Emilie Barruet, PhD
ASSOCIATE SPECIALIST
Orofacial Sciences
School of Dentistry

Education & Training

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• Ph.D Human Pathology & Genomics Mediterranean University of Medicine 2010
• M.S. Biochemistry, Cellular & Molecular Biology University of Burgundy 2006
• B.S. Biology Bucknell University 2005

Interests

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• Stem cell biology
• Regenerative medicine
• Induced pluripotent stem cell
• Musculoskeletal biology

Publications (29)

Top publication keywords:
Satellite Cells, Skeletal MuscleMitogen-Activated Protein Kinase 14OsteoblastsOssification, HeterotopicSmad ProteinsCell Culture TechniquesBone Morphogenetic Protein 4Activin Receptors, Type IMesodermMuscle Fibers, SkeletalInduced Pluripotent Stem CellsMyositis OssificansCellular ReprogrammingSequence Analysis, RNAMuscle, Skeletal

• Patterning and folding of intestinal villi by active mesenchymal dewetting.
  Cell 2024 Huycke TR, Häkkinen TJ, Miyazaki H, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, Oria R, Weaver VM, DeGrado WF, Thomson M, Garikipati K, Boffelli D, …
• Patterning and folding of intestinal villi by active mesenchymal dewetting.
  bioRxiv : the preprint server for biology 2023 Huycke TR, Miyazaki H, Häkkinen TJ, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ
• Loss of transcriptional heterogeneity in aged human muscle stem cells.
  PloS one 2023 Barruet E, Striedinger K, Marangoni P, Pomerantz JH
• Heterogeneous levels of delta-like 4 within a multinucleated niche cell maintains muscle stem cell diversity.
  eLife 2022 Eliazer S, Sun X, Barruet E, Brack AS
• ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.
  Pain 2022 Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC

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• Corrigendum to "ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages" [Bone. 153 2021 Dec; 116129. doi:10.1016/j.bone.2021.116129. Epub 2021 Jul 24. PMID: 34311122].
  Bone 2022 Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC
• Modeling the ACVR1R206H mutation in human skeletal muscle stem cells.
  eLife 2021 Barruet E, Garcia SM, Wu J, Morales BM, Tamaki S, Moody T, Pomerantz JH, Hsiao EC
• ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages.
  Bone 2021 Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC
• Purification and preservation of satellite cells from human skeletal muscle.
  STAR protocols 2021 Striedinger K, Barruet E, Pomerantz JH
• Satellite cell activation and retention of muscle regenerative potential after long-term denervation.
  Stem cells (Dayton, Ohio) 2020 Wong A, Garcia SM, Tamaki S, Striedinger K, Barruet E, Hansen SL, Young DM, Pomerantz JH
• MON-710 ACVR1 Activation in Primary and iPS-Derived Human Skeletal Muscle Stem Cells Impairs Myogenic Transcriptional Signature and Function.
  Journal of the Endocrine Society 2020 Emilie Barruet, Steven Garcia, Stanley Tamaki, Blanca M Morales, Jake Wu, Tania Moody, Jason H Pomerantz, Edward Chiaming Hsiao
• Functionally heterogeneous human satellite cells identified by single cell RNA sequencing.
  eLife 2020 Barruet E, Garcia SM, Striedinger K, Wu J, Lee S, Byrnes L, Wong A, Xuefeng S, Tamaki S, Brack AS, Pomerantz JH
• Inflammation in Fibrodysplasia Ossificans Progressiva and Other Forms of Heterotopic Ossification.
  Current osteoporosis reports 2019 Matsuo K, Chavez RD, Barruet E, Hsiao EC
• Effect of donor variation on osteogenesis and vasculogenesis in hydrogel cocultures.
  Journal of tissue engineering and regenerative medicine 2019 Pennings I, van Dijk LA, van Huuksloot J, Fledderus JO, Schepers K, Braat AK, Hsiao EC, Barruet E, Morales BM, Verhaar MC, Rosenberg AJWP, Gawlitta D
• NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification.
  JCI insight 2018 Barruet E, Morales BM, Cain CJ, Ton AN, Wentworth KL, Chan TV, Moody TA, Haks MC, Ottenhoff TH, Hellman J, Nakamura MC, Hsiao EC
• Application of human induced pluripotent stem cells to model fibrodysplasia ossificans progressiva.
  Bone 2017 Barruet E, Hsiao EC
• The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling.
  Stem cell research & therapy 2016 Barruet E, Morales BM, Lwin W, White MP, Theodoris CV, Kim H, Urrutia A, Wong SA, Srivastava D, Hsiao EC
• Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization.
  Bone reports 2016 Cain CJ, Gaborit N, Lwin W, Barruet E, Ho S, Bonnard C, Hamamy H, Shboul M, Reversade B, Kayserili H, Bruneau BG, Hsiao EC
• Using Human Induced Pluripotent Stem Cells to Model Skeletal Diseases.
  Methods in molecular biology (Clifton, N.J.) 2016 Barruet E, Hsiao EC
• Efficient and cost-effective generation of mature neurons from human induced pluripotent stem cells.
  Stem cells translational medicine 2014 Badja C, Maleeva G, El-Yazidi C, Barruet E, Lasserre M, Tropel P, Binetruy B, Bregestovski P, Magdinier F
• Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.
  Orphanet journal of rare diseases 2013 Matsumoto Y, Hayashi Y, Schlieve CR, Ikeya M, Kim H, Nguyen TD, Sami S, Baba S, Barruet E, Nasu A, Asaka I, Otsuka T, Yamanaka S, Conklin BR, Toguchida J, Hsiao EC
• A p38MAPK-p53 cascade regulates mesodermal differentiation and neurogenesis of embryonic stem cells.
  Cell death & disease 2013 Hadjal Y, Hadadeh O, Yazidi CE, Barruet E, Binétruy B
• The plasminogen activation system modulates differently adipogenesis and myogenesis of embryonic stem cells.
  PloS one 2012 Hadadeh O, Barruet E, Peiretti F, Verdier M, Bernot D, Hadjal Y, Yazidi CE, Robaglia-Schlupp A, De Paula AM, Nègre D, Iacovino M, Kyba M, Alessi MC, Binétruy B
• p38 mitogen activated protein kinase controls two successive-steps during the early mesodermal commitment of embryonic stem cells.
  Stem cells and development 2010 Barruet E, Hadadeh O, Peiretti F, Renault VM, Hadjal Y, Bernot D, Tournaire R, Negre D, Juhan-Vague I, Alessi MC, Binétruy B
• PO29 La down-régulation de TIMP-3 est nécessaire à la différenciation adipocytaire.
  Diabetes & Metabolism 2010 D. Bernot, E. Barruet, M. Poggi, B. Bonardo, M.C. Alessi, F. Peiretti
• Down-regulation of tissue inhibitor of metalloproteinase-3 (TIMP-3) expression is necessary for adipocyte differentiation.
  The Journal of biological chemistry 2010 Bernot D, Barruet E, Poggi M, Bonardo B, Alessi MC, Peiretti F
• B008 Régulation du « système ADAM17 » au cours de la différenciation adipocytaire.
  Archives of Cardiovascular Diseases 2009 D. Bernot, E. Barruet, M. Poggi, G. Nalbone, M.-C. Alessi, F. Peiretti
• D027 Role de la voie de transduction P38MAPK (mitogen-activated protein kinase) dans les differenciations endotheliales et myogeniques des cellules souches embryonnaires.
  Archives of Cardiovascular Diseases 2009 E. Barruet, F. Peiretti, O. Hadadeh, I. Juhan-vague, M.-C. Alessi, B. Binetruy
• D028 L’expression des gènes PAI-1, tPA et uPA est fortement régulée pendant la différenciation des cellules souches embryonnaires en myocytes et adipocytes.
  Archives of Cardiovascular Diseases 2009 O. Hadadeh, E. Barruet, F. Peiretti, M. Verdier, I. Juhan-vague, M.-C. Alessi, B. Binetruy