Elora Midavaine, PhD
Postdoctoral Scholar
Anatomy
School of Medicine

Awards

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• K99/R00 Pathway to Independence Award, NIH, 2025-2030
• Sandler Program for Breakthrough Biomedical Research, UCSF, 2024-2025
• Postdoctoral fellowship, Canadian Institutes of Health Research (CIHR), 2021-2024
• Postdoctoral fellowship, Fonds de Recherche du Québec en Santé, 2021-2024

Education & Training

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• PhD Pharmacology&Physiology Université de Sherbrooke 2021
• MSc Pharmacology&Physiology Université de Sherbrooke 2015
• BSc Biochemistry Université de Sherbrooke 2012

Interests

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• Pregnancy-induced analgesia
• Meninges
• Neuroimmunology
• Pain

Publications (15)

Top publication keywords:
Sensory Receptor CellsNociceptionT-Lymphocytes, RegulatoryEnkephalinsBone NeoplasmsReceptors, Opioid, deltaChemokine CXCL12NeuralgiaChronic PainPainMeningesChemokine CCL2Receptors, CCR2TRPV Cation ChannelsGanglia, Spinal

• A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function
  A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function 2025 Brouillette R L, Lussier F, Breault É, Meneboo N, Chartier M, Midavaine É, Côté J, Blais V, Mona C E, Longpré J-M, Grandbois M, Audet M, Besserer-Offroy É, Sarret P
• Keratinocyte-TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch.
  Proceedings of the National Academy of Sciences of the United States of America 2025 Crowther AJ, Kashem SW, Jewell ME, Le Chang H, Midavaine É, Rosa Casillas M, Danchine V, Rodriguez S, Kania A, Chen R, Braz JM, Basbaum AI
• Meningeal regulatory T cells inhibit nociception in female mice.
  Science (New York, N.Y.) 2025 Midavaine É, Moraes BC, Benitez J, Rodriguez SR, Braz JM, Kochhar NP, Eckalbar WL, Tian L, Domingos AI, Pintar JE, Basbaum AI, Kashem SW
• Regulatory T cell-derived enkephalin gates nociception.
  bioRxiv : the preprint server for biology 2024 Midavaine É, Moraes BC, Benitez J, Rodriguez SR, Braz JM, Kochhar NP, Eckalbar WL, Domingos AI, Pintar JE, Basbaum AI, Kashem SW
• CCR2 silencing in sensory neurons blocks bone cancer progression. bioRxiv. May 31
  2024 Midavaine É, Côté J, Trépanier A, Kashem SW, Dansereau MA, Longpré JM, Charbonneau M, Dubois C, Jacobi AM, Rose SD, Belkhe MA, Sarret P

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• Discovery of a CCR2-targeting pepducin therapy for chronic pain.
  Pharmacological research 2024 Midavaine É, Brouillette RL, Théberge E, Mona CE, Kashem SW, Côté J, Zeugin V, Besserer-Offroy É, Longpré JM, Marsault É, Sarret P
• Tetracycline transactivator overexpression in keratinocytes triggers a TRPV1 primary sensory neuron-dependent neuropathic itch
  Tetracycline transactivator overexpression in keratinocytes triggers a TRPV1 primary sensory neuron-dependent neuropathic itch 2023 Crowther AJ, Kashem SW, Jewell M E, Le Chang H, Rosa Casillas M, Midavaine É, Rodriguez S, Braz J M, Kania A, Basbaum AI
• The multifaceted roles of the chemokines CCL2 and CXCL12 in osteophilic metastatic cancers.
  Cancer metastasis reviews 2021 Midavaine É, Côté J, Sarret P
• Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity.
  Journal of neuroinflammation 2021 Dansereau MA, Midavaine É, Bégin-Lavallée V, Belkouch M, Beaudet N, Longpré JM, Mélik-Parsadaniantz S, Sarret P
• Glial and neuroimmune cell choreography in sexually dimorphic pain signaling.
  Neuroscience and biobehavioral reviews 2021 Midavaine É, Côté J, Marchand S, Sarret P
• Brain irradiation leads to persistent neuroinflammation and long-term neurocognitive dysfunction in a region-specific manner.
  Progress in neuro-psychopharmacology & biological psychiatry 2020 Constanzo J, Midavaine É, Fouquet J, Lepage M, Descoteaux M, Kirby K, Tremblay L, Masson-Côté L, Geha S, Longpré JM, Paquette B, Sarret P
• Publisher Correction: Dichotomic effects of clinically used drugs on tumor growth, bone remodeling and pain management.
  Scientific reports 2020 Barrière DA, Midavaine É, Doré-Savard L, Kirby K, Tremblay L, Beaudoin JF, Beaudet N, Longpré JM, Lecomte R, Lepage M, Sarret P
• Dichotomic effects of clinically used drugs on tumor growth, bone remodeling and pain management.
  Scientific reports 2019 Barrière DA, Midavaine É, Doré-Savard L, Kirby K, Tremblay L, Beaudoin JF, Beaudet N, Longpré JM, Lecomte R, Lepage M, Sarret P
• Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development.
  Molecular pain 2016 Bégin-Lavallée V, Midavaine É, Dansereau MA, Tétreault P, Longpré JM, Jacobi AM, Rose SD, Behlke MA, Beaudet N, Sarret P
• Mammary cancer bone metastasis follow-up using multimodal small-animal MR and PET imaging.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013 Doré-Savard L, Barrière DA, Midavaine É, Bélanger D, Beaudet N, Tremblay L, Beaudoin JF, Turcotte EE, Lecomte R, Lepage M, Sarret P