Emily Chan, MD, PhD
ASST PROF OF CLIN-HCOMP
Pathology
School of Medicine

Publications (66)

Top publication keywords:
AngiomyolipomaKidney NeoplasmsCarcinoma, Transitional CellLeiomyomatosisFumarate HydratasePaget Disease, ExtramammaryUrinary Bladder NeoplasmsTonsillitisProstatitisCarcinoma, Renal CellAdenocarcinomaGenital Neoplasms, MaleCarcinoma in SituProstatic NeoplasmsHamartoma

• Clinicopathologic and Molecular Characterization of High-Risk Human Papillomavirus-Positive Carcinomas of the Urinary Tract.
  Archives of pathology & laboratory medicine 2024 Kayraklioglu N, Stohr BA, Chan E
• GATA3 Expression in Prostatic Adenosquamous Carcinoma: A Potential Diagnostic Pitfall.
  International journal of surgical pathology 2024 Potterveld SK, Williamson SR, Al-Obaidy KI, Akgul M, Chan E, Giannico GA, Sangoi AR
• Development of CD46 targeted alpha theranostics in prostate cancer using 134Ce/225Ac-Macropa-PEG4-YS5.
  Theranostics 2024 Bobba KN, Bidkar AP, Wadhwa A, Meher N, Drona S, Sorlin AM, Bidlingmaier S, Zhang L, Wilson DM, Chan E, Greenland NY, Aggarwal R, VanBrocklin HF, He J, Chou J, Seo Y, Liu B, Flavell RR
• Diagnosis and management of neuroendocrine prostate cancer.
  The Prostate 2024 de Kouchkovsky I, Chan E, Schloss C, Poehlein C, Aggarwal R
• CD46-targeted theranostics for Positron Emission Tomography and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Wadhwa A, Wang S, Patiño-Escobar B, Bidkar AP, Bobba KN, Chan E, Meher N, Bidlingmaier S, Su Y, Dhrona S, Geng H, Sarin V, VanBrocklin HF, Wilson DM, He J, Zhang L, Steri V, Wong SW, Martin TG, Seo Y,…

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• Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs.
  Neuro-oncology 2023 Williams EA, Ravindranathan A, Gupta R, Stevers NO, Suwala AK, Hong C, Kim S, Yuan JB, Wu J, Barreto J, Lucas CG, Chan E, Pekmezci M, LeBoit PE, Mully T, Perry A, Bollen A, Van Ziffle J, Devine WP, …
• Large cribriform glands (> 0.25 mm diameter) as a predictor of adverse pathology in men with Grade Group 2 prostate cancer.
  Histopathology 2023 Greenland NY, Cowan JE, Stohr BA, Simko JP, Carroll PR, Chan E
• Evaluating Web-Based Care for Mental Health and Substance Use Issues for Lesbian, Gay, Bisexual, Transgender, Queer, Questioning, and 2-Spirit Youths in the Context of the COVID-19 Pandemic: Community-Based Participatory Research Study.
  Journal of medical Internet research 2023 Chaiton M, Thorburn R, Chan E, Copeland I, Luphuyong C, Feng P
• Somatic mosaic SOX10 indel mutations underlie a form of segmental schwannomatosis.
  Acta neuropathologica 2023 Terry M, Gupta R, Ravindranathan A, Wu J, Chan E, Bollen AW, Chang SM, Berger MS, Jacques L, Solomon DA
• Positive NKX3.1 as a diagnostic pitfall for prostate cancer in extramammary Paget's disease of genitourinary sites.
  Histopathology 2023 Chen CV, Francois RA, Mully TW, Sangoi A, LeBoit PE, Simko JP, Chan E
• Wilms Tumor: An Unexpected Diagnosis in Adult Patients.
  Archives of pathology & laboratory medicine 2023 Chan GJ, Stohr BA, Osunkoya AO, Croom NA, Cho SJ, Balassanian R, Charu V, Bean GR, Chan E
• Transcriptomic Heterogeneity of Expansile Cribriform and Other Gleason Pattern 4 Prostate Cancer Subtypes.
  European urology oncology 2023 Chappidi MR, Sjöström M, Greenland NY, Cowan JE, Baskin AS, Shee K, Simko JP, Chan E, Stohr BA, Washington SL, Nguyen HG, Quigley DA, Davicioni E, Feng FY, Carroll PR, Cooperberg MR
• Artificial Intelligence-Based PTEN Loss Assessment as an Early Predictor of Prostate Cancer Metastasis After Surgery: A Multicenter Retrospective Study.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2023 Patel P, Harmon S, Iseman R, Ludkowski O, Auman H, Hawley S, Newcomb LF, Lin DW, Nelson PS, Feng Z, Boyer HD, Tretiakova MS, True LD, Vakar-Lopez F, Carroll PR, Cooperberg MR, Chan E, Simko J, Fazli L…
• Covalent Proteins as Targeted Radionuclide Therapies Enhance Antitumor Effects.
  ACS central science 2023 Klauser PC, Chopra S, Cao L, Bobba KN, Yu B, Seo Y, Chan E, Flavell RR, Evans MJ, Wang L
• Impact of Squamous Histology on Clinical Outcomes and Molecular Profiling in Metastatic Urothelial Carcinoma Patients Treated With Immune Checkpoint Inhibitors or Enfortumab Vedotin.
  Clinical genitourinary cancer 2023 Jindal T, Zhang L, Deshmukh P, Reyes K, Chan E, Kumar V, Zhu X, Maldonado E, Feng S, Johnson M, Angelidakis A, Kwon D, Desai A, Borno HT, Bose R, Wong A, Hong J, Carroll P, Meng M, Porten S, Aggarwal …
• Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Bidkar AP, Wang S, Bobba KN, Chan E, Bidlingmaier S, Egusa EA, Peter R, Ali U, Meher N, Wadhwa A, Dhrona S, Dasari C, Beckford-Vera D, Su Y, Tang R, Zhang L, He J, Wilson DM, Aggarwal R, VanBrocklin …
• Epithelioid Angiomyolipoma With Prominent Papillary Architecture Mimicking Renal Cell Carcinoma: A Case Report.
  International journal of surgical pathology 2023 Xiao A, Van Ziffle J, Chan E
• IgG4-Related Prostatitis: A Potentially Underappreciated Finding for Pathologists.
  International journal of surgical pathology 2023 Sangoi AR, Maclean F, Myint E, Chan E
• Urothelial carcinoma in situ with "overriding" features can evade detection by mimicking umbrella cells.
  Human pathology 2023 Bahceci D, Nguyen JK, Sangoi AR, Stohr BA, Chan E
• Clear cell renal cell carcinoma with focal psammomatous calcifications: a rare occurrence mimicking translocation carcinoma.
  Histopathology 2023 Sangoi AR, Al-Obaidy KI, Cheng L, Kao CS, Chan E, Sadasivan S, Levin AM, Alvarado-Cabrero I, Kunju LP, Mehra R, Mannan R, Wang X, Dhillon J, Tretiakova M, Smith SC, Hes O, Williamson SR
• Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer.
  Cancer research 2023 Chou J, Egusa EA, Wang S, Badura ML, Lee F, Bidkar AP, Zhu J, Shenoy T, Trepka K, Robinson TM, Steri V, Huang J, Wang Y, Small EJ, Chan E, Stohr BA, Ashworth A, Delafontaine B, Rottey S, Cooke KS, …
• Scoping Review of Racial and Ethnic Representation of Participants in Mental Health Research Conducted in the Perinatal Period During the COVID-19 Pandemic.
  Journal of obstetric, gynecologic, and neonatal nursing : JOGNN 2022 Goyal D, Dol J, Leckey M, Naraine S, Dennis CL, Chan EK, Basu G
• Molecular characterization of adenocarcinomas arising in the urinary bladder following augmentation cystoplasty: a multi-institutional study.
  Human pathology 2022 Stohr BA, Chan E, Anderson JA, Matoso A, Murati Amador BI, Cheng L, Osunkoya AO
• Prostatic malakoplakia: clinicopathological assessment of a multi-institutional series of 49 patients.
  Histopathology 2022 Acosta AM, Sangoi AR, Maclean F, Trpkov K, Osunkoya AO, Collins K, Miyamoto H, Hirsch MS, Chan E, Tretiakova M, Mohanty SK, Kaushal S, Cornejo KM, Aron M, Quiroga-Garza G, Arora K, Nguyen JK, …
• Real-World Study of Characteristics and Treatment Outcomes Among Patients with KRAS p.G12C-Mutated or Other KRAS Mutated Metastatic Colorectal Cancer.
  The oncologist 2022 Fakih M, Tu H, Hsu H, Aggarwal S, Chan E, Rehn M, Chia V, Kopetz S
• CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, including PSMA Null Disease.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2022 Zhao N, Chopra S, Trepka K, Wang YH, Sakhamuri S, Hooshdaran N, Kim H, Zhou J, Lim SA, Leung KK, Egusa EA, Zhu J, Zhang L, Foye A, Sriram R, Chan E, Seo Y, Feng FY, Small EJ, Chou J, Wells JA, …
• Not your usual tonsillitis: a lesson for recognizing primary tonsillar syphilis.
  Histopathology 2022 Wu R, Babik J, Russell M, van Zante A, Chan E
• Deep brain stimulation in a young child with GNAO1 mutation - Feasible and helpful.
  Surgical neurology international 2022 Fung EL, Mo CY, Fung ST, Chan AY, Lau KY, Chan EK, Chan DY, Zhu XL, Chan DT, Poon WS
• An exploration in pitfalls in interpreting SDHB immunohistochemistry.
  Histopathology 2022 Ding CC, Chan S, Mak J, Umetsu SE, Simko JP, Ruiz-Cordero R, Saunders T, Chan E
• Case Report: Novel Biallelic Variants in the COL18A1 Gene in a Chinese Family With Knobloch Syndrome.
  Frontiers in neurology 2022 Chong SC, Yuen YP, Cao Y, Fan SS, Leung TY, Chan EKY, Zhu XL
• Granulomas associated with renal neoplasms: A multi-institutional clinicopathological study of 111 cases.
  Histopathology 2022 Sangoi AR, Maclean F, Mohanty S, Hes O, Daniel R, Lal P, Canete-Portillo S, Magi-Galluzzi C, Cornejo KM, Collins K, Hwang M, Falzarano SM, Feely MM, Dababneh M, Harik L, Tretiakova M, Akgul M, Manucha…
• p53 null phenotype is a "positive result" in urothelial carcinoma in situ.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2022 Sangoi AR, Chan E, Abdulfatah E, Stohr BA, Nguyen J, Trpkov K, Siadat F, Hirsch M, Falzarano S, Udager AM, Kunju LP
• APOBEC Mutational Signature and Tumor Mutational Burden as Predictors of Clinical Outcomes and Treatment Response in Patients With Advanced Urothelial Cancer.
  Frontiers in oncology 2022 Natesan D, Zhang L, Martell HJ, Jindal T, Devine P, Stohr B, Espinosa-Mendez C, Grenert J, Van Ziffle J, Joseph N, Umetsu S, Onodera C, Turski M, Chan E, Desai A, Aggarwal R, Wong A, Porten S, Chou J,…
• Papillary Renal Cell Carcinoma With Microcystic Architecture Is Strongly Associated With Extrarenal Invasion and Metastatic Disease.
  The American journal of surgical pathology 2022 Chan E, Stohr BA, Butler RS, Cox RM, Myles JL, Nguyen JK, Przybycin CG, Reynolds JP, Williamson SR, McKenney JK
• Gods and monsters: Greek mythology and Christian references in the neurosurgical lexicon.
  Surgical neurology international 2022 Woo PYM, Au D, Ko NMW, Wu O, Chan EKY, Cheng KKF, Wong AKS, Kirollos RW, Ribas G, Chan KY
• TROP2 Expression Across Molecular Subtypes of Urothelial Carcinoma and Enfortumab Vedotin-resistant Cells.
  European urology oncology 2022 Chou J, Trepka K, Sjöström M, Egusa EA, Chu CE, Zhu J, Chan E, Gibb EA, Badura ML, Contreras-Sanz A, Stohr BA, Meng MV, Pruthi RS, Lotan Y, Black PC, Porten SP, Koshkin VS, Friedlander TW, Feng FY
• Analysis of separate training and validation radical prostatectomy cohorts identifies 0.25 mm diameter as an optimal definition for "large" cribriform prostatic adenocarcinoma.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2022 Chan E, McKenney JK, Hawley S, Corrigan D, Auman H, Newcomb LF, Boyer HD, Carroll PR, Cooperberg MR, Klein E, Fazli L, Gleave ME, Hurtado-Coll A, Simko JP, Nelson PS, Thompson IM, Tretiakova MS, …
• Molecular risk classifier score and biochemical recurrence risk are associated with cribriform pattern type in Gleason 3+4=7 prostate cancer.
  Investigative and clinical urology 2022 Greenland NY, Cooperberg MR, Wong AC, Chan E, Carroll PR, Simko JP, Stohr BA
• Expanding the clinicopathological spectrum of succinate dehydrogenase-deficient renal cell carcinoma with a focus on variant morphologies: a study of 62 new tumors in 59 patients.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2021 Fuchs TL, Maclean F, Turchini J, Vargas AC, Bhattarai S, Agaimy A, Hartmann A, Kao CS, Ellis C, Bonert M, Leroy X, Kunju LP, Schwartz L, Matsika A, Williamson SR, Rao P, Divatia M, Guarch R, Algaba F,…
• Differential immunohistochemical and molecular profiling of conventional and aggressive components of chromophobe renal cell carcinoma: pitfalls for diagnosis.
  Human pathology 2021 Chen CV, Croom NA, Simko JP, Stohr BA, Chan E
• TERT promoter mutations and other prognostic factors in patients with advanced urothelial carcinoma treated with an immune checkpoint inhibitor.
  Journal for immunotherapy of cancer 2021 de Kouchkovsky I, Zhang L, Philip EJ, Wright F, Kim DM, Natesan D, Kwon D, Ho H, Ho S, Chan E, Porten SP, Wong AC, Desai A, Huang FW, Chou J, Oh DY, Pruthi RS, Fong L, Small EJ, Friedlander TW, …
• Prostate biopsy histopathologic features correlate with a commercial gene expression assay's reclassification of patient NCCN risk category.
  The Prostate 2020 Greenland NY, Cowan JE, Chan E, Carroll PR, Stohr BA, Simko JP
• Invasive poorly differentiated adenocarcinoma of the bladder following augmentation cystoplasty: a multi-institutional clinicopathological study.
  Pathology 2020 Anderson JA, Matoso A, Murati Amador BI, Cheng L, Stohr BA, Chan E, Osunkoya AO
• The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma.
  The American journal of surgical pathology 2020 van Leenders GJLH, van der Kwast TH, Grignon DJ, Evans AJ, Kristiansen G, Kweldam CF, Litjens G, McKenney JK, Melamed J, Mottet N, Paner GP, Samaratunga H, Schoots IG, Simko JP, Tsuzuki T, Varma M, …
• Invasive plasmacytoid urothelial carcinoma: A comparative study of E-cadherin and P120 catenin.
  Human pathology 2020 Sangoi AR, Chan E, Stohr BA, Kunju LP
• Prevalence and associated factors for carriage of Enterobacteriaceae producing ESBLs or carbapenemase and methicillin-resistant Staphylococcus aureus in Hong Kong community.
  The Journal of infection 2020 Kwok KO, Chan E, Chung PH, Tang A, Wei WI, Zhu C, Riley S, Ip M
• Molecular characterisation of metanephric adenomas beyond BRAF: genetic evidence for potential malignant evolution.
  Histopathology 2020 Chan E, Stohr BA, Croom NA, Cho SJ, Garg K, Troxell ML, Higgins JP, Bean GR
• Integrated immunohistochemical and molecular analysis improves diagnosis of high-grade carcinoma in the urinary bladder of patients with prior radiation therapy for prostate cancer.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2020 Chan E, Garg K, Stohr BA
• Expansile cribriform Gleason pattern 4 has histopathologic and molecular features of aggressiveness and greater risk of biochemical failure compared to glomerulation Gleason pattern 4.
  The Prostate 2020 Greenland NY, Cowan JE, Zhang L, Carroll PR, Chan E, Stohr BA, Simko JP
• STAT6 monoclonal antibody is highly specific for the distinction between solitary fibrous tumour and prostatic stromal proliferations.
  Histopathology 2020 Cox RM, Chan E, Sangoi AR, Zou Y, McKenney JK
• A Clinicopathologic and Molecular Analysis of Fumarate Hydratase-deficient Renal Cell Carcinoma in 32 Patients.
  The American journal of surgical pathology 2020 Lau HD, Chan E, Fan AC, Kunder CA, Williamson SR, Zhou M, Idrees MT, Maclean FM, Gill AJ, Kao CS
• Detailed Morphologic and Immunohistochemical Characterization of Myomectomy and Hysterectomy Specimens From Women With Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome (HLRCC).
  The American journal of surgical pathology 2019 Chan E, Rabban JT, Mak J, Zaloudek C, Garg K
• Beyond Depth of Invasion: Adverse Pathologic Tumor Features in Early Oral Tongue Squamous Cell Carcinoma.
  The Laryngoscope 2019 Larson AR, Kemmer J, Formeister E, El-Sayed I, Ha P, George J, Ryan W, Chan E, Heaton C
• Prospective Detection of Germline Mutation of Fumarate Hydratase in Women With Uterine Smooth Muscle Tumors Using Pathology-based Screening to Trigger Genetic Counseling for Hereditary Leiomyomatosis Renal Cell Carcinoma Syndrome: A 5-Year Single Institutional Experience.
  The American journal of surgical pathology 2019 Rabban JT, Chan E, Mak J, Zaloudek C, Garg K
• Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial.
  JAMA 2019 Ng K, Nimeiri HS, McCleary NJ, Abrams TA, Yurgelun MB, Cleary JM, Rubinson DA, Schrag D, Miksad R, Bullock AJ, Allen J, Zuckerman D, Chan E, Chan JA, Wolpin BM, Constantine M, Weckstein DJ, Faggen MA,…
• Phase I Study of AMG 337, a Highly Selective Small-molecule MET Inhibitor, in Patients with Advanced Solid Tumors.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Hong DS, LoRusso P, Hamid O, Janku F, Kittaneh M, Catenacci DVT, Chan E, Bekaii-Saab T, Gadgeel SM, Loberg RD, Amore BM, Hwang YC, Tang R, Ngarmchamnanrith G, Kwak EL
• Improved diagnostic precision of urine cytology by implementation of The Paris System and the use of cell blocks.
  Cancer cytopathology 2018 Chan E, Balassanian R, Tabatabai ZL, Lou H, Vohra P
• Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer.
  Cancer research 2017 Jin L, Garcia J, Chan E, de la Cruz C, Segal E, Merchant M, Kharbanda S, Raisner R, Haverty PM, Modrusan Z, Ly J, Choo E, Kaufman S, Beresini MH, Romero FA, Magnuson S, Gascoigne KE
• Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex.
  Acta neuropathologica 2017 Chan E, Bollen AW, Sirohi D, Van Ziffle J, Grenert JP, Kline CN, Tihan T, Perry A, Gupta N, Solomon DA
• Value of histopathology for predicting the post-operative complications of ileo-anal anastomosis (J-pouch) procedure in children with refractory ulcerative colitis.
  Pathology 2016 El Demellawy D, El Hallani S, de Nanassy J, Lee JY, Chan E, Sullivan K, Bass J, Mack D, Nasr A
• A phase I study of continuous oral dosing of OSI-906, a dual inhibitor of insulin-like growth factor-1 and insulin receptors, in patients with advanced solid tumors.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Puzanov I, Lindsay CR, Goff L, Sosman J, Gilbert J, Berlin J, Poondru S, Simantov R, Gedrich R, Stephens A, Chan E, Evans TR
• Polarized exocyst-mediated vesicle fusion directs intracellular lumenogenesis within the C. elegans excretory cell.
  Developmental biology 2014 Armenti ST, Chan E, Nance J
• Mechanisms of CDC-42 activation during contact-induced cell polarization.
  Journal of cell science 2013 Chan E, Nance J
• Safety, pharmacokinetics and pharmacodynamics of the anti-A33 fully-human monoclonal antibody, KRN330, in patients with advanced colorectal cancer.
  European journal of cancer (Oxford, England : 1990) 2013 Infante JR, Bendell JC, Goff LW, Jones SF, Chan E, Sudo T, Burris HA, Berlin JD
• Safety and pharmacokinetics of ganitumab (AMG 479) combined with sorafenib, panitumumab, erlotinib, or gemcitabine in patients with advanced solid tumors.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Rosen LS, Puzanov I, Friberg G, Chan E, Hwang YC, Deng H, Gilbert J, Mahalingam D, McCaffery I, Michael SA, Mita AC, Mita MM, Mulay M, Shubhakar P, Zhu M, Sarantopoulos J
• Anaerobic degradation of benzene, toluene, ethylbenzene, and xylene compounds by Dechloromonas strain RCB.
  Applied and environmental microbiology 2005 Chakraborty R, O'Connor SM, Chan E, Coates JD