, Rigante S, Pisano AP, Kuypers FA
• Secretory phospholipase A2: a marker of infection in febrile children presenting to a pediatric ED.
  The American journal of emergency medicine 2010 Mansour KM, Kuypers FA, Wang TN, Miller AM, Larkin SK, Morris CR
• Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton.
  Blood 2010 Moyer JD, Nowak RB, Kim NE, Larkin SK, Peters LL, Hartwig J, Kuypers FA, Fowler VM
• Activity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domains.
  BMC biochemistry 2010 Soupene E, Dinh NP, Siliakus M, Kuypers FA
• Augmentation Of Hematopoietic Engraftment Without Graft Versus Host Disease By “Add-Back” Of Photochemically Treated T Lymphocytes In Mismatched Cord Blood Transplantation.
  Biology of Blood and Marrow Transplantation 2010 B. Kanathezhath, L. Neumayr, H. Guo, M.C. Walters, F.A. Kuypers
• Hemoglobin Hakkari: an autosomal dominant form of beta thalassemia with inclusion bodies arising from de novo mutation in exon 2 of beta globin gene.
  Pediatric blood & cancer 2010 Kanathezhath B, Hazard FK, Guo H, Kidd J, Azimi M, Kuypers FA, Vichinsky EP, Lal A
• The effects of disruption of genes for peroxiredoxin-2, glutathione peroxidase-1, and catalase on erythrocyte oxidative metabolism.
  Free radical biology & medicine 2009 Johnson RM, Ho YS, Yu DY, Kuypers FA, Ravindranath Y, Goyette GW
• A Pilot Study of Tapered Oral Dexamethasone for the Acute Chest Syndrome of Sickle Cell Disease.
  Blood 2009 Charles T. Quinn, Marie J. Stuart, Karen Kesler, Kenneth I. Ataga, Winfred C. Wang, Lori Styles, Kim Smith-Whitley, Ted Wun, Suba Krishnan, Frans A. Kuypers, Yamaja Setty, Nigel S. Key, Seungshin Rhee…
• Arginine Therapy for Vaso-Occlusive Pain Episodes in Sickle Cell Disease.
  Blood 2009 Claudia R. Morris, Michael Ansari, Lisa Lavrisha, Nancy Sweeters, Frans A Kuypers, Elliott P Vichinsky
• Improved Engraftment without Graft-Versus-Host Disease After MHC-Mismatched Cord Blood Transplantation with Photochemically Treated Donor Lymphocytes.
  Blood 2009 Bindu Kanathezhath, Myra Mizokami, Lynne Neumayr, Hua Guo, Mark C. Walters, Frans A. Kuypers
• The Effect of Short-Term Simvastatin On Markers of Vascular Dysfunction in Patients with Sickle Cell Disease (SCD).
  Blood 2009 Carolyn C. Hoppe, Kathryn R. Stewart, Annie Higa, Sandra Larkin, James K. Liao, Lori A. Styles, Elliott P. Vichinsky, Frans A. Kuypers
• Human term placenta as a source of hematopoietic cells.
  Experimental biology and medicine (Maywood, N.J.) 2009 Serikov V, Hounshell C, Larkin S, Green W, Ikeda H, Walters MC, Kuypers FA
• Imaging of the diffusion of single band 3 molecules on normal and mutant erythrocytes.
  Blood 2009 Kodippili GC, Spector J, Sullivan C, Kuypers FA, Labotka R, Gallagher PG, Ritchie K, Low PS
• Erratum: Corrigendum: VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis.
  Nature Medicine 2009 Betty YFY Tam, Kevin Wei, John S Rudge, Jana Hoffman, Joceyln Holash, Sang-ki Park, Jenny Yuan, Colleen Hefner, Cecile Chartier, Jeng-Shin Lee, Shelly Jiang, Nihar R Nayak, Frans A Kuypers, Lisa Ma, …
• 108. Mobilization of Phosphatidyl Serine to the Outer Endothelial Cell Membrane Regulates Microvascular Fluid Leak During Ischemia-Reperfusion.
  Journal of Surgical Research 2009 E.L. Cureton, K.C. Dozier, R.O. Kwan, J. Sadjadi, B. Curran, A. Bhargava, F.A. Kuypers, G.P. Victorino
• Aldosterone Promotes Inflammation and Endothelial Cell-Sickle Cell Adhesion: Potential for a New Therapeutic Target in Sickle Cell Disease.
  Blood 2008 Wilbur Aaron Lam, Wendy R Hansen, James Huang, William Mentzer, Bertram Harold Lubin, Frans A. Kuypers, Daniel A. Fletcher
• Hydroxycarbamide-induced changes in E/beta thalassemia red blood cells.
  American journal of hematology 2008 Singer ST, Vichinsky EP, Larkin S, Olivieri N, Sweeters N, Kuypers FA, E/beta Thalassemia Study Group
• Red cell membrane lipids in hemoglobinopathies.
  Current molecular medicine 2008 Kuypers FA
• Lysophosphatidic acid formation in old packed red blood cells causes post transfusion vascular leak.
  Journal of the American College of Surgeons 2008 Michael W. Cripps, Alexander Q. Ereso, Gregory P. Victorino, Alden H. Harken, Eric Soupene, Frans Kuypers
• Mammalian long-chain acyl-CoA synthetases.
  Experimental biology and medicine (Maywood, N.J.) 2008 Soupene E, Kuypers FA
• Characterization of an acyl-coenzyme A binding protein predominantly expressed in human primitive progenitor cells.
  Journal of lipid research 2008 Soupene E, Serikov V, Kuypers FA
• QS386. Lysophosphatidic Acid Levels Increase in Stored Red Blood Cells.
  Journal of Surgical Research 2008 Michael W. Cripps, Eric Soupene, Frans Kuypers
• ATP8A1 activity and phosphatidylserine transbilayer movement.
  Journal of receptor, ligand and channel research 2008 Soupene E, Kemaladewi DU, Kuypers FA
• Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Soupene E, Fyrst H, Kuypers FA
• Anti-Oxidant Treatment with a-Lipoic Acid and Acetyl L-Carnitine in Hemoglobinopathies.
  Blood 2007 Ashutosh Lal, Jung Suh, Wafa Atamna, Bridget Canty, Ward Hagar, Elliott Vichinsky, Frans Kuypers, Bruce Ames
• Arginine Therapy Does Not Benefit Children with Sickle Cell Anemia — Results of the CSCC Clinical Trial Consortium Multi-Institutional Study.
  Blood 2007 Lori Styles, Frans Kuypers, Karen Kesler, Ulrike Reiss, Petra Lebeau, Ronald Nagel, Mary Fabry
• Enhanced Phosphatidylserine Scrambling in Oxidatively Challenged Red Blood Cells.
  Blood 2007 Kitty DeJong, Frans A. Kuypers
• Insight into Risk Factors for Pulmonary Hypertension in Thalassemia: Abnormal Platelet, Hemolysis and Vascular Markers.
  Blood 2007 Sylvia T. Singer, Frans Kuypers, Fineman Jeffrey, Larkin Sandy, Harmon Cynthia, Rosenfeld Howard, Lui Ann, Nugent Diane, Vichinsky Elliott
• Low Erythrocyte Glutamine-to-Glutamate Ratio: A Novel Biomarker of Hemolysis and Pulmonary Hypertension in Sickle Cell Disease.
  Blood 2007 Claudia R. Morris, Jung Suh, Ward Hagar, Sandra Larkin, D. Anton Bland, Martin Steinberg, Elliott Vichinsky, Mark Shigenaga, Bruce Ames, Frans Kuypers, Elizabeth Klings
• Oxidative Metabolism in Red Cells Deficient in Antioxidant Enzymes.
  Blood 2007 Robert M. Johnson, Ye-Shih Ho, Dae-Yeul Yu, Frans A. Kuypers, Yaddanapudi Ravindranath, Gerard W. Goyette
• Phospholipase D Activity Is Essential for PKC-Mediated Phosphatidylserine Exposure.
  Blood 2007 Kitty DeJong, Shahrzad A. Rahbar, Frans A. Kuypers
• Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease.
  Blood 2007 Morris CR, Suh JH, Hagar W, Larkin S, Bland DA, Steinberg MH, Vichinsky EP, Shigenaga M, Ames B, Kuypers FA, Klings ES
• Erythrocytes contain a membrane lysophosphatidic acid acyltransferase that modulates serum lysophosphatidic acid concentration.
  Journal of the American College of Surgeons 2007 Michael W. Cripps, Eric Soupene, Alden Harken, Frans Kuypers
• Flow cytometric determination of PMCA-mediated Ca2+-extrusion in individual red blood cells.
  Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007 de Jong K, Kuypers FA
• Interaction of an annexin V homodimer (Diannexin) with phosphatidylserine on cell surfaces and consequent antithrombotic activity.
  Thrombosis and haemostasis 2007 Kuypers FA, Larkin SK, Emeis JJ, Allison AC
• Membrane lipid alterations in hemoglobinopathies.
  Hematology. American Society of Hematology. Education Program 2007 Kuypers FA
• Modelling and rapid simulation of multiple red blood cell light scattering.
  Journal of the Royal Society, Interface 2006 Zohdi TI, Kuypers FA
• Transfusion prevents acute chest syndrome predicted by elevated secretory phospholipase A2.
  British journal of haematology 2006 Styles LA, Abboud M, Larkin S, Lo M, Kuypers FA
• Acyl-CoA Turnover in RBC.
  Blood 2006 Eric Soupene, Melvin Siliakus, Frans A. Kuypers
• Dysregulation of Phosphatidylserine Scrambling by Oxidative Stress.
  Blood 2006 Kitty DeJong, Frans A. Kuypers
• Erythrocyte Glutathione Depletion Is Associated with Severity of Anemia and Pulmonary Hypertension in Patients with Sickle Cell Disease.
  Blood 2006 Claudia R. Morris, Jung H. Suh, Sandra Larkin, D. Anton Bland, Adam Odhiambo, Martin H. Steinberg, Elliott P. Vichinsky, Mark Shigenaga, Bruce Ames, Frans A. Kuypers, Elizabeth S. Klings
• Flippase Activity Decreases throughout Erythrocyte Life-Span in Normal and Sickle Mice.
  Blood 2006 Kitty DeJong, Amrita Bhagat, Renee K. Emerson, Frans A. Kuypers
• High Calcium Requirement for Phosphatidylserine Exposure in Sickle Cell Disease.
  Blood 2006 Kitty DeJong, Annabeth M. Miller, Renee K. Emerson, Frans A. Kuypers
• Lysophospholipid Acylation in RBC.
  Blood 2006 Eric Soupene, Frans A. Kuypers
• Pulmonary hypertension in thalassemia: association with platelet activation and hypercoagulable state.
  American journal of hematology 2006 Singer ST, Kuypers FA, Styles L, Vichinsky EP, Foote D, Rosenfeld H
• Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains.
  BMC molecular biology 2006 Soupene E, Kuypers FA
• VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis.
  Nature medicine 2006 Tam BY, Wei K, Rudge JS, Hoffman J, Holash J, Park SK, Yuan J, Hefner C, Chartier C, Lee JS, Jiang S, Nayak NR, Niyak NR, Kuypers FA, Ma L, Sundram U, Wu G, Garcia JA, Schrier SL, Maher JJ, Johnson RS…
• Identification of an erythroid ATP-dependent aminophospholipid transporter.
  British journal of haematology 2006 Soupene E, Kuypers FA
• Sulphydryl modifications alter scramblase activity in murine sickle cell disease.
  British journal of haematology 2006 de Jong K, Kuypers FA
• Secretory phospholipase A2 levels in patients with sickle cell disease and acute chest syndrome.
  Hemoglobin 2006 Ballas SK, Files B, Luchtman-Jones L, Benjamin L, Swerdlow P, Hilliard L, Coates T, Abboud M, Wojtowicz-Praga S, Kuypers FA, Michael Grindel J
• A Novel Umbilical Cord Blood Collection System.
  Blood 2005 Frans A. Kuypers, William Atkinson, Catherine Hounshell, Bertram H. Lubin, Richard Meyst
• A Transgenic Mouse Model of Homozygous HbE Disease.
  Blood 2005 Qiuying Chen, Frans A. Kuypers, Anne C. Rybicki, Amrita Bhagat, Sandra M. Suzuka, Mary E. Fabry, Ronald L. Nagel, Rhoda Elison Hirsch
• Dysregulated Arginine Metabolism and Elevated Arginase Activity in Thalassemia.
  Blood 2005 Claudia R. Morris, Frans A. Kuypers, Greg Kato, Jennifer Gardner, Sandy Larkin, Titi Singer, Elliott Vichinsky
• Elevated Plasma Arginase Levels in Hemoglobinopathies.
  Blood 2005 Sandra K. Larkin, Claudia R. Morris, Lori A. Styles, Frans A. Kuypers
• Increased Chromosomal Breaks in Sickle Cell Disease as Evidenced by the Presence of Micronuclei in Erythrocytes.
  Blood 2005 Ashutosh Lal, Amrita Bhagat, Wafa Atamna, Tal Offer, Elliott P. Vichinsky, Frans A. Kuypers, Bruce N. Ames
• Multiple Erythroid Isoforms of Human Long-Chain acyl-CoA Synthetases Are Produced by a Switch of the Fatty Acid Gate-Domains.
  Blood 2005 Eric Soupene, Frans A. Kuypers
• Phosphatidylserine Scrambling Is Faster in Sickle Mouse Erythrocytes Because of Oxidative Damage.
  Blood 2005 Kitty DeJong, Frans A. Kuypers
• Hydrolysis of phosphatidylserine-exposing red blood cells by secretory phospholipase A2 generates lysophosphatidic acid and results in vascular dysfunction.
  The Journal of biological chemistry 2005 Neidlinger NA, Larkin SK, Bhagat A, Victorino GP, Kuypers FA
• Fetal haemoglobin augmentation in E/beta(0) thalassaemia: clinical and haematological outcome.
  British journal of haematology 2005 Singer ST, Kuypers FA, Olivieri NF, Weatherall DJ, Mignacca R, Coates TD, Davies S, Sweeters N, Vichinsky EP, E/beta Thalassaemia Study Group
• Post-traumatic circulating secretory phospholipase A2 lyses cells with exposed phosphatidylserine and causes microvascular fluid leak.
  Journal of the American College of Surgeons 2005 Nikole Neidlinger, Sandra Larkin, Brian Curran, Gregory Victorino, Frans Kuypers
• Serum C-reactive protein parallels secretory phospholipase A2 in sickle cell disease patients with vasoocclusive crisis or acute chest syndrome.
  Blood 2005 Bargoma EM, Mitsuyoshi JK, Larkin SK, Styles LA, Kuypers FA, Test ST
• Postinjury serum secretory phospholipase A2 correlates with hypoxemia and clinical status at 72 hours.
  Journal of the American College of Surgeons 2005 Neidlinger NA, Hirvela ER, Skinner RA, Larkin SK, Harken AH, Kuypers FA
• Hemolysis-associated pulmonary hypertension in thalassemia.
  Annals of the New York Academy of Sciences 2005 Morris CR, Kuypers FA, Kato GJ, Lavrisha L, Larkin S, Singer T, Vichinsky EP
• Measuring chromosome breaks in patients with thalassemia.
  Annals of the New York Academy of Sciences 2005 Offer T, Bhagat A, Lal A, Atamna W, Singer ST, Vichinsky EP, Kuypers FA, Ames BN
• Rescued mice with Hb E transgene-developed red cell changes similar to human beta-thalassemia/HbE disease.
  Annals of the New York Academy of Sciences 2005 Wannasuphaphol B, Kalpravidh R, Pattanapanyasat K, Ioannau P, Kuypers FA, Fucharoen S, Winichagoon P
• Single and combination drug therapy for fetal hemoglobin augmentation in hemoglobin E-beta 0-thalassemia: Considerations for treatment.
  Annals of the New York Academy of Sciences 2005 Singer ST, Kuypers FA, Olivieri NF, Weatherall DJ, Mignacca R, Coates TD, Davies S, Sweeters N, Vichinsky EP
• Stem cell transplantation with S-59 photochemically treated T-cell add-backs to establish allochimerism in murine thalassemia.
  Annals of the New York Academy of Sciences 2005 Kuypers FA, Watson G, Sage E, Walters MC, Hamrick J, Hearst JE
• A simple assay for frequency of chromosome breaks and loss (micronuclei) by flow cytometry of human reticulocytes.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004 Offer T, Ho E, Traber MG, Bruno RS, Kuypers FA, Ames BN
• Biotin-Labeled RBC Survival in Thalassemia and Impact of Treatment.
  Blood 2004 Sylvia Titi Singer, Nancy E. Olivieri, Nancy Sweeters, Carmen Rodwell, Christina Oliver, Elliott P. Vichinsky, Frans A. Kuypers
• Di-Annexin, a Novel Tool To Identify and Protect Phosphatidylserine Exposing Cells.
  Blood 2004 Frans A. Kuypers, Sandra K. Larkin, Renee K. Emerson, Anthony C. Allison
• Oxidative Modifications to Flippase and Scramblase Affect Phosphatidylserine Exposure in Mouse Sickle Cells.
  Blood 2004 Kitty DeJong, Frans A. Kuypers
• Reactive Oxygen Species and RBC Membrane Integrity in Peroxyredoxin II Deficient Mice.
  Blood 2004 Amrita Bhagat, Renee Emerson, Kitty DeJong, Frans A. Kuypers
• Red Blood Cells Facilitate Reverse Cholesterol Transport.
  Blood 2004 Frans A. Kuypers, Sandra Larkin, Jenifer Beckstead, Michael Oda, Kazumitsu Ueda, Robert O. Ryan
• In vivo reduction of erythrocyte oxidant stress in a murine model of beta-thalassemia.
  Haematologica 2004 de Franceschi L, Turrini F, Honczarenko M, Ayi K, Rivera A, Fleming MD, Law T, Mannu F, Kuypers FA, Bast A, van der Vijgh WJ, Brugnara C
• Secretory phospholipase A2 attacks erythrocytes with externalized phosphatidylserine.
  Journal of Surgical Research 2004 N.A. Neidlinger, S.K. Larkin, F.A. Kuypers
• Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.
  Journal of lipid research 2004 Mashek DG, Bornfeldt KE, Coleman RA, Berger J, Bernlohr DA, Black P, DiRusso CC, Farber SA, Guo W, Hashimoto N, Khodiyar V, Kuypers FA, Maltais LJ, Nebert DW, Renieri A, Schaffer JE, Stahl A, Watkins …
• Decreased arginine bioavailability and increased serum arginase activity in asthma.
  American journal of respiratory and critical care medicine 2004 Morris CR, Poljakovic M, Lavrisha L, Machado L, Kuypers FA, Morris SM
• The role of phosphatidylserine in recognition and removal of erythrocytes.
  Cellular and molecular biology (Noisy-le-Grand, France) 2004 Kuypers FA, de Jong K
• Reactive oxygen species and phosphatidylserine externalization in murine sickle red cells.
  British journal of haematology 2004 Banerjee T, Kuypers FA
• The role of secretory phospholipase A2 in acute chest syndrome.
  Cellular and molecular biology (Noisy-le-Grand, France) 2004 Kuypers FA, Styles LA
• Hydroxyurea and arginine therapy: impact on nitric oxide production in sickle cell disease.
  Journal of pediatric hematology/oncology 2003 Morris CR, Vichinsky EP, van Warmerdam J, Machado L, Kepka-Lenhart D, Morris SM, Kuypers FA
• Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease?
  American journal of respiratory and critical care medicine 2003 Morris CR, Morris SM, Hagar W, Van Warmerdam J, Claster S, Kepka-Lenhart D, Machado L, Kuypers FA, Vichinsky EP
• Protein kinase C activation induces phosphatidylserine exposure on red blood cells.
  Biochemistry 2002 de Jong K, Rettig MP, Low PS, Kuypers FA
• Altered red cell turnover in diabetic mice.
  The Journal of laboratory and clinical medicine 2002 Manodori AB, Kuypers FA
• A 29-kDa protein associated with p67phox expresses both peroxiredoxin and phospholipase A2 activity and enhances superoxide anion production by a cell-free system of NADPH oxidase activity.
  The Journal of biological chemistry 2002 Leavey PJ, Gonzalez-Aller C, Thurman G, Kleinberg M, Rinckel L, Ambruso DW, Freeman S, Kuypers FA, Ambruso DR
• Selective increase of autoimmune epitope expression on aged erythrocytes in mice: implications in anti-erythrocyte autoimmune responses.
  Journal of autoimmunity 2002 Fossati-Jimack L, Azeredo da Silveira S, Moll T, Kina T, Kuypers FA, Oldenborg PA, Reininger L, Izui S
• Short survival of phosphatidylserine-exposing red blood cells in murine sickle cell anemia.
  Blood 2001 de Jong K, Emerson RK, Butler J, Bastacky J, Mohandas N, Kuypers FA
• Characterization of the phosphatidylserine-exposing subpopulation of sickle cells.
  Blood 2001 de Jong K, Larkin SK, Styles LA, Bookchin RM, Kuypers FA
• Secretory phospholipase A2 activity correlates with postinjury multiple organ failure.
  Critical care medicine 2001 Partrick DA, Moore EE, Silliman CC, Barnett CC, Kuypers FA
• Absence of mitochondrial superoxide dismutase results in a murine hemolytic anemia responsive to therapy with a catalytic antioxidant.
  The Journal of experimental medicine 2001 Friedman JS, Rebel VI, Derby R, Bell K, Huang TT, Kuypers FA, Epstein CJ, Burakoff SJ
• Reduced oxidative-stress response in red blood cells from p45NFE2-deficient mice.
  Blood 2001 Chan JY, Kwong M, Lo M, Emerson R, Kuypers FA
• Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly Asian descent.
  Blood 2000 Sylvia T. Singer, Vivian Wu, Robert Mignacca, Frans A. Kuypers, Phyllis Morel, Elliott P. Vichinsky
• Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly asian descent.
  Blood 2000 Singer ST, Wu V, Mignacca R, Kuypers FA, Morel P, Vichinsky EP
• Arginine therapy: a novel strategy to induce nitric oxide production in sickle cell disease.
  British Journal of Haematology 2000 Claudia R. Morris, Frans A. Kuypers, Sandra Larkin, Nancy Sweeters, Julie Simon, Elliott P. Vichinsky, Lori A. Styles
• Arginine therapy: a novel strategy to induce nitric oxide production in sickle cell disease.
  British journal of haematology 2000 Morris CR, Kuypers FA, Larkin S, Sweeters N, Simon J, Vichinsky EP, Styles LA
• Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome.
  Journal of pediatric hematology/oncology 2000 Morris CR, Kuypers FA, Larkin S, Vichinsky EP, Styles LA
• Secretory phospholipase A(2) predicts impending acute chest syndrome in sickle cell disease.
  Blood 2000 Styles LA, Aarsman AJ, Vichinsky EP, Kuypers FA
• Secretory phospholipase A2 predicts impending acute chest syndrome in sickle cell disease.
  Blood 2000 Lori A. Styles, Anton J. Aarsman, Elliott P. Vichinsky, Frans A. Kuypers
• Sera of patients suffering from inflammatory diseases contain group IIA but not group V phospholipase A(2).
  Biochimica et biophysica acta 2000 Aarsman AJ, Neys FW, van der Helm HA, Kuypers FA, van den Bosch H
• Adherence of phosphatidylserine-exposing erythrocytes to endothelial matrix thrombospondin.
  Blood 2000 Manodori AB, Barabino GA, Lubin BH, Kuypers FA
• SECRETORY PHOSPHOLIPASE A2: A POTENTIAL MARKER FOR RESPIRATORY FAILURE IN TRAUMA PATIENTS.
  Critical Care Medicine 1999 Elsa R Hirvela, Ruby Skinner, Vernon J Henderson, Sandra Larkin, Lori Styles, Frans Kuypers
• Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors.
  The Biochemical journal 1999 Malhotra KT, Malhotra K, Lubin BH, Kuypers FA
• Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors.
  Biochemical Journal 1999 Kiran T. MALHOTRA, Khushbeer MALHOTRA, Bertram H. LUBIN, Frans A. KUYPERS
• Hereditary spherocytosis and elliptocytosis erythrocytes show a normal transbilayer phospholipid distribution.
  Blood 1999 de Jong K, Larkin SK, Eber S, Franck PF, Roelofsen B, Kuypers FA
• The PLB2 gene of Saccharomyces cerevisiae confers resistance to lysophosphatidylcholine and encodes a phospholipase B/lysophospholipase.
  Biochemistry 1999 Fyrst H, Oskouian B, Kuypers FA, Saba JD
• Detection of phosphatidylserine surface exposure on human erythrocytes using annexin V-ferrofluid.
  Biochemical and biophysical research communications 1999 Geldwerth D, Helley D, de Jong K, Sabolovic' D, Sestier C, Roger J, Pons JN, Freyssinet JM, Devaux PF, Kuypers FA
• Creation of Chimerism in a Thalassemic Mouse Model.
  Pediatric Research 1999 Peter Quesenberry, Suju Zhong, Han Wang, Kimberly Werme, Frans Kuypers, Gordon Watson, Bertram H Lubin
• L-Arginine Therapy Paradoxically Decreases Nitric Oxide Production in Patients with Sickle Cell Disease.
  Pediatric Research 1999 Claudia R Morris, Frans Kuypers, Sandra Larkin, Nancy Kennedy, Julie Simon, Elliott Vichinsky, Lori Styles
• Low Molecular Weight Heparin in Sickle Cell Disease.
  Pediatric Research 1999 Lori Styles, Sandra Larkin, Nancy Kennedy, Julie Simon, Frans Kuypers, Elliott Vichinsky
• Stomatocytosis Is Absent in “Stomatin”-Deficient Murine Red Blood Cells.
  Blood 1999 Yiwen Zhu, Chris Paszty, Tikva Turetsky, Susan Tsai, Frans A. Kuypers, Gloria Lee, Philip Cooper, Patrick G. Gallagher, Mary E. Stevens, Edward Rubin, Narla Mohandas, William C. Mentzer
• Stomatocytosis is absent in "stomatin"-deficient murine red blood cells.
  Blood 1999 Zhu Y, Paszty C, Turetsky T, Tsai S, Kuypers FA, Lee G, Cooper P, Gallagher PG, Stevens ME, Rubin E, Mohandas N, Mentzer WC
• Structural and functional consequences of antigenic modulation of red blood cells with methoxypoly(ethylene glycol).
  Blood 1999 Murad KL, Mahany KL, Brugnara C, Kuypers FA, Eaton JW, Scott MD
• Red cell membrane damage.
  The Journal of heart valve disease 1998 Kuypers FA
• Whole Blood Tissue Factor Procoagulant Activity Is Elevated in Patients With Sickle Cell Disease.
  Blood 1998 Nigel S. Key, Arne Slungaard, Luke Dandelet, Stephen C. Nelson, Christopher Moertel, Lori A. Styles, Frans A. Kuypers, Ronald R. Bach
• Whole blood tissue factor procoagulant activity is elevated in patients with sickle cell disease.
  Blood 1998 Key NS, Slungaard A, Dandelet L, Nelson SC, Moertel C, Styles LA, Kuypers FA, Bach RR
• Membrane phospholipid asymmetry in human thalassemia.
  Blood 1998 Kuypers FA, Yuan J, Lewis RA, Snyder LM, Kiefer CR, Bunyaratvej A, Fucharoen S, Ma L, Styles L, de Jong K, Schrier SL
• Effects of phosphatidylinositol diphosphate on phospholipid asymmetry in the human erythrocyte membrane.
  Biochemistry 1998 Shiffer KA, Rood L, Emerson RK, Kuypers FA
• Phospholipid asymmetry in health and disease.
  Current opinion in hematology 1998 Kuypers FA
• Removal of erythrocyte membrane iron in vivo ameliorates the pathobiology of murine thalassemia.
  The Journal of clinical investigation 1997 Browne PV, Shalev O, Kuypers FA, Brugnara C, Solovey A, Mohandas N, Schrier SL, Hebbel RP
• Acyl-CoA binding protein (ACBP) in the human red-cell.
  Biochemical Journal 1997 Henrik FYRST, Frans A. KUYPERS
• Oxidative damage does not alter membrane phospholipid asymmetry in human erythrocytes.
  Biochemistry 1997 de Jong K, Geldwerth D, Kuypers FA
• Decrease of very late activation antigen-4 and CD36 on reticulocytes in sickle cell patients treated with hydroxyurea.
  Blood 1997 Styles LA, Lubin B, Vichinsky E, Lawrence S, Hua M, Test S, Kuypers F
• Phospholipase A2 levels in acute chest syndrome of sickle cell disease.
  Blood 1996 Styles LA, Schalkwijk CG, Aarsman AJ, Vichinsky EP, Lubin BH, Kuypers FA
• Formation of vesicles by the action of acyl-CoA:1-acyllsophosphatidylcholine acyltransferase from rat liver microsomes: optimal solubilization conditions and analysis of lipid composition and enzyme activity.
  Biochemistry 1996 Fyrst H, Pham DV, Lubin BH, Kuypers FA
• Detection of altered membrane phospholipid asymmetry in subpopulations of human red blood cells using fluorescently labeled annexin V.
  Blood 1996 Kuypers FA, Lewis RA, Hua M, Schott MA, Discher D, Ernst JD, Lubin BH
• Correlation of membrane lipid peroxidation with oxidation of hemoglobin variants: possibly related to the rates of hemin release.
  Free radical biology & medicine 1996 Chiu DT, van den Berg J, Kuypers FA, Hung IJ, Wei JS, Liu TZ
• Phospholipid composition and organization in model beta-thalassemic erythrocytes.
  American journal of hematology 1996 Kuypers FA, Schott MA, Scott MD
• Effects of bacterial endotoxin on human cross-linked and native hemoglobins.
  Biochemistry 1995 Kaca W, Roth RI, Vandegriff KD, Chen GC, Kuypers FA, Winslow RM, Levin J
• Detection of acyl-CoA-binding protein in human red blood cells and investigation of its role in membrane phospholipid renewal.
  The Biochemical journal 1995 Fyrst H, Knudsen J, Schott MA, Lubin BH, Kuypers FA
• Copper and gas-phase cigarette smoke inhibit plasma lecithin:cholesterol acyltransferase activity by different mechanisms.
  Journal of lipid research 1995 Bielicki JK, McCall MR, van den Berg JJ, Kuypers FA, Forte TM
• Membrane changes associated with lysis of red blood cells by hypochlorous acid.
  Free radical biology & medicine 1994 Vissers MC, Stern A, Kuypers F, van den Berg J, Winterbourn CC
• Modification of LCAT activity and HDL structure. New links between cigarette smoke and coronary heart disease risk.
  Arteriosclerosis and thrombosis : a journal of vascular biology 1994 McCall MR, van den Berg JJ, Kuypers FA, Tribble DL, Krauss RM, Knoff LJ, Forte TM
• Loss of Red Blood Cell Viability Associated with Limited Thermal Inactivation of Extracellular HIV-1.
  Vox Sanguinis 1994 R.R. Stromberg, F.A. Kuypers, L. Sawyer, L.I. Friedman, M. Cole, K. Tran, C.V. Hanson
• Loss of red blood cell viability associated with limited thermal inactivation of extracellular HIV-1.
  Vox sanguinis 1994 Stromberg RR, Kuypers FA, Sawyer L, Friedman LI, Cole M, Tran K, Hanson CV
• Compartmentalization of oxidative injury in low density lipoproteins (LDL): Evidence for two kinetic pools corresponding to the LDL surface monolayer and hydrophobic core.
  Free Radical Biology and Medicine 1993 Diane L. Tribble, Maarten G. Lansberg, Ronald M. Krauss, Frans A. Kuypers, Jeroen J.M. van den Berg
• Hypochlorous acid-mediated modification of cholesterol and phospholipid: analysis of reaction products by gas chromatography-mass spectrometry.
  Journal of lipid research 1993 van den Berg JJ, Winterbourn CC, Kuypers FA
• Oxidation of unsaturated membrane phospholipids and cholesterol by hypochlorous acid.
  Free Radical Biology and Medicine 1993 Jeroen J.M. van den Berg, Frans A. Kuypers, Christine C. Winterbourn
• Effects of dietary fats from animal and plant sources on diet-induced fatty streak lesions in C57BL/6J mice.
  Journal of lipid research 1993 Nishina PM, Lowe S, Verstuyft J, Naggert JK, Kuypers FA, Paigen B
• Atherosclerosis and plasma and liver lipids in nine inbred strains of mice.
  Lipids 1993 Nishina PM, Wang J, Toyofuku W, Kuypers FA, Ishida BY, Paigen B
• Transbilayer mobility and distribution of red cell phospholipids during storage.
  The Journal of clinical investigation 1993 Geldwerth D, Kuypers FA, Bütikofer P, Allary M, Lubin BH, Devaux PF
• Conformational changes in oxidized phospholipids and their preferential hydrolysis by phospholipase A2: a monolayer study.
  Biochemistry 1993 van den Berg JJ, Op den Kamp JA, Lubin BH, Kuypers FA
• Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu).
  Antimicrobial agents and chemotherapy 1993 Meshnick SR, Yang YZ, Lima V, Kuypers F, Kamchonwongpaisan S, Yuthavong Y
• Generation of phosphatidic acid during calcium-loading of human erythrocytes. Evidence for a phosphatidylcholine-hydrolyzing phospholipase D.
  European journal of biochemistry 1993 Bütikofer P, Yee MC, Schott MA, Lubin BH, Kuypers FA
• Role of oxygen and carbon radicals in hemoglobin oxidation.
  Archives of biochemistry and biophysics 1993 Minetti M, Mallozzi C, Scorza G, Scott MD, Kuypers FA, Lubin BH
• The distribution of erythrocyte phospholipids in hereditary spherocytosis demonstrates a minimal role for erythrocyte spectrin on phospholipid diffusion and asymmetry.
  Blood 1993 FA Kuypers, BH Lubin, M Yee, P Agre, PF Devaux, D Geldwerth
• The distribution of erythrocyte phospholipids in hereditary spherocytosis demonstrates a minimal role for erythrocyte spectrin on phospholipid diffusion and asymmetry.
  Blood 1993 Kuypers FA, Lubin BH, Yee M, Agre P, Devaux PF, Geldwerth D
• Chlorohydrin formation from unsaturated fatty acids reacted with hypochlorous acid.
  Archives of biochemistry and biophysics 1992 Winterbourn CC, van den Berg JJ, Roitman E, Kuypers FA
• Kinetics and site specificity of hydroperoxide-induced oxidative damage in red blood cells.
  Free radical biology & medicine 1992 van den Berg JJ, Op den Kamp JA, Lubin BH, Roelofsen B, Kuypers FA
• Oxidative Damage and Repair of Human Erythrocyte Lipids.
  Dynamics of Membrane Assembly 1992 Jeroen J. M. van den Berg, Frans A. Kuypers
• Characterization of the complement sensitivity of calcium loaded human erythrocytes.
  Blood 1991 ST Test, P Butikofer, MC Yee, FA Kuypers, B Lubin
• Characterization of the complement sensitivity of calcium loaded human erythrocytes.
  Blood 1991 Test ST, Bütikofer P, Yee MC, Kuypers FA, Lubin B
• Erythrocyte defense against hydrogen peroxide: preeminent importance of catalase.
  The Journal of laboratory and clinical medicine 1991 Scott MD, Lubin BH, Zuo L, Kuypers FA
• Application of liquid chromatography-thermospray mass spectrometry in the analysis of glycerophospholipid molecular species.
  Journal of chromatography 1991 Kuypers FA, Bütikofer P, Shackleton CH
• Direct and continuous measurement of hydroperoxide-induced oxidative stress on the membrane of intact erythrocytes.
  Free radical biology & medicine 1991 van den Berg JJ, Kuypers FA, Lubin BH, Roelofsen B, Op den Kamp JA
• Increased n-3 polyunsaturated fatty acid content of red blood cells from fish oil-fed rabbits increases in vitro lipid peroxidation, but decreases hemolysis.
  Free radical biology & medicine 1991 van den Berg JJ, de Fouw NJ, Kuypers FA, Roelofsen B, Houtsmuller UM, Op den Kamp JA
• PHOSPHOLIPID REPAIR IN HUMAN ERYTHROCYTES.
  Oxidative Damage & Repair 1991 Bertram H. Lubin, Frans A. Kuypers
• Recognition signals for phagocytic removal of favic, malaria-infected and sickled erythrocytes.
  Advances in experimental medicine and biology 1991 Arese P, Turrini F, Bussolino F, Lutz HU, Chiu D, Zuo L, Kuypers F, Ginsburg H
• Molecular species analysis of the glycosylphosphatidylinositol anchor of Torpedo marmorata acetylcholinesterase.
  The Journal of biological chemistry 1990 Bütikofer P, Kuypers FA, Shackleton C, Brodbeck U, Stieger S
• Use of ektacytometry to determine red cell susceptibility to oxidative stress.
  The Journal of laboratory and clinical medicine 1990 Kuypers FA, Scott MD, Schott MA, Lubin B, Chiu DT
• Transbilayer distribution and mobility of phosphatidylinositol in human red blood cells.
  The Journal of biological chemistry 1990 Bütikofer P, Lin ZW, Chiu DT, Lubin B, Kuypers FA
• Parasite uptake of desferroxamine: a prerequisite for antimalarial activity.
  British journal of haematology 1990 Scott MD, Ranz A, Kuypers FA, Lubin BH, Meshnick SR
• Excess of red cell membrane proteins in hereditary high-phosphatidylcholine hemolytic anemia.
  American journal of hematology 1990 Lane PA, Kuypers FA, Clark MR, Andrews DA, Wagner GM, Butikofer P, Shapiro AD, Chiu DT, Lubin BH, Mentzer WC
• Effect of osmotic lysis and resealing on red cell structure and function.
  The Journal of laboratory and clinical medicine 1990 Scott MD, Kuypers FA, Butikofer P, Bookchin RM, Ortiz OE, Lubin BH
• The cooperative action of vitamins E and C in the protection against peroxidation of parinaric acid in human erythrocyte membranes.
  Chemistry and physics of lipids 1990 van den Berg JJ, Kuypers FA, Roelofsen B, Op den Kamp JA
• Lability of red blood cell membranes to lipid peroxidation: application to humans fed polyunsaturated lipids.
  Lipids 1990 Fraga CG, Tappel AL, Leibovitz BE, Kuypers F, Chiu D, Iacono JM, Kelley DS
• Preferential Release of Glycosyl-Phosphatidylinositol Anchored Proteins from Human Red Blood Cells during Vesiculation.
  Dynamics and Biogenesis of Membranes 1990 Peter Bütikofer, Samuel T. Test, Daniel T. Y. Chiu, Bertram Lubin, Frans A. Kuypers
• Role of carbon-centered radicals in the conversion of hemoglobin to hemicromes.
  Free Radical Biology and Medicine 1990 M. Minetti, C. Mallozzi, G. Scorza, M. Scott, F. Kuypers, B. Lubin
• The Role of Oxidation in Diseases of the Human Erythrocyte.
  Topics in Pediatrics 1990 Bertram Lubin, Frans Kuypers, Elliott Vichinsky, Daniel Chiu
• The hydroperoxide-induced oxidation kinetics of hemoglobin and parinaric acid in red blood cells.
  Free Radical Biology and Medicine 1990 Jeroen J.M. van den Berg, Jos A.F. Op den Kamp, Ben Roelofsen, Bertram H. Lubin, Frans A. Kuypers
• Enhancement of erythrocyte superoxide dismutase activity: effects on cellular oxidant defense.
  Blood 1989 MD Scott, JW Eaton, FA Kuypers, DT Chiu, BH Lubin
• Enhancement of erythrocyte superoxide dismutase activity: effects on cellular oxidant defense.
  Blood 1989 Scott MD, Eaton JW, Kuypers FA, Chiu DT, Lubin BH
• Enrichment of two glycosyl-phosphatidylinositol-anchored proteins, acetylcholinesterase and decay accelerating factor, in vesicles released from human red blood cells.
  Blood 1989 Bütikofer P, Kuypers FA, Xu CM, Chiu DT, Lubin B
• Enrichment of two glycosyl-phosphatidylinositol-anchored proteins, acetylcholinesterase and decay accelerating factor, in vesicles released from human red blood cells.
  Blood 1989 P Butikofer, FA Kuypers, CM Xu, DT Chiu, B Lubin
• Lipid peroxidation in human red cells.
  Seminars in hematology 1989 Chiu D, Kuypers F, Lubin B
• Qinghaosu-mediated oxidation in normal and abnormal erythrocytes.
  The Journal of laboratory and clinical medicine 1989 Scott MD, Meshnick SR, Williams RA, Chiu DT, Pan HC, Lubin BH, Kuypers FA
• Chlorpromazine inhibits vesiculation, alters phosphoinositide turnover and changes deformability of ATP-depleted RBCs.
  Blood 1989 Bütikofer P, Lin ZW, Kuypers FA, Scott MD, Xu CM, Wagner GM, Chiu DT, Lubin B
• Chlorpromazine inhibits vesiculation, alters phosphoinositide turnover and changes deformability of ATP-depleted RBCs.
  Blood 1989 P Butikofer, ZW Lin, FA Kuypers, MD Scott, CM Xu, GM Wagner, DT Chiu, B Lubin
• Influence of phosphatidylcholine molecular species composition on stability of the erythrocyte membrane.
  Biochemical Society transactions 1989 Roelofsen B, Kuypers FA, Op den Kamp JA, van Deenen LL
• Red cell deformability and lipid composition in two forms of acanthocytosis: enrichment of acanthocytic populations by density gradient centrifugation.
  The Journal of laboratory and clinical medicine 1989 Clark MR, Aminoff MJ, Chiu DT, Kuypers FA, Friend DS
• Erythrocyte phospholipid organization and vesiculation in hereditary high red cell membrane phosphatidylcholine hemolytic anemia.
  The Journal of laboratory and clinical medicine 1989 Butikofer P, Kuypers FA, Lane P, Chiu DT, Lubin BH, Ott P
• Activated oxygen mediates the antimalarial activity of qinghaosu.
  Progress in clinical and biological research 1989 Meshnick SR, Tsang TW, Lin FB, Pan HZ, Chang CN, Kuypers F, Chiu D, Lubin B
• Lipid alterations and cellular properties of sickle red cells.
  Annals of the New York Academy of Sciences 1989 Lubin B, Kuypers F, Chiu D
• Red cell membrane lipid dynamics.
  Progress in clinical and biological research 1989 Lubin B, Kuypers F, Chiu D
• The use of cis-parinaric acid to determine lipid peroxidation in human erythrocyte membranes. Comparison of normal and sickle erythrocyte membranes.
  Biochimica et biophysica acta 1988 Van den Berg JJ, Kuypers FA, Qju JH, Chiu D, Lubin B, Roelofsen B, Op den Kamp JA
• Diet-induced asymmetry of the phosphatidylcholine fatty acyl composition in rat erythrocyte membranes.
  The Journal of laboratory and clinical medicine 1988 Kuypers FA, Abraham S, Lubin B, Chiu D
• The molecular species composition of phosphatidylcholine affects cellular properties in normal and sickle erythrocytes.
  Blood 1987 FA Kuypers, D Chiu, N Mohandas, B Roelofsen, JA Op den Kamp, B Lubin
• The molecular species composition of phosphatidylcholine affects cellular properties in normal and sickle erythrocytes.
  Blood 1987 Kuypers FA, Chiu D, Mohandas N, Roelofsen B, Op den Kamp JA, Lubin B
• Parinaric acid as a sensitive fluorescent probe for the determination of lipid peroxidation.
  Biochimica et biophysica acta 1987 Kuypers FA, van den Berg JJ, Schalkwijk C, Roelofsen B, Op den Kamp JA
• Effects of altered phospholipid molecular species on erythrocyte membranes.
  Annals of the New York Academy of Sciences 1987 van Deenen LL, Kuypers FA, Op den Kamp JA, Roelofsen B
• The rate of uptake and efflux of phosphatidylcholine from human erythrocytes depends on the fatty acyl composition of the exchanging species.
  Biochimica et biophysica acta 1986 Kuypers FA, Andriesse X, Child P, Roelofsen B, Op den Kamp JA, van Deenen LL
• Effect of membrane cholesterol on dimyristoylphosphatidylcholine-induced vesiculation of human red blood cells.
  Biochimica et biophysica acta 1986 Frenkel EJ, Kuypers FA, Op den Kamp JA, Roelofsen B, Ott P
• Survival of rabbit and horse erythrocytes in vivo after changing the fatty acyl composition of their phosphatidylcholine.
  Biochimica et biophysica acta 1985 Kuypers FA, Easton EW, van den Hoven R, Wensing T, Roelofsen B, op den Kamp JA, van Deenen LL
• Lipid molecular shape affects erythrocyte morphology: a study involving replacement of native phosphatidylcholine with different species followed by treatment of cells with sphingomyelinase C or phospholipase A2.
  The Journal of cell biology 1985 Christiansson A, Kuypers FA, Roelofsen B, Op den Kamp JA, van Deenen LL
• The phospholipid organisation in the membranes of McLeod and Leach phenotype erythrocytes.
  FEBS letters 1985 Kuypers FA, van Linde-Sibenius Trip M, Roelofsen B, Op den Kamp JA, Tanner MJ, Anstee DJ
• Acyl selectivity in the transfer of molecular species of phosphatidylcholines from human erythrocytes.
  Biochimica et biophysica acta 1985 Child P, Myher JJ, Kuypers FA, Op den Kamp JA, Kuksis A, Van Deenen LL
• Shape changes in human erythrocytes induced by replacement of the native phosphatidylcholine with species containing various fatty acids.
  The Journal of cell biology 1984 Kuypers FA, Roelofsen B, Berendsen W, Op den Kamp JA, van Deenen LL
• A comparative fluorescence polarization study of cis-parinaroyl-phosphatidylcholine and diphenylhexatriene in membranes containing different amounts of cholesterol.
  Chemistry and physics of lipids 1984 Christiansson A, Kuypers FA, Roelofsen B, Wirtz KW, Op den Kamp JA
• Rhnull human erythrocytes have an abnormal membrane phospholipid organization.
  The Biochemical journal 1984 Kuypers F, van Linde-Sibenius-Trip M, Roelofsen B, Tanner MJ, Anstee DJ, Op den Kamp JA
• The membrane of intact human erythrocytes tolerates only limited changes in the fatty acid composition of its phosphatidylcholine.
  Biochimica et biophysica acta 1984 Kuypers FA, Roelofsen B, Op den Kamp JA, Van Deenen LL