Eric Tse, PhD
Assistant Professor
Institute for Neurodegenerative Diseases
School of Medicine

Publications (29)

Top publication keywords:
tau ProteinsTacrolimus Binding ProteinsProto-Oncogene Proteins c-mdm2Escherichia coli ProteinsPeroxiredoxinsEndopeptidase ClpHSP70 Heat-Shock ProteinsAnkyrinsCryoelectron MicroscopyPolyphosphatesHSP90 Heat-Shock ProteinsMolecular ChaperonesApoferritinsProtein UnfoldingHeat-Shock Proteins

• The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
  Nature structural & molecular biology 2023 Braxton JR, Altobelli CR, Tucker MR, Tse E, Thwin AC, Arkin MR, Southworth DR
• Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments.
  Nature communications 2023 Merz GE, Chalkley MJ, Tan SK, Tse E, Lee J, Prusiner SB, Paras NA, DeGrado WF, Southworth DR
• Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly.
  bioRxiv : the preprint server for biology 2023 Braxton JR, Shao H, Tse E, Gestwicki JE, Southworth DR
• The p97/VCP adapter UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
  bioRxiv : the preprint server for biology 2023 Braxton JR, Altobelli CR, Tucker MR, Tse E, Thwin AC, Arkin MR, Southworth DR
• Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3.
  Cell reports 2022 Cupo RR, Rizo AN, Braun GA, Tse E, Chuang E, Gupta K, Southworth DR, Shorter J

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• Epigenetic Silencing of PTEN and Epi-Transcriptional Silencing of MDM2 Underlied Progression to Secondary Acute Myeloid Leukemia in Myelodysplastic Syndrome Treated with Hypomethylating Agents.
  International journal of molecular sciences 2022 Lee P, Yim R, Miu KK, Fung SH, Liao JJ, Wang Z, Li J, Yung Y, Chu HT, Yip PK, Lee E, Tse E, Kwong YL, Gill H
• The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state.
  Molecular cell 2021 Lee K, Thwin AC, Nadel CM, Tse E, Gates SN, Gestwicki JE, Southworth DR
• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  Research square 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  bioRxiv : the preprint server for biology 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM.
  Journal of structural biology 2021 Sun M, Azumaya CM, Tse E, Bulkley DP, Harrington MB, Gilbert G, Frost A, Southworth D, Verba KA, Cheng Y, Agard DA
• Rapid deployment of SARS-CoV-2 testing: The CLIAHUB.
  PLoS pathogens 2020 Crawford ED, Acosta I, Ahyong V, Anderson EC, Arevalo S, Asarnow D, Axelrod S, Ayscue P, Azimi CS, Azumaya CM, Bachl S, Bachmutsky I, Bhaduri A, Brown JB, Batson J, Behnert A, Boileau RM, Bollam SR, …
• Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
  Science (New York, N.Y.) 2020 Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor…
• Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
  Nature structural & molecular biology 2020 Lopez KE, Rizo AN, Tse E, Lin J, Scull NW, Thwin AC, Lucius AL, Shorter J, Southworth DR
• Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.
  The Journal of biological chemistry 2019 Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M
• Mechanistic insights into the protective roles of polyphosphate against amyloid cytotoxicity.
  Life science alliance 2019 Lempart J, Tse E, Lauer JA, Ivanova MI, Sutter A, Yoo N, Huettemann P, Southworth D, Jakob U
• Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.
  Nature communications 2019 Rizo AN, Lin J, Gates SN, Tse E, Bart SM, Castellano LM, DiMaio F, Shorter J, Southworth DR
• Chaperone activation and client binding of a 2-cysteine peroxiredoxin.
  Nature communications 2019 Teixeira F, Tse E, Castro H, Makepeace KAT, Meinen BA, Borchers CH, Poole LB, Bardwell JC, Tomás AM, Southworth DR, Jakob U
• Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau.
  Nature communications 2018 Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE
• Polyphosphate Stabilizes Protein Unfolding Intermediates as Soluble Amyloid-like Oligomers.
  Journal of molecular biology 2018 Yoo NG, Dogra S, Meinen BA, Tse E, Haefliger J, Southworth DR, Gray MJ, Dahl JU, Jakob U
• X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.
  The Journal of biological chemistry 2017 Cesa LC, Shao H, Srinivasan SR, Tse E, Jain C, Zuiderweg ERP, Southworth DR, Mapp AK, Gestwicki JE
• Aggregation of Mod5 is affected by tRNA binding with implications for tRNA gene-mediated silencing.
  FEBS letters 2017 Read DF, Waller TJ, Tse E, Southworth DR, Engelke DR, Smaldino PJ
• BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins.
  Journal of molecular biology 2016 Rauch JN, Tse E, Freilich R, Mok SA, Makley LN, Southworth DR, Gestwicki JE
• A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis.
  eLife 2015 Rajagopal P, Tse E, Borst AJ, Delbecq SP, Shi L, Southworth DR, Klevit RE
• Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Teixeira F, Castro H, Cruz T, Tse E, Koldewey P, Southworth DR, Tomás AM, Jakob U
• The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.
  The Journal of biological chemistry 2013 Connarn JN, Assimon VA, Reed RA, Tse E, Southworth DR, Zuiderweg ER, Gestwicki JE, Sun D
• MGAT3 mRNA: a biomarker for prognosis and therapy of Alzheimer's disease by vitamin D and curcuminoids.
  Journal of Alzheimer's disease : JAD 2011 Fiala M, Mahanian M, Rosenthal M, Mizwicki MT, Tse E, Cho T, Sayre J, Weitzman R, Porter V
• IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients.
  Journal of neuroinflammation 2010 Fiala M, Chattopadhay M, La Cava A, Tse E, Liu G, Lourenco E, Eskin A, Liu PT, Magpantay L, Tse S, Mahanian M, Weitzman R, Tong J, Nguyen C, Cho T, Koo P, Sayre J, Martinez-Maza O, Rosenthal MJ, …
• Immune blood biomarkers of Alzheimer disease patients.
  Journal of neuroimmunology 2009 Avagyan H, Goldenson B, Tse E, Masoumi A, Porter V, Wiedau-Pazos M, Sayre J, Ong R, Mahanian M, Koo P, Bae S, Micic M, Liu PT, Rosenthal MJ, Fiala M
• High incidence of tuberculosis after alemtuzumab treatment in Hong Kong Chinese patients.
  Leukemia research 2007 Au WY, Leung AY, Tse EW, Cheung WW, Shek TW, Kwong YL