Fernaldo Richtia Winnerdy, PhD
Postdoctoral Scholar
Biochemistry and Biophysics
School of Medicine

Education & Training

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• PhD Biophysics Nanyang Technological University 02/2019
• BSc Physics National University of Singapore 05/2014

Publications (26)

Top publication keywords:
HIV IntegraseNucleotide MotifsBiofilmsMagnetic Resonance SpectroscopyDinucleoside PhosphatesG-QuadruplexesIonic LiquidsNucleic Acid ConformationProto-Oncogene Proteins c-pim-1GuanineBase PairingPseudomonas aeruginosaDNACircular DichroismNucleotides

• Interlocking G-Quadruplexes Using a G-Triad•G Connection: Implications for G-Wire Assembly.
  Journal of the American Chemical Society 2024 Singh A, Winnerdy FR, Avila CA, Nogues C, Phan AT, Heddi B
• Functional and Promiscuity Studies of Three-Residue Cyclophane Forming Enzymes Show Nonnative C-C Cross-Linked Products and Leader-Dependent Cyclization.
  ACS chemical biology 2024 Suarez AFL, Nguyen TQN, Chang L, Tooh YW, Yong RHS, Leow LC, Koh IYF, Chen H, Koh JWH, Selvanayagam A, Lim V, Tan YE, Agatha I, Winnerdy FR, Morinaka BI
• RNA is a key component of extracellular DNA networks in Pseudomonas aeruginosa biofilms.
  Nature communications 2023 Mugunthan S, Wong LL, Winnerdy FR, Summers S, Bin Ismail MH, Foo YH, Jaggi TK, Meldrum OW, Tiew PY, Chotirmall SH, Rice SA, Phan AT, Kjelleberg S, Seviour T
• Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein.
  RSC chemical biology 2023 Jelinska C, Kannan S, Frosi Y, Ramlan SR, Winnerdy F, Lakshminarayanan R, Johannes CW, Brown CJ, Phan AT, Rhodes D, Verma CS
• Stable bulged G-quadruplexes in the human genome: identification, experimental validation and functionalization.
  Nucleic acids research 2023 Papp C, Mukundan VT, Jenjaroenpun P, Winnerdy FR, Ow GS, Phan AT, Kuznetsov VA

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• Crystal structures of an HIV-1 integrase aptamer: Formation of a water-mediated A•G•G•G•G pentad in an interlocked G-quadruplex.
  Biochemical and biophysical research communications 2022 Ngo KH, Liew CW, Lattmann S, Winnerdy FR, Phan AT
• Four-Layered Intramolecular Parallel G-Quadruplex with Non-Nucleotide Loops: An Ultra-Stable Self-Folded DNA Nano-Scaffold.
  ACS nano 2021 Devi G, Winnerdy FR, Ang JCY, Lim KW, Phan AT
• Unprecedented hour-long residence time of a cation in a left-handed G-quadruplex.
  Chemical science 2021 Winnerdy FR, Bakalar B, Das P, Heddi B, Marchand A, Rosu F, Gabelica V, Phan AT
• Duplexes Formed by G4C2 Repeats Contain Alternate Slow- and Fast-Flipping G·G Base Pairs.
  Biochemistry 2021 Maity A, Winnerdy FR, Chen G, Phan AT
• The biofilm matrix scaffold of Pseudomonas aeruginosa contains G-quadruplex extracellular DNA structures.
  NPJ biofilms and microbiomes 2021 Seviour T, Winnerdy FR, Wong LL, Shi X, Mugunthan S, Foo YH, Castaing R, Adav SS, Subramoni S, Kohli GS, Shewan HM, Stokes JR, Rice SA, Phan AT, Kjelleberg S
• A novel minimal motif for left-handed G-quadruplex formation.
  Chemical communications (Cambridge, England) 2021 Das P, Winnerdy FR, Maity A, Mechulam Y, Phan AT
• Bulges in left-handed G-quadruplexes.
  Nucleic acids research 2021 Das P, Ngo KH, Winnerdy FR, Maity A, Bakalar B, Mechulam Y, Schmitt E, Phan AT
• Coexistence of two quadruplex-duplex hybrids in the PIM1 gene.
  Nucleic acids research 2020 Tan DJY, Winnerdy FR, Lim KW, Phan AT
• Post-translational formation of strained cyclophanes in bacteria.
  Nature chemistry 2020 Nguyen TQN, Tooh YW, Sugiyama R, Nguyen TPD, Purushothaman M, Leow LC, Hanif K, Yong RHS, Agatha I, Winnerdy FR, Gugger M, Phan AT, Morinaka BI
• Guanine anchoring: a strategy for specific targeting of a G-quadruplex using short PNA, LNA and DNA molecules.
  Chemical communications (Cambridge, England) 2020 Tan DJY, Das P, Winnerdy FR, Lim KW, Phan AT
• Intra-locked G-quadruplex structures formed by irregular DNA G-rich motifs.
  Nucleic acids research 2020 Maity A, Winnerdy FR, Chang WD, Chen G, Phan AT
• Extracellular protein isolation from the matrix of anammox biofilm using ionic liquid extraction.
  Applied microbiology and biotechnology 2020 Wong LL, Natarajan G, Boleij M, Thi SS, Winnerdy FR, Mugunthan S, Lu Y, Lee JM, Lin Y, van Loosdrecht M, Law Y, Kjelleberg S, Seviour T
• Cytosine epigenetic modification modulates the formation of an unprecedented G4 structure in the WNT1 promoter.
  Nucleic acids research 2020 Wang ZF, Li MH, Chu IT, Winnerdy FR, Phan AT, Chang TC
• Solution Structures of a G-Quadruplex Bound to Linear- and Cyclic-Dinucleotides.
  Journal of the American Chemical Society 2019 Winnerdy FR, Das P, Heddi B, Phan AT
• NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes.
  Nucleic acids research 2019 Winnerdy FR, Bakalar B, Maity A, Vandana JJ, Mechulam Y, Schmitt E, Phan AT
• An Unprecedented Knot-like G-Quadruplex Peripheral Motif.
  Angewandte Chemie (International ed. in English) 2019 Truong THA, Winnerdy FR, Phan AT
• Bright G-Quadruplex Nanostructures Functionalized with Porphyrin Lanterns.
  Journal of the American Chemical Society 2019 Pathak P, Yao W, Hook KD, Vik R, Winnerdy FR, Brown JQ, Gibb BC, Pursell ZF, Phan AT, Jayawickramarajah J
• Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter.
  Nucleic acids research 2019 Sengar A, Vandana JJ, Chambers VS, Di Antonio M, Winnerdy FR, Balasubramanian S, Phan AT
• A Catalytic and Selective Scissoring Molecular Tool for Quadruplex Nucleic Acids.
  Journal of the American Chemical Society 2018 Nadai M, Doria F, Scalabrin M, Pirota V, Grande V, Bergamaschi G, Amendola V, Winnerdy FR, Phan AT, Richter SN, Freccero M
• Analysis of Interactions between Telomeric i-Motif DNA and a Cyclic Tetraoxazole Compound.
  Chembiochem : a European journal of chemical biology 2018 Sedghi Masoud S, Yamaoki Y, Ma Y, Marchand A, Winnerdy FR, Gabelica V, Phan AT, Katahira M, Nagasawa K
• Rotation of Guanine Amino Groups in G-Quadruplexes: A Probe for Local Structure and Ligand Binding.
  Biophysical journal 2017 Adrian M, Winnerdy FR, Heddi B, Phan AT