Ethan Geier, PhD
Staff Scientist
Neurology
School of Medicine

Publications (40)

Top publication keywords:
Membrane Transport ProteinsLipoproteins, HDLDrug Delivery SystemsFrontotemporal DementiaLarge Neutral Amino Acid-Transporter 1Frontotemporal Lobar Degeneration3-IodobenzylguanidineNeurodegenerative DiseasesNorepinephrine Plasma Membrane Transport ProteinsLysosomesMicrovesselsHydroxamic AcidsTauopathiesBlood-Brain BarrierLoss of Function Mutation

• Expansion of highly interferon-responsive T cells in early-onset Alzheimer's disease.
  bioRxiv : the preprint server for biology 2024 Sirkis DW, Solsberg CW, Johnson TP, Bonham LW, Oddi AP, Geier EG, Miller BL, Rabinovici GD, Yokoyama JS
• Early-onset Alzheimer's disease explained by polygenic risk of late-onset disease?
  Alzheimer's & dementia (Amsterdam, Netherlands) 2023 Mantyh WG, Cochran JN, Taylor JW, Broce IJ, Geier EG, Bonham LW, Anderson AG, Sirkis DW, Joie R, Iaccarino L, Chaudhary K, Edwards L, Strom A, Grant H, Allen IE, Miller ZA, Gorno-Tempini ML, Kramer JH…
• Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy.
  Genome medicine 2023 Sirkis DW, Warly Solsberg C, Johnson TP, Bonham LW, Sturm VE, Lee SE, Rankin KP, Rosen HJ, Boxer AL, Seeley WW, Miller BL, Geier EG, Yokoyama JS
• Radiogenomics of C9orf72 Expansion Carriers Reveals Global Transposable Element Derepression and Enables Prediction of Thalamic Atrophy and Clinical Impairment.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Bonham LW, Geier EG, Sirkis DW, Leong JK, Ramos EM, Wang Q, Karydas A, Lee SE, Sturm VE, Sawyer RP, Friedberg A, Ichida JK, Gitler AD, Sugrue L, Cordingley M, Bee W, Weber E, Kramer JH, Rankin KP, …
• TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy.
  Science advances 2021 Alquezar C, Schoch KM, Geier EG, Ramos EM, Scrivo A, Li KH, Argouarch AR, Mlynarski EE, Dombroski B, DeTure M, Dickson DW, Yokoyama JS, Cuervo AM, Burlingame AL, Schellenberg GD, Miller TM, Miller BL,…

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• Genetic pleiotropy and the shared pathological features of corticobasal degeneration and progressive supranuclear palsy: a case report and a review of the literature.
  Neurocase 2021 Rini J, Asken B, Geier E, Rankin K, Kramer J, Boxer A, Miller B, Yokoyama J, Spina S
• SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan.
  Nature communications 2021 Johnson AE, Orr BO, Fetter RD, Moughamian AJ, Primeaux LA, Geier EG, Yokoyama JS, Miller BL, Davis GW
• Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases.
  American journal of human genetics 2020 Cochran JN, Geier EG, Bonham LW, Newberry JS, Amaral MD, Thompson ML, Lasseigne BN, Karydas AM, Roberson ED, Cooper GM, Rabinovici GD, Miller BL, Myers RM, Yokoyama JS, Alzheimer’s Disease …
• Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles.
  Cold Spring Harbor molecular case studies 2019 Cochran JN, McKinley EC, Cochran M, Amaral MD, Moyers BA, Lasseigne BN, Gray DE, Lawlor JMJ, Prokop JW, Geier EG, Holt JM, Thompson ML, Newberry JS, Yokoyama JS, Worthey EA, Geldmacher DS, Love MN, …
• Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia.
  Scientific reports 2019 Bonham LW, Steele NZR, Karch CM, Broce I, Geier EG, Wen NL, Momeni P, Hardy J, Miller ZA, Gorno-Tempini ML, Hess CP, Lewis P, Miller BL, Seeley WW, Manzoni C, Desikan RS, Baranzini SE, Ferrari R, …
• LOSS-OF-FUNCTION CODING AND NON-CODING VARIANTS IN TET2 ARE ASSOCIATED WITH NEURODEGENERATIVE DISEASES.
  Alzheimer's & Dementia 2019 J. Nicholas Cochran, Ethan G. Geier, Juliana Acosta-Uribe, Michelle L. Thompson, Michelle D. Amaral, J. Scott Newberry, James M.J. Lawlor, Brittany N. Lasseigne, Meagan E. Cochran, Luke W. Bonham, …
• Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr).
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2019 Ramirez Aguilar L, Acosta-Uribe J, Giraldo MM, Moreno S, Baena A, Alzate D, Cuastumal R, Aguillón D, Madrigal L, Saldarriaga A, Navarro A, Garcia GP, Aguirre-Acevedo DC, Geier EG, Cochran JN, Quiroz …
• Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.
  Acta neuropathologica 2019 Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, Matchett …
• Recent advances in the genetics of frontotemporal dementia.
  Current genetic medicine reports 2019 Sirkis DW, Geier EG, Bonham LW, Karch CM, Yokoyama JS
• Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia.
  Acta neuropathologica 2018 Geier EG, Bourdenx M, Storm NJ, Cochran JN, Sirkis DW, Hwang JH, Bonham LW, Ramos EM, Diaz A, Van Berlo V, Dokuru D, Nana AL, Karydas A, Balestra ME, Huang Y, Russo SP, Spina S, Grinberg LT, Seeley WW…
• Protein network analysis reveals selectively vulnerable regions and biological processes in FTD.
  Neurology. Genetics 2018 Bonham LW, Steele NZR, Karch CM, Manzoni C, Geier EG, Wen N, Ofori-Kuragu A, Momeni P, Hardy J, Miller ZA, Hess CP, Lewis P, Miller BL, Seeley WW, Baranzini SE, Desikan RS, Ferrari R, Yokoyama JS, …
• Genetic Variation in the Androgen Receptor and Measures of Plasma Testosterone Levels Suggest Androgen Dysfunction in Alzheimer's Disease.
  Frontiers in neuroscience 2018 Carr JS, Bonham LW, Morgans AK, Ryan CJ, Yokoyama JS, Geier EG, Alzheimer’s Disease Neuroimaging Initiative
• Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer's Disease Pathology and Shows Differential Expression in Transgenic Mice.
  Frontiers in neuroscience 2018 Bonham LW, Geier EG, Steele NZR, Holland D, Miller BL, Dale AM, Desikan RS, Yokoyama JS, Alzheimer’s Disease Neuroimaging Initiative
• ASSOCIATION OF ALZHEIMER’S DISEASE WITH ANDROGEN RECEPTOR VARIANTS AND PLASMA TESTOSTERONE LEVELS IMPLICATES DECREASED TESTOSTERONE SIGNALING IN NEURODEGENERATION.
  Alzheimer's & Dementia 2018 Jessie S. Carr, Luke W. Bonham, Charles J. Ryan, Jennifer S. Yokoyama, Ethan G. Geier, Alzheimer's Disease Neuroimaging Initiative
• STOP-GAIN VARIANT IN MICROGLIA-EXPRESSED GENE GMIP IS ASSOCIATED WITH EARLY-ONSET ALZHEIMER’S DISEASE.
  Alzheimer's & Dementia 2018 Raiyan R. Khan, Andre Altmann, Valerio Napolioni, Yongha Kim, Rita Guerreiro, Jose T. Bras, Susana Carmona, Miguel Pereira, Isabel Santana, John Hardy, Simon Mead, Carlos Cruchaga, Maria Victoria …
• CXCR4 involvement in neurodegenerative diseases.
  Translational psychiatry 2018 Bonham LW, Karch CM, Fan CC, Tan C, Geier EG, Wang Y, Wen N, Broce IJ, Li Y, Barkovich MJ, Ferrari R, Hardy J, Momeni P, Höglinger G, Müller U, Hess CP, Sugrue LP, Dillon WP, Schellenberg GD, Miller …
• FINE-MAPPING OF THE HUMAN LEUKOCYTE ANTIGEN (HLA) LOCUS AS A RISK FACTOR FOR ALZHEIMER'S DISEASE.
  Alzheimer's & Dementia 2017 Jessie S. Carr, Natasha ZR. Steele, Luke W. Bonham, Ethan G. Geier, Vincent Damotte, Zachary A. Miller, Rahul S. Desikan, Kevin L. Boehme, Shubhabrata Mukherjee, Paul K. Crane, John Kauwe, Joel H. …
• Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study.
  PLoS medicine 2017 Steele NZ, Carr JS, Bonham LW, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe JS, Kramer JH, Miller BL, Coppola G, Hollenbach JA, Huang Y, Yokoyama JS
• Expression and splicing of ABC and SLC transporters in the human blood-brain barrier measured with RNAseq.
  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Suhy AM, Webb A, Papp AC, Geier EG, Sadee W
• Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression.
  Acta neuropathologica communications 2016 Sirkis DW, Bonham LW, Aparicio RE, Geier EG, Ramos EM, Wang Q, Karydas A, Miller ZA, Miller BL, Coppola G, Yokoyama JS
• Age-dependent effects of APOE ε4 in preclinical Alzheimer's disease.
  Annals of clinical and translational neurology 2016 Bonham LW, Geier EG, Fan CC, Leong JK, Besser L, Kukull WA, Kornak J, Andreassen OA, Schellenberg GD, Rosen HJ, Dillon WP, Hess CP, Miller BL, Dale AM, Desikan RS, Yokoyama JS
• Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin.
  Molecular pharmacology 2015 Chen EC, Liang X, Yee SW, Geier EG, Stocker SL, Chen L, Giacomini KM
• Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2015 DuBois SG, Groshen S, Park JR, Haas-Kogan DA, Yang X, Geier E, Chen E, Giacomini K, Weiss B, Cohn SL, Granger MM, Yanik GA, Hawkins R, Courtier J, Jackson H, Goodarzian F, Shimada H, Czarnecki S, Tsao…
• Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.
  Drug metabolism and disposition: the biological fate of chemicals 2014 Salphati L, Chu X, Chen L, Prasad B, Dallas S, Evers R, Mamaril-Fishman D, Geier EG, Kehler J, Kunta J, Mezler M, Laplanche L, Pang J, Rode A, Soars MG, Unadkat JD, van Waterschoot RA, Yabut J, …
• Conservation of apolipoprotein A-I's central domain structural elements upon lipid association on different high-density lipoprotein subclasses.
  Biochemistry 2013 Oda MN, Budamagunta MS, Geier EG, Chandradas SH, Shao B, Heinecke JW, Voss JC, Cavigiolio G
• Profiling solute carrier transporters in the human blood-brain barrier.
  Clinical pharmacology and therapeutics 2013 Geier EG, Chen EC, Webb A, Papp AC, Yee SW, Sadee W, Giacomini KM
• Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Geier EG, Schlessinger A, Fan H, Gable JE, Irwin JJ, Sali A, Giacomini KM
• Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures.
  Molecular pharmaceutics 2013 Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M, Siegenthaler J, Xu L, Basile AS, Tang-Liu DD, Giacomini KM
• Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group.
  International journal of molecular imaging 2012 Dubois SG, Geier E, Batra V, Yee SW, Neuhaus J, Segal M, Martinez D, Pawel B, Yanik G, Naranjo A, London WB, Kreissman S, Baker D, Attiyeh E, Hogarty MD, Maris JM, Giacomini K, Matthay KK
• Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Schlessinger A, Geier E, Fan H, Irwin JJ, Shoichet BK, Giacomini KM, Sali A
• Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2011 More SS, Itsara M, Yang X, Geier EG, Tadano MK, Seo Y, Vanbrocklin HF, Weiss WA, Mueller S, Haas-Kogan DA, Dubois SG, Matthay KK, Giacomini KM
• Role of the copper transporter, CTR1, in platinum-induced ototoxicity.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 More SS, Akil O, Ianculescu AG, Geier EG, Lustig LR, Giacomini KM
• Exchange of apolipoprotein A-I between lipid-associated and lipid-free states: a potential target for oxidative generation of dysfunctional high density lipoproteins.
  The Journal of biological chemistry 2010 Cavigiolio G, Geier EG, Shao B, Heinecke JW, Oda MN
• Real-Time Detection of Apolipoprotein A-I's Lipidation State by Fluorescence Resonance Energy Transfer.
  Biophysical Journal 2010 Giorgio Cavigiolio, Ethan G. Geier, Michael N. Oda
• The interplay between size, morphology, stability, and functionality of high-density lipoprotein subclasses.
  Biochemistry 2008 Cavigiolio G, Shao B, Geier EG, Ren G, Heinecke JW, Oda MN