Emil Lin, PhD
Professor Emeritus
Bioengineering
School of Pharmacy

Grants and Projects

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• Non-Clinical ADME Studies, NIH, 2004-2009
• Non-clinical Adme Studies, NIH, 2004-2008

Publications (38)

Top publication keywords:
ErythromycinPropionatesSpectrometry, Mass, Electrospray IonizationChromatography, High Pressure LiquidParenteral NutritionFuransDieteticsAdenosine A2 Receptor AntagonistsWorkflowUremiaBronchoalveolar Lavage FluidPulmonary AlveoliQuinacrineKetolidesCytochrome P-450 Enzyme System

• Semisupervised Learning for Generalizable Intracranial Hemorrhage Detection and Segmentation.
  Radiology. Artificial intelligence 2024 Lin E, Yuh EL
• Beyond the AJR: Exploring the Yield of Head CT in Patients With Altered Mental Status.
  AJR. American journal of roentgenology 2023 Lin E, Yuh EL
• Computational Approaches for Acute Traumatic Brain Injury Image Recognition.
  Frontiers in neurology 2022 Lin E, Yuh EL
• A Call to Action for Optimizing the Electronic Health Record in the Parenteral Nutrition Workflow: Executive Summary.
  Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 2018 Vanek VW, Ayers P, Kraft M, Bouche JM, Do VT, Durham CW, Guenter P, Hoggle L, Kent S, Lin ET, Molinar LS, Plogsted SW, Poehls JM, Turner P, Van Way C, American Society for Parenteral and Enteral …
• A Call to Action for Optimizing the Electronic Health Record in the Parenteral Nutrition Workflow.
  Journal of the Academy of Nutrition and Dietetics 2018 Vanek VW, Ayers P, Kraft M, Bouche JM, Do VT, Durham CW, Guenter P, Hoggle L, Kent S, Lin ET, Molinar LS, Plogsted SW, Poehls JM, Turner P, Van Way C

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• A call to action for optimizing the electronic health record in the parenteral nutrition workflow.
  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2018 Vanek VW, Ayers P, Kraft M, Bouche JM, Do VT, Durham CW, Guenter P, Hoggle L, Kent S, Lin ET, Molinar LS, Plogsted SW, Poehls JM, Turner P, Van Way C
• A Call to Action for Optimizing the Electronic Health Record in the Parenteral Nutrition Workflow.
  Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 2018 Vanek VW, Ayers P, Kraft M, Bouche JM, Do VT, Durham CW, Guenter P, Hoggle L, Kent S, Lin ET, Molinar LS, Plogsted SW, Poehls JM, Turner P, Van Way C, American Society for Parenteral and Enteral …
• Nuclear F-actin and myosins drive relocalization of heterochromatic breaks.
  Nature 2018 Caridi CP, D'Agostino C, Ryu T, Zapotoczny G, Delabaere L, Li X, Khodaverdian VY, Amaral N, Lin E, Rau AR, Chiolo I
• Microanalysis of the antiretroviral nevirapine in human hair from HIV-infected patients by liquid chromatography-tandem mass spectrometry.
  Analytical and bioanalytical chemistry 2011 Huang Y, Yang Q, Yoon K, Lei Y, Shi R, Gee W, Lin ET, Greenblatt RM, Gandhi M
• A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion.
  BMC clinical pharmacology 2009 Harris DS, Everhart T, Jacob P, Lin E, Mendelson JE, Jones RT
• Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice.
  Neurobiology of disease 2009 Li M, Huang Y, Ma AA, Lin E, Diamond MI
• Lead optimization of 4-acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A adenosine receptor antagonists for the treatment of Parkinson's disease.
  Journal of medicinal chemistry 2008 Zhang X, Tellew JE, Luo Z, Moorjani M, Lin E, Lanier MC, Chen Y, Williams JP, Saunders J, Lechner SM, Markison S, Joswig T, Petroski R, Piercey J, Kargo W, Malany S, Santos M, Gross RS, Wen J, Jalali …
• Sensitive analysis of anti-HIV drugs, efavirenz, lopinavir and ritonavir, in human hair by liquid chromatography coupled with tandem mass spectrometry.
  Rapid communications in mass spectrometry : RCM 2008 Huang Y, Gandhi M, Greenblatt RM, Gee W, Lin ET, Messenkoff N
• Pharmacokinetics and tolerability of oseltamivir combined with probenecid.
  Antimicrobial agents and chemotherapy 2008 Holodniy M, Penzak SR, Straight TM, Davey RT, Lee KK, Goetz MB, Raisch DW, Cunningham F, Lin ET, Olivo N, Deyton LR
• Increased indomethacin dosing for persistent patent ductus arteriosus in preterm infants: a multicenter, randomized, controlled trial.
  The Journal of pediatrics 2008 Jegatheesan P, Ianus V, Buchh B, Yoon G, Chorne N, Ewig A, Lin E, Fields S, Moon-Grady A, Tacy T, Milstein J, Schreiber M, Padbury J, Clyman R
• 2-Amino-N-pyrimidin-4-ylacetamides as A2A receptor antagonists: 1. Structure-activity relationships and optimization of heterocyclic substituents.
  Journal of medicinal chemistry 2008 Slee DH, Chen Y, Zhang X, Moorjani M, Lanier MC, Lin E, Rueter JK, Williams JP, Lechner SM, Markison S, Malany S, Santos M, Gross RS, Jalali K, Sai Y, Zuo Z, Yang C, Castro-Palomino JC, Crespo MI, …
• 2-Amino-N-pyrimidin-4-ylacetamides as A2A receptor antagonists: 2. Reduction of hERG activity, observed species selectivity, and structure-activity relationships.
  Journal of medicinal chemistry 2008 Slee DH, Moorjani M, Zhang X, Lin E, Lanier MC, Chen Y, Rueter JK, Lechner SM, Markison S, Malany S, Joswig T, Santos M, Gross RS, Williams JP, Castro-Palomino JC, Crespo MI, Prat M, Gual S, Díaz JL, …
• Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists.
  Bioorganic & medicinal chemistry letters 2008 Zhang X, Rueter JK, Chen Y, Moorjani M, Lanier MC, Lin E, Gross RS, Tellew JE, Williams JP, Lechner SM, Markison S, Joswig T, Malany S, Santos M, Castro-Palomino JC, Crespo MI, Prat M, Gual S, Díaz JL…
• Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy.
  Journal of medicinal chemistry 2008 Slee DH, Zhang X, Moorjani M, Lin E, Lanier MC, Chen Y, Rueter JK, Lechner SM, Markison S, Malany S, Joswig T, Santos M, Gross RS, Williams JP, Castro-Palomino JC, Crespo MI, Prat M, Gual S, Díaz JL, …
• Risk factors for persistent ductus arteriosus patency during indomethacin treatment.
  The Journal of pediatrics 2007 Chorne N, Jegatheesan P, Lin E, Shi R, Clyman RI
• Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice.
  The Journal of biological chemistry 2007 Yang R, Wilcox DM, Haasch DL, Jung PM, Nguyen PT, Voorbach MJ, Doktor S, Brodjian S, Bush EN, Lin E, Jacobson PB, Collins CA, Landschulz KT, Trevillyan JM, Rondinone CM, Surowy TK
• Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha.
  Drug metabolism and disposition: the biological fate of chemicals 2007 Ng VY, Huang Y, Reddy LM, Falck JR, Lin ET, Kroetz DL
• Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein.
  Drug metabolism and disposition: the biological fate of chemicals 2006 Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET
• Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid.
  The Journal of pharmacology and experimental therapeutics 2006 Yu Z, Ng VY, Su P, Engler MM, Engler MB, Huang Y, Lin E, Kroetz DL
• Dose-response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulation.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006 Lee CZ, Yao JS, Huang Y, Zhai W, Liu W, Guglielmo BJ, Lin E, Yang GY, Young WL
• Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma.
  Rapid communications in mass spectrometry : RCM 2006 Huang Y, Sun H, Frassetto L, Benet LZ, Lin ET
• Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1).
  Pharmacogenetics and genomics 2005 Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin ET, Brett CM, Burchard EG, Ferrin TE, Huang CC, Leabman MK, Giacomini KM
• Relative bioavailability of ketoprofen 20% in a poloxamer-lecithin organogel.
  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2004 Dowling TC, Arjomand M, Lin ET, Allen LV, McPherson ML
• Pharmacokinetics of quinacrine in the treatment of prion disease.
  BMC infectious diseases 2004 Yung L, Huang Y, Lessard P, Legname G, Lin ET, Baldwin M, Prusiner SB, Ryou C, Guglielmo BJ
• 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone.
  Nature medicine 2004 Scanlan TS, Suchland KL, Hart ME, Chiellini G, Huang Y, Kruzich PJ, Frascarelli S, Crossley DA, Bunzow JR, Ronca-Testoni S, Lin ET, Hatton D, Zucchi R, Grandy DK
• Liquid chromatographic-tandem mass spectrometric assay for the simultaneous determination of didanosine and stavudine in human plasma, bronchoalveolar lavage fluid, alveolar cells, peripheral blood mononuclear cells, seminal plasma, cerebrospinal fluid and tonsil tissue.
  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004 Huang Y, Zurlinden E, Lin E, Li X, Tokumoto J, Golden J, Murr A, Engstrom J, Conte J
• Effect of sex and AIDS status on the plasma and intrapulmonary pharmacokinetics of rifampicin.
  Clinical pharmacokinetics 2004 Conte JE, Golden JA, Kipps JE, Lin ET, Zurlinden E
• Pharmacokinetics and subjective effects of sublingual buprenorphine, alone or in combination with naloxone: lack of dose proportionality.
  Clinical pharmacokinetics 2004 Harris DS, Mendelson JE, Lin ET, Upton RA, Jones RT
• Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence.
  The Journal of pharmacology and experimental therapeutics 2003 Wang D, Raehal KM, Lin ET, Lowery JJ, Kieffer BL, Bilsky EJ, Sadée W
• No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects.
  Clinical pharmacology and therapeutics 2003 Pauli-Magnus C, Feiner J, Brett C, Lin E, Kroetz DL
• A high-performance liquid chromatographic-tandem mass spectrometric method for the determination of cethromycin (ABT-773) in human plasma, bronchoalveolar lavage fluid, and alveolar cells.
  Journal of chromatographic science 2003 Ren Q, Conte JE, Zurlinden E, Lin ET
• Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitor.
  Antimicrobial agents and chemotherapy 2003 Phan DD, Chin-Hong P, Lin ET, Anderle P, Sadee W, Guglielmo BJ
• A high-pressure liquid chromatographic-tandem mass spectrometric method for the determination of ethambutol in human plasma, bronchoalveolar lavage fluid, and alveolar cells.
  Journal of chromatographic science 2002 Conte JE, Lin E, Zhao Y, Zurlinden E