Farid Chehab, PhD
Professor
Laboratory Medicine
School of Medicine

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California 10/2022
• Fellow Molecular Genetics University of California, HHMI 1987
• PhD Molecular Genetics American University of Beirut 1983
• MS Endocrinology American University of Beirut 1979
• BS Biology American University of Beirut 1976

Grants and Projects

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• Critical CpG Sites of MGMT Promoter in Glioblastoma, UC Cancer Research Coordinating Committee (CRCC), 2019-2020
• Gene Therapy Strategies for Sickle Cell Disease, NIH, 1994-2007
• Leptin and Initiation of Reproductive Function, NIH, 1998-2004
• Gene Therapy Core--Cystic Fibrosis &Non-cf Genetic Dis, NIH, 1993-1999

Publications (75)

Top publication keywords:
Hand Deformities, CongenitalAlkaptonuriaSequence DeletionReproductionChromosome Duplicationbeta-ThalassemiaLeptinLeukemia, Myelomonocytic, JuvenileHomogentisate 1,2-DioxygenaseLipodystrophyMicrognathismSterol 14-DemethylaseSexual MaturationSterol Regulatory Element Binding Protein 2Globins

• A systematic review of high impact CpG sites and regions for MGMT methylation in glioblastoma [A systematic review of MGMT methylation in GBM].
  BMC neurology 2024 Gibson D, Vo AH, Lambing H, Bhattacharya P, Tahir P, Chehab FF, Butowski N
• LNK/SH2B3 as a novel driver in juvenile myelomonocytic leukemia.
  Haematologica 2023 Wintering A, Hecht A, Meyer J, Wong EB, Hübner J, Abelson S, Feldman K, Kennedy VE, Peretz CAC, French DL, Maguire JA, Jobaliya C, Vasquez MR, Desai S, Dulman R, Nemecek E, Haines H, Hammad M, El …
• Quantitative analysis of MGMT promoter methylation in glioblastoma suggests nonlinear prognostic effect.
  Neuro-oncology advances 2023 Gibson D, Ravi A, Rodriguez E, Chang S, Oberheim Bush N, Taylor J, Clarke J, Solomon D, Scheffler A, Witte J, Lambing H, Okada H, Berger M, Chehab F, Butowski NA
• Parietal mass caused by a fish bone: case report.
  Annals of medicine and surgery (2012) 2023 Erguibi D, Kamal K, Eddaoudi Y, Hajri A, Boufettal R, Rifki El Jai S, Chehab F
• LNK/SH2B3 As a Novel Driver in Juvenile Myelomonocytic Leukemia.
  Blood 2022 Astrid Wintering, Anna Hecht, Julia Meyer, Eric Brandon Wong, Deborah L French, Jean Ann Maguire, Chintan Jobaliya, Marta Rojas Vasquez, Sunil J. Desai, Robin Yates Dulman, Eneida R. Nemecek, Farid F …

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• Epidemiology, incidence and treatment of rectal cancer in young women case serie about 11 cases (case series).
  Annals of medicine and surgery (2012) 2022 Hajri A, Fatine A, Eddaoudi Y, Rifki El Jay S, Boufettal R, Erreguibi D, Chehab F
• Molecular and phenotypic diversity of CBL-mutated juvenile myelomonocytic leukemia.
  Haematologica 2022 Hecht A, Meyer JA, Behnert A, Wong E, Chehab F, Olshen A, Hechmer A, Aftandilian C, Bhat R, Choi SW, Chonat S, Farrar JE, Fluchel M, Frangoul H, Han JH, Kolb EA, Kuo DJ, MacMillan ML, Maese L, Maloney…
• BIOM-07. QUANTITATIVE MGMT PROMOTER METHYLATION INDEX INDICATES A NON-LINEAR PROGNOSTIC EFFECT IN GLIOBLASTOMA, SUGGESTING THAT USE OF OPTIMAL CUTOFF POINTS MAY BE CLINICALLY DISADVANTAGEOUS.
  Neuro-Oncology 2021 David Gibson, Akshay Ravi, Eduardo Rodriguez Almaraz, Susan Chang, Nancy Ann Oberheim-Bush, Jennie Taylor, Jennifer Clarke, David Solomon, Aaron Scheffler, John Witte, Hannah Lambing, Mitchel Berger, …
• NGMA-6. Quantitative MGMT Promoter Methylation Index Indicates Non-Linear, Prognostic Effect in Glioblastoma.
  Neuro-Oncology Advances 2021 David Gibson, Akshay Ravi, Eduardo Rodriguez, Susan Chang, Nancy Bush, Jennie Taylor, Jennifer Clarke, David Solomon, Aaron Scheffler, John Witte, Hideho Okada, Mitchel Berger, Farid Chehab, Nicholas …
• Molecular assessment of pretransplant chemotherapy in the treatment of juvenile myelomonocytic leukemia.
  Pediatric blood & cancer 2019 Hecht A, Meyer J, Chehab FF, White KL, Magruder K, Dvorak CC, Loh ML, Stieglitz E
• PAX5, NOTCH3, CBFB, and ACD drive an activated RAS pathway and monosomy 7 to B-ALL and AML in donor cell leukemia.
  Bone marrow transplantation 2018 Assi R, Mahfouz R, Owen R, Gunthorpe M, Chehab FF, Bazarbachi A
• Upregulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain.
  Pediatric research 2018 Lu F, Zhu J, Guo S, Wong BJ, Chehab FF, Ferriero DM, Jiang X
• Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia.
  Nature communications 2017 Stieglitz E, Mazor T, Olshen AB, Geng H, Gelston LC, Akutagawa J, Lipka DB, Plass C, Flotho C, Chehab FF, Braun BS, Costello JF, Loh ML
• PATH-08. THE PROGNOSTIC VALUE OF A NOVEL QUANTITATIVE MGMT PROMOTER METHYLATION SCORE FOR PATIENTS WITH GLIOBLASTOMA.
  Neuro-Oncology 2017 Akshay Ravi, Annette Molinaro, Seunggu J Han, Farid Chehab, Mitchel S Berger, Nicholas Butowski
• MPTH-25. THE PROGNOSTIC VALUE OF A NOVEL QUANTITATIVE MGMT PROMOTER METHYLATION SCORE FOR PATIENTS WITH GLIOBLASTOMA.
  Neuro-Oncology 2016 Seunggu Han, Akshay Ravi, Annette Molinaro, Jennie Taylor, Jennifer Clarke, Nancy Ann Oberheim-Bush, Susan Chang, Mitchel S. Berger, Farid Chehab, Nicholas Butowski
• Novel TKI-resistant BCR-ABL1 gatekeeper residue mutations retain in vitro sensitivity to axitinib.
  Leukemia 2015 Lasater EA, Massi ES, Stecula A, Politi J, Tan SK, Smith CC, Gunthorpe M, Holmes JP, Chehab F, Sali A, Shah NP
• First report of a deletion encompassing an entire exon in the homogentisate 1,2-dioxygenase gene causing alkaptonuria.
  PloS one 2014 Zouheir Habbal M, Bou-Assi T, Zhu J, Owen R, Chehab FF
• 20 years of leptin: leptin and reproduction: past milestones, present undertakings, and future endeavors.
  The Journal of endocrinology 2014 Chehab FF
• FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter.
  Journal of lipid research 2013 Zhu J, Jiang X, Chehab FF
• Duplication of C7orf58, WNT16 and FAM3C in an obese female with a t(7;22)(q32.1;q11.2) chromosomal translocation and clinical features resembling Coffin-Siris Syndrome.
  PloS one 2012 Zhu J, Qiu J, Magrane G, Abedalthagafi M, Zanko A, Golabi M, Chehab FF
• Homozygous deletion of six olfactory receptor genes in a subset of individuals with Beta-thalassemia.
  PloS one 2011 Van Ziffle J, Yang W, Chehab FF
• Chapter 36 Molecular Diagnostic Challenges of the Thalassemias.
  Molecular Diagnostics 2010 Farid F. Chehab
• Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake.
  Journal of lipid research 2009 Zhu J, Mounzih K, Chehab EF, Mitro N, Saez E, Chehab FF
• Overexpression of the transcription factor Foxo4 is associated with rapid glucose clearance.
  Molecular and cellular endocrinology 2009 Wang B, Zhu J, Mounzih K, Chehab EF, Ke Y, Chehab FF
• Obesity and lipodystrophy--where do the circles intersect?
  Endocrinology 2008 Chehab FF
• Deletion of the serotonin 2c receptor from transgenic mice overexpressing leptin does not affect their lipodystrophy but exacerbates their diet-induced obesity.
  Biochemical and biophysical research communications 2006 Wang B, Chehab FF
• Mosaicism for a full mutation, premutation, and deletion of the CGG repeats results in 22% FMRP and elevated FMR1 mRNA levels in a high-functioning fragile X male.
  American journal of medical genetics. Part A 2006 Han XD, Powell BR, Phalin JL, Chehab FF
• The use of animal models to dissect the biology of leptin.
  Recent progress in hormone research 2004 Chehab FF, Qiu J, Ogus S
• Overexpression of leptin in transgenic mice leads to decreased basal lipolysis, PKA activity, and perilipin levels.
  Biochemical and biophysical research communications 2003 Ke Y, Qiu J, Ogus S, Shen WJ, Kraemer FB, Chehab FF
• Hyperleptinemia precipitates diet-induced obesity in transgenic mice overexpressing leptin.
  Endocrinology 2003 Ogus S, Ke Y, Qiu J, Wang B, Chehab FF
• Genetics and Physiology Link Leptin to the Reproductive System.
  Leptin and Reproduction 2003 Farid F. Chehab, Amanda Ewart-Toland, Khalid Mounzih, Jun Qiu, Scott Ogus
• Leptin-deficient mice backcrossed to the BALB/cJ genetic background have reduced adiposity, enhanced fertility, normal body temperature, and severe diabetes.
  Endocrinology 2001 Qiu J, Ogus S, Mounzih K, Ewart-Toland A, Chehab FF
• Transgenic mice overexpressing leptin accumulate adipose mass at an older, but not younger, age.
  Endocrinology 2001 Qiu J, Ogus S, Lu R, Chehab FF
• Leptin as a regulator of adipose mass and reproduction.
  Trends in pharmacological sciences 2000 Chehab FF
• Effect of the genetic background on the reproduction of leptin-deficient obese mice.
  Endocrinology 1999 Ewart-Toland A, Mounzih K, Qiu J, Chehab FF
• Leptin is not necessary for gestation and parturition but regulates maternal nutrition via a leptin resistance state.
  Endocrinology 1998 Mounzih K, Qiu J, Ewart-Toland A, Chehab FF
• Cross-species characterization of the promoter region of the cystic fibrosis transmembrane conductance regulator gene reveals multiple levels of regulation.
  The Biochemical journal 1997 Vuillaumier S, Dixmeras I, Messaï H, Lapouméroulie C, Lallemand D, Gekas J, Chehab FF, Perret C, Elion J, Denamur E
• The reproductive side of leptin.
  Nature medicine 1997 Chehab FF
• Molecular basis of asymptomatic beta-thalassemia major in an African American individual.
  American journal of medical genetics 1997 Ballas SK, Cai SP, Gabuzda T, Chehab FF
• Leptin treatment rescues the sterility of genetically obese ob/ob males.
  Endocrinology 1997 Mounzih K, Lu R, Chehab FF
• Early onset of reproductive function in normal female mice treated with leptin.
  Science (New York, N.Y.) 1997 Chehab FF, Mounzih K, Lu R, Lim ME
• Trinucleotide repeats in the human genome: size distributions for all possible triplets and detection of expanded disease alleles in a group of Huntington disease individuals by the repeat expansion detection method.
  Human molecular genetics 1997 Hofferbert S, Schanen NC, Chehab F, Francke U
• A broader role for leptin.
  Nature medicine 1996 Chehab FF
• Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin.
  Nature genetics 1996 Chehab FF, Lim ME, Lu R
• Comparison of PCR detection of mecA with standard susceptibility testing methods to determine methicillin resistance in coagulase-negative staphylococci.
  Journal of clinical microbiology 1996 York MK, Gibbs L, Chehab F, Brooks GF
• New frameshift mutation, insertion of A, at codon 95 of the beta-globin gene causes beta-thalassemia in two Vietnamese families.
  Human mutation 1996 Cai S, Chehab FF
• Detection of viral deoxyribonucleic acid in the amniotic fluid of low-risk pregnancies by polymerase chain reaction.
  American journal of obstetrics and gynecology 1995 McLean LK, Chehab FF, Goldberg JD
• Methylation status of CpG sites in the mouse and human CFTR promoters.
  DNA and cell biology 1995 Denamur E, Chehab FF
• 10 Analysis of PCR Products by Covalent Reverse Dot Blot Hybridization.
  PCR Strategies 1995 Farid F. Chehab, Jeff Wall, Shi-ping Cai
• A 31-mutation assay for cystic fibrosis testing in the clinical molecular diagnostics laboratory.
  Human mutation 1995 Wall J, Cai S, Chehab FF
• Uniparental isodisomy for paternal 7p and maternal 7q in a child with growth retardation.
  American journal of human genetics 1994 Eggerding FA, Schonberg SA, Chehab FF, Norton ME, Cox VA, Epstein CJ
• Analysis of the mouse and rat CFTR promoter regions.
  Human molecular genetics 1994 Denamur E, Chehab FF
• A new frameshift mutation, insertion of ATCT, at codon 48 in the beta-globin gene causes beta-thalassemia in an Indian proband.
  Human mutation 1994 Jain PK, Dozy AM, Verma IC, Chehab FF
• Analysis of gene sequences by hybridization of PCR-amplified DNA to covalently bound oligonucleotide probes. The reverse dot blot method.
  Methods in molecular biology (Clifton, N.J.) 1994 Kawasaki ES, Chehab FF
• Reverse dot blot probes for the screening of beta-thalassemia mutations in Asians and American blacks.
  Human mutation 1994 Cai SP, Wall J, Kan YW, Chehab FF
• Molecular diagnostics: past, present, and future.
  Human mutation 1993 Chehab FF
• Rapid and simultaneous typing of hemoglobin S, hemoglobin C, and seven Mediterranean beta-thalassemia mutations by covalent reverse dot-blot analysis: application to prenatal diagnosis in Sicily.
  Blood 1993 Maggio A, Giambona A, Cai SP, Wall J, Kan YW, Chehab FF
• DNA amplification and reverse dot blot hybridization for detection and identification of mycobacteria to the species level in the clinical laboratory.
  Journal of clinical microbiology 1992 Fiss EH, Chehab FF, Brooks GF
• Detection of multiple cystic fibrosis mutations by reverse dot blot hybridization: a technology for carrier screening.
  Human genetics 1992 Chehab FF, Wall J
• Amplification and detection of specific DNA sequences with fluorescent PCR primers: application to delta F508 mutation in cystic fibrosis.
  Methods in enzymology 1992 Chehab FF, Wall J, Kan YW
• A dimorphic 4-bp repeat in the cystic fibrosis gene is in absolute linkage disequilibrium with the delta F508 mutation: implications for prenatal diagnosis and mutation origin.
  American journal of human genetics 1991 Chehab FF, Johnson J, Louie E, Goossens M, Kawasaki E, Erlich H
• Detection of the hemoglobin E mutation using the color complementation assay: application to complex genotyping.
  Blood 1990 Embury SH, Kropp GL, Stanton TS, Warren TC, Cornett PA, Chehab FF
• Detection of the hemoglobin E mutation using the color complementation assay: application to complex genotyping.
  Blood 1990 SH Embury, GL Kropp, TS Stanton, TC Warren, PA Cornett, FF Chehab
• Detection of sickle cell anaemia mutation by colour DNA amplification.
  Lancet (London, England) 1990 Chehab FF, Kan YW
• The use of direct gene analysis to define beta-thalassemia.
  Annals of the New York Academy of Sciences 1990 Dozy AM, Cai SP, Chehab F, Kan YW
• Detection of specific DNA sequences by fluorescence amplification: a color complementation assay.
  Proceedings of the National Academy of Sciences of the United States of America 1989 Chehab FF, Kan YW
• Characterization of a spontaneous mutation in beta-thalassemia associated with advanced paternal age.
  Blood 1989 Chehab FF, Winterhalter KH, Kan YW
• Detection of cytomegalovirus infection in paraffin-embedded tissue specimens with the polymerase chain reaction.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1989 Chehab FF, Xiao X, Kan YW, Yen TS
• Molecular basis of beta thalassemia in south China. Strategy for DNA analysis.
  Human genetics 1988 Zhang JZ, Cai SP, He X, Lin HX, Lin HJ, Huang ZG, Chehab FF, Kan YW
• Human placental Na+,K+-ATPase alpha subunit: cDNA cloning, tissue expression, DNA polymorphism, and chromosomal localization.
  Proceedings of the National Academy of Sciences of the United States of America 1987 Chehab FF, Kan YW, Law ML, Hartz J, Kao FT, Blostein R
• Detection of sickle cell anaemia and thalassaemias.
  Nature 1987 Chehab FF, Doherty M, Cai SP, Kan YW, Cooper S, Rubin EM
• The molecular basis of beta-thalassemia in Lebanon: application to prenatal diagnosis.
  Blood 1987 Chehab FF, Der Kaloustian V, Khouri FP, Deeb SS, Kan YW
• Spontaneous mutation in beta-thalassaemia producing the same nucleotide substitution as that in a common hereditary form.
  Lancet (London, England) 1986 Chehab FF, Honig GR, Kan YW
• Genetic studies in a selected group of Lebanese beta-thalassemic patients.
  Le Journal medical libanais. The Lebanese medical journal 1986 Khouri FP, Chehab FF, Deeb SS, Habbal ZM, Muallem HE
• Globin synthetic ratios in homozygous beta-thalassemia patients from Lebanon.
  Hemoglobin 1984 Chehab FF, Khouri FP, Deeb SS