Emily Goldberg, PhD
Assistant Professor
Physiology
School of Medicine

We use integrative approaches to understand how immune-metabolic interactions regulate inflammation and can be harnessed to improve immunity and health during aging.

• Non-specific recognition of histone modifications by H3K9bhb antibody.
  iScience 2023 Tsusaka T, Oses-Prieto JA, Lee C, DeFelice BC, Burlingame AL, Goldberg EL
• Non-specific recognition of histone modifications by H3K9bhb antibody.
  bioRxiv : the preprint server for biology 2023 Tsusaka T, Oses-Prieto JA, Lee C, DeFelice BC, Burlingame AL, Goldberg E
• Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammation.
  The Journal of biological chemistry 2023 Goldberg EL, Letian A, Dlugos T, Leveau C, Dixit VD
• Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Zhang X, McDonald JG, Aryal B, Canfrán-Duque A, Goldberg EL, Araldi E, Ding W, Fan Y, Thompson BM, Singh AK, Li Q, Tellides G, Ordovás-Montanes J, García Milian R, Dixit VD, Ikonen E, Suárez Y, …
• IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2.
  Cell metabolism 2021 Goldberg EL, Shchukina I, Youm YH, Ryu S, Tsusaka T, Young KC, Camell CD, Dlugos T, Artyomov MN, Dixit VD
• Integration of immune-metabolic signals to preserve healthy aging.
  Translational medicine of aging 2020 Goldberg EL
• Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections.
  Med (New York, N.Y.) 2020 Stubbs BJ, Koutnik AP, Goldberg EL, Upadhyay V, Turnbaugh PJ, Verdin E, Newman JC
• How Inflammation Blunts Innate Immunity in Aging.
  Interdisciplinary topics in gerontology and geriatrics 2020 Goldberg EL, Shaw AC, Montgomery RR
• Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue.
  Nature metabolism 2020 Goldberg EL, Shchukina I, Asher JL, Sidorov S, Artyomov MN, Dixit VD
• Ketogenic diet activates protective γδ T cell responses against influenza virus infection.
  Science immunology 2019 Goldberg EL, Molony RD, Kudo E, Sidorov S, Kong Y, Dixit VD, Iwasaki A
• Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.
  Cell metabolism 2019 Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD
• Bone Marrow: An Immunometabolic Refuge during Energy Depletion.
  Cell metabolism 2019 Goldberg EL, Dixit VD
• Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance.
  The Journal of physiology 2019 Camporez JP, Lyu K, Goldberg EL, Zhang D, Cline GW, Jurczak MJ, Dixit VD, Petersen KF, Shulman GI
• Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing.
  Nature 2017 Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, Goldberg EL, Youm YH, Brown CW, Elsworth J, Rodeheffer MS, Schultze JL, Dixit VD
• β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares.
  Cell reports 2017 Goldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, Wang C, Morozova-Roche LA, Herzog RI, Iwasaki A, Dixit VD
• Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation.
  Molecular metabolism 2017 Goldberg EL, Dixit VD
• Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence.
  Cell reports 2016 Spadaro O, Goldberg EL, Camell CD, Youm YH, Kopchick JJ, Nguyen KY, Bartke A, Sun LY, Dixit VD
• Editorial: "Crowning" eosinophils in adipose tissue: does location matter?
  Journal of leukocyte biology 2015 Goldberg EL, Dixit VD
• Regulation of Nlrp3 inflammasome by dietary metabolites.
  Seminars in immunology 2015 Camell C, Goldberg E, Dixit VD
• Drivers of age-related inflammation and strategies for healthspan extension.
  Immunological reviews 2015 Goldberg EL, Dixit VD
• The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
  Nature medicine 2015 Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD
• Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms.
  Aging cell 2014 Goldberg EL, Romero-Aleshire MJ, Renkema KR, Ventevogel MS, Chew WM, Uhrlaub JL, Smithey MJ, Limesand KH, Sempowski GD, Brooks HL, Nikolich-Žugich J
• Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections.
  Journal of immunology (Baltimore, Md. : 1950) 2014 Goldberg EL, Smithey MJ, Lutes LK, Uhrlaub JL, Nikolich-Žugich J
• Acute neonatal infections 'lock-in' a suboptimal CD8+ T cell repertoire with impaired recall responses.
  PLoS pathogens 2013 Rudd BD, Venturi V, Smith NL, Nzingha K, Goldberg EL, Li G, Nikolich-Zugich J, Davenport MP
• Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice.
  Age (Dordrecht, Netherlands) 2013 Kusne Y, Goldberg EL, Parker SS, Hapak SM, Maskaykina IY, Chew WM, Limesand KH, Brooks HL, Price TJ, Sanai N, Nikolich-Zugich J, Ghosh S