Feroz Papa, MD, PhD
Professor
Medicine
School of Medicine

Education & Training

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• Postdoctoral fellowship Biochemistry University of California, San Francisco
• Clinical fellowship Endocrinology University of California, San Francisco
• Residency Internal medicine University of California, San Francisco
• PhD Biochemistry and Molecular Biology University of Chicago
• MD Medicine University of Chicago

Websites

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• Papa Lab at UCSF (papalab.ucsf.edu)
• Profile at endocrine.medicine.ucsf.edu (endocrine.medicine.ucsf.edu)

Grants and Projects

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• Modulating intrinsic beta cell stress to block diabetes pathogenesis, NIH, 2021-2025
• Partial Antagonists of IRE1 RNase—‘PAIR’s—to treat Type 1 Diabetes, NIH, 2019-2023
• Developing UPR inhibitory KIRAs into oral antidiabetic beta cell-sparing drugs, NIH, 2014-2023
• Role of the Unfolded Protein Response in Photoreceptor Degeneration, NIH, 2018-2023
• Interventional Targeting of the IRE1alpha-TGFbeta signaling loop in pulmonary fibrosis, NIH, 2019-2022
• Interrogation of the Roles of Tyrosine Kinases in the Unfolded Protein Response, NIH, 2018-2021
• Cytoprotection of Beta Cells Through Modulation of Ire1Alpha Function, NIH, 2008-2019
• Attenuating ER and oxidative stress signaling to reduce cell degeneration in vivo, NIH, 2013-2018
• Targeting epithelial cells to treat pulmonary fibrosis, NIH, 2012-2018
• Expanding beta-cell mass, NIH, 2010-2015
• New Tools to Measure and Correct Endoplasmic Reticulum Stress in Single Living, NIH, 2007-2012
• HTS to discover drugs effecting protein folding in the endoplasmic reticulum, NIH, 2008-2010
• Role of the Unfolded Protein Response in Type 2 Diabetes, NIH, 2004-2009

Publications (54)

Top publication keywords:
Insulin-Secreting CellsProto-Oncogene Proteins c-ablEndoribonucleasesApoptosisProtein Kinase InhibitorsAlveolar Epithelial CellsCytosolUnfolded Protein ResponseeIF-2 KinaseEndoplasmic ReticulumEndoplasmic Reticulum StressDiabetes MellitusIdiopathic Pulmonary FibrosisProtein FoldingMitochondrial Proton-Translocating ATPases

• BCL-2 Modulates IRE1α Activation to Attenuate Endoplasmic Reticulum Stress and Pulmonary Fibrosis.
  American journal of respiratory cell and molecular biology 2024 Le Saux CJ, Ho TC, Brumwell AM, Kathiriya JJ, Wei Y, Hughes JB, Garakani K, Atabai K, Auyeung VC, Papa FR, Chapman HA
• Deletion of the Unfolded Protein Response Transducer IRE1α Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration.
  Investigative ophthalmology & visual science 2023 Massoudi D, Gorman S, Kuo YM, Iwawaki T, Oakes SA, Papa FR, Gould DB
• IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis.
  American journal of physiology. Lung cellular and molecular physiology 2022 Auyeung VC, Downey MS, Thamsen M, Wenger TA, Backes BJ, Sheppard D, Papa FR
• ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR.
  Nature chemical biology 2021 Feldman HC, Ghosh R, Auyeung VC, Mueller JL, Kim JH, Potter ZE, Vidadala VN, Perera BGK, Olivier A, Backes BJ, Zikherman J, Papa FR, Maly DJ
• Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib.
  International journal of molecular sciences 2020 Yamashita Y, Morita S, Hosoi H, Kobata H, Kishimoto S, Ishibashi T, Mishima H, Kinoshita A, Backes BJ, Yoshiura KI, Papa FR, Sonoki T, Tamura S

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• Nicotinic acetylcholine receptor signaling regulates inositol-requiring enzyme 1α activation to protect β-cells against terminal unfolded protein response under irremediable endoplasmic reticulum stress.
  Journal of diabetes investigation 2020 Ishibashi T, Morita S, Kishimoto S, Uraki S, Takeshima K, Furukawa Y, Inaba H, Ariyasu H, Iwakura H, Furuta H, Nishi M, Papa FR, Akamizu T
• Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival.
  Cancer research 2019 Moore PC, Qi JY, Thamsen M, Ghosh R, Peng J, Gliedt MJ, Meza-Acevedo R, Warren RE, Hiniker A, Kim GE, Maly DJ, Backes BJ, Papa FR, Oakes SA
• Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1.
  ACS chemical biology 2019 Feldman HC, Vidadala VN, Potter ZE, Papa FR, Backes BJ, Maly DJ
• Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes.
  Molecular metabolism 2019 Ghosh R, Colon-Negron K, Papa FR
• Small Molecules to Improve ER Proteostasis in Disease.
  Trends in pharmacological sciences 2019 Gonzalez-Teuber V, Albert-Gasco H, Auyeung VC, Papa FR, Mallucci GR, Hetz C
• Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Igbaria A, Merksamer PI, Trusina A, Tilahun F, Johnson JR, Brandman O, Krogan NJ, Weissman JS, Papa FR
• Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.
  PloS one 2019 Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR
• Pancreatic Neuroendocrine Tumors Require Homeostatic Signaling from the Unfolded Protein Response.
  The FASEB Journal 2018 Scott A. Oakes, Paul C. Moore, Jenny Y. Qi, Rachel Warren, Maike Thamsen, Rajarshi Ghosh, Micah J. Gliedt, Anne Hiniker, Grace E. Kim, Dustin J. Maly, Bradley J. Backes, Feroz R. Papa
• The Unfolded Protein Response and Cell Fate Control.
  Molecular cell 2017 Hetz C, Papa FR
• Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.
  Cell metabolism 2017 Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR
• Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.
  Cell metabolism 2017 Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR
• The Unfolded Protein Response Regulates Pancratic Neuroendocrine Tumor Growth.
  The FASEB Journal 2017 Scott A. Oakes, Jenny Y. Qi, Paul C Moore, Rachel A. Warren, Maike Thamsen, Rajarshi Ghosh, Micah J. Gliedt, Dustin J. Maly, Bradley J Backes, Feroz R. Papa
• All trans retinoic acid depresses the content and activity of the mitochondrial ATP synthase in human keratinocytes.
  Biochemical and biophysical research communications 2016 Papa F, Lippolis R, Sardaro N, Gnoni A, Scacco S
• Abstract 2862: The balance of divergent IRE1a signaling regulates pancreatic neuroendocrine tumor growth.
  Molecular and Cellular Biology, Genetics 2016 Jenny Y. Qi, Paul C. Moore, Maike Thamsen, Rajarshi Ghosh, Micah J. Gliedt, Dustin J. Maly, Bradley J. Backes, Feroz R. Papa, Scott A. Oakes
• Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands.
  ACS chemical biology 2016 Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa FR, Seeliger MA, Maly DJ
• Correction: X-Box Binding Protein 1 (XBP1s) Is a Critical Determinant of Pseudomonas aeruginosa Homoserine Lactone-Mediated Apoptosis.
  PLoS pathogens 2016 Valentine CD, Anderson MO, Papa FR, Haggie PM
• COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis.
  Nature genetics 2015 Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas …
• Druggable sensors of the unfolded protein response.
  Nature chemical biology 2014 Maly DJ, Papa FR
• The role of endoplasmic reticulum stress in human pathology.
  Annual review of pathology 2014 Oakes SA, Papa FR
• Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.
  Cell 2014 Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, …
• Feroz Papa: Saving cells from themselves.
  The Journal of cell biology 2014 Sedwick C, Papa F
• Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells.
  Laboratory investigation; a journal of technical methods and pathology 2013 Kanekura K, Ishigaki S, Merksamer PI, Papa FR, Urano F
• X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis.
  PLoS pathogens 2013 Valentine CD, Anderson MO, Papa FR, Haggie PM
• Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis.
  Respiratory research 2012 Cha SI, Ryerson CJ, Lee JS, Kukreja J, Barry SS, Jones KD, Elicker BM, Kim DS, Papa FR, Collard HR, Wolters PJ
• Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors.
  Nature chemical biology 2012 Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa FR, Maly DJ
• IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.
  Science (New York, N.Y.) 2012 Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA
• Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes.
  Cold Spring Harbor perspectives in medicine 2012 Papa FR
• IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
  Cell metabolism 2012 Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR
• IRE1-dependent activation of AMPK in response to nitric oxide.
  Molecular and cellular biology 2011 Meares GP, Hughes KJ, Naatz A, Papa FR, Urano F, Hansen PA, Benveniste EN, Corbett JA
• Signaling cell death from the endoplasmic reticulum stress response.
  Current opinion in cell biology 2010 Shore GC, Papa FR, Oakes SA
• The UPR and cell fate at a glance.
  Journal of cell science 2010 Merksamer PI, Papa FR
• Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1.
  The Journal of biological chemistry 2009 Lei X, Zhang S, Barbour SE, Bohrer A, Ford EL, Koizumi A, Papa FR, Ramanadham S
• IRE1a Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates.
  Journal of End-to-End-testing 2009 Dan Han, Alana G. Lerner, Lieselotte Vande Walle, John-Paul Upton, Weihong Xu, Andrew Hagen, Bradley J. Backes, Scott A. Oakes, Feroz R. Papa
• IRE1a Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates.
  Journal of End-to-End-testing 2009 Dan Han, Alana G. Lerner, Lieselotte Vande Walle, John-Paul Upton, Weihong Xu, Andrew Hagen, Bradley J. Backes, Scott A. Oakes, Feroz R. Papa
• IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.
  Cell 2009 Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR
• Rationalizing translation attenuation in the network architecture of the unfolded protein response.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Trusina A, Papa FR, Tang C
• Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions.
  Cell 2008 Merksamer PI, Trusina A, Papa FR
• Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress.
  Molecular and cellular biology 2008 Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa FR, Oakes SA
• Translation Attenuation Mechanism in Unfolded Protein Response.
  Evolution from Cellular to Social Scales 2008 Ala Trusina, Feroz Papa, Chao Tang
• A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress.
  Biochemical and biophysical research communications 2007 Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa FR
• Intracellular signaling by the unfolded protein response.
  Annual review of cell and developmental biology 2006 Bernales S, Papa FR, Walter P
• On the mechanism of sensing unfolded protein in the endoplasmic reticulum.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P
• Bypassing a kinase activity with an ATP-competitive drug.
  Science (New York, N.Y.) 2003 Papa FR, Zhang C, Shokat K, Walter P
• Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome.
  Molecular biology of the cell 1999 Papa FR, Amerik AY, Hochstrasser M
• An evolutionarily conserved gene on human chromosome 5q33-q34, UBH1, encodes a novel deubiquitinating enzyme.
  Genomics 1998 Hansen-Hagge TE, Janssen JW, Hameister H, Papa FR, Zechner U, Seriu T, Jauch A, Becke D, Hochstrasser M, Bartram CR
• DUB-1, a deubiquitinating enzyme with growth-suppressing activity.
  Proceedings of the National Academy of Sciences of the United States of America 1996 Zhu Y, Carroll M, Papa FR, Hochstrasser M, D'Andrea AD
• The yeast SEN3 gene encodes a regulatory subunit of the 26S proteasome complex required for ubiquitin-dependent protein degradation in vivo.
  Molecular and cellular biology 1995 DeMarini DJ, Papa FR, Swaminathan S, Ursic D, Rasmussen TP, Culbertson MR, Hochstrasser M
• The DOA pathway: studies on the functions and mechanisms of ubiquitin-dependent protein degradation in the yeast Saccharomyces cerevisiae.
  Cold Spring Harbor symposia on quantitative biology 1995 Hochstrasser M, Papa FR, Chen P, Swaminathan S, Johnson P, Stillman L, Amerik AY, Li SJ
• The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene.
  Nature 1993 Papa FR, Hochstrasser M