Eric Figueroa, PhD
Postdoctoral Scholar
Physiology
School of Medicine

Awards

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• Ruth L. Kirschstein National Research Service Award (1F31DK120225-01), NIH/NIDDK, 2018-2020

Education & Training

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• Ph.D. Pharmacology Vanderbilt University 12/2020
• B.S./B.S. Biochemistry/Molecular and Cellular Biology University of Arizona 8/2014

Publications (10)

Top publication keywords:
Voltage-Dependent Anion ChannelsPyridinesEpithelial CellsAntioxidantsReceptors, LeukotrieneHEK293 CellsPotassium Channels, Inwardly RectifyingReactive Oxygen SpeciesOrganometallic CompoundsChromonesCell SizeMembrane ProteinsPotassium Channel BlockersAnionsLeukotriene Antagonists

• Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
  Nature communications 2023 Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
• A SWELL time to develop the molecular pharmacology of the volume-regulated anion channel (VRAC).
  Channels (Austin, Tex.) 2022 Figueroa EE, Denton JS
• Identification of a conserved drug binding pocket in TMEM16 proteins.
  Research square 2022 Cheng Y, Feng S, Puchades C, Ko J, Figueroa E, Chen Y, Wu H, Gu S, Han T, Li J, Ho B, Shoichet B, Jan YN, Jan L
• Zinc pyrithione activates the volume-regulated anion channel through an antioxidant-sensitive mechanism.
  American journal of physiology. Cell physiology 2021 Figueroa EE, Denton JS
• LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology.
  American journal of physiology. Cell physiology 2020 Yamada T, Figueroa EE, Denton JS, Strange K

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• The LRRC8 volume-regulated anion channel inhibitor, DCPIB, inhibits mitochondrial respiration independently of the channel.
  Physiological reports 2019 Afzal A, Figueroa EE, Kharade SV, Bittman K, Matlock BK, Flaherty DK, Denton JS
• CysLT1 receptor antagonists pranlukast and zafirlukast inhibit LRRC8-mediated volume regulated anion channels independently of the receptor.
  American journal of physiology. Cell physiology 2019 Figueroa EE, Kramer M, Strange K, Denton JS
• Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992.
  Molecular pharmacology 2018 Kharade SV, Kurata H, Bender AM, Blobaum AL, Figueroa EE, Duran A, Kramer M, Days E, Vinson P, Flores D, Satlin LM, Meiler J, Weaver CD, Lindsley CW, Hopkins CR, Denton JS
• Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590.
  Molecular pharmacology 2017 Kharade SV, Sheehan JH, Figueroa EE, Meiler J, Denton JS
• ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels.
  ACS chemical neuroscience 2016 Swale DR, Kurata H, Kharade SV, Sheehan J, Raphemot R, Voigtritter KR, Figueroa EE, Meiler J, Blobaum AL, Lindsley CW, Hopkins CR, Denton JS