Emily Blythe, PhD
Postdoctoral Scholar
Psychiatry
School of Medicine

Grants and Projects

Show all (1) Hide

• Effects of GPCR trafficking on the spatiotemporal control of signaling, NIH, 2021-2024

Publications (8)

Top publication keywords:
MutationSignal TransductionMuscular Dystrophies, Limb-GirdleIntracellular Signaling Peptides and ProteinsNuclear ProteinsMyositis, Inclusion Bodybeta-ArrestinsValosin Containing ProteinProteinsOsteitis Deformansbeta-Arrestin 1Peptide HormonesSubstrate SpecificityProteostasis DeficienciesFrontotemporal Dementia

• Profiling the proximal proteome of the activated μ-opioid receptor.
  Nature chemical biology 2024 Polacco BJ, Lobingier BT, Blythe EE, Abreu N, Khare P, Howard MK, Gonzalez-Hernandez AJ, Xu J, Li Q, Novy B, Naing ZZC, Shoichet BK, Coyote-Maestas W, Levitz J, Krogan NJ, Von Zastrow M, Hüttenhain R
• β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR.
  Nature chemical biology 2023 Blythe EE, von Zastrow M
• State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides.
  Cell 2022 Dai SA, Hu Q, Gao R, Blythe EE, Touhara KK, Peacock H, Zhang Z, von Zastrow M, Suga H, Shokat KM
• Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing.
  Structure (London, England : 1993) 2019 Blythe EE, Gates SN, Deshaies RJ, Martin A
• Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2.
  The Journal of biological chemistry 2017 Xu ER, Blythe EE, Fischer G, Hyvönen M
• Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Blythe EE, Olson KC, Chau V, Deshaies RJ
• Valosin-containing protein (VCP)-Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor.
  Molecular & cellular proteomics : MCP 2016 Xue L, Blythe EE, Freiberger EC, Mamrosh JL, Hebert AS, Reitsma JM, Hess S, Coon JJ, Deshaies RJ
• An unusual pattern of ligand-receptor interactions for the α7 nicotinic acetylcholine receptor, with implications for the binding of varenicline.
  Molecular pharmacology 2013 Van Arnam EB, Blythe EE, Lester HA, Dougherty DA