Finn Wolfreys, PhD
Assistant Researcher
Ophthalmology
School of Medicine

Publications (11)

Top publication keywords:
Multidrug Resistance-Associated ProteinsMutation, MissenseCorneal InjuriesGenetic PleiotropyImmune ToleranceAntiphospholipid SyndromeBurns, ChemicalPrimatesCorneal Dystrophies, HereditaryB-LymphocytesEndothelium, Cornealgamma-GlutamyltransferaseFuchs' Endothelial DystrophyReceptors, Purinergic P2YGlutathione

• Phenotypic pleiotropy of missense variants in human B cell confinement receptor P2RY8.
  Cell genomics 2025 LaFlam TN, Billesbølle CB, Dinh T, Wolfreys FD, Lu E, Matteson T, An J, Xu Y, Singhal A, Brandes N, Ntranos V, Manglik A, Cyster JG, Ye CJ
• Phenotypic pleiotropy of missense variants in human B cell-confinement receptor P2RY8.
  bioRxiv : the preprint server for biology 2025 LaFlam TN, Billesbølle CB, Dinh T, Wolfreys FD, Lu E, Matteson T, An J, Xu Y, Singhal A, Brandes N, Ntranos V, Manglik A, Cyster JG, Ye CJ
• Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates.
  Nature communications 2024 Yee SW, Ferrández-Peral L, Alentorn-Moron P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Wolfreys FD, Yang J, Gestwicki…
• Novel Mechanisms Guide Innovative Molecular-Based Therapeutic Strategies for Fuchs Endothelial Corneal Dystrophy.
  Cornea 2023 Chan MF, Pan P, Wolfreys FD
• Characterization of Recruited Mononuclear Phagocytes following Corneal Chemical Injury.
  International journal of molecular sciences 2022 Lamy R, Wolf M, Bispo C, Clay SM, Zheng S, Wolfreys F, Pan P, Chan MF

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• P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
  The Journal of experimental medicine 2021 He Y, Gallman AE, Xie C, Shen Q, Ma J, Wolfreys FD, Sandy M, Arsov T, Wu X, Qin Y, Zhang P, Jiang S, Stanley M, Wu P, Tan J, Ding H, Xue H, Chen W, Xu J, Criswell LA, Nititham J, Adamski M, Kitching …
• Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione.
  Science immunology 2021 Gallman AE, Wolfreys FD, Nguyen DN, Sandy M, Xu Y, An J, Li Z, Marson A, Lu E, Cyster JG
• S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8.
  Nature 2019 Lu E, Wolfreys FD, Muppidi JR, Xu Y, Cyster JG
• Halogenaromatische p-Wechselwirkungen modulieren die Verweilzeit von Inhibitoren.
  Angewandte Chemie 2018 Christina Heroven, Victoria Georgi, Gaurav K. Ganotra, Paul Brennan, Finn Wolfreys, Rebecca C. Wade, Amaury E. Fernández-Montalván, Apirat Chaikuad, Stefan Knapp
• Halogen-Aromatic π Interactions Modulate Inhibitor Residence Times.
  Angewandte Chemie (International ed. in English) 2018 Heroven C, Georgi V, Ganotra GK, Brennan P, Wolfreys F, Wade RC, Fernández-Montalván AE, Chaikuad A, Knapp S
• Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.
  ACS chemical biology 2016 Mathea S, Abdul Azeez KR, Salah E, Tallant C, Wolfreys F, Konietzny R, Fischer R, Lou HJ, Brennan PE, Schnapp G, Pautsch A, Kessler BM, Turk BE, Knapp S