Francis Szoka, PhD
Professor
Bioengineering
School of Pharmacy

His group has extensively investigated the role of lipids in membrane fusion and his designed, synthesized and studied the mechanism of fusogenic peptides. With group members, he has published over 220 manuscripts and has received 35 U.S. patents. One FDA approved drug product Amphotec™ and one biotechnology product Superfect™ have been commercialized from the patents. In addition to his University commitments, Dr. Szoka is a founder of Sequus Pharmaceuticals, Inc., GeneMedicine, Inc., and ZoneOne Pharma, Inc. Sequus introduced sterically stabilized liposomes for anti-cancer drug delivery (Doxil™).

• Development of a flow-through USP 4 apparatus drug release assay for the evaluation of amphotericin B liposome.
  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2018 Tang J, Srinivasan S, Yuan W, Ming R, Liu Y, Dai Z, Noble CO, Hayes ME, Zheng N, Jiang W, Szoka FC, Schwendeman A
• Correction: Sterol-modified PEG lipids: alteration of the bilayer anchoring moiety has an unexpected effect on liposome circulation.
  Chemical communications (Cambridge, England) 2018 Dolor A, Kierstead P, Dai Z, Szoka FC
• Sterol-modified PEG lipids: alteration of the bilayer anchoring moiety has an unexpected effect on liposome circulation.
  Chemical communications (Cambridge, England) 2018 Dolor A, Kierstead P, Dai Z, Szoka FC
• Digesting a Path Forward: The Utility of Collagenase Tumor Treatment for Improved Drug Delivery.
  Molecular pharmaceutics 2018 Dolor A, Szoka FC
• Constrained Versus Free Cholesterol in DPPC Membranes: A Comparison of Chain Ordering Ability Using Deuterium NMR.
  Langmuir : the ACS journal of surfaces and colloids 2017 Shaghaghi M, Keyvanloo A, Huang Z, Szoka FC, Thewalt JL
• Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice.
  Molecular therapy. Methods & clinical development 2017 Lee S, Kivimäe S, Szoka FC
• Biodistribution and In Vivo Antileishmanial Activity of 1,2-Distigmasterylhemisuccinoyl-sn-Glycero-3-Phosphocholine Liposome-Intercalated Amphotericin B.
  Antimicrobial agents and chemotherapy 2017 Iman M, Huang Z, Alavizadeh SH, Szoka FC, Jaafari MR
• Encapsulation, controlled release, and antitumor efficacy of cisplatin delivered in liposomes composed of sterol-modified phospholipids.
  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Kieler-Ferguson HM, Chan D, Sockolosky J, Finney L, Maxey E, Vogt S, Szoka FC
• Co-localization of fluorescent labeled lipid nanoparticles with specifically tagged subcellular compartments by single particle tracking at low nanoparticle to cell ratios.
  Journal of drug targeting 2016 Tiffany M, Szoka FC
• Development of a Flow-Through USP-4 Apparatus Drug Release Assay to Evaluate Doxorubicin Liposomes.
  The AAPS journal 2016 Yuan W, Kuai R, Dai Z, Yuan Y, Zheng N, Jiang W, Noble C, Hayes M, Szoka FC, Schwendeman A
• Macrophage-based cell therapies: The long and winding road.
  Journal of controlled release : official journal of the Controlled Release Society 2016 Lee S, Kivimäe S, Dolor A, Szoka FC
• The effect of polymer backbone chemistry on the induction of the accelerated blood clearance in polymer modified liposomes.
  Journal of controlled release : official journal of the Controlled Release Society 2015 Kierstead PH, Okochi H, Venditto VJ, Chuong TC, Kivimae S, Fréchet JMJ, Szoka FC
• The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy.
  Advanced drug delivery reviews 2015 Sockolosky JT, Szoka FC
• Sulfated quaternary amine lipids: a new class of inverse charge zwitterlipids.
  Chemical communications (Cambridge, England) 2014 Venditto VJ, Dolor A, Kohli A, Salentinig S, Boyd BJ, Szoka FC
• Fusion of a short peptide that binds immunoglobulin G to a recombinant protein substantially increases its plasma half-life in mice.
  PloS one 2014 Sockolosky JT, Kivimäe S, Szoka FC
• Chemically modified peptides based on the membrane-proximal external region of the HIV-1 envelope induce high-titer, epitope-specific nonneutralizing antibodies in rabbits.
  Clinical and vaccine immunology : CVI 2014 Venditto VJ, Wieczorek L, Molnar S, Teque F, Landucci G, Watson DS, Forthal D, Polonis VR, Levy JA, Szoka FC
• Improving the distribution of Doxil® in the tumor matrix by depletion of tumor hyaluronan.
  Journal of controlled release : official journal of the Controlled Release Society 2014 Kohli AG, Kivimäe S, Tiffany MR, Szoka FC
• Designer lipids for drug delivery: from heads to tails.
  Journal of controlled release : official journal of the Controlled Release Society 2014 Kohli AG, Kierstead PH, Venditto VJ, Walsh CL, Szoka FC
• Chemoenzymatic synthesis of oligohyaluronan-lipid conjugates.
  Bioconjugate chemistry 2014 Ruhela D, Kivimäe S, Szoka FC
• A robust and quantitative method for tracking liposome contents after intravenous administration.
  Journal of controlled release : official journal of the Controlled Release Society 2013 Kohli AG, Kieler-Ferguson HM, Chan D, Szoka FC
• Novel ortho ester-based, pH-sensitive cationic lipid for gene delivery in vitro and in vivo.
  Journal of liposome research 2013 Guo X, Gagne L, Chen H, Szoka FC
• Intravitreal administration of HA-1077, a ROCK inhibitor, improves retinal function in a mouse model of huntington disease.
  PloS one 2013 Li M, Yasumura D, Ma AA, Matthes MT, Yang H, Nielson G, Huang Y, Szoka FC, Lavail MM, Diamond MI
• Clinical developments of chemotherapeutic nanomedicines: polymers and liposomes for delivery of camptothecins and platinum (II) drugs.
  Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2013 Kieler-Ferguson HM, Fréchet JM, Szoka FC
• Synthesis, characterization, and evaluation of ionizable lysine-based lipids for siRNA delivery.
  Bioconjugate chemistry 2012 Walsh CL, Nguyen J, Tiffany MR, Szoka FC
• Periplasmic production via the pET expression system of soluble, bioactive human growth hormone.
  Protein expression and purification 2012 Sockolosky JT, Szoka FC
• Rational design of membrane proximal external region lipopeptides containing chemical modifications for HIV-1 vaccination.
  Clinical and vaccine immunology : CVI 2012 Venditto VJ, Watson DS, Motion M, Montefiori D, Szoka FC
• Cancer nanomedicines: so many papers and so few drugs!
  Advanced drug delivery reviews 2012 Venditto VJ, Szoka FC
• Engineering neonatal Fc receptor-mediated recycling and transcytosis in recombinant proteins by short terminal peptide extensions.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Sockolosky JT, Tiffany MR, Szoka FC
• Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds.
  Angewandte Chemie (International ed. in English) 2012 Motion JP, Nguyen J, Szoka FC
• Controlled nucleation of lipid nanoparticles.
  Pharmaceutical research 2012 Nguyen J, Walsh CL, Motion JP, Perttu EK, Szoka F
• Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties.
  Chemical communications (Cambridge, England) 2012 Walsh CL, Nguyen J, Szoka FC
• Nucleic acid delivery: the missing pieces of the puzzle?
  Accounts of chemical research 2012 Nguyen J, Szoka FC
• Inverse-phosphocholine lipids: a remix of a common phospholipid.
  Journal of the American Chemical Society 2012 Perttu EK, Kohli AG, Szoka FC
• Synthesis and characterization of betaine-like diacyl lipids: zwitterionic lipids with the cationic amine at the bilayer interface.
  Chemistry and physics of lipids 2012 Kohli AG, Walsh CL, Szoka FC
• Zwitterionic sulfobetaine lipids that form vesicles with salt-dependent thermotropic properties.
  Chemical communications (Cambridge, England) 2011 Perttu EK, Szoka FC
• Asymmetric 1-alkyl-2-acyl phosphatidylcholine: a helper lipid for enhanced non-viral gene delivery.
  International journal of pharmaceutics 2011 Huang Z, Li W, Szoka FC
• Structural studies of the monolayers and bilayers formed by a novel cholesterol-phospholipid chimera.
  Langmuir : the ACS journal of surfaces and colloids 2011 Foglia F, Barlow DJ, Szoka FC, Huang Z, Rogers SE, Lawrence MJ
• Anti-tumor activity of liposome encapsulated fluoroorotic acid as a single agent and in combination with liposome irinotecan.
  Journal of controlled release : official journal of the Controlled Release Society 2011 Riviere K, Kieler-Ferguson HM, Jerger K, Szoka FC
• Synthesis and properties of star-comb polymers and their doxorubicin conjugates.
  Bioconjugate chemistry 2011 Chen B, van der Poll DG, Jerger K, Floyd WC, Fréchet JM, Szoka FC
• Perturbation of solute transport at a liquid-liquid interface by polyethylene glycol (PEG): implications for PEG-induced biomembrane fusion.
  Physical chemistry chemical physics : PCCP 2011 Guy RH, Szoka FC
• Characterization of the colloidal properties, in vitro antifungal activity, antileishmanial activity and toxicity in mice of a di-stigma-steryl-hemi-succinoyl-glycero-phosphocholine liposome-intercalated amphotericin B.
  International journal of pharmaceutics 2011 Iman M, Huang Z, Szoka FC, Jaafari MR
• Chemotherapeutic evaluation of a synthetic tubulysin analogue-dendrimer conjugate in c26 tumor bearing mice.
  ChemMedChem 2011 Floyd WC, Datta GK, Imamura S, Kieler-Ferguson HM, Jerger K, Patterson AW, Fox ME, Szoka FC, Fréchet JM, Ellman JA
• Antibody response to polyhistidine-tagged peptide and protein antigens attached to liposomes via lipid-linked nitrilotriacetic acid in mice.
  Clinical and vaccine immunology : CVI 2010 Watson DS, Platt VM, Cao L, Venditto VJ, Szoka FC
• Convection and retro-convection enhanced delivery: some theoretical considerations related to drug targeting.
  Pharmaceutical research 2010 Motion JP, Huynh GH, Szoka FC, Siegel RA
• Influence of multivalent nitrilotriacetic acid lipid-ligand affinity on the circulation half-life in mice of a liposome-attached His6-protein.
  Bioconjugate chemistry 2010 Platt V, Huang Z, Cao L, Tiffany M, Riviere K, Szoka FC
• Design, synthesis, and biological evaluation of a robust, biodegradable dendrimer.
  Bioconjugate chemistry 2010 van der Poll DG, Kieler-Ferguson HM, Floyd WC, Guillaudeu SJ, Jerger K, Szoka FC, Fréchet JM
• Antitumor effect of folate-targeted liposomal doxorubicin in KB tumor-bearing mice after intravenous administration.
  Journal of drug targeting 2010 Riviere K, Huang Z, Jerger K, Macaraeg N, Szoka FC
• Utilizing the O-antigen lipopolysaccharide biosynthesis pathway in Escherichia coli to interrogate the substrate specificities of exogenous glycosyltransferase genes in a combinatorial approach.
  Glycobiology 2010 Johansen EB, Szoka FC, Zaleski A, Apicella MA, Gibson BW
• Synthesis and in vivo antitumor efficacy of PEGylated poly(l-lysine) dendrimer-camptothecin conjugates.
  Molecular pharmaceutics 2009 Fox ME, Guillaudeu S, Fréchet JM, Jerger K, Macaraeg N, Szoka FC
• Soluble polymer carriers for the treatment of cancer: the importance of molecular architecture.
  Accounts of chemical research 2009 Fox ME, Szoka FC, Fréchet JM
• Tris-nitrilotriacetic acids of subnanomolar affinity toward hexahistidine tagged molecules.
  Bioconjugate chemistry 2009 Huang Z, Hwang P, Watson DS, Cao L, Szoka FC
• All-trans retinoic acid potentiates the antibody response in mice to a lipopeptide antigen adjuvanted with liposomal lipid A.
  Immunology and cell biology 2009 Watson DS, Huang Z, Szoka FC
• Role of lipid structure in the humoral immune response in mice to covalent lipid-peptides from the membrane proximal region of HIV-1 gp41.
  Vaccine 2009 Watson DS, Szoka FC
• The influence of polymer topology on pharmacokinetics: differences between cyclic and linear PEGylated poly(acrylic acid) comb polymers.
  Journal of controlled release : official journal of the Controlled Release Society 2009 Chen B, Jerger K, Fréchet JM, Szoka FC
• Antitumor therapy mediated by 5-fluorocytosine and a recombinant fusion protein containing TSG-6 hyaluronan binding domain and yeast cytosine deaminase.
  Molecular pharmaceutics 2009 Park JI, Cao L, Platt VM, Huang Z, Stull RA, Dy EE, Sperinde JJ, Yokoyama JS, Szoka FC
• Dependence of pharmacokinetics and biodistribution on polymer architecture: effect of cyclic versus linear polymers.
  Journal of the American Chemical Society 2009 Nasongkla N, Chen B, Macaraeg N, Fox ME, Fréchet JM, Szoka FC
• Quantification of plasmid DNA copies in the nucleus after lipoplex and polyplex transfection.
  Journal of controlled release : official journal of the Controlled Release Society 2009 Cohen RN, van der Aa MA, Macaraeg N, Lee AP, Szoka FC
• Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery.
  Angewandte Chemie (International ed. in English) 2009 Huang Z, Jaafari MR, Szoka FC
• Sterol-modified phospholipids: cholesterol and phospholipid chimeras with improved biomembrane properties.
  Journal of the American Chemical Society 2008 Huang Z, Szoka FC
• Anticancer therapeutics: targeting macromolecules and nanocarriers to hyaluronan or CD44, a hyaluronan receptor.
  Molecular pharmaceutics 2008 Platt VM, Szoka FC
• HIV TAT peptide modifies the distribution of DNA nanolipoparticles following convection-enhanced delivery.
  Molecular therapy : the journal of the American Society of Gene Therapy 2008 MacKay JA, Li W, Huang Z, Dy EE, Huynh G, Tihan T, Collins R, Deen DF, Szoka FC
• Molecular biology. The art of assembly.
  Science (New York, N.Y.) 2008 Szoka F
• PEGylated dendrimers with core functionality for biological applications.
  Bioconjugate chemistry 2008 Guillaudeu SJ, Fox ME, Haidar YM, Dy EE, Szoka FC, Fréchet JM
• Unsaturated cationic ortho esters for endosome permeation in gene delivery.
  Journal of medicinal chemistry 2007 Chen H, Zhang H, McCallum CM, Szoka FC, Guo X
• Reconstitution of the M13 major coat protein and its transmembrane peptide segment on a DNA template.
  Biochemistry 2007 Li W, Suez I, Szoka FC
• Lipid-based nanoparticles for nucleic acid delivery.
  Pharmaceutical research 2007 Li W, Szoka FC
• Phosphorothioate oligonucleotides reduce PrP levels and prion infectivity in cultured cells.
  Molecular medicine (Cambridge, Mass.) 2007 Karpuj MV, Giles K, Gelibter-Niv S, Scott MR, Lingappa VR, Szoka FC, Peretz D, Denetclaw W, Prusiner SB
• Retro-convection enhanced delivery to increase blood to brain transfer of macromolecules.
  Brain research 2006 Huynh GH, Ozawa T, Deen DF, Tihan T, Szoka FC
• Facile synthesis of multivalent nitrilotriacetic acid (NTA) and NTA conjugates for analytical and drug delivery applications.
  Bioconjugate chemistry 2006 Huang Z, Park JI, Watson DS, Hwang P, Szoka FC
• A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Lee CC, Gillies ER, Fox ME, Guillaudeu SJ, Fréchet JM, Dy EE, Szoka FC
• An intramolecular cyclization reaction is responsible for the in vivo inefficacy and apparent pH insensitive hydrolysis kinetics of hydrazone carboxylate derivatives of doxorubicin.
  Bioconjugate chemistry 2006 Lee CC, Cramer AT, Szoka FC, Fréchet JM
• Efficient synthesis of an aldehyde functionalized hyaluronic acid and its application in the preparation of hyaluronan-lipid conjugates.
  Bioconjugate chemistry 2006 Ruhela D, Riviere K, Szoka FC
• Bioresponsive targeted charge neutral lipid vesicles for systemic gene delivery.
  CSH protocols 2006 Li W, Szoka FC
• Acid-triggered transformation of diortho ester phosphocholine liposome.
  Journal of the American Chemical Society 2006 Huang Z, Guo X, Li W, MacKay JA, Szoka FC
• Designing dendrimers for biological applications.
  Nature biotechnology 2005 Lee CC, MacKay JA, Fréchet JM, Szoka FC
• Barriers to carrier mediated drug and gene delivery to brain tumors.
  Journal of controlled release : official journal of the Controlled Release Society 2005 Huynh GH, Deen DF, Szoka FC
• In vitro and in vivo evaluation of hydrophilic dendronized linear polymers.
  Bioconjugate chemistry 2005 Lee CC, Yoshida M, Fréchet JM, Dy EE, Szoka FC
• Biological evaluation of polyester dendrimer: poly(ethylene oxide) "bow-tie" hybrids with tunable molecular weight and architecture.
  Molecular pharmaceutics 2005 Gillies ER, Dy E, Fréchet JM, Szoka FC
• Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers.
  Molecular therapy : the journal of the American Society of Gene Therapy 2005 Huang Z, Li W, MacKay JA, Szoka FC
• Toroid formation in charge neutralized flexible or semi-flexible biopolymers: potential pathway for assembly of DNA carriers.
  The journal of gene medicine 2005 Tang MX, Li W, Szoka FC
• Identification of a deoxyribonuclease I inhibitor from a phage-peptide library.
  Molecules and cells 2005 Choi SJ, Sperinde JJ, Szoka FC
• Distribution in brain of liposomes after convection enhanced delivery; modulation by particle charge, particle diameter, and presence of steric coating.
  Brain research 2005 MacKay JA, Deen DF, Szoka FC
• Low-pH-sensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery.
  The journal of gene medicine 2005 Li W, Huang Z, MacKay JA, Grube S, Szoka FC
• Molecular motors as drug delivery vehicles.
  Drug discovery today. Technologies 2005 Cohen RN, Rashkin MJ, Wen X, Szoka FC
• GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery.
  Advanced drug delivery reviews 2004 Li W, Nicol F, Szoka FC
• Determination and modeling of kinetics of cancer cell killing by doxorubicin and doxorubicin encapsulated in targeted liposomes.
  Cancer research 2004 Eliaz RE, Nir S, Marty C, Szoka FC
• Improved preparation of PEG-diortho ester-diacyl glycerol conjugates.
  Methods in enzymology 2004 Guo X, Huang Z, Szoka FC
• Interactions of hyaluronan-targeted liposomes with cultured cells: modeling of binding and endocytosis.
  Methods in enzymology 2004 Eliaz RE, Nir S, Szoka FC
• Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes.
  The Journal of biological chemistry 2003 Sonawane ND, Szoka FC, Verkman AS
• Chemical approaches to triggerable lipid vesicles for drug and gene delivery.
  Accounts of chemical research 2003 Guo X, Szoka FC
• Development of a high throughput Pseudomonas aeruginosa epithelial cell adhesion assay.
  Journal of microbiological methods 2003 Swanson B, Savel R, Szoka F, Sawa T, Wiener-Kronish J
• Low-pH-sensitive PEG-stabilized plasmid-lipid nanoparticles: preparation and characterization.
  Bioconjugate chemistry 2003 Choi JS, MacKay JA, Szoka FC
• Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid.
  Biophysical journal 2003 Guo X, MacKay JA, Szoka FC
• HIV TAT Protein Transduction Domain Mediated Cell Binding and Intracellular Delivery of Nanoparticles.
  Journal of dispersion science and technology 2003 Mackay JA, Szoka FC
• Robust and prolonged gene expression from injectable polymeric implants.
  Gene therapy 2002 Eliaz RE, Szoka FC
• Polyester dendritic systems for drug delivery applications: design, synthesis, and characterization.
  Bioconjugate chemistry 2002 Ihre HR, Padilla De Jesús OL, Szoka FC, Fréchet JM
• Polyester dendritic systems for drug delivery applications: in vitro and in vivo evaluation.
  Bioconjugate chemistry 2002 Padilla De Jesús OL, Ihre HR, Gagne L, Fréchet JM, Szoka FC
• Mechanism of lipoplex gene delivery in mouse lung: binding and internalization of fluorescent lipid and DNA components.
  Gene therapy 2001 Uyechi LS, Gagné L, Thurston G, Szoka FC
• Branched polyamines cure prion-infected neuroblastoma cells.
  Journal of virology 2001 Supattapone S, Wille H, Uyechi L, Safar J, Tremblay P, Szoka FC, Cohen FE, Prusiner SB, Scott MR
• Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells.
  Cancer research 2001 Eliaz RE, Szoka FC
• Phage display selection of a peptide DNase II inhibitor that enhances gene delivery.
  The journal of gene medicine 2001 Sperinde JJ, Choi SJ, Szoka FC
• Steric stabilization of fusogenic liposomes by a low-pH sensitive PEG--diortho ester--lipid conjugate.
  Bioconjugate chemistry 2001 Guo X, Szoka FC
• Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein.
  Science (New York, N.Y.) 2000 Sparrer HE, Santoso A, Szoka FC, Weissman JS
• Fluorometric determination of deoxyribonuclease I activity with PicoGreen.
  Analytical biochemistry 2000 Choi SJ, Szoka FC
• Effect of phospholipid composition on an amphipathic peptide-mediated pore formation in bilayer vesicles.
  Biophysical journal 2000 Nicol F, Nir S, Szoka FC
• Controlled template-assisted assembly of plasmid DNA into nanometric particles with high DNA concentration.
  Bioconjugate chemistry 2000 Ouyang M, Remy JS, Szoka FC
• Gene delivery and expression in human retinal pigment epithelial cells: effects of synthetic carriers, serum, extracellular matrix and viral promoters.
  Journal of drug targeting 2000 Urtti A, Polansky J, Lui GM, Szoka FC
• Simple mixing device to reproducibly prepare cationic lipid-DNA complexes (lipoplexes).
  BioTechniques 1999 Hirota S, de Ilarduya CT, Barron LG, Szoka FC
• Lipoplex-mediated gene delivery to the lung occurs within 60 minutes of intravenous administration.
  Human gene therapy 1999 Barron LG, Gagné L, Szoka FC
• Physicochemical characterization and purification of cationic lipoplexes.
  Biophysical journal 1999 Xu Y, Hui SW, Frederik P, Szoka FC
• Cationic lipids are essential for gene delivery mediated by intravenous administration of lipoplexes.
  Gene therapy 1999 Barron LG, Uyechi LS, Szoka FC
• Orientation of the pore-forming peptide GALA in POPC vesicles determined by a BODIPY-avidin/biotin binding assay.
  Biophysical journal 1999 Nicol F, Nir S, Szoka FC
• Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes.
  Human gene therapy 1999 Plank C, Tang MX, Wolfe AR, Szoka FC
• Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer-plasmid complexes.
  Gene therapy 1999 Turunen MP, Hiltunen MO, Ruponen M, Virkamäki L, Szoka FC, Urtti A, Ylä-Herttuala S
• Surface aggregation and membrane penetration by peptides: relation to pore formation and fusion.
  Molecular membrane biology 1999 Nir S, Nicol F, Szoka FC
• A simple in vitro model to study the release kinetics of liposome encapsulated material.
  Journal of controlled release : official journal of the Controlled Release Society 1998 Peschka R, Dennehy C, Szoka FC
• Cholesterol phosphate derivatives: synthesis and incorporation into a phosphatase and calcium-sensitive triggered release liposome.
  Bioconjugate chemistry 1998 Davis SC, Szoka FC
• Synthesis and characterization of long chain alkyl acyl carnitine esters. Potentially biodegradable cationic lipids for use in gene delivery.
  Journal of medicinal chemistry 1998 Wang J, Guo X, Xu Y, Barron L, Szoka FC
• Effect of serum components on the physico-chemical properties of cationic lipid/oligonucleotide complexes and on their interactions with cells.
  Biochimica et biophysica acta 1998 Zelphati O, Uyechi LS, Barron LG, Szoka FC
• Effects of complement depletion on the pharmacokinetics and gene delivery mediated by cationic lipid-DNA complexes.
  Human gene therapy 1998 Barron LG, Meyer KB, Szoka FC
• Molecular modeling of the intestinal bile acid carrier: a comparative molecular field analysis study.
  Journal of computer-aided molecular design 1997 Swaan PW, Szoka FC, Oie S
• The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes.
  Gene therapy 1997 Tang MX, Szoka FC
• Enhanced transepithelial transport of peptides by conjugation to cholic acid.
  Bioconjugate chemistry 1997 Swaan PW, Hillgren KM, Szoka FC, Oie S
• Many are probed, but few are chosen.
  Nature biotechnology 1997 Szoka FC
• Nomenclature for synthetic gene delivery systems.
  Human gene therapy 1997 Felgner PL, Barenholz Y, Behr JP, Cheng SH, Cullis P, Huang L, Jessee JA, Seymour L, Szoka F, Thierry AR, Wagner E, Wu G
• Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers.
  Biochemistry 1997 Wyman TB, Nicol F, Zelphati O, Scaria PV, Plank C, Szoka FC
• Use of the intestinal bile acid transporter for the uptake of cholic acid conjugates with HIV-1 protease inhibitory activity.
  Pharmaceutical research 1997 Kågedahl M, Swaan PW, Redemann CT, Tang M, Craik CS, Szoka FC, Oie S
• Effect of cholesterol and charge on pore formation in bilayer vesicles by a pH-sensitive peptide.
  Biophysical journal 1996 Nicol F, Nir S, Szoka FC
• In vitro gene delivery by degraded polyamidoamine dendrimers.
  Bioconjugate chemistry 1996 Tang MX, Redemann CT, Szoka FC
• Mechanism of oligonucleotide release from cationic liposomes.
  Proceedings of the National Academy of Sciences of the United States of America 1996 Zelphati O, Szoka FC
• Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids.
  Pharmaceutical research 1996 Zelphati O, Szoka FC
• Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery.
  Human gene therapy 1996 Plank C, Mechtler K, Szoka FC, Wagner E
• Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection.
  Biochemistry 1996 Xu Y, Szoka FC
• Iontophoresis of bases, nucleosides, and nucleotides.
  Pharmaceutical research 1996 van der Geest R, Hueber F, Szoka FC, Guy RH
• Characterization of plasmid DNA transfer into mouse skeletal muscle: evaluation of uptake mechanism, expression and secretion of gene products into blood.
  Gene therapy 1996 Levy MY, Barron LG, Meyer KB, Szoka FC
• An in vitro messenger RNA binding assay as a tool for identifying hybridization-competent antisense oligonucleotides.
  Antisense & nucleic acid drug development 1996 Stull RA, Zon G, Szoka FC
• Intratracheal gene delivery to the mouse airway: characterization of plasmid DNA expression and pharmacokinetics.
  Gene therapy 1995 Meyer KB, Thompson MM, Levy MY, Barron LG, Szoka FC
• Antigene, ribozyme and aptamer nucleic acid drugs: progress and prospects.
  Pharmaceutical research 1995 Stull RA, Szoka FC
• Gene expression following direct injection of DNA into liver.
  Human gene therapy 1994 Hickman MA, Malone RW, Lehmann-Bruinsma K, Sih TR, Knoell D, Szoka FC, Walzem R, Carlson DM, Powell JS
• Pore-forming peptides induce rapid phospholipid flip-flop in membranes.
  Biochemistry 1994 Fattal E, Nir S, Parente RA, Szoka FC
• Intracellular oligonucleotide hybridization detected by fluorescence resonance energy transfer (FRET).
  Nucleic acids research 1994 Sixou S, Szoka FC, Green GA, Giusti B, Zon G, Chin DJ
• Polyamidoamine cascade polymers mediate efficient transfection of cells in culture.
  Bioconjugate chemistry 1993 Haensler J, Szoka FC
• Cyclic amphipathic peptide-DNA complexes mediate high-efficiency transfection of adherent mammalian cells.
  Proceedings of the National Academy of Sciences of the United States of America 1993 Legendre JY, Szoka FC
• Single-stranded phosphodiester and phosphorothioate oligonucleotides bind actinomycin D and interfere with tumor necrosis factor-induced lysis in the L929 cytotoxicity assay.
  Antisense research and development 1993 Stull RA, Zon G, Szoka FC
• Synthesis and characterization of a trigalactosylated bisacridine compound to target DNA to hepatocytes.
  Bioconjugate chemistry 1993 Haensler J, Szoka FC
• Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: comparison with cationic liposomes.
  Pharmaceutical research 1992 Legendre JY, Szoka FC
• Predicting antisense oligonucleotide inhibitory efficacy: a computational approach using histograms and thermodynamic indices.
  Nucleic acids research 1992 Stull RA, Taylor LA, Szoka FC
• Amino acid side-chain contributions to free energy of transfer of tripeptides from water to octanol.
  Pharmaceutical research 1992 Kim A, Szoka FC
• Prolonged systemic delivery of peptide drugs by long-circulating liposomes: illustration with vasopressin in the Brattleboro rat.
  Pharmaceutical research 1992 Woodle MC, Storm G, Newman MS, Jekot JJ, Collins LR, Martin FJ, Szoka FC
• The macrophage as the principal antigen-presenting cell for liposome-encapsulated antigen.
  Research in immunology 1992 Szoka FC
• Iontophoretic delivery of a series of tripeptides across the skin in vitro.
  Pharmaceutical research 1991 Green PG, Hinz RS, Kim A, Szoka FC, Guy RH
• Secondary structure and orientation of the amphipathic peptide GALA in lipid structures. An infrared-spectroscopic approach.
  European journal of biochemistry 1991 Goormaghtigh E, De Meutter J, Szoka F, Cabiaux V, Parente RA, Ruysschaert JM
• Rapid nuclear accumulation of injected oligodeoxyribonucleotides.
  The New biologist 1990 Chin DJ, Green GA, Zon G, Szoka FC, Straubinger RM
• The future of liposomal drug delivery.
  Biotechnology and applied biochemistry 1990 Szoka FC
• Association of a pH-sensitive peptide with membrane vesicles: role of amino acid sequence.
  Biochemistry 1990 Parente RA, Nadasdi L, Subbarao NK, Szoka FC
• Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA.
  Biochemistry 1990 Parente RA, Nir S, Szoka FC
• Efficiency of cytoplasmic delivery by pH-sensitive liposomes to cells in culture.
  Pharmaceutical research 1990 Chu CJ, Dijkstra J, Lai MZ, Hong K, Szoka FC
• Fibre optic sensor for the detection of potassium using fluorescence energy transfer.
  The Analyst 1990 Roe JN, Szoka FC, Verkman AS
• Antigen presentation by B cells and macrophages of cytochrome c and its antigenic fragment when conjugated to the surface of liposomes.
  Vaccine 1989 Dal Monte PR, Szoka FC
• Optical measurement of aqueous potassium concentration by a hydrophobic indicator in lipid vesicles.
  Biophysical chemistry 1989 Roe JN, Szoka FC, Verkman AS
• Treatment of experimental invasive aspergillosis with novel amphotericin B/cholesterol-sulfate complexes.
  The Journal of infectious diseases 1989 Patterson TF, Miniter P, Dijkstra J, Szoka FC, Ryan JL, Andriole VT
• Effect of liposome encapsulation on antigen presentation in vitro. Comparison of presentation by peritoneal macrophages and B cell tumors.
  Journal of immunology (Baltimore, Md. : 1950) 1989 Dal Monte P, Szoka FC
• A procedure for the efficient incorporation of wild-type lipopolysaccharide into liposomes for use in immunological studies.
  Journal of immunological methods 1988 Dijkstra J, Ryan JL, Szoka FC
• Increased efficacy of phosphonoformate and phosphonoacetate inhibition of herpes simplex virus type 2 replication by encapsulation in liposomes.
  Antimicrobial agents and chemotherapy 1988 Szoka FC, Chu CJ
• Incorporation of LPS in liposomes diminishes its ability to induce tumoricidal activity and tumor necrosis factor secretion in murine macrophages.
  Journal of leukocyte biology 1988 Dijkstra J, Larrick JW, Ryan JL, Szoka FC
• pH-dependent fusion of phosphatidylcholine small vesicles. Induction by a synthetic amphipathic peptide.
  The Journal of biological chemistry 1988 Parente RA, Nir S, Szoka FC
• Lecithin:cholesterol acyltransferase activation by synthetic amphipathic peptides.
  Proteins 1988 Subbarao NK, Fielding CJ, Hamilton RL, Szoka FC
• pH-dependent bilayer destabilization by an amphipathic peptide.
  Biochemistry 1987 Subbarao NK, Parente RA, Szoka FC, Nadasdi L, Pongracz K
• Effect of size and lipid composition on the pharmacokinetics of intravitreal liposomes.
  Investigative ophthalmology & visual science 1987 Barza M, Stuart M, Szoka F
• Destabilization of phosphatidylethanolamine-containing liposomes: hexagonal phase and asymmetric membranes.
  Biochemistry 1987 Bentz J, Ellens H, Szoka FC
• Modulation of the biological activity of bacterial endotoxin by incorporation into liposomes.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Dijkstra J, Mellors JW, Ryan JL, Szoka FC
• Effect of lipid composition and liposome size on toxicity and in vitro fungicidal activity of liposome-intercalated amphotericin B.
  Antimicrobial agents and chemotherapy 1987 Szoka FC, Milholland D, Barza M
• Uptake of liposome-encapsulated agents.
  Methods in enzymology 1987 Szoka FC, Jones CS
• Fusion of phosphatidylethanolamine-containing liposomes and mechanism of the L alpha-HII phase transition.
  Biochemistry 1986 Ellens H, Bentz J, Szoka FC
• Destabilization of phosphatidylethanolamine liposomes at the hexagonal phase transition temperature.
  Biochemistry 1986 Ellens H, Bentz J, Szoka FC
• On the correlation between HII phase and the contact-induced destabilization of phosphatidylethanolamine-containing membranes.
  Proceedings of the National Academy of Sciences of the United States of America 1985 Bentz J, Ellens H, Lai MZ, Szoka FC
• Ocular toxicity of intravitreally injected liposomal amphotericin B in rhesus monkeys.
  American journal of ophthalmology 1985 Barza M, Baum J, Tremblay C, Szoka F, D'Amico DJ
• H+- and Ca2+-induced fusion and destabilization of liposomes.
  Biochemistry 1985 Ellens H, Bentz J, Szoka FC
• Reduced toxicity of liposome-associated amphotericin B injected intravitreally in rabbits.
  Investigative ophthalmology & visual science 1985 Tremblay C, Barza M, Szoka F, Lahav M, Baum J
• Acid- and calcium-induced structural changes in phosphatidylethanolamine membranes stabilized by cholesteryl hemisuccinate.
  Biochemistry 1985 Lai MZ, Vail WJ, Szoka FC
• Effects of replacement of the hydroxyl group of cholesterol and tocopherol on the thermotropic behavior of phospholipid membranes.
  Biochemistry 1985 Lai MZ, Düzgünes N, Szoka FC
• Efficacy of liposome-intercalated amphotericin B in the treatment of systemic candidiasis in mice.
  Antimicrobial agents and chemotherapy 1984 Tremblay C, Barza M, Fiore C, Szoka F
• Treatment of experimental cutaneous leishmaniasis with liposome-intercalated amphotericin B.
  Antimicrobial agents and chemotherapy 1984 Panosian CB, Barza M, Szoka F, Wyler DJ
• Pharmacokinetics of subconjunctival liposome-encapsulated gentamicin in normal rabbit eyes.
  Investigative ophthalmology & visual science 1984 Barza M, Baum J, Szoka F
• pH-induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact.
  Biochemistry 1984 Ellens H, Bentz J, Szoka FC
• Alteration of liposome disposition in vivo by bilayer situated carbohydrates.
  Biochemical and biophysical research communications 1983 Szoka FC, Mayhew E
• The use of a new radioactive-iodine labeled lipid marker to follow in vivo disposition of liposomes: comparison with an encapsulated aqueous space marker.
  Research communications in chemical pathology and pharmacology 1982 Abra RM, Schreier H, Szoka FC
• Lectins as a probe for carbohydrate residues in non-neoplastic urothelium of human urinary bladder.
  The Journal of urology 1982 Alroy J, Szoka FC, Heaney JA, Ucci AA
• Characterization, toxicity and therapeutic efficacy of adriamycin encapsulated in liposomes.
  European journal of cancer & clinical oncology 1982 Olson F, Mayhew E, Maslow D, Rustum Y, Szoka F
• Sedimentation field flow fractionation of liposomes.
  Science (New York, N.Y.) 1982 Kirkland JJ, Yau WW, Szoka FC
• Inability of liposome encapsulated 1-beta-D-arabinofuranosylcytosine nucleotides to overcome drug resistance in L1210 cells.
  European journal of cancer & clinical oncology 1981 Rustum YM, Mayhew E, Szoka F, Campbell J
• Use of lectins and polyethylene glycol for fusion of glycolipid-containing liposomes with eukaryotic cells.
  Proceedings of the National Academy of Sciences of the United States of America 1981 Szoka F, Magnusson KE, Wojcieszyn J, Hou Y, Derzko Z, Jacobson K
• Preparation of unilamellar liposomes of intermediate size (0.1-0.2 mumol) by a combination of reverse phase evaporation and extrusion through polycarbonate membranes.
  Biochimica et biophysica acta 1980 Szoka F, Olson F, Heath T, Vail W, Mayhew E, Papahadjopoulos D
• Fluorescence studies on the mechanism of liposome-cell interactions in vitro.
  Biochimica et biophysica acta 1980 Szoka F, Jacobson K, Derzko Z, Papahadjopoulos D
• Comparative properties and methods of preparation of lipid vesicles (liposomes).
  Annual review of biophysics and bioengineering 1980 Szoka F, Papahadjopoulos D
• Photoaffinity labeling of three renal cyclic 3',5'-adenosine monophosphate-binding proteins.
  Biochimica et biophysica acta 1979 Near JA, Szoka FC, Olsen R, Ettinger MJ
• Role of cholesterol in enhancing the antitumor activity of cytosine arabinoside entrapped in liposomes.
  Cancer treatment reports 1979 Mayhew E, Rustum YM, Szoka F, Papahadjopoulos D
• Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes.
  Biochimica et biophysica acta 1979 Olson F, Hunt CA, Szoka FC, Vail WJ, Papahadjopoulos D
• A model for the study of the oral administration of peptide hormones.
  Canadian journal of biochemistry 1979 Saffran M, Franco-Saenz R, Kong A, Papahadjopoulos D, Szoka F
• The use of aqueous space markers to determine the mechanism of interaction between phospholipid vesicles and cells.
  Biochimica et biophysica acta 1979 Szoka FC, Jacobson K, Papahadjopoulos D
• Lateral diffusion of a hydrophobic peptide, N-4-nitrobenz-2-oxa-1,3-diazole gramicidin S, in phospholipid multibilayers.
  Biochemistry 1978 Wu ES, Jacobson K, Szoka F, Portis A
• Adenosine 3' :5' -monophosphate-dependnet phosphorylations of renal subcellular fractions. Differences between cortical and medullary membrane preparations.
  The Journal of biological chemistry 1978 Szoka FC, Ettinger MJ
• Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.
  Proceedings of the National Academy of Sciences of the United States of America 1978 Szoka F, Papahadjopoulos D