Elizabeth Crouch, MD, PhD
Assistant Professor
Pediatrics
School of Medicine

Approximately 20% of preterm babies born between 24-28 gestation weeks will develop germinal matrix hemorrhage (GMH). This hemorrhage can cause hydrocephalus, cerebral palsy, and death, and unfortunately there are currently no treatments. It remains unclear why vasculature in this developmental window is particularly sensitive. One critical barrier is the lack of a comprehensive understanding of the spatiotemporal dynamics of vascular cell development in the prenatal brain. Our research resolves around defining the stages of vascular stem cells in the developing brain and understanding the mechanisms that regulate their functions. We then apply this knowledge to produce novel technologies and therapeutic strategies for different brain hemorrhages in neonatal and pediatric patients. Towards these goals, we utilize neuropathological specimens, flow cytometry (FACS), bioinformatics, and cell culture, including organoid models. We are always interested in hiring motivated and talented individuals. Send an email to inquire; women and URM especially encouraged to apply. For fun, we run the BreakingDownBiology blog (also funded by UCSF ImmunoX) to explain exciting scientific journal articles with every day language. I also co-host "At the Bench: Neonatal Physician Scientists" for the Incubator Podcast network.

• NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy.
  bioRxiv : the preprint server for biology 2023 Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC, Bush NAO, Hervey-Jumper SL, Klein OD, Toedebusch CM, Horbinski CM, Magill ST, Bhaduri A, …
• Disentangling brain vasculature in neurogenesis and neurodegeneration using single-cell transcriptomics.
  Trends in neurosciences 2023 Crouch EE, Joseph T, Marsan E, Huang EJ
• A Case of Neonatal Lupus Presenting with Myocardial Dysfunction in the Absence of Congenital Heart Block (CHB): Clinical Management and Brief Literature Review of Neonatal Cardiac Lupus.
  Pediatric cardiology 2022 Jain S, Spadafora R, Maxwell S, Botas C, Nawaytou H, von Scheven E, Crouch EE
• Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain.
  Cell 2022 Crouch EE, Bhaduri A, Andrews MG, Cebrian-Silla A, Diafos LN, Birrueta JO, Wedderburn-Pugh K, Valenzuela EJ, Bennett NK, Eze UC, Sandoval-Espinosa C, Chen J, Mora C, Ross JM, Howard CE, Gonzalez-…
• Developmental dynamics of RNA translation in the human brain.
  Nature neuroscience 2022 Duffy EE, Finander B, Choi G, Carter AC, Pritisanac I, Alam A, Luria V, Karger A, Phu W, Sherman MA, Assad EG, Pajarillo N, Khitun A, Crouch EE, Ganesh S, Chen J, Berger B, Sestan N, O'Donnell-Luria A…
• Tropism of SARS-CoV-2 for human cortical astrocytes.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Ross J, Parikshak N, Wang S, Zhou L, Koontz M, Velmeshev D, Siebert CV, Gemenes KM, Tabata T, Perez Y, Wang L, Mostajo-Radji MA, de Majo M, Donohue KC, Shin…
• Individual human cortical progenitors can produce excitatory and inhibitory neurons.
  Nature 2021 Delgado RN, Allen DE, Keefe MG, Mancia Leon WR, Ziffra RS, Crouch EE, Alvarez-Buylla A, Nowakowski TJ
• The Expanding Cell Diversity of the Brain Vasculature.
  Frontiers in physiology 2020 Ross JM, Kim C, Allen D, Crouch EE, Narsinh K, Cooke DL, Abla AA, Nowakowski TJ, Winkler EA
• Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon.
  Cell reports 2020 Di Marco B, Crouch EE, Shah B, Duman C, Paredes MF, Ruiz de Almodovar C, Huang EJ, Alfonso J
• Human organoids to model the developing human neocortex in health and disease.
  Brain research 2020 Khakipoor S, Crouch EE, Mayer S
• Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.
  Cell stem cell 2020 Bhaduri A, Di Lullo E, Jung D, Müller S, Crouch EE, Espinosa CS, Ozawa T, Alvarado B, Spatazza J, Cadwell CR, Wilkins G, Velmeshev D, Liu SJ, Malatesta M, Andrews MG, Mostajo-Radji MA, Huang EJ, …
• FACS isolation of endothelial cells and pericytes from mouse brain microregions.
  Nature protocols 2018 Crouch EE, Doetsch F
• Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Crouch EE, Liu C, Silva-Vargas V, Doetsch F
• Novel association of early onset hepatocellular carcinoma with transaldolase deficiency.
  JIMD reports 2013 Leduc CA, Crouch EE, Wilson A, Lefkowitch J, Wamelink MM, Jakobs C, Salomons GS, Sun X, Shen Y, Chung WK
• Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging.
  Current opinion in neurobiology 2013 Silva-Vargas V, Crouch EE, Doetsch F
• The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.
  Nature 2007 Kruhlak M, Crouch EE, Orlov M, Montaño C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R
• Regulation of AID expression in the immune response.
  The Journal of experimental medicine 2007 Crouch EE, Li Z, Takizawa M, Fichtner-Feigl S, Gourzi P, Montaño C, Feigenbaum L, Wilson P, Janz S, Papavasiliou FN, Casellas R