Ethan Weiss, MD
Assoc Prof In Res
Medicine
School of Medicine

RESEARCH INTERESTS: In his research, Dr. Weiss uses genetic models to better understand the mechanism of metabolic disorders such as obesity, fatty liver disease, and diabetes. He also studies the blood clotting system and has interest in identifying novel ways to safely block clots associated with diseases such as heart attack and stroke without causing an increase in bleeding.

• An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice.
  Science (New York, N.Y.) 2022 Nikkanen J, Leong YA, Krause WC, Dermadi D, Maschek JA, Van Ry T, Cox JE, Weiss EJ, Gokcumen O, Chawla A, Ingraham HA
• Three-dimensional optical body shape and features improve prediction of metabolic disease risk in a diverse sample of adults.
  Obesity (Silver Spring, Md.) 2022 Bennett JP, Liu YE, Quon BK, Kelly NN, Leong LT, Wong MC, Kennedy SF, Chow DC, Garber AK, Weiss EJ, Heymsfield SB, Shepherd JA
• Use of an mHealth Ketogenic Diet App Intervention and User Behaviors Associated With Weight Loss in Adults With Overweight or Obesity: Secondary Analysis of a Randomized Clinical Trial.
  JMIR mHealth and uHealth 2022 Falkenhain K, Locke SR, Lowe DA, Lee T, Singer J, Weiss EJ, Little JP
• Assessment of clinical measures of total and regional body composition from a commercial 3-dimensional optical body scanner.
  Clinical nutrition (Edinburgh, Scotland) 2021 Bennett JP, Liu YE, Quon BK, Kelly NN, Wong MC, Kennedy SF, Chow DC, Garber AK, Weiss EJ, Heymsfield SB, Shepherd JA
• Effect of carbohydrate-restricted dietary interventions on LDL particle size and number in adults in the context of weight loss or weight maintenance: a systematic review and meta-analysis.
  The American journal of clinical nutrition 2021 Falkenhain K, Roach LA, McCreary S, McArthur E, Weiss EJ, Francois ME, Little JP
• Keyto app and device versus WW app on weight loss and metabolic risk in adults with overweight or obesity: A randomized trial.
  Obesity (Silver Spring, Md.) 2021 Falkenhain K, Locke SR, Lowe DA, Reitsma NJ, Lee T, Singer J, Weiss EJ, Little JP
• The Impact of Carbohydrate Restriction and Nutritional Ketosis on Cardiovascular Health.
  2021 Dylan Lowe, Kevin C. Corbit, Ethan J. Weiss
• A Mediterranean-Based Ketogenic Diet Application Compared to a Calorie-Restricted Low-Fat Diet Application on Cardiometabolic Risk in Adults With Overweight or Obesity.
  Current Developments in Nutrition 2021 Kaja Falkenhain, Sean Locke, Dylan Lowe, Nicholas Reitsma, Ethan Weiss, Jonathan Little
• Caution Against Overinterpreting Time-Restricted Eating Results-Reply.
  JAMA internal medicine 2021 Weiss EJ, Lowe DA, Vittinghoff E
• 4β-Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor.
  Journal of lipid research 2021 Moldavski O, Zushin PH, Berdan CA, Van Eijkeren RJ, Jiang X, Qian M, Ory DS, Covey DF, Nomura DK, Stahl A, Weiss EJ, Zoncu R
• Comparing the Keyto App and Device with Weight Watchers' WW App for Weight Loss: Protocol for a Randomized Trial.
  JMIR research protocols 2020 Locke SR, Falkenhain K, Lowe DA, Lee T, Singer J, Weiss EJ, Little JP
• Diet Quality and Visceral Adiposity among a Multiethnic Population of Young, Middle, and Older Aged Adults.
  Current developments in nutrition 2020 Panizza CE, Wong MC, Kelly N, Liu YE, Shvetsov YB, Lowe DA, Weiss EJ, Heymsfield SB, Kennedy S, Boushey CJ, Maskarinec G, Shepherd JA
• MON-LB107 Treat: A Randomized Controlled Trial Examining the Effects of Time Restricted Eating on Weight Loss and Metabolic Markers.
  Journal of the Endocrine Society 2020 Dylan A Lowe, Ethan James Weiss, Jeffrey E Olgin, Eric Vittinghoff, John A Shepherd, Steven B Heymsfield, Linnea Rohdin-Bibby, Nisa Kelly, Nancy Wu
• Billy Idol.
  Perspectives in biology and medicine 2020 Weiss EJ
• Growth hormone receptor antagonism with pegvisomant in insulin resistant non-diabetic men: A phase II pilot study.
  F1000Research 2017 Lee AP, Mulligan K, Schambelan M, Murphy EJ, Weiss EJ
• HIV infection is associated with decreased thrombin generation.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012 Hsue PY, Scherzer R, Grunfeld C, Nordstrom SM, Schnell A, Kohl LP, Nitta E, Martin JN, Deeks SG, Weiss EJ
• Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH.
  Molecular endocrinology (Baltimore, Md.) 2011 Nordstrom SM, Tran JL, Sos BC, Wagner KU, Weiss EJ
• Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2.
  The Journal of clinical investigation 2011 Sos BC, Harris C, Nordstrom SM, Tran JL, Balázs M, Caplazi P, Febbraio M, Applegate MA, Wagner KU, Weiss EJ
• Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development.
  Arteriosclerosis, thrombosis, and vascular biology 2010 Williams MS, Weiss EJ, Sabatine MS, Simon DI, Bahou WF, Becker LC, Parise LV, Dauerman HL, French PA, Smyth SS, Becker RC, 2010 Platelet Colloquium Participants
• Increased thrombosis susceptibility and altered fibrin formation in STAT5-deficient mice.
  Blood 2010 Nordstrom SM, Holliday BA, Sos BC, Smyth JW, Levy RE, Dukes JW, Lord ST, Weiss EJ
• A Novel Tissue Factor Resistance Locus on Mouse Chromosome 11 Confers Protection from Thrombosis through Reduced Activity of Factor XI.
  Blood 2008 Katelyn M Dow, Sarah M Nordstrom, Brandon C Sos, Richard C Davis, Aldons J Lusis, Ethan J Weiss
• Increased Thrombosis in Vivo and Altered Coagulation in Vitro in STAT5AB-Deficient Mice.
  Blood 2008 Sarah M Nordstrom, Brandon C Sos, Katelyn M Dow, Tina S Fong, Robert E Levy, Jonathan Dukes, Ethan J Weiss
• Sex differences in thrombosis.
  Expert review of hematology 2008 Nordstrom SM, Weiss EJ
• Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns.
  The Journal of clinical investigation 2008 Wong JH, Dukes J, Levy RE, Sos B, Mason SE, Fong TS, Weiss EJ
• Increased Thrombosis in Male Versus Female Mice Is Mediated by Pulsatile Growth Hormone Secretion Possibly through Inhibition of TFPI Expression in the Vasculature.
  Blood 2007 Joshua H. Wong, Robert E. Levy, Jonathan Dukes, Sara A. Mason, Brandon Sos, Ethan J. Weiss
• Role of thrombin signalling in platelets in haemostasis and thrombosis.
  Nature 2001 Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR
• Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin.
  The Journal of biological chemistry 2000 Shapiro MJ, Weiss EJ, Faruqi TR, Coughlin SR
• Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function.
  The Journal of biological chemistry 2000 Faruqi TR, Weiss EJ, Shapiro MJ, Huang W, Coughlin SR
• PAR3 is a cofactor for PAR4 activation by thrombin.
  Nature 2000 Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR
• Higher prevalence of GPIIIa PlA2 polymorphism in siblings of patients with premature coronary heart disease.
  Archives of pathology & laboratory medicine 1999 Goldschmidt-Clermont PJ, Coleman LD, Pham YM, Cooke GE, Shear WS, Weiss EJ, Kral BG, Moy TF, Yook RM, Blumenthal RS, Becker DM, Becker LC, Bray PF
• PlA1/A2 polymorphism of platelet glycoprotein IIIa and risk of cardiovascular disease.
  Lancet (London, England) 1997 Bray PF, Weiss EJ, Tayback M, Goldschmidt-Clermont PJ
• Self-expanding metal stent for obstructing adenocarcinoma of the sigmoid.
  Gastrointestinal endoscopy 1996 Vandervoort J, Weiss EJ, Somnay K, Tham TC, Wong RC, Carr-Locke DL
• A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis.
  The New England journal of medicine 1996 Weiss EJ, Bray PF, Tayback M, Schulman SP, Kickler TS, Becker LC, Weiss JL, Gerstenblith G, Goldschmidt-Clermont PJ
• A monoclonal antibody (SZ21) specific for platelet GPIIIa distinguishes P1A1 from P1A2.
  Tissue antigens 1995 Weiss EJ, Goldschmidt-Clermont PJ, Grigoryev D, Jin Y, Kickler TS, Bray PF