Elvira Mennillo, PhD
Specialist
Medicine
School of Medicine

I have authored a range of research publications that delve into various topics exploring the role of microbial signals and molecular pathways in intestinal tissue damage, the protective effects of UDP-Glucuronosyltransferase 1A1 against irinotecan-induced toxicity, and the role of nuclear receptor corepressor 1 (NCoR1) in maintaining intestinal homeostasis and protecting from ulcerative colitis.

Additionally, my work has investigated the regulation of gene expression and the impact of environmental factors on cellular responses in various organisms, including fish and avian species. Through my research efforts, I aim to contribute to the understanding of disease mechanisms and develop novel approaches for improved patient care and outcomes.

• Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development.
  Environmental health perspectives 2023 Yang X, Weber AA, Mennillo E, Secrest P, Chang M, Wong S, Le S, Liu J, Benner CW, Karin M, Gordts PLSM, Tukey RH, Chen S
• Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR.
  The Journal of biological chemistry 2023 Yang X, Weber AA, Mennillo E, Paszek M, Wong S, Le S, Teo JYA, Chang M, Benner CW, Tukey RH, Chen S
• Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice.
  Nature communications 2022 Weber AA, Yang X, Mennillo E, Ding J, Watrous JD, Jain M, Chen S, Karin M, Tukey RH
• Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage.
  The Journal of clinical investigation 2022 Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG
• Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model.
  Drug metabolism and disposition: the biological fate of chemicals 2021 Mennillo E, Yang X, Weber AA, Maruo Y, Verreault M, Barbier O, Chen S, Tukey RH
• Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia.
  Scientific reports 2021 van der Schoor LWE, Verkade HJ, Bertolini A, de Wit S, Mennillo E, Rettenmeier E, Weber AA, Havinga R, Valášková P, Jašprová J, Struik D, Bloks VW, Chen S, Schreuder AB, Vítek L, Tukey RH, Jonker JW
• Novel organ-specific effects of Ketoprofen and its enantiomer, dexketoprofen on toxicological response transcripts and their functional products in salmon.
  Aquatic toxicology (Amsterdam, Netherlands) 2020 Mennillo E, Pretti C, Cappelli F, Luci G, Intorre L, Meucci V, Arukwe A
• Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation.
  Drug metabolism and disposition: the biological fate of chemicals 2020 Weber AA, Mennillo E, Yang X, van der Schoor LWE, Jonker JW, Chen S, Tukey RH
• NCoR1 Protects Mice From Dextran Sodium Sulfate-Induced Colitis by Guarding Colonic Crypt Cells From Luminal Insult.
  Cellular and molecular gastroenterology and hepatology 2020 Mennillo E, Yang X, Paszek M, Auwerx J, Benner C, Chen S
• Differential Role of Liver X Receptor (LXR) α and LXRβ in the Regulation of UDP-Glucuronosyltransferase 1A1 in Humanized UGT1 Mice.
  Drug metabolism and disposition: the biological fate of chemicals 2020 Hansmann E, Mennillo E, Yoda E, Verreault M, Barbier O, Chen S, Tukey RH
• Quality screening of the Lagos lagoon sediment by assessing the cytotoxicity and toxicological responses of rat hepatoma H4IIE and fish PLHC-1 cell-lines using different extraction approaches.
  Environmental research 2019 Mennillo E, Adeogun AO, Arukwe A
• Biotransformation and oxidative stress responses in rat hepatic cell-line (H4IIE) exposed to organophosphate esters (OPEs).
  Toxicology and applied pharmacology 2019 Mennillo E, Cappelli F, Arukwe A
• Assessing the effects of Awba dam sediment (Nigeria) on the steroidogenesis of H295R cells using different extraction methods.
  The Science of the total environment 2018 Natoli L, Luci G, Mennillo E, Adeogun AO, Arukwe A
• Biotransformation and oxidative stress responses in rat hepatic cell-line (H4IIE) exposed to racemic ketoprofen (RS-KP) and its enantiomer, dexketoprofen (S(+)-KP).
  Environmental toxicology and pharmacology 2018 Mennillo E, Krøkje Å, Pretti C, Meucci V, Arukwe A
• Ecotoxicological properties of ketoprofen and the S(+)-enantiomer (dexketoprofen): Bioassays in freshwater model species and biomarkers in fish PLHC-1 cell line.
  Environmental toxicology and chemistry 2017 Mennillo E, Arukwe A, Monni G, Meucci V, Intorre L, Pretti C
• Oxidative stress responses in relationship to persistent organic pollutant levels in feathers and blood of two predatory bird species from Pakistan.
  The Science of the total environment 2016 Abbasi NA, Arukwe A, Jaspers VLB, Eulaers I, Mennilo E, Ibor OR, Frantz A, Covaci A, Malik RN
• Suitability of cholinesterase of polychaete Diopatra neapolitana as biomarker of exposure to pesticides: In vitro characterization.
  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2016 Mennillo E, Casu V, Tardelli F, De Marchi L, Freitas R, Pretti C
• The serpulid Ficopomatus enigmaticus () as candidate organisms for ecotoxicological assays in brackish and marine waters.
  Ecotoxicology and environmental safety 2015 Oliva M, Mennillo E, Barbaglia M, Monni G, Tardelli F, Casu V, Pretti C
• Photopolymerized Network Polysiloxane Films with Dangling Hydrophilic/Hydrophobic Chains for the Biofouling Release of Invasive Marine Serpulid Ficopomatus enigmaticus.
  ACS applied materials & interfaces 2015 Martinelli E, Del Moro I, Galli G, Barbaglia M, Bibbiani C, Mennillo E, Oliva M, Pretti C, Antonioli D, Laus M
• An ecotoxicological study on tin- and bismuth-catalysed PDMS based coatings containing a surface-active polymer.
  Ecotoxicology and environmental safety 2013 Pretti C, Oliva M, Mennillo E, Barbaglia M, Funel M, Reddy Yasani B, Martinelli E, Galli G