Emin Maltepe, MD, PhD
Professor
Pediatrics
School of Medicine

Education & Training

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• Fellowship Neonatal-Perinatal Medicine University of California, San Francisco 2007
• Residency University of California, San Francisco 2004
• M.D. Pritzker School of Medicine University of Chicago 2001
• PhD Pathology University of Chicago 1998

Websites

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• Clinical Profile at UCSF Benioff Children's Hospital (ucsfbenioffchildrens.org)
• My Lab Site (maltepelab.com)
• Initiative for Pediatric Drug and Device Development (ipd3.org)

Grants and Projects

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• Metabolic Reprogramming and Pulmonary Vascular Disease in Congenital Heart Disease, NIH/NHLBI, 2020-2030
• OMX-A Novel Oxygen Carrier for Non-compressible Hemorrhage in Austere Environments, Department of Defense, 2024-2027
• Large Mammal Neuroprotective Clinical Platform, Bill and Melinda Gates Foundation, 2018-2027
• Altered Lymphatic Function and Development in Congenital Heart Disease, NIH/NHLBI, 2006-2027
• Development of an oxygen delivery biotherapeutic for the preservation of myocardial function during pediatric cardiopulmonary bypass, NIH/NICHD, 2023-2026
• An Anticoagulation-Free Artificial Placenta Device, NIH, 2023-2025
• Precision Therapy for Neonatal Brain Injury, NIH, 2016-2024
• OMX-CV, A Novel Oxygen Delivery Biotherapeutic for Treatment of Hemorrhagic Shock in the Battlefield, DOD, 2020-2024
• Integrating Environmental Cues at the Maternal-Fetal Vascular Interface, NIH, 2012-2024

Publications (94)

Top publication keywords:
PlacentaGliosisShock, HemorrhagicCaffeineLim KinasesPentose Phosphate PathwayOxygenHypoxia-Ischemia, BrainSheepHypoxia-Inducible Factor 1, alpha SubunitHypothermia, InducedTrophoblastsDisease Models, AnimalHypoxia-Inducible Factor 1Hypoxia

• Abstract 4372620: Pulmonary Vascular Endothelial Dysfunction is Induced by Non-Pulsatile Pulmonary Blood Flow in an Ovine Classic Glenn Model.
  Circulation 2025 Jonathan Hyde, Michael Smith, Naveen Swami, Gary Raff, Yen-Chen Chao, Johnny Hwang, Jason Boehme, Sanjeev Datar, Emin Maltepe, Jeffrey Fineman
• Microvascular preservation and cardiomyocyte hyperplasia underlie adaptive right ventricle development in congenital heart disease-pulmonary arterial hypertension.
  American journal of physiology. Heart and circulatory physiology 2025 Smith MA, Guardado ES, Boehme J, Datar SA, Maltepe E, Swami N, Raff GW, Bodansky A, Chelladurai P, Moreno J, Prince AR, Powers N, Huang GN, de Jesus Perez V, Fineman JR
• Mouse placentae generated by in vitro fertilization exhibit altered gene expression, activated hypoxia responses and reduced fitness†.
  Biology of reproduction 2025 Oqani RK, Maltepe E, Rinaudo P, Wagner DE
• c-Myc promotes metabolic reprogramming in pulmonary hypertension via the stimulation of glutaminolysis and the reductive tricarboxylic acid cycle.
  Redox biology 2025 Yegambaram M, Sun X, Lu Q, Flores AG, Zemskova M, Soto J, Rauckhorst A, Maltepe E, Wang T, Fineman JR, Black SM
• Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation.
  Scientific reports 2025 Boehme JT, Datar SA, Sun X, Gong W, Lu Q, Soto J, Smith MA, Garcia-Flores AE, Raff GW, Wang T, Maltepe E, Black SM, Fineman JR

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• Restoration of pp60Src Re-Establishes Electron Transport Chain Complex I Activity in Pulmonary Hypertensive Endothelial Cells.
  International journal of molecular sciences 2025 Yegambaram M, Pokharel MD, Sun X, Lu Q, Soto J, Aggarwal S, Maltepe E, Fineman JR, Wang T, Black SM
• Perinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia.
  Stroke 2024 Mike JK, White Y, Ha J, Iranmahboub A, Hawkins C, Hutchings RS, Vento C, Manzoor H, Wang A, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Fineman JR, Ferriero DM, Maltepe E
• Pre-eclampsia and barker's hypothesis: are we beginning to see the trees within the forest?
  Pediatric research 2024 Tsoi SM, Steurer M, Maltepe E, Fineman JR
• OMX: A NOVEL OXYGEN DELIVERY BIOTHERAPEUTIC IMPROVES OUTCOMES IN AN OVINE MODEL OF CONTROLLED HEMORRHAGIC SHOCK.
  Shock (Augusta, Ga.) 2024 Maltepe E, Smith M, Boehme J, Datar SA, Hutchings RS, Vento CA, Manzoor H, Loucks A, Winger JA, Fineman JR
• The effect of fertility treatment and socioeconomic status on neonatal and post-neonatal mortality in the United States.
  Journal of perinatology : official journal of the California Perinatal Association 2024 Sharma M, Fineman DC, Keller RL, Maltepe E, Rinaudo PF, Steurer MA
• 3 Development, Function, and Pathology of the Placenta.
  Avery's Diseases of the Newborn 2024 EMIN MALTEPE, ANNA A. PENN
• Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy.
  Children (Basel, Switzerland) 2023 Mike JK, White Y, Hutchings RS, Vento C, Ha J, Iranmahboub A, Manzoor H, Gunewardena A, Cheah C, Wang A, Goudy BD, Lakshminrusimha S, Long-Boyle J, Fineman JR, Ferriero DM, Maltepe E
• Perinatal Azithromycin Provides Limited Neuroprotection in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy.
  Stroke 2023 Mike JK, White Y, Hutchings RS, Vento C, Ha J, Manzoor H, Lee D, Losser C, Arellano K, Vanhatalo O, Seifert E, Gunewardena A, Wen B, Wang L, Wang A, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, …
• Comparing the efficacy in reducing brain injury of different neuroprotective agents following neonatal hypoxia-ischemia in newborn rats: a multi-drug randomized controlled screening trial.
  Scientific reports 2023 Sabir H, Maes E, Zweyer M, Schleehuber Y, Imam FB, Silverman J, White Y, Pang R, Pasca AM, Robertson NJ, Maltepe E, Bernis ME
• Fertility treatment increases the risk of preterm birth independent of multiple gestations.
  F&S reports 2023 Fineman DC, Keller RL, Maltepe E, Rinaudo PF, Steurer MA
• Abstract 13625: Autophagy Plays a Key Role in the Loss of Nitric Oxide Signaling and Endothelial Dysfunction in Pulmonary Vascular Diseases.
  Circulation 2022 Ying Liang, Wojciech Ornatowski, Qing Lu, Xutong Sun, Alejandro E Garcia, Evgeny A Zemskov, Emin Maltepe, Jeffrey R Fineman, Kim Tieu, Ting Wang, Stephen M Black
• Placental pathology is necessary to understand common pregnancy complications and achieve an improved taxonomy of obstetrical disease.
  American journal of obstetrics and gynecology 2022 Redline RW, Roberts DJ, Parast MM, Ernst LM, Morgan TK, Greene MF, Gyamfi-Bannerman C, Louis JM, Maltepe E, Mestan KK, Romero R, Stone J
• Defining Longer-Term Outcomes in an Ovine Model of Moderate Perinatal Hypoxia-Ischemia.
  Developmental neuroscience 2022 Mike JK, Wu KY, White Y, Pathipati P, Ndjamen B, Hutchings RS, Losser C, Vento C, Arellano K, Vanhatalo O, Ostrin S, Windsor C, Ha J, Alhassen Z, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long…
• Autophagy plays a key role in hyper-proliferative phenotype in pulmonary vascular diseases.
  Free Radical Biology and Medicine 2022 Wojciech Ornatowski, Qing Lu, Xutong Sun, Alejandro Garcia Flores, Anlin Feng, Evgeny Zemskov, Emin Maltepe, Jeffrey Fineman, Ting Wang, Stephen Black
• Cellular Oxygen Sensing, Mitochondrial Oxygen Sensing and Reactive Oxygen Species.
  2021 Jason Boehme, Emin Maltepe
• Outcomes of Very Preterm Infants Conceived with Assisted Reproductive Technologies.
  The Journal of pediatrics 2021 Fineman DC, Keller RL, Maltepe E, Rinaudo PF, Steurer MA
• Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant.
  Nature biotechnology 2021 Sonmezoglu S, Fineman JR, Maltepe E, Maharbiz MM
• HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow.
  Scientific reports 2021 Boehme JT, Morris CJ, Chiacchia SR, Gong W, Wu KY, Kameny RJ, Raff GW, Fineman JR, Maltepe E, Datar SA
• Sex-specific epigenetic profile of inner cell mass of mice conceived in vivo or by IVF.
  Molecular human reproduction 2020 Ruggeri E, Lira-Albarrán S, Grow EJ, Liu X, Harner R, Maltepe E, Ramalho-Santos M, Donjacour A, Rinaudo P
• Effect of culture conditions and method of conception on mouse live birth rate.
  F&S science 2020 Xiao Z, Donjacour A, Harner R, Simbulan R, Kao CN, Ruggeri E, Liu X, Maltepe E, Rinaudo P
• Defining the ATPome reveals cross-optimization of metabolic pathways.
  Nature communications 2020 Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K
• Human placental trophoblast progenitor cells (hTPCs) promote angiogenesis and neurogenesis after focal cerebral ischemia in rats.
  The International journal of neuroscience 2020 Molbay M, Özaydin-Goksu E, Kipmen-Korgun D, Unal A, Ozekinci M, Cebeci E, Maltepe E, Korgun ET
• Complex interplay between autophagy and oxidative stress in the development of pulmonary disease.
  Redox biology 2020 Ornatowski W, Lu Q, Yegambaram M, Garcia AE, Zemskov EA, Maltepe E, Fineman JR, Wang T, Black SM
• Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease.
  Pulmonary circulation 2020 Zhu T, Chiacchia S, Kameny RJ, Garcia De Herreros A, Gong W, Raff GW, Boehme JB, Maltepe E, Lasheras JC, Black SM, Datar SA, Fineman JR
• Mechanical Forces Alter Endothelin-1 Signaling: Comparative Ovine Models of Congenital Heart Disease.
  Biophysical Journal 2020 Antoni Garcia-Herreros, Rebecca J. Kameny, Terry Zhu, Jason Boehme, Gary Raff, Juan C. Lasheras, Stephen M. Black, Emin Maltepe, Sanjeev A. Datar, Jeffrey R. Fineman
• Outcomes of pulmonary vascular disease in infants conceived with non-IVF fertility treatment and assisted reproductive technologies at 1 year of age.
  Pediatric pulmonology 2019 Fineman DC, Baer RJ, Chambers CD, Rajagopal S, Maltepe E, Rinaudo PF, Fineman JR, Jelliffe-Pawlowski LL, Steurer MA
• Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling.
  American journal of respiratory cell and molecular biology 2019 Johnson Kameny R, Datar SA, Boehme JB, Morris C, Zhu T, Goudy BD, Johnson EG, Galambos C, Raff GW, Sun X, Wang T, Chiacchia SR, Lu Q, Black SM, Maltepe E, Fineman JR
• Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury.
  Frontiers in physiology 2019 Kelly GT, Faraj R, Zhang Y, Maltepe E, Fineman JR, Black SM, Wang T
• The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification.
  PloS one 2019 Abed M, Verschueren E, Budayeva H, Liu P, Kirkpatrick DS, Reja R, Kummerfeld SK, Webster JD, Gierke S, Reichelt M, Anderson KR, Newman RJ, Roose-Girma M, Modrusan Z, Pektas H, Maltepe E, Newton K, …
• Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease.
  Antioxidants & redox signaling 2019 Zemskov EA, Lu Q, Ornatowski W, Klinger CN, Desai AA, Maltepe E, Yuan JX, Wang T, Fineman JR, Black SM
• Murine trophoblast-derived and pregnancy-associated exosome-enriched extracellular vesicle microRNAs: Implications for placenta driven effects on maternal physiology.
  PloS one 2019 Stefanski AL, Martinez N, Peterson LK, Callahan TJ, Treacy E, Luck M, Friend SF, Hermesch A, Maltepe E, Phang T, Dragone LL, Winn VD
• Correction: Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.
  PLoS biology 2019 Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, …
• Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.
  PLoS biology 2018 Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, …
• KLF2-mediated disruption of PPAR-γ signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.
  American journal of physiology. Heart and circulatory physiology 2018 Morris CJ, Kameny RJ, Boehme J, Gong W, He Y, Zhu T, Maltepe E, Raff GW, Fineman JR, Datar SA
• Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury.
  Cerebellum (London, England) 2018 Nguyen V, Sabeur K, Maltepe E, Ameri K, Bayraktar O, Rowitch DH
• 5 Development, Function, and Pathology of the Placenta.
  2018 Emin Maltepe, Anna A. Penn
• Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2017 Black SM, Field-Ridley A, Sharma S, Kumar S, Keller RL, Kameny R, Maltepe E, Datar SA, Fineman JR
• Common and specific transcriptional signatures in mouse embryos and adult tissues induced by in vitro procedures.
  Reproduction (Cambridge, England) 2016 Feuer S, Liu X, Donjacour A, Simbulan R, Maltepe E, Rinaudo P
• Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation.
  American journal of physiology. Heart and circulatory physiology 2016 Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E
• Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.
  American journal of physiology. Heart and circulatory physiology 2016 Datar SA, Gong W, He Y, Johengen M, Kameny RJ, Raff GW, Maltepe E, Oishi PE, Fineman JR
• Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung.
  PloS one 2016 Rafikova O, Meadows ML, Kinchen JM, Mohney RP, Maltepe E, Desai AA, Yuan JX, Garcia JG, Fineman JR, Rafikov R, Black SM
• Adult male mice conceived by in vitro fertilization exhibit increased glucocorticoid receptor expression in fat tissue.
  Journal of developmental origins of health and disease 2015 Simbulan RK, Liu X, Feuer SK, Maltepe E, Donjacour A, Rinaudo P
• Placenta: the forgotten organ.
  Annual review of cell and developmental biology 2015 Maltepe E, Fisher SJ
• Abstract 640: PASMC Hyperproliferation and Metabolic Shift in a Model of Pulmonary Overcirculation.
  Arteriosclerosis Thrombosis and Vascular Biology 2015 Jason Boehme, Kathryn Tormos, Jeff Fineman, Emin Maltepe
• HIGD1A-mediated dormancy and tumor survival.
  Molecular & cellular oncology 2015 Ameri K, Maltepe E
• Embryonic stem cells derived from in vivo or in vitro-generated murine blastocysts display similar transcriptome and differentiation potential.
  PloS one 2015 Simbulan RK, Di Santo M, Liu X, Lin W, Donjacour A, Maltepe E, Shenoy A, Borini A, Rinaudo P
• Spare hypoxia, spoil the child?
  The Journal of clinical investigation 2015 Boehme J, Maltepe E
• HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth.
  Cell reports 2015 Ameri K, Jahangiri A, Rajah AM, Tormos KV, Nagarajan R, Pekmezci M, Nguyen V, Wheeler ML, Murphy MP, Sanders TA, Jeffrey SS, Yeghiazarians Y, Rinaudo PF, Costello JF, Aghi MK, Maltepe E
• LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia.
  The American journal of pathology 2014 Zhou Y, Yuge A, Rajah AM, Unek G, Rinaudo PF, Maltepe E
• Sexually dimorphic effect of in vitro fertilization (IVF) on adult mouse fat and liver metabolomes.
  Endocrinology 2014 Feuer SK, Donjacour A, Simbulan RK, Lin W, Liu X, Maltepe E, Rinaudo PF
• Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis.
  Cell 2014 Yuen TJ, Silbereis JC, Griveau A, Chang SM, Daneman R, Fancy SPJ, Zahed H, Maltepe E, Rowitch DH
• Therapeutic delivery of placental stem cells to modulate vasculature and promote fracture repair (342.6).
  The FASEB Journal 2014 Chelsea Bahney, Aaron Taylor, Ali Sadat, Kathryn Tormos, Ted Miclau, Emin Maltepe, Ralph Marcucio
• Use of a mouse in vitro fertilization model to understand the developmental origins of health and disease hypothesis.
  Endocrinology 2014 Feuer SK, Liu X, Donjacour A, Lin W, Simbulan RK, Giritharan G, Piane LD, Kolahi K, Ameri K, Maltepe E, Rinaudo PF
• Placental syncytium forms a biophysical barrier against pathogen invasion.
  PLoS pathogens 2013 Zeldovich VB, Clausen CH, Bradford E, Fletcher DA, Maltepe E, Robbins JR, Bakardjiev AI
• Hypoxia and trophoblast differentiation: a key role for PPARγ.
  Stem cells and development 2013 Tache V, Ciric A, Moretto-Zita M, Li Y, Peng J, Maltepe E, Milstone DS, Parast MM
• Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress.
  PloS one 2013 Ameri K, Rajah AM, Nguyen V, Sanders TA, Jahangiri A, Delay M, Donne M, Choi HJ, Tormos KV, Yeghiazarians Y, Jeffrey SS, Rinaudo PF, Rowitch DH, Aghi M, Maltepe E
• The effect of hypoxia on facial shape variation and disease phenotypes in chicken embryos.
  Disease models & mechanisms 2013 Smith F, Hu D, Young NM, Lainoff AJ, Jamniczky HA, Maltepe E, Hallgrimsson B, Marcucio RS
• ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement.
  PloS one 2013 Choi HJ, Sanders TA, Tormos KV, Ameri K, Tsai JD, Park AM, Gonzalez J, Rajah AM, Liu X, Quinonez DM, Rinaudo PF, Maltepe E
• Effect of ICSI on gene expression and development of mouse preimplantation embryos.
  Human Reproduction 2013 G. Giritharan, M.W. Li, F. Di Sebastiano, F.J. Esteban, J.A. Horcajadas, K.C.K. Lloyd, A. Donjacour, E. Maltepe, P.F. Rinaudo
• Effect of substrate stiffness on early mouse embryo development.
  PloS one 2012 Kolahi KS, Donjacour A, Liu X, Lin W, Simbulan RK, Bloise E, Maltepe E, Rinaudo P
• Impaired placental nutrient transport in mice generated by in vitro fertilization.
  Endocrinology 2012 Bloise E, Lin W, Liu X, Simbulan R, Kolahi KS, Petraglia F, Maltepe E, Donjacour A, Rinaudo P
• In vitro culture of mouse embryos reduces differential gene expression between inner cell mass and trophectoderm.
  Reproductive sciences (Thousand Oaks, Calif.) 2012 Giritharan G, Delle Piane L, Donjacour A, Esteban FJ, Horcajadas JA, Maltepe E, Rinaudo P
• A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia.
  Development (Cambridge, England) 2011 Hunkapiller NM, Gasperowicz M, Kapidzic M, Plaks V, Maltepe E, Kitajewski J, Cross JC, Fisher SJ
• Effect of ICSI on gene expression and development of mouse preimplantation embryos.
  Human reproduction (Oxford, England) 2010 Giritharan G, Li MW, Di Sebastiano F, De Sebastiano F, Esteban FJ, Horcajadas JA, Lloyd KC, Donjacour A, Maltepe E, Rinaudo PF
• Hypoxia-inducible factor (HIF) and HIF-stabilizing agents in neonatal care.
  Seminars in fetal & neonatal medicine 2010 Park AM, Sanders TA, Maltepe E
• Effect of the method of conception and embryo transfer procedure on mid-gestation placenta and fetal development in an IVF mouse model.
  Human reproduction (Oxford, England) 2010 Delle Piane L, Lin W, Liu X, Donjacour A, Minasi P, Revelli A, Maltepe E, Rinaudo PF
• The placenta: transcriptional, epigenetic, and physiological integration during development.
  The Journal of clinical investigation 2010 Maltepe E, Bakardjiev AI, Fisher SJ
• Oxygen in health and disease: regulation of oxygen homeostasis--clinical implications.
  Pediatric research 2009 Maltepe E, Saugstad OD
• Role of oxygen in early development and embryonic stem cell derivation.
  Stem Cells in Human Reproduction 2006 Olga Genbacev, Paolo F Rinaudo, Emin Maltepe
• Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.
  Journal of Clinical Investigation 2006 K. Red-Horse, J. Rivera, A. Schanz, Y. Zhou, V. Winn, M. Kapidzic, E. Maltepe, K. Okazaki, R. Kochman, K. C. Vo, L. Giudice, A. Erlebacher, J. M. McCune, C. A. Stoddart, S. J. Fisher
• Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.
  The Journal of clinical investigation 2006 Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ
• Literature watch. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.
  Lymphatic research and biology 2006 Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ
• Oxygen, epigenetics and stem cell fate.
  Regenerative medicine 2006 Okazaki K, Maltepe E
• Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation.
  Molecular and cellular biology 2005 Cowden Dahl KD, Fryer BH, Mack FA, Compernolle V, Maltepe E, Adelman DM, Carmeliet P, Simon MC
• Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta.
  Development (Cambridge, England) 2005 Maltepe E, Krampitz GW, Okazaki KM, Red-Horse K, Mak W, Simon MC, Fisher SJ
• Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses.
  Genes & development 2000 Adelman DM, Gertsenstein M, Nagy A, Simon MC, Maltepe E
• Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses.
  Genes & Development 2000 David M. Adelman, Marina Gertsenstein, Andras Nagy, M. Celeste Simon, Emin Maltepe
• TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs.
  The American journal of pathology 2000 Shiels H, Li X, Schumacker PT, Maltepe E, Padrid PA, Sperling A, Thompson CB, Lindsten T
• The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia.
  Biochemical and biophysical research communications 2000 Maltepe E, Keith B, Arsham AM, Brorson JR, Simon MC
• HIF-1 is essential for multilineage hematopoiesis in the embryo.
  Advances in experimental medicine and biology 2000 Adelman DM, Maltepe E, Simon MC
• Multilineage embryonic hematopoiesis requires hypoxic ARNT activity.
  Genes & development 1999 Adelman DM, Maltepe E, Simon MC
• Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT
• Oxygen, genes, and development: an analysis of the role of hypoxic gene regulation during murine vascular development.
  Journal of molecular medicine (Berlin, Germany) 1998 Maltepe E, Simon MC
• Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.
  Mechanisms of development 1998 Jain S, Maltepe E, Lu MM, Simon C, Bradfield CA
• Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha.
  Nature 1998 An WG, Kanekal M, Simon MC, Maltepe E, Blagosklonny MV, Neckers LM
• Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.
  Nature 1997 Maltepe E, Schmidt JV, Baunoch D, Bradfield CA, Simon MC
• Structure of the human type-I interferon gene cluster determined from a YAC clone contig.
  Genomics 1994 Díaz MO, Pomykala HM, Bohlander SK, Maltepe E, Malik K, Brownstein B, Olopade OI
• The use of methylthioadenosine phosphorylase activity to select for human chromosome 9 in interspecies and intraspecies hybrid cells.
  Somatic cell and molecular genetics 1993 Porterfield BW, Pomykala H, Maltepe E, Bohlander SK, Rowley JD, Diaz MO
• Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia.
  Genomics 1992 Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO