Frances Brodsky, PhD
Professor Emeritus
Bioengineering
School of Pharmacy

Malfunction of clathrin pathways is associated with development of cancer, heart disease and neuronal defects. Clathrin-mediated pathways are also subverted by certain viruses and intracellular bacteria to facilitate their infection. A novel isoform of clathrin (CHC22) that is primarily expressed in skeletal muscle, cardiac muscle and fat has been recently characterized by the Brodsky laboratory. Its tissue-specific function is to package the GLUT4 glucose transporter into intracellular vesicles that are released in response to insulin stimulation, leading to clearance of glucose from the bloodstream. This CHC22 clathrin isoform is therefore associated with pathways that are defective in type 2 diabetes. The focus of the Brodsky laboratory since 1982 has been to define the biochemistry, regulation, evolution and physiological function of the clathrin subunits and their isoforms, focusing on their role in disease states, as well as in normal cellular physiology. The laboratory has made significant contributions in these areas over the years and maintains an international reputation for expertise on clathrin structure and function. There are four current projects in the laboratory. These projects aim to define the comparative functions of the two clathrin heavy chain (CHC) isoforms (CHC17 and CHC22) and the two clathrin light chain isoforms (LCa and LCb). The regulation of CHC17 clathrin function by signaling pathways and the cooperation of CHC17 clathrin with the actin cytoskeleton through clathrin light chain interaction with the actin-binding Hip proteins is being investigated in the context of cell adhesion and migration. Establishing the mechanistic role of CHC22 clathrin in GLUT4 transport and pathways that malfunction in type 2 diabetes is also a major goal for the laboratory.

• A new direction for Traffic.
  Traffic (Copenhagen, Denmark) 2020 Marks MS, Parton RG, Schroer TA, Tooze SA, Brodsky FM, Marsh M, Schmid SL, Griffiths GM, Stevens TH, van Meer G
• Ernst Joachim Ungewickell: 1950-2020.
  The Journal of cell biology 2020 Traub LM, Brodsky FM
• Clathrin light chain diversity regulates membrane deformation in vitro and synaptic vesicle formation in vivo.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Redlingshöfer L, McLeod F, Chen Y, Camus MD, Burden JJ, Palomer E, Briant K, Dannhauser PN, Salinas PC, Brodsky FM
• Clathrin's life beyond 40: Connecting biochemistry with physiology and disease.
  Current opinion in cell biology 2020 Briant K, Redlingshöfer L, Brodsky FM
• Editorial overview: Membrane traffic in the time of COVID-19.
  Current opinion in cell biology 2020 Brodsky FM, Stow JL
• Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch.
  Trends in cell biology 2020 Gould GW, Brodsky FM, Bryant NJ
• Lipid Metabolism Links Nutrient-Exercise Timing to Insulin Sensitivity in Men Classified as Overweight or Obese.
  The Journal of clinical endocrinology and metabolism 2020 Edinburgh RM, Bradley HE, Abdullah NF, Robinson SL, Chrzanowski-Smith OJ, Walhin JP, Joanisse S, Manolopoulos KN, Philp A, Hengist A, Chabowski A, Brodsky FM, Koumanov F, Betts JA, Thompson D, Wallis …
• CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis.
  The Journal of cell biology 2020 Camus SM, Camus MD, Figueras-Novoa C, Boncompain G, Sadacca LA, Esk C, Bigot A, Gould GW, Kioumourtzoglou D, Perez F, Bryant NJ, Mukherjee S, Brodsky FM
• Twenty years of Traffic.
  Traffic (Copenhagen, Denmark) 2020 Marks MS, Tooze SA, Brodsky FM, Marsh M, Parton RG, Schroer TA
• Looking back to traffic forward: A tribute to Thomas Kreis (1952-1998) and his inspiration.
  Traffic (Copenhagen, Denmark) 2019 Brodsky FM, Perez F
• Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension.
  Nature communications 2019 Biancospino M, Buel GR, Niño CA, Maspero E, Scotto di Perrotolo R, Raimondi A, Redlingshöfer L, Weber J, Brodsky FM, Walters KJ, Polo S
• The AP2 adaptor enhances clathrin coat stiffness.
  The FEBS journal 2019 Lherbette M, Redlingshöfer L, Brodsky FM, Schaap IAT, Dannhauser PN
• Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism.
  eLife 2019 Fumagalli M, Camus SM, Diekmann Y, Burke A, Camus MD, Norman PJ, Joseph A, Abi-Rached L, Benazzo A, Rasteiro R, Mathieson I, Topf M, Parham P, Thomas MG, Brodsky FM
• CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.
  The Journal of biological chemistry 2017 Dannhauser PN, Camus SM, Sakamoto K, Sadacca LA, Torres JA, Camus MD, Briant K, Vassilopoulos S, Rothnie A, Smith CJ, Brodsky FM
• Clathrin light chains' role in selective endocytosis influences antibody isotype switching.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Wu S, Majeed SR, Evans TM, Camus MD, Wong NM, Schollmeier Y, Park M, Muppidi JR, Reboldi A, Parham P, Cyster JG, Brodsky FM
• A Distinctive Cytoplasmic Tail Contributes to Low Surface Expression and Intracellular Retention of the Patr-AL MHC Class I Molecule.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Goyos A, Guethlein LA, Horowitz A, Hilton HG, Gleimer M, Brodsky FM, Parham P
• Unconventional functions for clathrin, ESCRTs, and other endocytic regulators in the cytoskeleton, cell cycle, nucleus, and beyond: links to human disease.
  Cold Spring Harbor perspectives in biology 2014 Brodsky FM, Sosa RT, Ybe JA, O'Halloran TJ
• Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration.
  Nature communications 2014 Majeed SR, Vasudevan L, Chen CY, Luo Y, Torres JA, Evans TM, Sharkey A, Foraker AB, Wong NM, Esk C, Freeman TA, Moffett A, Keen JH, Brodsky FM
• Actin scaffolding by clathrin heavy chain is required for skeletal muscle sarcomere organization.
  The Journal of cell biology 2014 Vassilopoulos S, Gentil C, Lainé J, Buclez PO, Franck A, Ferry A, Précigout G, Roth R, Heuser JE, Brodsky FM, Garcia L, Bonne G, Voit T, Piétri-Rouxel F, Bitoun M
• The adaptor protein GULP promotes Jedi-1-mediated phagocytosis through a clathrin-dependent mechanism.
  Molecular biology of the cell 2014 Sullivan CS, Scheib JL, Ma Z, Dang RP, Schafer JM, Hickman FE, Brodsky FM, Ravichandran KS, Carter BD
• Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway.
  Developmental cell 2013 Asensio CS, Sirkis DW, Maas JW, Egami K, To TL, Brodsky FM, Shu X, Cheng Y, Edwards RH
• The CHC22 clathrin-GLUT4 transport pathway contributes to skeletal muscle regeneration.
  PloS one 2013 Hoshino S, Sakamoto K, Vassilopoulos S, Camus SM, Griffin CA, Esk C, Torres JA, Ohkoshi N, Ishii A, Tamaoka A, Funke BH, Kucherlapati R, Margeta M, Rando TA, Brodsky FM
• Frances Brodsky: so you think you know all about clathrin? Interview by Caitlin Sedwick.
  The Journal of cell biology 2013 Brodsky F
• A cost-benefit analysis of the physical mechanisms of membrane curvature.
  Nature cell biology 2013 Stachowiak JC, Brodsky FM, Miller EA
• Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Holmes BB, DeVos SL, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja MO, Brodsky FM, Marasa J, Bagchi DP, Kotzbauer PT, Miller TM, Papy-Garcia D, Diamond MI
• Hsc70-induced changes in clathrin-auxilin cage structure suggest a role for clathrin light chains in cage disassembly.
  Traffic (Copenhagen, Denmark) 2013 Young A, Stoilova-McPhie S, Rothnie A, Vallis Y, Harvey-Smith P, Ranson N, Kent H, Brodsky FM, Pearse BM, Roseman A, Smith CJ
• Anisotropic nanocrystal arrays organized on protein lattices formed by recombinant clathrin fragments.
  Journal of materials chemistry 2012 Hom N, Mehta KR, Chou T, Foraker AB, Brodsky FM, Kirshenbaum K, Montclare JK
• A common clathrin-mediated machinery co-ordinates cell-cell adhesion and bacterial internalization.
  Traffic (Copenhagen, Denmark) 2012 Bonazzi M, Kühbacher A, Toledo-Arana A, Mallet A, Vasudevan L, Pizarro-Cerdá J, Brodsky FM, Cossart P
• Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.
  The Journal of cell biology 2012 Foraker AB, Camus SM, Evans TM, Majeed SR, Chen CY, Taner SB, Corrêa IR, Doxsey SJ, Brodsky FM
• Diversity of clathrin function: new tricks for an old protein.
  Annual review of cell and developmental biology 2012 Brodsky FM
• Evolutionary cell biology: Lessons from diversity.
  Nature cell biology 2012 Brodsky FM, Thattai M, Mayor S
• Clathrin phosphorylation is required for actin recruitment at sites of bacterial adhesion and internalization.
  The Journal of cell biology 2011 Bonazzi M, Vasudevan L, Mallet A, Sachse M, Sartori A, Prevost MC, Roberts A, Taner SB, Wilbur JD, Brodsky FM, Cossart P
• The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice.
  Oncogene 2011 Stoddart A, Tennant TR, Fernald AA, Anastasi J, Brodsky FM, Le Beau MM
• Endocytosis regulates cell soma translocation and the distribution of adhesion proteins in migrating neurons.
  PloS one 2011 Shieh JC, Schaar BT, Srinivasan K, Brodsky FM, McConnell SK
• Interactions of NK cell receptor KIR3DL1*004 with chaperones and conformation-specific antibody reveal a functional folded state as well as predominant intracellular retention.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Taner SB, Pando MJ, Roberts A, Schellekens J, Marsh SG, Malmberg KJ, Parham P, Brodsky FM
• Conformation switching of clathrin light chain regulates clathrin lattice assembly.
  Developmental cell 2010 Wilbur JD, Hwang PK, Ybe JA, Lane M, Sellers BD, Jacobson MP, Fletterick RJ, Brodsky FM
• Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain.
  Acta crystallographica. Section D, Biological crystallography 2010 Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ
• The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.
  The Journal of cell biology 2010 Esk C, Chen CY, Johannes L, Brodsky FM
• [The CHC22 human clathrin heavy chain isoform, intracellular traffic of the glucose transporter GLUT4, and type 2 diabetes].
  Medecine sciences : M/S 2010 Vassilopoulos S, Esk C, Hoshino S, Brodsky FM
• Dimorphic motifs in D0 and D1+D2 domains of killer cell Ig-like receptor 3DL1 combine to form receptors with high, moderate, and no avidity for the complex of a peptide derived from HIV and HLA-A*2402.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Sharma D, Bastard K, Guethlein LA, Norman PJ, Yawata N, Yawata M, Pando M, Thananchai H, Dong T, Rowland-Jones S, Brodsky FM, Parham P
• A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.
  Science (New York, N.Y.) 2009 Vassilopoulos S, Esk C, Hoshino S, Funke BH, Chen CY, Plocik AM, Wright WE, Kucherlapati R, Brodsky FM
• Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain.
  The Journal of biological chemistry 2008 Wilbur JD, Chen CY, Manalo V, Hwang PK, Fletterick RJ, Brodsky FM
• Evolutionary analysis and molecular dissection of caveola biogenesis.
  Journal of cell science 2008 Kirkham M, Nixon SJ, Howes MT, Abi-Rached L, Wakeham DE, Hanzal-Bayer M, Ferguson C, Hill MM, Fernandez-Rojo M, Brown DA, Hancock JF, Brodsky FM, Parton RG
• Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission.
  Nature cell biology 2008 Sowinski S, Jolly C, Berninghausen O, Purbhoo MA, Chauveau A, Köhler K, Oddos S, Eissmann P, Brodsky FM, Hopkins C, Onfelt B, Sattentau Q, Davis DM
• Novel binding sites on clathrin and adaptors regulate distinct aspects of coat assembly.
  Traffic (Copenhagen, Denmark) 2006 Knuehl C, Chen CY, Manalo V, Hwang PK, Ota N, Brodsky FM
• TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis.
  The Journal of experimental medicine 2005 Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR
• Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Wakeham DE, Abi-Rached L, Towler MC, Wilbur JD, Parham P, Brodsky FM
• New faces of the familiar clathrin lattice.
  Traffic (Copenhagen, Denmark) 2005 Wilbur JD, Hwang PK, Brodsky FM
• Plasticity of B cell receptor internalization upon conditional depletion of clathrin.
  Molecular biology of the cell 2005 Stoddart A, Jackson AP, Brodsky FM
• Cell biology: clathrin's Achilles' ankle.
  Nature 2004 Brodsky FM
• Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo.
  The Journal of biological chemistry 2004 Chen CY, Brodsky FM
• The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Niiro H, Allam A, Stoddart A, Brodsky FM, Marshall AJ, Clark EA
• Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.
  Molecular biology of the cell 2004 Towler MC, Gleeson PA, Hoshino S, Rahkila P, Manalo V, Ohkoshi N, Ordahl C, Parton RG, Brodsky FM
• T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization.
  The Journal of experimental medicine 2004 Crotzer VL, Mabardy AS, Weiss A, Brodsky FM
• Membrane traffic in skeletal muscle.
  Traffic (Copenhagen, Denmark) 2004 Towler MC, Kaufman SJ, Brodsky FM
• Clathrin self-assembly involves coordinated weak interactions favorable for cellular regulation.
  The EMBO journal 2003 Wakeham DE, Chen CY, Greene B, Hwang PK, Brodsky FM
• The long and short of adaptor appendages.
  Nature structural biology 2003 Knuehl C, Brodsky FM
• Clathrin light and heavy chain interface: alpha-helix binding superhelix loops via critical tryptophans.
  The EMBO journal 2002 Chen CY, Reese ML, Hwang PK, Ota N, Agard D, Brodsky FM
• Lipid rafts unite signaling cascades with clathrin to regulate BCR internalization.
  Immunity 2002 Stoddart A, Dykstra ML, Brown BK, Song W, Pierce SK, Brodsky FM
• Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Yang D, Buchholz F, Huang Z, Goga A, Chen CY, Brodsky FM, Bishop JM
• Clathrin hub expression dissociates the actin-binding protein Hip1R from coated pits and disrupts their alignment with the actin cytoskeleton.
  Traffic (Copenhagen, Denmark) 2001 Bennett EM, Chen CY, Engqvist-Goldstein AE, Drubin DG, Brodsky FM
• Clathrin hub expression affects early endosome distribution with minimal impact on receptor sorting and recycling.
  Molecular biology of the cell 2001 Bennett EM, Lin SX, Towler MC, Maxfield FR, Brodsky FM
• Role of clathrin in the regulated secretory pathway of pancreatic beta-cells.
  Journal of cell science 2001 Molinete M, Dupuis S, Brodsky FM, Halban PA
• A novel clathrin homolog that co-distributes with cytoskeletal components functions in the trans-Golgi network.
  The EMBO journal 2001 Liu SH, Towler MC, Chen E, Chen CY, Song W, Apodaca G, Brodsky FM
• Biological basket weaving: formation and function of clathrin-coated vesicles.
  Annual review of cell and developmental biology 2001 Brodsky FM, Chen CY, Knuehl C, Towler MC, Wakeham DE
• NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2000 Beattie EC, Howe CL, Wilde A, Brodsky FM, Mobley WC
• Molecular structures of proteins involved in vesicle fusion.
  Traffic (Copenhagen, Denmark) 2000 Ybe JA, Wakeham DE, Brodsky FM, Hwang PK
• Molecular structures of proteins involved in vesicle coat formation.
  Traffic (Copenhagen, Denmark) 2000 Wakeham DE, Ybe JA, Brodsky FM, Hwang PK
• Transport of proteins and membrane in eukaryotic cells (Göttingen, September 29-October 1, 1999).
  Traffic (Copenhagen, Denmark) 2000 Jahn R, Brodsky FM
• Complete reconstitution of clathrin basket formation with recombinant protein fragments: adaptor control of clathrin self-assembly.
  Traffic (Copenhagen, Denmark) 2000 Greene B, Liu SH, Wilde A, Brodsky FM
• ADP-ribosylation factor 6 and endocytosis at the apical surface of Madin-Darby canine kidney cells.
  The Journal of cell biology 1999 Altschuler Y, Liu S, Katz L, Tang K, Hardy S, Brodsky F, Apodaca G, Mostov K
• Clathrin self-assembly is mediated by a tandemly repeated superhelix.
  Nature 1999 Ybe JA, Brodsky FM, Hofmann K, Lin K, Liu SH, Chen L, Earnest TN, Fletterick RJ, Hwang PK
• Cutting edge: adenovirus E19 has two mechanisms for affecting class I MHC expression.
  Journal of immunology (Baltimore, Md. : 1950) 1999 Bennett EM, Bennink JR, Yewdell JW, Brodsky FM
• Human pathogen subversion of antigen presentation.
  Immunological reviews 1999 Brodsky FM, Lem L, Solache A, Bennett EM
• Stealth, sabotage and exploitation.
  Immunological reviews 1999 Brodsky FM
• EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake.
  Cell 1999 Wilde A, Beattie EC, Lem L, Riethof DA, Liu SH, Mobley WC, Soriano P, Brodsky FM
• Enhanced interaction of HLA-DM with HLA-DR in enlarged vacuoles of hereditary and infectious lysosomal diseases.
  Journal of immunology (Baltimore, Md. : 1950) 1999 Lem L, Riethof DA, Scidmore-Carlson M, Griffiths GM, Hackstadt T, Brodsky FM
• Clathrin self-assembly is regulated by three light-chain residues controlling the formation of critical salt bridges.
  The EMBO journal 1998 Ybe JA, Greene B, Liu SH, Pley U, Parham P, Brodsky FM
• Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4.
  Immunity 1998 Lu X, Yu H, Liu SH, Brodsky FM, Peterlin BM
• A novel AP180-related protein in vesicles that concentrate at acetylcholine receptor clusters.
  Journal of cellular biochemistry 1998 Bursztajn S, Vincent S, Brodsky FM, Benes F, Morris SA
• A dominant-negative clathrin mutant differentially affects trafficking of molecules with distinct sorting motifs in the class II major histocompatibility complex (MHC) pathway.
  The Journal of cell biology 1998 Liu SH, Marks MS, Brodsky FM
• Localization of class I histocompatibility molecule assembly by subfractionation of the early secretory pathway.
  Human immunology 1997 Bresnahan PA, Barber LD, Brodsky FM
• A membrane-associated protein complex with selective binding to the clathrin coat adaptor AP1.
  Journal of cell science 1996 Mallet WG, Brodsky FM
• In vivo phosphorylation of adaptors regulates their interaction with clathrin.
  The Journal of cell biology 1996 Wilde A, Brodsky FM
• Antigen processing and presentation.
  Tissue antigens 1996 Brodsky FM, Lem L, Bresnahan PA
• Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs.
  Cell 1995 Liu SH, Wong ML, Craik CS, Brodsky FM
• The interaction of calmodulin with clathrin-coated vesicles, triskelions, and light chains. Localization of a binding site.
  The Journal of biological chemistry 1995 Pley UM, Hill BL, Alibert C, Brodsky FM, Parham P
• Alteration of clathrin light chain expression by transfection and gene disruption.
  Molecular biology of the cell 1993 Acton SL, Wong DH, Parham P, Brodsky FM, Jackson AP
• Adaptor self-aggregation, adaptor-receptor recognition and binding of alpha-adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin-coated pits.
  The EMBO journal 1993 Chang MP, Mallet WG, Mostov KE, Brodsky FM
• Clathrin assembly protein AP-2 induces aggregation of membrane vesicles: a possible role for AP-2 in endosome formation.
  The Journal of cell biology 1992 Beck KA, Chang M, Brodsky FM, Keen JH
• Lysosomal acid phosphatase is internalized via clathrin-coated pits.
  European journal of cell biology 1992 Hille A, Klumperman J, Geuze HJ, Peters C, Brodsky FM, von Figura K
• 100-kD proteins of Golgi- and trans-Golgi network-associated coated vesicles have related but distinct membrane binding properties.
  The Journal of cell biology 1992 Wong DH, Brodsky FM
• Antigen processing and presentation: close encounters in the endocytic pathway.
  Trends in cell biology 1992 Brodsky FM
• Folding and trimerization of clathrin subunits at the triskelion hub.
  Cell 1992 Näthke IS, Heuser J, Lupas A, Stock J, Turck CW, Brodsky FM
• Clathrin light chains: arrays of protein motifs that regulate coated-vesicle dynamics.
  Trends in biochemical sciences 1991 Brodsky FM, Hill BL, Acton SL, Näthke I, Wong DH, Ponnambalam S, Parham P
• Cellular and subcellular distribution of PBP72/74, a peptide-binding protein that plays a role in antigen processing.
  Journal of immunology (Baltimore, Md. : 1950) 1991 VanBuskirk AM, DeNagel DC, Guagliardi LE, Brodsky FM, Pierce SK
• Immunology. The invariant dating service.
  Nature 1990 Brodsky FM
• The calcium-binding site of clathrin light chains.
  The Journal of biological chemistry 1990 Näthke I, Hill BL, Parham P, Brodsky FM
• Predominance of clathrin light chain LCb correlates with the presence of a regulated secretory pathway.
  The Journal of cell biology 1990 Acton SL, Brodsky FM
• Clathrin-coated pits contain an integral membrane protein that binds the AP-2 subunit with high affinity.
  The Journal of biological chemistry 1990 Mahaffey DT, Peeler JS, Brodsky FM, Anderson RG
• Neuron-specific expression of high-molecular-weight clathrin light chain.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1990 Wong DH, Ignatius MJ, Parosky G, Parham P, Trojanowski JQ, Brodsky FM
• Antibodies to clathrin inhibit endocytosis but not recycling to the trans Golgi network in vitro.
  Science (New York, N.Y.) 1990 Draper RK, Goda Y, Brodsky FM, Pfeffer SR
• Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment.
  Nature 1990 Guagliardi LE, Koppelman B, Blum JS, Marks MS, Cresswell P, Brodsky FM
• 100-kDa polypeptides in peripheral clathrin-coated vesicles are required for receptor-mediated endocytosis.
  Proceedings of the National Academy of Sciences of the United States of America 1989 Chin DJ, Straubinger RM, Acton S, Näthke I, Brodsky FM
• Physical association between MHC class I and class II molecules detected on the cell surface by flow cytometric energy transfer.
  Journal of immunology (Baltimore, Md. : 1950) 1989 Szöllösi J, Damjanovich S, Balàzs M, Nagy P, Trón L, Fulwyler MJ, Brodsky FM
• Coat proteins isolated from clathrin coated vesicles can assemble into coated pits.
  The Journal of cell biology 1989 Mahaffey DT, Moore MS, Brodsky FM, Anderson RG
• The occurrence of disulphide bonds in purified clathrin light chains.
  The Biochemical journal 1989 Parham P, Brodsky FM, Drickamer K
• Intracellular colocalization of molecules involved in antigen processing and presentation by B cells.
  Cold Spring Harbor symposia on quantitative biology 1989 Brodsky FM, Koppelman B, Blum JS, Marks MS, Cresswell P, Guagliardi L
• Living with clathrin: its role in intracellular membrane traffic.
  Science (New York, N.Y.) 1988 Brodsky FM
• Identification of the phosphorylation sites of clathrin light chain LCb.
  The Journal of biological chemistry 1988 Hill BL, Drickamer K, Brodsky FM, Parham P
• Analysis of coated vesicle structure and function using anti-clathrin monoclonal antibodies.
  Progress in clinical and biological research 1988 Brodsky FM
• Clathrin assembly involves a light chain-binding region.
  The Journal of cell biology 1987 Blank GS, Brodsky FM
• Inhibition of endocytosis by anti-clathrin antibodies.
  Cell 1987 Doxsey SJ, Brodsky FM, Blank GS, Helenius A
• Assembly of clathrin-coated pits onto purified plasma membranes.
  Science (New York, N.Y.) 1987 Moore MS, Mahaffey DT, Brodsky FM, Anderson RG
• Identification and characterization of two novel lymphocyte function-associated antigens, L24 and L25.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Clayberger C, Krensky AM, McIntyre BW, Koller TD, Parham P, Brodsky F, Linn DJ, Evans EL
• Localization of clathrin light-chain sequences mediating heavy-chain binding and coated vesicle diversity.
  Nature 1987 Brodsky FM, Galloway CJ, Blank GS, Jackson AP, Seow HF, Drickamer K, Parham P
• Site-specific disruption of clathrin assembly produces novel structures.
  The EMBO journal 1986 Blank GS, Brodsky FM
• Clathrin structure characterized with monoclonal antibodies. I. Analysis of multiple antigenic sites.
  The Journal of cell biology 1985 Brodsky FM
• Clathrin structure characterized with monoclonal antibodies. II. Identification of in vivo forms of clathrin.
  The Journal of cell biology 1985 Brodsky FM
• Comparison of the primary structures of clathrin light chains from bovine brain and adrenal gland by peptide mapping.
  The EMBO journal 1984 Holmes N, Biermann JS, Brodsky FM, Bharucha D, Parham P
• Polymorphism in clathrin light chains from different tissues.
  Journal of molecular biology 1983 Brodsky FM, Parham P
• Location and distribution of the light chains in clathrin trimers.
  Proceedings of the National Academy of Sciences of the United States of America 1983 Kirchhausen T, Harrison SC, Parham P, Brodsky FM
• Tropomyosin-like properties of clathrin light chains allow a rapid, high-yield purification.
  The Journal of cell biology 1983 Brodsky FM, Holmes NJ, Parham P
• Monoclonal antibodies: purification, fragmentation and application to structural and functional studies of class I MHC antigens.
  Journal of immunological methods 1982 Parham P, Androlewicz MJ, Brodsky FM, Holmes NJ, Ways JP
• Evolution of HLA antigenic determinants: species cross-reactions of monoclonal antibodies.
  Immunogenetics 1982 Brodsky FM, Parham P
• Monomorphic anti-HLA-A,B,C monoclonal antibodies detecting molecular subunits and combinatorial determinants.
  Journal of immunology (Baltimore, Md. : 1950) 1982 Brodsky FM, Parham P
• Partial purification and some properties of BB7.2. A cytotoxic monoclonal antibody with specificity for HLA-A2 and a variant of HLA-A28.
  Human immunology 1981 Parham P, Brodsky FM
• Of cows and men: a comparative study of histocompatibility antigens.
  Human immunology 1981 Brodsky FM, Stone WH, Parham P
• A monoclonal antibody that recognizes an antigenic determinant shared by HLA A2 and B17.
  Human immunology 1980 McMichael AJ, Parham P, Rust N, Brodsky F
• Influenza virus-specific cytotoxic T lymphocytes recognize HLA-molecules. Blocking by monoclonal anti-HLA antibodies.
  The Journal of experimental medicine 1980 McMichael AJ, Parham P, Brodsky FM, Pilch JR
• Monoclonal antibodies to HLA--DRw determinants.
  Tissue antigens 1980 Brodsky FM, Parham P, Bodmer WF
• Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens.
  European journal of immunology 1979 Brodsky FM, Bodmer WF, Parham P
• Anti-HLA-A,B,C monoclonal antibodies with no alloantigenic specificity in humans define polymorphisms in other primate species.
  Nature 1979 Parham P, Sehgal PK, Brodsky FM
• Monoclonal antibodies for analysis of the HLA system.
  Immunological reviews 1979 Brodsky FM, Parham P, Barnstable CJ, Crumpton MJ, Bodmer WF