Ernest Lee, MD, PhD
RESIDENT PHYSICIAN
Dermatology
School of Medicine

Awards

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• Forbes 30 under 30 in Science, 2021
• Emil Bogen Research Prize, UCLA, 2020
• Alpha Omega Alpha Honor Society, Junior Member, UCLA, 2019
• Edward K. Rice Outstanding Doctoral Student Award, UCLA, 2019
• Department of Bioengineering Outstanding PhD Student Award, UCLA, 2018
• National Psoriasis Foundation Early Career Research Grant, UCLA, 2017
• Hertz Foundation Graduate Fellowship Finalist, UCLA, 2015

Education & Training

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• Residency Dermatology University of California, San Francisco 2024
• Internship Internal Medicine Cedars-Sinai Medical Center 2021
• MD Medicine David Geffen School of Medicine at UCLA 2020
• PhD Bioengineering University of California, Los Angeles 2018
• BS Physics California Institute of Technology 2012

Interests

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• computational biology
• antimicrobial peptides
• innate immunity
• autoimmune skin disease
• machine learning
• biophysics

Websites

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• Personal Website (ernest-lee.github.io)

Publications (38)

Top publication keywords:
CathelicidinsLichen PlanusRNA, Double-StrandedToll-Like ReceptorsMachine LearningAntimicrobial Cationic PeptidesPituitary Adenylate Cyclase-Activating PolypeptidePore Forming Cytotoxic ProteinsToll-Like Receptor 9DermatofibrosarcomaToll-Like Receptor 3Pyoderma GangrenosumDefensinsSulfonesAnti-Infective Agents

• PACAP is a pathogen-inducible resident antimicrobial neuropeptide affording rapid and contextual molecular host defense of the brain.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Lee EY, Chan LC, Wang H, Lieng J, Hung M, Srinivasan Y, Wang J, Waschek JA, Ferguson AL, Lee KF, Yount NY, Yeaman MR, Wong GCL
• Machine learning for precision dermatology: Advances, opportunities, and outlook.
  Journal of the American Academy of Dermatology 2020 Lee EY, Maloney NJ, Cheng K, Bach DQ
• Circulating biomarkers predictive of tumor response to cancer immunotherapy.
  Expert review of molecular diagnostics 2019 Lee EY, Kulkarni RP
• Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9.
  Nature communications 2019 Lee EY, Zhang C, Di Domizio J, Jin F, Connell W, Hung M, Malkoff N, Veksler V, Gilliet M, Ren P, Wong GCL
• Modulation of toll-like receptor signaling by antimicrobial peptides.
  Seminars in cell & developmental biology 2018 Lee EY, Lee MW, Wong GCL
• Crystallinity of Double-Stranded RNA-Antimicrobial Peptide Complexes Modulates Toll-Like Receptor 3-Mediated Inflammation.
  ACS nano 2017 Lee EY, Takahashi T, Curk T, Dobnikar J, Gallo RL, Wong GCL
• Machine learning-enabled discovery and design of membrane-active peptides.
  Bioorganic & medicinal chemistry 2017 Lee EY, Wong GCL, Ferguson AL
• Mapping membrane activity in undiscovered peptide sequence space using machine learning.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Lee EY, Fulan BM, Wong GC, Ferguson AL

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• Excess psoriasis and psoriatic arthritis mortality during the COVID-19 pandemic in the United States: A nationwide population-based study from 2010 to 2021.
  Journal of the European Academy of Dermatology and Venereology : JEADV 2023 Liu Y, He X, Lee EY, Lv F, Yao L, Meng Q, Zhang L, Ng WH, Zhang Y, Elias PM, Man M, Yeo YH, Li Z
• Severe recurrence of reactive infectious mucocutaneous eruption with extensive ocular involvement in an adult due to SARS-CoV-2.
  JAAD case reports 2023 Wu D, Lee EY, Lifton J, Zullo SW, Seiger K, Nadadur R, Fox LP, Escobar DJ, Dobry AS, Yung M, Kangelaris KN, Arakaki RY
• Phenol-Soluble Modulins From Staphylococcus aureus Biofilms Form Complexes With DNA to Drive Autoimmunity.
  Frontiers in cellular and infection microbiology 2022 Grando K, Nicastro LK, Tursi SA, De Anda J, Lee EY, Wong GCL, Tükel Ç
• Histidine-Mediated Ion Specific Effects Enable Salt Tolerance of a Pore-Forming Marine Antimicrobial Peptide.
  Angewandte Chemie (International ed. in English) 2022 Xian W, Hennefarth MR, Lee MW, Do T, Lee EY, Alexandrova AN, Wong GCL
• Quantitative readability analysis of online patient educational materials for dermatofibrosarcoma protuberans.
  International journal of dermatology 2021 Kirchner A, Patel M, Kulkarni V, Usman A, Lee EY
• Readability assessment of patient-facing online educational content for pyoderma gangrenosum.
  Journal of the American Academy of Dermatology 2021 Kirchner A, Kulkarni V, Rajkumar J, Usman A, Hassan S, Lee EY
• Ocular lichen planus treated with lifitegrast.
  International journal of dermatology 2020 Lee EY, Arzeno J, Ni C, Holland V
• Discovery of Novel Type II Bacteriocins Using a New High-Dimensional Bioinformatic Algorithm.
  Frontiers in immunology 2020 Yount NY, Weaver DC, de Anda J, Lee EY, Lee MW, Wong GCL, Yeaman MR
• Functional Reciprocity of Amyloids and Antimicrobial Peptides: Rethinking the Role of Supramolecular Assembly in Host Defense, Immune Activation, and Inflammation.
  Frontiers in immunology 2020 Lee EY, Srinivasan Y, de Anda J, Nicastro LK, Tükel Ç, Wong GCL
• Standing electric scooter injuries: Impact on a community.
  American journal of surgery 2020 Bloom MB, Noorzad A, Lin C, Little M, Lee EY, Margulies DR, Torbati SS
• Telehealth Solutions for In-hospital Communication with Patients Under Isolation During COVID-19.
  The western journal of emergency medicine 2020 Fang J, Liu YT, Lee EY, Yadav K
• Switchable Membrane Remodeling and Antifungal Defense by Metamorphic Chemokine XCL1.
  ACS infectious diseases 2020 Dishman AF, Lee MW, de Anda J, Lee EY, He J, Huppler AR, Wong GCL, Volkman BF
• Improved prediction of HIT in the SICU using an improved model of the Warkentin 4-T system: 3-T.
  American journal of surgery 2019 Bloom MB, Johnson J, Volod O, Lee EY, White T, Margulies DR
• CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis.
  Nature communications 2019 Lande R, Lee EY, Palazzo R, Marinari B, Pietraforte I, Santos GS, Mattenberger Y, Spadaro F, Stefanantoni K, Iannace N, Dufour AM, Falchi M, Bianco M, Botti E, Bianchi L, Alvarez M, Riccieri V, …
• Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.
  Nature 2019 Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-…
• Off-label studies on apremilast in dermatology: a review.
  The Journal of dermatological treatment 2019 Maloney NJ, Zhao J, Tegtmeyer K, Lee EY, Cheng K
• Unifying structural signature of eukaryotic α-helical host defense peptides.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Yount NY, Weaver DC, Lee EY, Lee MW, Wang H, Chan LC, Wong GCL, Yeaman MR
• Machine learning antimicrobial peptide sequences: Some surprising variations on the theme of amphiphilic assembly.
  Current opinion in colloid & interface science 2018 Lee MW, Lee EY, Ferguson AL, Wong GCL
• What Can Pleiotropic Proteins in Innate Immunity Teach Us about Bioconjugation and Molecular Design?
  Bioconjugate chemistry 2018 Lee MW, Lee EY, Wong GCL
• Multigenerational memory and adaptive adhesion in early bacterial biofilm communities.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Lee CK, de Anda J, Baker AE, Bennett RR, Luo Y, Lee EY, Keefe JA, Helali JS, Ma J, Zhao K, Golestanian R, O'Toole GA, Wong GCL
• Cathelicidin promotes inflammation by enabling binding of self-RNA to cell surface scavenger receptors.
  Scientific reports 2018 Takahashi T, Kulkarni NN, Lee EY, Zhang LJ, Wong GCL, Gallo RL
• Molecular Motor Dnm1 Synergistically Induces Membrane Curvature To Facilitate Mitochondrial Fission.
  ACS central science 2017 Lee MW, Lee EY, Lai GH, Kennedy NW, Posey AE, Xian W, Ferguson AL, Hill RB, Wong GCL
• What can machine learning do for antimicrobial peptides, and what can antimicrobial peptides do for machine learning?
  Interface focus 2017 Lee EY, Lee MW, Fulan BM, Ferguson AL, Wong GCL
• High-Speed "4D" Computational Microscopy of Bacterial Surface Motility.
  ACS nano 2017 de Anda J, Lee EY, Lee CK, Bennett RR, Ji X, Soltani S, Harrison MC, Baker AE, Luo Y, Chou T, O'Toole GA, Armani AM, Golestanian R, Wong GCL
• A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity.
  Journal of innate immunity 2017 Stolzenberg E, Berry D, Lee EY, Kroemer A, Kaufman S, Wong GCL, Oppenheim JJ, Sen S, Fishbein T, Bax A, Harris B, Barbut D, Zasloff MA
• Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9.
  PLoS pathogens 2017 Tursi SA, Lee EY, Medeiros NJ, Lee MH, Nicastro LK, Buttaro B, Gallucci S, Wilson RP, Wong GCL, Tükel Ç
• Direct Antimicrobial Activity of IFN-β.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Kaplan A, Lee MW, Wolf AJ, Limon JJ, Becker CA, Ding M, Murali R, Lee EY, Liu GY, Wong GCL, Underhill DM
• S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages.
  PLoS pathogens 2016 Realegeno S, Kelly-Scumpia KM, Dang AT, Lu J, Teles R, Liu PT, Schenk M, Lee EY, Schmidt NW, Wong GC, Sarno EN, Rea TH, Ochoa MT, Pellegrini M, Modlin RL
• Oxidation of Membrane Curvature-Regulating Phosphatidylethanolamine Lipid Results in Formation of Bilayer and Cubic Structures.
  Langmuir : the ACS journal of surfaces and colloids 2016 Sankhagowit S, Lee EY, Wong GC, Malmstadt N
• A review of immune amplification via ligand clustering by self-assembled liquid-crystalline DNA complexes.
  Advances in colloid and interface science 2016 Lee EY, Lee CK, Schmidt NW, Jin F, Lande R, Curk T, Frenkel D, Dobnikar J, Gilliet M, Wong GCL