Evan Feinberg, PhD
Associate Professor
Anatomy
School of Medicine
My lab (www.evanfeinberglab.com) aims to understand how sensory input is represented in the brain and transformed into behavioral commands. We study this problem in the superior colliculus (SC), a structure comprising functionally diverse sensory and motor neurons interleaved with fibers from myriad cortical and subcortical areas.
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This remarkable neuroanatomy poises the SC as an integrative hub, but has also hindered efforts to dissect SC circuitry using classical methods, such as lesions, that offer poor spatial and temporal resolution. In order to record from and manipulate genetically defined cell types, we study the mouse SC, where we capitalize on an experimental preparation I developed that allows two-photon imaging of neuronal population activity in the SC of awake animals. We apply these methods to decipher computations in the context of quantitative behavioral assays. Our long-term goal is to understand how the brain encodes information from input to output.
Education & Training
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- A.B. Harvard University
- Postdoctoral fellowship Harvard University
- Ph.D. The Rockefeller University
Websites
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- @@FeinbergLab on Twitter (twitter.com)
Publications (14)
Top publication keywords:
Caenorhabditis elegans ProteinsSynapsesHigh-Throughput Screening AssaysNeuronsSequence Analysis, RNASuperior ColliculiOrientationPsychomotor PerformanceHead MovementsSaccadesSingle-Cell AnalysisRNACaenorhabditis elegansHigh-Throughput Nucleotide SequencingFixation, Ocular
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Hindbrain modules differentially transform activity of single collicular neurons to coordinate movements.
Cell 2023 Zahler SH, Taylor DE, Wright BS, Wong JY, Shvareva VA, Park YA, Feinberg EH -
Superior colliculus drives stimulus-evoked directionally biased saccades and attempted head movements in head-fixed mice.
eLife 2021 Zahler SH, Taylor DE, Wong JY, Adams JM, Feinberg EH -
Virally encoded connectivity transgenic overlay RNA sequencing (VECTORseq) defines projection neurons involved in sensorimotor integration.
Cell reports 2021 Cheung V, Chung P, Bjorni M, Shvareva VA, Lopez YC, Feinberg EH -
Orientation columns in the mouse superior colliculus.
Nature 2014 Feinberg EH, Meister M -
Transport of dsRNA into cells by the transmembrane protein SID-1.
Science (New York, N.Y.) 2003 Feinberg EH, Hunter CP
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Transcriptional profiling of mouse projection neurons with VECTORseq.
STAR protocols 2022 Cheung V, Chung P, Feinberg EH -
Soma-Targeted Imaging of Neural Circuits by Ribosome Tethering.
Neuron 2020 Chen Y, Jang H, Spratt PWE, Kosar S, Taylor DE, Essner RA, Bai L, Leib DE, Kuo TW, Lin YC, Patel M, Subkhangulova A, Kato S, Feinberg EH, Bender KJ, Knight ZA, Garrison JL -
New technologies for imaging synaptic partners.
Current opinion in neurobiology 2012 Wickersham IR, Feinberg EH -
A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans.
Nature 2009 Macosko EZ, Pokala N, Feinberg EH, Chalasani SH, Butcher RA, Clardy J, Bargmann CI -
GFP Reconstitution Across Synaptic Partners (GRASP) defines cell contacts and synapses in living nervous systems.
Neuron 2008 Feinberg EH, Vanhoven MK, Bendesky A, Wang G, Fetter RD, Shen K, Bargmann CI -
Caenorhabditis elegans SID-2 is required for environmental RNA interference.
Proceedings of the National Academy of Sciences of the United States of America 2007 Winston WM, Sutherlin M, Wright AJ, Feinberg EH, Hunter CP -
Global 'worming'.
Genome biology 2007 Chalasani SH, Feinberg EH, Hilliard MA -
Systemic RNAi in Caenorhabditis elegans.
Cold Spring Harbor symposia on quantitative biology 2006 Hunter CP, Winston WM, Molodowitch C, Feinberg EH, Shih J, Sutherlin M, Wright AJ, Fitzgerald MC -
Analysis of mouse embryonic patterning and morphogenesis by forward genetics.
Proceedings of the National Academy of Sciences of the United States of America 2005 García-García MJ, Eggenschwiler JT, Caspary T, Alcorn HL, Wyler MR, Huangfu D, Rakeman AS, Lee JD, Feinberg EH, Timmer JR, Anderson KV