Elizabeth Blackburn, PhD
Professor
Biochemistry and Biophysics
School of Medicine
elizabeth.blackburn@ucsf.edu 415-476-7284
Dr. Elizabeth H. Blackburn, Morris Herztein Professor of Biology and Physiology in the Department of Biochemistry and Biophysics at the University of California, San Francisco, is a leader in the area of telomere and telomerase research.
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She discovered the molecular nature of telomeres - the ends of eukaryotic chromosomes that serve as protective caps essential for preserving the genetic information - and the ribonucleoprotein enzyme, telomerase. Blackburn and her research team at the University of California, San Francisco are working with various cells including human cells, with the goal of understanding telomerase and telomere biology.
Blackburn earned her B.Sc. (1970) and M.Sc. (1972) degrees from the University of Melbourne in Australia, and her Ph.D. (1975) from the University of Cambridge in England. She did her postdoctoral work in Molecular and Cellular Biology from 1975 to 1977 at Yale.
In 1978, Blackburn joined the faculty at the University of California at Berkeley in the Department of Molecular Biology. In 1990, she joined the Department of Microbiology and Immunology at UC San Francisco, where she served as Department Chair from 1993 to 1999. Blackburn is currently a faculty member in Department of Biochemistry and Biophysics at UCSF. She is also a Non-Resident Fellow of the Salk Institute.
Throughout her career, Blackburn has been honored by her peers as the recipient of many prestigious awards. She was elected President of the American Society for Cell Biology for the year 1998. Blackburn is an elected Fellow of the American Academy of Arts and Sciences (1991), the Royal Society of London (1992), the American Academy of Microbiology (1993), and the American Association for the Advancement of Science (2000).
She was elected Foreign Associate of the National Academy of Sciences in 1993, and was elected as a Member of the Institute of Medicine in 2000. She was awarded the Albert Lasker Medical Research Award in Basic Medical Research (2006). In 2007 she was named one of TIME Magazine’s 100 Most influential People and she is the 2008 North American Laureate for L’Oreal-UNESCO For Women in Science.
Awards
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- Nobel Prize for Physiology or Medicine, 2009
- Paul Ehrlich and Ludwig Darmstaedter Prize, 2009
Websites
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- Elizabeth Blackburn Nobel Prize Physiology or Medicine 2009 (nobelprize.org)
- UCSF Cancer Center (cancer.ucsf.edu)
- Lindau Guidelines (lindauguidelines.org)
- Profile at biochemistry.ucsf.edu (biochemistry.ucsf.edu)
- TED Talk (youtube.com)
- Elizabeth Blackburn (youtube.com)
- Women Who Changed Science (nobelprize.org)
Grants and Projects
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- Inflammation, Aging, Microbes, Obstructive Lung Disease and Diffusion Abnormalities (I AM OLD-DA) Study, NIH, 2015-2025
- Social Disadvantage and Fetal Programming of Newborn-Infant Telomere Biology, NIH, 2016-2021
- Synergism of telomere maintenance and telomerase with cancer-promoting signaling, NIH, 2002-2018
- The function of telomerase and telomeres, NIH, 1978-2016
- Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
- SPORE in Breast Cancer, NIH, 1992-2013
- Molecular Biology of Eukaryotic Cells and Viruses, NIH, 1976-2006
- Structure and Function of Telomeres, NIH, 1978-1999
- Telomerase as a Novel Drug Target in Candida Species, NIH, 1994-1997
- Rdna Amplification and Replication in Tetrahymena, NIH, 1983-1996
- 1986 Gordon Research Conference on Nucleic Acids, NIH, 1986-1987
Publications (320)
Top publication keywords:
TelomeraseSaccharomyces cerevisiaeKluyveromycesTelomere-Binding ProteinsTetrahymena thermophilaStress, PsychologicalRNATelomereTelomere ShorteningRepetitive Sequences, Nucleic AcidCellular SenescenceTelomere HomeostasisTetrahymenaDNA NucleotidylexotransferaseLeukocytes
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Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression.
Scientific reports 2023 Rampersaud R, Wu GWY, Reus VI, Lin J, Blackburn EH, Epel ES, Hough CM, Mellon SH, Wolkowitz OM -
Predictors of long-term neutralizing antibody titers following COVID-19 vaccination by three vaccine types: the BOOST study.
Scientific reports 2023 Prather AA, Dutcher EG, Robinson J, Lin J, Blackburn E, Hecht FM, Mason AE, Fromer E, Merino B, Frazier R, O'Bryan J, Drury S, Epel ES -
The fluctuation-dissipation measurement instrument at the Linac Coherent Light Source.
The Review of scientific instruments 2022 Assefa TA, Seaberg MH, Reid AH, Shen L, Esposito V, Dakovski GL, Schlotter W, Holladay B, Streubel R, Montoya SA, Hart P, Nakahara K, Moeller S, Kevan SD, Fischer P, Fullerton EE, Colocho W, Lutman A,… -
Mechanistic basis for Sgo1-mediated centromere localization and function of the CPC.
The Journal of cell biology 2022 Abad MA, Gupta T, Hadders MA, Meppelink A, Wopken JP, Blackburn E, Zou J, Gireesh A, Buzuk L, Kelly DA, McHugh T, Rappsilber J, Lens SMA, Jeyaprakash AA -
Maternal Psychological Resilience During Pregnancy and Newborn Telomere Length: A Prospective Study.
The American journal of psychiatry 2020 Verner G, Epel E, Lahti-Pulkkinen M, Kajantie E, Buss C, Lin J, Blackburn E, Räikkönen K, Wadhwa PD, Entringer S
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Spatially inhomogeneous competition between superconductivity and the charge density wave in YBa2Cu3O6.67.
Nature communications 2020 Choi J, Ivashko O, Blackburn E, Liang R, Bonn DA, Hardy WN, Holmes AT, Christensen NB, Hücker M, Gerber S, Gutowski O, Rütt U, Zimmermann MV, Forgan EM, Hayden SM, Chang J -
Telomere length and socioeconomic status at neighborhood and individual levels among 80,000 adults in the Genetic Epidemiology Research on Adult Health and Aging cohort.
Environmental epidemiology (Philadelphia, Pa.) 2019 Alexeeff SE, Schaefer CA, Kvale MN, Shan J, Blackburn EH, Risch N, Ranatunga DK, Jorgenson E, Hoffmann TJ, Sakoda LC, Quesenberry CP, Van Den Eeden SK -
Maternal pro-inflammatory state during pregnancy and newborn leukocyte telomere length: A prospective investigation.
Brain, behavior, and immunity 2019 Lazarides C, Epel ES, Lin J, Blackburn EH, Voelkle MC, Buss C, Simhan HN, Wadhwa PD, Entringer S -
An investigation of racial/ethnic and sex differences in the association between experiences of everyday discrimination and leukocyte telomere length among patients with coronary artery disease.
Psychoneuroendocrinology 2019 Sullivan S, Hammadah M, Al Mheid I, Shah A, Sun YV, Kutner M, Ward L, Blackburn E, Zhao J, Lin J, Bremner JD, Quyyumi AA, Vaccarino V, Lewis TT -
Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection.
Nature communications 2018 Chow TT, Shi X, Wei JH, Guan J, Stadler G, Huang B, Blackburn EH -
In vitro proinflammatory gene expression predicts in vivo telomere shortening: A preliminary study.
Psychoneuroendocrinology 2018 Lin J, Sun J, Wang S, Milush JM, Baker CAR, Coccia M, Effros RB, Puterman E, Blackburn E, Prather AA, Epel E -
Chronic Obesity and Incident Hypertension in Latina Women Are Associated with Accelerated Telomere Length Loss over a 1-Year Period.
Metabolic syndrome and related disorders 2018 Wojcicki JM, Elwan D, Lin J, Blackburn E, Epel E -
Quantitative Characterization of the Nanoscale Local Lattice Strain Induced by Sr Dopants in La_{1.92}Sr_{0.08}CuO_{4}.
Physical review letters 2018 Lin JQ, Liu X, Blackburn E, Wakimoto S, Ding H, Islam Z, Sinha SK -
Telomere attrition is associated with declines in medial temporal lobe volume and white matter microstructure in functionally independent older adults.
Neurobiology of aging 2018 Staffaroni AM, Tosun D, Lin J, Elahi FM, Casaletto KB, Wynn MJ, Patel N, Neuhaus J, Walters SM, Epel ES, Blackburn EH, Kramer JH -
Shorter preschool, leukocyte telomere length is associated with obesity at age 9 in Latino children.
Clinical obesity 2017 Kjaer TW, Faurholt-Jepsen D, Mehta KM, Christensen VB, Epel E, Lin J, Blackburn E, Wojcicki JM -
Validation of Minimally-Invasive Sample Collection Methods for Measurement of Telomere Length.
Frontiers in aging neuroscience 2017 Stout SA, Lin J, Hernandez N, Davis EP, Blackburn E, Carroll JE, Glynn LM -
Socioeconomic Status, Financial Strain, and Leukocyte Telomere Length in a Sample of African American Midlife Men.
Journal of racial and ethnic health disparities 2017 Schrock JM, Adler NE, Epel ES, Nuru-Jeter AM, Lin J, Blackburn EH, Taylor RJ, Chae DH -
Telomere length is inversely correlated with urinary stress hormone levels in healthy controls but not in un-medicated depressed individuals-preliminary findings.
Journal of psychosomatic research 2017 Fair B, Mellon SH, Epel ES, Lin J, Révész D, Verhoeven JE, Penninx BW, Reus VI, Rosser R, Hough CM, Mahan L, Burke HM, Blackburn EH, Wolkowitz OM -
The Longitudinal Relationship Between Cortisol Responses to Mental Stress and Leukocyte Telomere Attrition.
The Journal of clinical endocrinology and metabolism 2017 Steptoe A, Hamer M, Lin J, Blackburn EH, Erusalimsky JD -
Correction: Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study.
PloS one 2016 Goglin SE, Farzaneh-Far R, Epel ES, Lin J, Blackburn EH, Whooley MA -
Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults.
PLoS medicine 2016 Rehkopf DH, Needham BL, Lin J, Blackburn EH, Zota AR, Wojcicki JM, Epel ES -
Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study.
PloS one 2016 Goglin SE, Farzaneh-Far R, Epel ES, Lin J, Blackburn EH, Whooley MA -
Leukocyte telomere length and ideal cardiovascular health in American Indians: the Strong Heart Family Study.
European journal of epidemiology 2016 Peng H, Mete M, Desale S, Fretts AM, Cole SA, Best LG, Lin J, Blackburn E, Lee ET, Howard BV, Zhao J -
HIV Infection Is Associated with Shortened Telomere Length in Ugandans with Suspected Tuberculosis.
PloS one 2016 Auld E, Lin J, Chang E, Byanyima P, Ayakaka I, Musisi E, Worodria W, Davis JL, Segal M, Blackburn E, Huang L -
Meditation and vacation effects have an impact on disease-associated molecular phenotypes.
Translational psychiatry 2016 Epel ES, Puterman E, Lin J, Blackburn EH, Lum PY, Beckmann ND, Zhu J, Lee E, Gilbert A, Rissman RA, Tanzi RE, Schadt EE -
Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects.
Viruses 2016 Usadi B, Bruhn R, Lin J, Lee TH, Blackburn E, Murphy EL -
Impact of biological aging on arterial aging in American Indians: findings from the Strong Heart Family Study.
Aging 2016 Peng H, Zhu Y, Yeh F, Cole SA, Best LG, Lin J, Blackburn E, Devereux RB, Roman MJ, Lee ET, Howard BV, Zhao J -
Early exclusive breastfeeding is associated with longer telomeres in Latino preschool children.
The American journal of clinical nutrition 2016 Wojcicki JM, Heyman MB, Elwan D, Lin J, Blackburn E, Epel E -
Early Loss of Telomerase Action in Yeast Creates a Dependence on the DNA Damage Response Adaptor Proteins.
Molecular and cellular biology 2016 Jay KA, Smith DL, Blackburn EH -
Leukocyte telomere length predicts SSRI response in major depressive disorder: A preliminary report.
Molecular neuropsychiatry 2016 Hough CM, Bersani FS, Mellon SH, Epel ES, Reus VI, Lindqvist D, Lin J, Mahan L, Rosser R, Burke H, Coetzee J, Nelson JC, Blackburn EH, Wolkowitz OM -
Sugary beverage and food consumption, and leukocyte telomere length maintenance in pregnant women.
European journal of clinical nutrition 2016 Leung CW, Laraia BA, Coleman-Phox K, Bush NR, Lin J, Blackburn EH, Adler NE, Epel ES -
Magnetic field controlled charge density wave coupling in underdoped YBa2Cu3O6+x.
Nature communications 2016 Chang J, Blackburn E, Ivashko O, Holmes AT, Christensen NB, Hücker M, Liang R, Bonn DA, Hardy WN, Rütt U, Zimmermann MV, Forgan EM, Hayden SM -
Telomere length change plateaus at 4 years of age in Latino children: associations with baseline length and maternal change.
Molecular genetics and genomics : MGG 2016 Wojcicki JM, Shiboski S, Heyman MB, Elwan D, Lin J, Blackburn E, Epel E -
Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes.
Journal of immunology research 2016 Lin J, Cheon J, Brown R, Coccia M, Puterman E, Aschbacher K, Sinclair E, Epel E, Blackburn EH -
Telomere length as a predictor of response to Pioglitazone in patients with unremitted depression: a preliminary study.
Translational psychiatry 2016 Rasgon N, Lin KW, Lin J, Epel E, Blackburn E -
The yeast telomerase RNA, TLC1, participates in two distinct modes of TLC1-TLC1 association processes in vivo.
PeerJ 2016 Matsuguchi T, Blackburn E -
Transforming Cancer Prevention through Precision Medicine and Immune-oncology.
Cancer prevention research (Philadelphia, Pa.) 2016 Kensler TW, Spira A, Garber JE, Szabo E, Lee JJ, Dong Z, Dannenberg AJ, Hait WN, Blackburn E, Davidson NE, Foti M, Lippman SM -
The microscopic structure of charge density waves in underdoped YBa2Cu3O6.54 revealed by X-ray diffraction.
Nature communications 2015 Forgan EM, Blackburn E, Holmes AT, Briffa AK, Chang J, Bouchenoire L, Brown SD, Liang R, Bonn D, Hardy WN, Christensen NB, Zimmermann MV, Hücker M, Hayden SM -
Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection.
Science (New York, N.Y.) 2015 Blackburn EH, Epel ES, Lin J -
Cord blood telomere length in Latino infants: relation with maternal education and infant sex.
Journal of perinatology : official journal of the California Perinatal Association 2015 Wojcicki JM, Olveda R, Heyman MB, Elwan D, Lin J, Blackburn E, Epel E -
Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder.
Translational psychiatry 2015 Henje Blom E, Han LK, Connolly CG, Ho TC, Lin J, LeWinn KZ, Simmons AN, Sacchet MD, Mobayed N, Luna ME, Paulus M, Epel ES, Blackburn EH, Wolkowitz OM, Yang TT -
Movement-Based Behaviors and Leukocyte Telomere Length among US Adults.
Medicine and science in sports and exercise 2015 Loprinzi PD, Loenneke JP, Blackburn EH -
Association of dimensional psychological health measures with telomere length in male war veterans.
Journal of affective disorders 2015 Bersani FS, Lindqvist D, Mellon SH, Epel ES, Yehuda R, Flory J, Henn-Hasse C, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM -
Q&A: End-game winner.
Nature 2015 Blackburn E, Tucker E -
Discrimination, mental health, and leukocyte telomere length among African American men.
Psychoneuroendocrinology 2015 Chae DH, Epel ES, Nuru-Jeter AM, Lincoln KD, Taylor RJ, Lin J, Blackburn EH, Thomas SB -
Leukocyte telomere length and mortality in the National Health and Nutrition Examination Survey, 1999-2002.
Epidemiology (Cambridge, Mass.) 2015 Needham BL, Rehkopf D, Adler N, Gregorich S, Lin J, Blackburn EH, Epel ES -
Mitochondrial DNA copy number is reduced in male combat veterans with PTSD.
Progress in neuro-psychopharmacology & biological psychiatry 2015 Bersani FS, Morley C, Lindqvist D, Epel ES, Picard M, Yehuda R, Flory J, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM, Mellon SH -
Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.
Genetics 2015 Lapham K, Kvale MN, Lin J, Connell S, Croen LA, Dispensa BP, Fang L, Hesselson S, Hoffmann TJ, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Matsuguchi T, McGuire WB, Miles S, Quesenberry CP, Rowell S… -
Telomere length is associated with oppositional defiant behavior and maternal clinical depression in Latino preschool children.
Translational psychiatry 2015 Wojcicki JM, Heyman MB, Elwan D, Shiboski S, Lin J, Blackburn E, Epel E -
Maternal Folate Concentration in Early Pregnancy and Newborn Telomere Length.
Annals of nutrition & metabolism 2015 Entringer S, Epel ES, Lin J, Blackburn EH, Buss C, Shahbaba B, Gillen DL, Venkataramanan R, Simhan HN, Wadhwa PD -
Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.
Neuroscience and biobehavioral reviews 2015 Lindqvist D, Epel ES, Mellon SH, Penninx BW, Révész D, Verhoeven JE, Reus VI, Lin J, Mahan L, Hough CM, Rosser R, Bersani FS, Blackburn EH, Wolkowitz OM -
Race-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-based Sample.
Journal of health and social behavior 2015 Geronimus AT, Pearson JA, Linnenbringer E, Schulz AJ, Reyes AG, Epel ES, Lin J, Blackburn EH -
Early telomerase inactivation accelerates aging independently of telomere length.
Cell 2015 Xie Z, Jay KA, Smith DL, Zhang Y, Liu Z, Zheng J, Tian R, Li H, Blackburn EH -
PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression.
Psychiatry research 2015 Wolkowitz OM, Mellon SH, Lindqvist D, Epel ES, Blackburn EH, Lin J, Reus VI, Burke H, Rosser R, Mahan L, Mackin S, Yang T, Weiner M, Mueller S -
Maternal estriol concentrations in early gestation predict infant telomere length.
The Journal of clinical endocrinology and metabolism 2015 Entringer S, Epel ES, Lin J, Blackburn EH, Buss C, Simhan HN, Wadhwa PD -
Phosphomimetic mutation of the N-terminal lid of MDM2 enhances the polyubiquitination of p53 through stimulation of E2-ubiquitin thioester hydrolysis.
Journal of molecular biology 2014 Fraser JA, Worrall EG, Lin Y, Landre V, Pettersson S, Blackburn E, Walkinshaw M, Muller P, Vojtesek B, Ball K, Hupp TR -
Tired telomeres: Poor global sleep quality, perceived stress, and telomere length in immune cell subsets in obese men and women.
Brain, behavior, and immunity 2014 Prather AA, Gurfein B, Moran P, Daubenmier J, Acree M, Bacchetti P, Sinclair E, Lin J, Blackburn E, Hecht FM, Epel ES -
Associations of cadmium and lead exposure with leukocyte telomere length: findings from National Health and Nutrition Examination Survey, 1999-2002.
American journal of epidemiology 2014 Zota AR, Needham BL, Blackburn EH, Lin J, Park SK, Rehkopf DH, Epel ES -
Telomere length and the risk of atrial fibrillation: insights into the role of biological versus chronological aging.
Circulation. Arrhythmia and electrophysiology 2014 Roberts JD, Dewland TA, Longoria J, Fitzpatrick AL, Ziv E, Hu D, Lin J, Glidden DV, Psaty BM, Burchard EG, Blackburn EH, Olgin JE, Heckbert SR, Marcus GM -
Soda and cell aging: associations between sugar-sweetened beverage consumption and leukocyte telomere length in healthy adults from the National Health and Nutrition Examination Surveys.
American journal of public health 2014 Leung CW, Laraia BA, Needham BL, Rehkopf DH, Adler NE, Lin J, Blackburn EH, Epel ES -
An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity.
Blood 2014 Gazzaniga FS, Blackburn EH -
Depression, anxiety and telomere length in young adults: evidence from the National Health and Nutrition Examination Survey.
Molecular psychiatry 2014 Needham BL, Mezuk B, Bareis N, Lin J, Blackburn EH, Epel ES -
Adverse childhood experiences and leukocyte telomere maintenance in depressed and healthy adults.
Journal of affective disorders 2014 Chen SH, Epel ES, Mellon SH, Lin J, Reus VI, Rosser R, Kupferman E, Burke H, Mahan L, Blackburn EH, Wolkowitz OM -
Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter.
Molecular psychiatry 2014 Puterman E, Lin J, Krauss J, Blackburn EH, Epel ES -
Relationship between leukocyte telomere length, telomerase activity, and hippocampal volume in early aging.
JAMA neurology 2014 Jacobs EG, Epel ES, Lin J, Blackburn EH, Rasgon NL -
Short leukocyte telomere length is associated with obesity in American Indians: the Strong Heart Family study.
Aging 2014 Chen S, Yeh F, Lin J, Matsuguchi T, Blackburn E, Lee ET, Howard BV, Zhao J -
Short leukocyte telomere length predicts incidence and progression of carotid atherosclerosis in American Indians: the Strong Heart Family Study.
Aging 2014 Chen S, Lin J, Matsuguchi T, Blackburn E, Yeh F, Best LG, Devereux RB, Lee ET, Howard BV, Roman MJ, Zhao J -
Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources.
Proceedings of the National Academy of Sciences of the United States of America 2014 Zalli A, Carvalho LA, Lin J, Hamer M, Erusalimsky JD, Blackburn EH, Steptoe A -
Metabolic profiles of biological aging in American Indians: the Strong Heart Family Study.
Aging 2014 Zhao J, Zhu Y, Uppal K, Tran VT, Yu T, Lin J, Matsuguchi T, Blackburn E, Jones D, Lee ET, Howard BV -
Seasonal variation of peripheral blood leukocyte telomere length in Costa Rica: A population-based observational study.
American journal of human biology : the official journal of the Human Biology Council 2014 Rehkopf DH, Dow WH, Rosero-Bixby L, Lin J, Epel ES, Blackburn EH -
Discrimination, racial bias, and telomere length in African-American men.
American journal of preventive medicine 2014 Chae DH, Nuru-Jeter AM, Adler NE, Brody GH, Lin J, Blackburn EH, Epel ES -
Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity?
Appetite 2014 Buss J, Havel PJ, Epel E, Lin J, Blackburn E, Daubenmier J -
Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system.
Cell 2013 Chen B, Gilbert LA, Cimini BA, Schnitzbauer J, Zhang W, Li GW, Park J, Blackburn EH, Weissman JS, Qi LS, Huang B -
Q&A: Elizabeth Blackburn on telomerase and tumors.
Cancer discovery 2013 Blackburn E -
An investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells.
Molecular and cellular biology 2013 Listerman I, Gazzaniga FS, Blackburn EH -
Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study.
The Lancet. Oncology 2013 Ornish D, Lin J, Chan JM, Epel E, Kemp C, Weidner G, Marlin R, Frenda SJ, Magbanua MJM, Daubenmier J, Estay I, Hills NK, Chainani-Wu N, Carroll PR, Blackburn EH -
QTL mapping of leukocyte telomere length in American Indians: the Strong Heart Family Study.
Aging 2013 Zhu Y, Voruganti VS, Lin J, Matsuguchi T, Blackburn E, Best LG, Lee ET, MacCluer JW, Cole SA, Zhao J -
Longer leukocyte telomere length in Costa Rica's Nicoya Peninsula: a population-based study.
Experimental gerontology 2013 Rehkopf DH, Dow WH, Rosero-Bixby L, Lin J, Epel ES, Blackburn EH -
Short leukocyte telomere length predicts risk of diabetes in american indians: the strong heart family study.
Diabetes 2013 Zhao J, Zhu Y, Lin J, Matsuguchi T, Blackburn E, Zhang Y, Cole SA, Best LG, Lee ET, Howard BV -
Multisystem resiliency moderates the major depression-telomere length association: findings from the Heart and Soul Study.
Brain, behavior, and immunity 2013 Puterman E, Epel ES, Lin J, Blackburn EH, Gross JJ, Whooley MA, Cohen BE -
The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis.
Cancer research 2013 Listerman I, Sun J, Gazzaniga FS, Lukas JL, Blackburn EH -
X-ray diffraction observations of a charge-density-wave order in superconducting ortho-II YBa2Cu3O6.54 single crystals in zero magnetic field.
Physical review letters 2013 Blackburn E, Chang J, Hücker M, Holmes AT, Christensen NB, Liang R, Bonn DA, Hardy WN, Rütt U, Gutowski O, von Zimmermann M, Forgan EM, Hayden SM -
Visualization of actin filaments and monomers in somatic cell nuclei.
Molecular biology of the cell 2013 Belin BJ, Cimini BA, Blackburn EH, Mullins RD -
Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999-2002.
Social science & medicine (1982) 2013 Needham BL, Adler N, Gregorich S, Rehkopf D, Lin J, Blackburn EH, Epel ES -
Accelerated cell aging in female APOE-ε4 carriers: implications for hormone therapy use.
PloS one 2013 Jacobs EG, Kroenke C, Lin J, Epel ES, Kenna HA, Blackburn EH, Rasgon NL -
Cytomegalovirus is associated with reduced telomerase activity in the Whitehall II cohort.
Experimental gerontology 2013 Dowd JB, Bosch JA, Steptoe A, Blackburn EH, Lin J, Rees-Clayton E, Aiello AE -
Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length.
American journal of obstetrics and gynecology 2012 Entringer S, Epel ES, Lin J, Buss C, Shahbaba B, Blackburn EH, Simhan HN, Wadhwa PD -
Association between kidney function and telomere length: the heart and soul study.
American journal of nephrology 2012 Bansal N, Whooley MA, Regan M, McCulloch CE, Ix JH, Epel E, Blackburn E, Lin J, Hsu CY -
Telomeres and adversity: Too toxic to ignore.
Nature 2012 Blackburn EH, Epel ES -
Chronic stress elevates telomerase activity in rats.
Biology letters 2012 Beery AK, Lin J, Biddle JS, Francis DD, Blackburn EH, Epel ES -
Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial.
Brain, behavior, and immunity 2012 Kiecolt-Glaser JK, Epel ES, Belury MA, Andridge R, Lin J, Glaser R, Malarkey WB, Hwang BS, Blackburn E -
The telomere syndromes.
Nature reviews. Genetics 2012 Armanios M, Blackburn EH -
Educational attainment and late life telomere length in the Health, Aging and Body Composition Study.
Brain, behavior, and immunity 2012 Adler N, Pantell MS, O'Donovan A, Blackburn E, Cawthon R, Koster A, Opresko P, Newman A, Harris TB, Epel E -
Socioeconomic status and cell aging in children.
Social science & medicine (1982) 2012 Needham BL, Fernandez JR, Lin J, Epel ES, Blackburn EH -
A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activity.
International journal of geriatric psychiatry 2012 Lavretsky H, Epel ES, Siddarth P, Nazarian N, Cyr NS, Khalsa DS, Lin J, Blackburn E, Irwin MR -
Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere length.
Brain, behavior, and immunity 2012 O'Donovan A, Tomiyama AJ, Lin J, Puterman E, Adler NE, Kemeny M, Wolkowitz OM, Blackburn EH, Epel ES -
Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot study.
Psychoneuroendocrinology 2011 Daubenmier J, Lin J, Blackburn E, Hecht FM, Kristeller J, Maninger N, Kuwata M, Bacchetti P, Havel PJ, Epel E -
Does cellular aging relate to patterns of allostasis? An examination of basal and stress reactive HPA axis activity and telomere length.
Physiology & behavior 2011 Tomiyama AJ, O'Donovan A, Lin J, Puterman E, Lazaro A, Chan J, Dhabhar FS, Wolkowitz O, Kirschbaum C, Blackburn E, Epel E -
Physical fitness and telomere length in patients with coronary heart disease: findings from the Heart and Soul Study.
PloS one 2011 Krauss J, Farzaneh-Far R, Puterman E, Na B, Lin J, Epel E, Blackburn E, Whooley MA -
Telomerase, telomere length, and coronary artery calcium in black and white men in the CARDIA study.
Atherosclerosis 2011 Kroenke CH, Pletcher MJ, Lin J, Blackburn E, Adler N, Matthews K, Epel E -
Shorter leukocyte telomere length in midlife women with poor sleep quality.
Journal of aging research 2011 Prather AA, Puterman E, Lin J, O'Donovan A, Krauss J, Tomiyama AJ, Epel ES, Blackburn EH -
Shorter telomeres are associated with obesity and weight gain in the elderly.
International journal of obesity (2005) 2011 Njajou OT, Cawthon RM, Blackburn EH, Harris TB, Li R, Sanders JL, Newman AB, Nalls M, Cummings SR, Hsueh WC -
Hostility and cellular aging in men from the Whitehall II cohort.
Biological psychiatry 2011 Brydon L, Lin J, Butcher L, Hamer M, Erusalimsky JD, Blackburn EH, Steptoe A -
Actuary of the cell. Interview by Thea Singer.
Scientific American 2011 Blackburn EH -
Autonomic and adrenocortical reactivity and buccal cell telomere length in kindergarten children.
Psychosomatic medicine 2011 Kroenke CH, Epel E, Adler N, Bush NR, Obradovic J, Lin J, Blackburn E, Stamperdahl JL, Boyce WT -
Telomeres and lifestyle factors: roles in cellular aging.
Mutation research 2011 Lin J, Epel E, Blackburn E -
Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR.
Nucleic acids research 2011 Aviv A, Hunt SC, Lin J, Cao X, Kimura M, Blackburn E -
Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood.
Proceedings of the National Academy of Sciences of the United States of America 2011 Entringer S, Epel ES, Kumsta R, Lin J, Hellhammer DH, Blackburn EH, Wüst S, Wadhwa PD -
Cancer interception.
Cancer prevention research (Philadelphia, Pa.) 2011 Blackburn EH -
Depression and leukocyte telomere length in patients with coronary heart disease: data from the Heart and Soul Study.
Psychosomatic medicine 2011 Hoen PW, de Jonge P, Na BY, Farzaneh-Far R, Epel E, Lin J, Blackburn E, Whooley MA -
Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study.
PloS one 2011 O'Donovan A, Pantell MS, Puterman E, Dhabhar FS, Blackburn EH, Yaffe K, Cawthon RM, Opresko PL, Hsueh WC, Satterfield S, Newman AB, Ayonayon HN, Rubin SM, Harris TB, Epel ES, Health Aging and Body … -
Telomerase: an RNP enzyme synthesizes DNA.
Cold Spring Harbor perspectives in biology 2011 Blackburn EH, Collins K -
Educational attainment but not measures of current socioeconomic circumstances are associated with leukocyte telomere length in healthy older men and women.
Brain, behavior, and immunity 2011 Steptoe A, Hamer M, Butcher L, Lin J, Brydon L, Kivimäki M, Marmot M, Blackburn E, Erusalimsky JD -
Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder.
Biological psychiatry 2011 O'Donovan A, Epel E, Lin J, Wolkowitz O, Cohen B, Maguen S, Metzler T, Lenoci M, Blackburn E, Neylan TC -
Walking the walk from genes through telomere maintenance to cancer risk.
Cancer prevention research (Philadelphia, Pa.) 2011 Blackburn EH -
Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings.
PloS one 2011 Wolkowitz OM, Mellon SH, Epel ES, Lin J, Dhabhar FS, Su Y, Reus VI, Rosser R, Burke HM, Kupferman E, Compagnone M, Nelson JC, Blackburn EH -
Telomere shortening in formerly abused and never abused women.
Biological research for nursing 2011 Humphreys J, Epel ES, Cooper BA, Lin J, Blackburn EH, Lee KA -
Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response.
Molecular psychiatry 2011 Wolkowitz OM, Mellon SH, Epel ES, Lin J, Reus VI, Rosser R, Burke H, Compagnone M, Nelson JC, Dhabhar FS, Blackburn EH -
Intensive meditation training, immune cell telomerase activity, and psychological mediators.
Psychoneuroendocrinology 2010 Jacobs TL, Epel ES, Lin J, Blackburn EH, Wolkowitz OM, Bridwell DA, Zanesco AP, Aichele SR, Sahdra BK, MacLean KA, King BG, Shaver PR, Rosenberg EL, Ferrer E, Wallace BA, Saron CD -
Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline.
Brain research 2010 Lin J, Kroenke CH, Epel E, Kenna HA, Wolkowitz OM, Blackburn E, Rasgon NL -
Telomeres and telomerase: the means to the end (Nobel lecture).
Angewandte Chemie (International ed. in English) 2010 Blackburn EH -
A common variant in the telomerase RNA component is associated with short telomere length.
PloS one 2010 Njajou OT, Blackburn EH, Pawlikowska L, Mangino M, Damcott CM, Kwok PY, Spector TD, Newman AB, Harris TB, Cummings SR, Cawthon RM, Shuldiner AR, Valdes AM, Hsueh WC -
A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53.
The Journal of biological chemistry 2010 Fraser JA, Madhumalar A, Blackburn E, Bramham J, Walkinshaw MD, Verma C, Hupp TR -
Characterization of the yeast telomere nucleoprotein core: Rap1 binds independently to each recognition site.
The Journal of biological chemistry 2010 Williams TL, Levy DL, Maki-Yonekura S, Yonekura K, Blackburn EH -
The terminal telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion.
Molecular cell 2010 Stohr BA, Xu L, Blackburn EH -
The power of exercise: buffering the effect of chronic stress on telomere length.
PloS one 2010 Puterman E, Lin J, Blackburn E, O'Donovan A, Adler N, Epel E -
Climate change and the integrity of science.
Science (New York, N.Y.) 2010 Gleick PH, Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, Berenbaum MR, Berlin OB, Bjorkman… -
Highlighting the science of cancer prevention.
Cancer prevention research (Philadelphia, Pa.) 2010 Blackburn EH -
Unprecedented opportunities and promise for cancer prevention research.
Cancer prevention research (Philadelphia, Pa.) 2010 Blackburn EH, Tlsty TD, Lippman SM -
The effects of phosphomimetic lid mutation on the thermostability of the N-terminal domain of MDM2.
Journal of molecular biology 2010 Worrall EG, Worrall L, Blackburn E, Walkinshaw M, Hupp TR -
Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease.
JAMA 2010 Farzaneh-Far R, Lin J, Epel ES, Harris WS, Blackburn EH, Whooley MA -
Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study.
PloS one 2010 Farzaneh-Far R, Lin J, Epel E, Lapham K, Blackburn E, Whooley MA -
Dynamics of telomerase activity in response to acute psychological stress.
Brain, behavior, and immunity 2009 Epel ES, Lin J, Dhabhar FS, Wolkowitz OM, Puterman E, Karan L, Blackburn EH -
2009 Nobels: break or breakthrough for women? Interview by Jeffrey Mervis and Kate Travis.
Science (New York, N.Y.) 2009 Blackburn E, Greider C, Yonath A, Ostrom E -
Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance.
Journal of immunological methods 2009 Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, Bigos M, Wolkowitz O, Mellon S, Blackburn E -
Telomeres and Tetrahymena: an interview with Elizabeth Blackburn.
Disease models & mechanisms 2009 Blackburn E -
DNA damage signalling prevents deleterious telomere addition at DNA breaks.
Nature cell biology 2009 Makovets S, Blackburn EH -
Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres.
Annals of the New York Academy of Sciences 2009 Epel E, Daubenmier J, Moskowitz JT, Folkman S, Blackburn E -
Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009 Njajou OT, Hsueh WC, Blackburn EH, Newman AB, Wu SH, Li R, Simonsick EM, Harris TM, Cummings SR, Cawthon RM, Health ABC study -
A conversation with Elizabeth Blackburn. Interview by Misia Landau.
Clinical chemistry 2009 Blackburn E -
Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression.
Cell 2009 Li S, Makovets S, Matsuguchi T, Blethrow JD, Shokat KM, Blackburn EH -
Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women.
Brain, behavior, and immunity 2008 O'Donovan A, Lin J, Tillie J, Tillie JM, Dhabhar FS, Wolkowitz OM, Wolkowitz O, Blackburn EH, Blackburn E, Epel ES, Epel E -
Mec1 function in the DNA damage response does not require its interaction with Tel2.
Cell cycle (Georgetown, Tex.) 2008 Anderson CM, Blackburn EH -
The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men.
Aging 2008 Epel ES, Merkin SS, Cawthon R, Blackburn EH, Adler NE, Pletcher MJ, Seeman TE -
Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy.
Epigenetics & chromatin 2008 Wang X, Kam Z, Carlton PM, Xu L, Sedat JW, Blackburn EH -
Dietary restraint and telomere length in pre- and postmenopausal women.
Psychosomatic medicine 2008 Kiefer A, Lin J, Blackburn E, Epel E -
Increased telomerase activity and comprehensive lifestyle changes: a pilot study.
The Lancet. Oncology 2008 Ornish D, Lin J, Daubenmier J, Weidner G, Epel E, Kemp C, Magbanua MJ, Marlin R, Yglecias L, Carroll PR, Blackburn EH -
A novel Tel1/ATM N-terminal motif, TAN, is essential for telomere length maintenance and a DNA damage response.
Molecular and cellular biology 2008 Seidel JJ, Anderson CM, Blackburn EH -
ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells.
Cancer research 2008 Stohr BA, Blackburn EH -
Interview with Elizabeth Blackburn, Ph.D. Interview by Vicki Glaser.
Rejuvenation research 2008 Blackburn E -
Elizabeth Blackburn: because science is worth it. Interview by Ruth Williams.
The Journal of cell biology 2008 Blackburn E -
Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.
Genes & development 2008 Anderson CM, Korkin D, Smith DL, Makovets S, Seidel JJ, Sali A, Blackburn EH -
The telotype defines the telomere state in Saccharomyces cerevisiae and is inherited as a dominant non-Mendelian characteristic in cells lacking telomerase.
Genetics 2008 Makovets S, Williams TL, Blackburn EH -
Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres.
Molecular cell 2007 Xu L, Blackburn EH -
Telomere length is paternally inherited and is associated with parental lifespan.
Proceedings of the National Academy of Sciences of the United States of America 2007 Njajou OT, Cawthon RM, Damcott CM, Wu SH, Ott S, Garant MJ, Blackburn EH, Mitchell BD, Shuldiner AR, Hsueh WC -
Telomerase core components protect Candida telomeres from aberrant overhang accumulation.
Proceedings of the National Academy of Sciences of the United States of America 2007 Hsu M, McEachern MJ, Dandjinou AT, Tzfati Y, Orr E, Blackburn EH, Lue NF -
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging.
Nature medicine 2006 Blackburn EH, Greider CW, Szostak JW -
Genes and pathways downstream of telomerase in melanoma metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2006 Bagheri S, Nosrati M, Li S, Fong S, Torabian S, Rangel J, Moore DH, Federman S, Laposa RR, Baehner FL, Sagebiel RW, Cleaver JE, Haqq C, Debs RJ, Blackburn EH, Kashani-Sabet M -
Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells.
Cancer research 2006 Goldkorn A, Blackburn EH -
Expression and suppression of human telomerase RNA.
Cold Spring Harbor symposia on quantitative biology 2006 Li S, Blackburn EH -
Cell aging in relation to stress arousal and cardiovascular disease risk factors.
Psychoneuroendocrinology 2005 Epel ES, Lin J, Wilhelm FH, Wolkowitz OM, Cawthon R, Adler NE, Dolbier C, Mendes WB, Blackburn EH -
Telomerase and Cancer: Kirk A. Landon--AACR prize for basic cancer research lecture.
Molecular cancer research : MCR 2005 Blackburn EH -
Cell biology: Shaggy mouse tales.
Nature 2005 Blackburn EH -
Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita.
Blood 2005 Ly H, Schertzer M, Jastaniah W, Davis J, Yong SL, Ouyang Q, Blackburn EH, Parslow TG, Lansdorp PM -
Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA.
The Journal of biological chemistry 2005 Li S, Crothers J, Haqq CM, Blackburn EH -
Telomeres and telomerase: their mechanisms of action and the effects of altering their functions.
FEBS letters 2005 Blackburn EH -
Stem cell science and politics: a talk with Elizabeth Blackburn.
Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees 2005 Blackburn E -
Thoughts of a former Council member.
Perspectives in biology and medicine 2005 Blackburn E -
Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules.
The Journal of cell biology 2004 Xu L, Blackburn EH -
Accelerated telomere shortening in response to life stress.
Proceedings of the National Academy of Sciences of the United States of America 2004 Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM -
Counting of Rif1p and Rif2p on Saccharomyces cerevisiae telomeres regulates telomere length.
Molecular and cellular biology 2004 Levy DL, Blackburn EH -
Processive utilization of the human telomerase template: lack of a requirement for template switching.
The Journal of biological chemistry 2004 Rivera MA, Blackburn EH -
A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein.
Proceedings of the National Academy of Sciences of the United States of America 2004 Lin J, Ly H, Hussain A, Abraham M, Pearl S, Tzfati Y, Parslow TG, Blackburn EH -
Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004 Nosrati M, Li S, Bagheri S, Ginzinger D, Blackburn EH, Debs RJ, Kashani-Sabet M -
Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA.
Cancer research 2004 Li S, Rosenberg JE, Donjacour AA, Botchkina IL, Hom YK, Cunha GR, Blackburn EH -
Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions.
Molecular and cellular biology 2004 Makovets S, Herskowitz I, Blackburn EH -
Bioethics and the political distortion of biomedical science.
The New England journal of medicine 2004 Blackburn E -
A 'full range' of bioethical views just got narrower.
The Washington post 2004 Blackburn EH -
Reason as our guide.
PLoS biology 2004 Blackburn E, Rowley J -
Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA.
Genes & development 2004 Lin J, Blackburn EH -
Telomeres and telomerase.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2004 Chan SR, Blackburn EH -
Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response.
Molecular biology of the cell 2004 Lin J, Smith DL, Blackburn EH -
Tracking telomerase.
Cell 2004 Greider CW, Blackburn EH -
A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity.
RNA (New York, N.Y.) 2003 Seto AG, Umansky K, Tzfati Y, Zaug AJ, Blackburn EH, Cech TR -
Comprehensive structure-function analysis of the core domain of human telomerase RNA.
Molecular and cellular biology 2003 Ly H, Blackburn EH, Parslow TG -
Catalytically active human telomerase mutants with allele-specific biological properties.
Experimental cell research 2003 Kim M, Xu L, Blackburn EH -
A novel pseudoknot element is essential for the action of a yeast telomerase.
Genes & development 2003 Tzfati Y, Knight Z, Roy J, Blackburn EH -
A role for a novel 'trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase.
Genes & development 2003 Ly H, Xu L, Rivera MA, Parslow TG, Blackburn EH -
Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining.
Molecular cell 2003 Chan SW, Blackburn EH -
Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae.
Molecular biology of the cell 2003 Smith CD, Smith DL, DeRisi JL, Blackburn EH -
A molecular switch underlies a human telomerase disease.
Proceedings of the National Academy of Sciences of the United States of America 2002 Comolli LR, Smirnov I, Xu L, Blackburn EH, James TL -
A bulged stem tethers Est1p to telomerase RNA in budding yeast.
Genes & development 2002 Seto AG, Livengood AJ, Tzfati Y, Blackburn EH, Cech TR -
Harmful moratorium on stem cell research.
Science (New York, N.Y.) 2002 Rowley JD, Blackburn E, Gazzaniga MS, Foster DW -
The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 2002 Nautiyal S, DeRisi JL, Blackburn EH -
New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin.
Oncogene 2002 Chan SW, Blackburn EH -
Dynamics of telomeric DNA turnover in yeast.
Genetics 2002 McEachern MJ, Underwood DH, Blackburn EH -
A Trypanosoma brucei protein complex that binds G-overhangs and co-purifies with telomerase activity.
The Journal of biological chemistry 2001 Cano MI, Blake JJ, Blackburn EH, Agabian N -
Switching and signaling at the telomere.
Cell 2001 Blackburn EH -
Altering telomere structure allows telomerase to act in yeast lacking ATM kinases.
Current biology : CB 2001 Chan SW, Chang J, Prescott J, Blackburn EH -
A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2001 Kim MM, Rivera MA, Botchkina IL, Shalaby R, Thor AD, Blackburn EH -
Telomere states and cell fates.
Nature 2000 Blackburn EH -
Telomere fusions caused by mutating the terminal region of telomeric DNA.
Proceedings of the National Academy of Sciences of the United States of America 2000 McEachern MJ, Iyer S, Fulton TB, Blackburn EH -
The end of the (DNA) line.
Nature structural biology 2000 Blackburn EH -
Three telomerases with completely non-telomeric template replacements are catalytically active.
The EMBO journal 2000 Ware TL, Wang H, Blackburn EH -
Telomeres and telomerase.
The Keio journal of medicine 2000 Blackburn EH -
Template boundary in a yeast telomerase specified by RNA structure.
Science (New York, N.Y.) 2000 Tzfati Y, Fulton TB, Roy J, Blackburn EH -
Telomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres.
Molecular and cellular biology 2000 Prescott JC, Blackburn EH -
Molecular manifestations and molecular determinants of telomere capping.
Cold Spring Harbor symposia on quantitative biology 2000 Blackburn EH, Chan S, Chang J, Fulton TB, Krauskopf A, McEachern M, Prescott J, Roy J, Smith C, Wang H -
Studying the telomerase RNA in Tetrahymena.
Methods in cell biology 2000 Blackburn E, Gilley D, Ware T, Bhattacharyya A, Kirk K, Wang H -
Telomeres and their control.
Annual review of genetics 2000 McEachern MJ, Krauskopf A, Blackburn EH -
Ku is associated with the telomere in mammals.
Proceedings of the National Academy of Sciences of the United States of America 1999 Hsu HL, Gilley D, Blackburn EH, Chen DJ -
The telomere and telomerase: how Do they interact?
The Mount Sinai journal of medicine, New York 1999 Blackburn E -
The telomerase RNA pseudoknot is critical for the stable assembly of a catalytically active ribonucleoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1999 Gilley D, Blackburn EH -
Telomerase: Dr Jekyll or Mr Hyde?
Current opinion in genetics & development 1999 Prescott JC, Blackburn EH -
Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast.
The Journal of cell biology 1999 Smith CD, Blackburn EH -
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening.
Proceedings of the National Academy of Sciences of the United States of America 1999 Zhu J, Wang H, Bishop JM, Blackburn EH -
Telomerase in kinetoplastid parasitic protozoa.
Proceedings of the National Academy of Sciences of the United States of America 1999 Cano MI, Dungan JM, Agabian N, Blackburn EH -
Specific telomerase RNA residues distant from the template are essential for telomerase function.
Genes & development 1998 Roy J, Fulton TB, Blackburn EH -
Rap1 protein regulates telomere turnover in yeast.
Proceedings of the National Academy of Sciences of the United States of America 1998 Krauskopf A, Blackburn EH -
Identification of Kluyveromyces lactis telomerase: discontinuous synthesis along the 30-nucleotide-long templating domain.
Molecular and cellular biology 1998 Fulton TB, Blackburn EH -
Two types of telomeric chromatin in Tetrahymena thermophila.
Journal of molecular biology 1998 Cohen P, Blackburn EH -
The rate of telomere sequence loss in human leukocytes varies with age.
Proceedings of the National Academy of Sciences of the United States of America 1998 Frenck RW, Blackburn EH, Shannon KM -
A promoter region mutation affecting replication of the Tetrahymena ribosomal DNA minichromosome.
Molecular and cellular biology 1998 Gallagher RC, Blackburn EH -
Not so peculiar: fission yeast telomere repeats.
Trends in biochemical sciences 1998 Hiraoka Y, Henderson E, Blackburn EH -
A novel specificity for the primer-template pairing requirement in Tetrahymena telomerase.
The EMBO journal 1998 Wang H, Gilley D, Blackburn EH -
Telomeric sequence diversity within the genus Saccharomyces.
Current genetics 1998 Cohn M, McEachern MJ, Blackburn EH -
Functionally interacting telomerase RNAs in the yeast telomerase complex.
Genes & development 1997 Prescott J, Blackburn EH -
The telomere and telomerase: nucleic acid-protein complexes acting in a telomere homeostasis system. A review.
Biochemistry. Biokhimiia 1997 Blackburn EH -
A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains.
Proceedings of the National Academy of Sciences of the United States of America 1997 Bhattacharyya A, Blackburn EH -
Aspergillus nidulans maintains short telomeres throughout development.
Nucleic acids research 1997 Bhattacharyya A, Blackburn EH -
Block in anaphase chromosome separation caused by a telomerase template mutation.
Science (New York, N.Y.) 1997 Kirk KE, Harmon BP, Reichardt IK, Sedat JW, Blackburn EH -
De novo telomere addition by Tetrahymena telomerase in vitro.
The EMBO journal 1997 Wang H, Blackburn EH -
Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro.
Genes & development 1997 Prescott J, Blackburn EH -
The telomere and telomerase: how do they interact?
Ciba Foundation symposium 1997 Blackburn E, Bhattacharyya A, Gilley D, Kirk K, Krauskopf A, McEachern M, Prescott J, Ware T -
Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats.
Nature 1996 Krauskopf A, Blackburn EH -
Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase.
Genes & development 1996 McEachern MJ, Blackburn EH -
Telomeres, telomerase and cancer.
Scientific American 1996 Greider CW, Blackburn EH -
Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines.
Molecular and cellular biology 1996 Strahl C, Blackburn EH -
Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase.
Molecular and cellular biology 1996 Gilley D, Blackburn EH -
Altering specific telomerase RNA template residues affects active site function.
Genes & development 1995 Gilley D, Lee MS, Blackburn EH -
Runaway telomere elongation caused by telomerase RNA gene mutations.
Nature 1995 McEachern MJ, Blackburn EH -
Telomerase in yeast.
Science (New York, N.Y.) 1995 Cohn M, Blackburn EH -
Replication of an rRNA gene origin plasmid in the Tetrahymena thermophila macronucleus is prevented by transcription through the origin from an RNA polymerase I promoter.
Molecular and cellular biology 1995 Pan WJ, Gallagher RC, Blackburn EH -
Tandem repeats of the 5' non-transcribed spacer of Tetrahymena rDNA function as high copy number autonomous replicons in the macronucleus but do not prevent rRNA gene dosage regulation.
Nucleic acids research 1995 Pan WJ, Blackburn EH -
An unusual sequence arrangement in the telomeres of the germ-line micronucleus in Tetrahymena thermophila.
Genes & development 1995 Kirk KE, Blackburn EH -
Circular rDNA replicons persist in Tetrahymena thermophila transformants synthesizing GGGGTC telomeric repeats.
The Journal of eukaryotic microbiology 1995 Romero DP, Blackburn EH -
Architecture of telomerase RNA.
The EMBO journal 1994 Bhattacharyya A, Blackburn EH -
Telomeres: no end in sight.
Cell 1994 Blackburn EH -
Tetrahymena thermophila mutants defective in the developmentally programmed maturation and maintenance of the rDNA minichromosome.
Genetics 1994 Kapler GM, Orias E, Blackburn EH -
A conserved sequence motif within the exceptionally diverse telomeric sequences of budding yeasts.
Proceedings of the National Academy of Sciences of the United States of America 1994 McEachern MJ, Blackburn EH -
The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena.
Nucleic acids research 1994 Strahl C, Blackburn EH -
Lack of telomere shortening during senescence in Paramecium.
Proceedings of the National Academy of Sciences of the United States of America 1994 Gilley D, Blackburn EH -
DNA bound by the Oxytricha telomere protein is accessible to telomerase and other DNA polymerases.
Proceedings of the National Academy of Sciences of the United States of America 1994 Shippen DE, Blackburn EH, Price CM -
A weak germ-line excision mutation blocks developmentally controlled amplification of the rDNA minichromosome of Tetrahymena thermophila.
Genes & development 1994 Kapler GM, Blackburn EH -
Sequence-specific DNA primer effects on telomerase polymerization activity.
Molecular and cellular biology 1993 Lee MS, Blackburn EH -
An alternative pathway for yeast telomere maintenance rescues est1- senescence.
Cell 1993 Lundblad V, Blackburn EH -
In vivo and in vitro studies of telomeres and telomerase.
Cold Spring Harbor symposia on quantitative biology 1993 Lee MS, Gallagher RC, Bradley J, Blackburn EH -
Avidity and titer of immunoglobulin G subclasses to Porphyromonas gingivalis in adult periodontitis patients.
Oral microbiology and immunology 1992 Lopatin DE, Blackburn E -
Telomerases.
Annual review of biochemistry 1992 Blackburn EH -
Developmentally programmed healing of chromosomes by telomerase in Tetrahymena.
Cell 1991 Yu GL, Blackburn EH -
A conserved secondary structure for telomerase RNA.
Cell 1991 Romero DP, Blackburn EH -
Telomeres.
Trends in biochemical sciences 1991 Blackburn EH -
Tel-1 transposon-like elements of Tetrahymena thermophila are associated with micronuclear genome rearrangements.
Genetics 1991 Wyman C, Blackburn EH -
Structure and function of telomeres.
Nature 1991 Blackburn EH -
RNA editing. Copy editing--what's the U's?
Nature 1990 Blackburn EH -
Telomeres and their synthesis.
Science (New York, N.Y.) 1990 Blackburn EH -
Amplification of tandemly repeated origin control sequences confers a replication advantage on rDNA replicons in Tetrahymena thermophila.
Molecular and cellular biology 1990 Yu GL, Blackburn EH -
Telomeres: structure and synthesis.
The Journal of biological chemistry 1990 Blackburn EH -
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs.
Nature 1990 Yu GL, Bradley JD, Attardi LD, Blackburn EH -
RNA-dependent polymerase motifs in EST1: tentative identification of a protein component of an essential yeast telomerase.
Cell 1990 Lundblad V, Blackburn EH -
Functional evidence for an RNA template in telomerase.
Science (New York, N.Y.) 1990 Shippen-Lentz D, Blackburn EH -
Cell biology: telomeres sans frontières.
Nature 1990 Blackburn EH -
Telomeres and their synthesis.
Harvey lectures 1990 Blackburn EH -
Transformation of Tetrahymena thermophila with a mutated circular ribosomal DNA plasmid vector.
Proceedings of the National Academy of Sciences of the United States of America 1989 Yu GL, Blackburn EH -
A novel DNA deletion-ligation reaction catalyzed in vitro by a developmentally controlled activity from Tetrahymena cells.
Cell 1989 Robinson EK, Cohen PD, Blackburn EH -
Analysis of Paramecium macronuclear DNA using pulsed field gel electrophoresis.
The Journal of protozoology 1989 Phan HL, Forney J, Blackburn EH -
Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers.
Molecular and cellular biology 1989 Shippen-Lentz D, Blackburn EH -
Tetrahymena micronuclear sequences that function as telomeres in yeast.
Nucleic acids research 1989 Shampay J, Blackburn EH -
The replication advantage of a free linear rRNA gene is restored by somatic recombination in Tetrahymena thermophila.
Molecular and cellular biology 1989 Yaeger PC, Orias E, Shaiu WL, Larson DD, Blackburn EH -
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis.
Nature 1989 Greider CW, Blackburn EH -
An overhanging 3' terminus is a conserved feature of telomeres.
Molecular and cellular biology 1989 Henderson ER, Blackburn EH -
Recognition and elongation of telomeres by telomerase.
Genome 1989 Blackburn EH, Greider CW, Henderson E, Lee MS, Shampay J, Shippen-Lentz D -
Replacement of the macronuclear ribosomal RNA genes of a mutant Tetrahymena using electroporation.
Gene 1988 Orias E, Larson D, Hu YF, Yu GL, Karttunen J, Løvlie A, Haller B, Blackburn EH -
Circular ribosomal DNA plasmids transform Tetrahymena thermophila by homologous recombination with endogenous macronuclear ribosomal DNA.
Proceedings of the National Academy of Sciences of the United States of America 1988 Yu GL, Hasson M, Blackburn EH -
Developmentally regulated telomere addition in Tetrahymena thermophila.
Nucleic acids research 1988 Spangler EA, Ryan T, Blackburn EH -
Developmentally controlled telomere addition in wild-type and mutant paramecia.
Molecular and cellular biology 1988 Forney JD, Blackburn EH -
Generation of telomere-length heterogeneity in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1988 Shampay J, Blackburn EH -
Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs.
Cell 1987 Henderson E, Hardin CC, Walk SK, Tinoco I, Blackburn EH -
The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity.
Cell 1987 Greider CW, Blackburn EH -
Identification of the telomeric sequence of the acellular slime molds Didymium iridis and Physarum polycephalum.
Nucleic acids research 1987 Forney J, Henderson ER, Blackburn EH -
S1 nuclease sensitivity of a double-stranded telomeric DNA sequence.
Nucleic acids research 1987 Budarf M, Blackburn E -
Dynamics of telomere length variation in Tetrahymena thermophila.
Cell 1987 Larson DD, Spangler EA, Blackburn EH -
Control of rDNA replication in Tetrahymena involves a cis-acting upstream repeat of a promoter element.
Cell 1986 Larson DD, Blackburn EH, Yaeger PC, Orias E -
Conservation of sequences adjacent to the telomeric C4A2 repeats of ciliate macronuclear ribosomal RNA gene molecules.
Nucleic acids research 1986 Challoner PB, Blackburn EH -
Chromatin structure of the telomeric region and 3'-nontranscribed spacer of Tetrahymena ribosomal RNA genes.
The Journal of biological chemistry 1986 Budarf ML, Blackburn EH -
Genomic reorganization in ciliated protozoans.
Annual review of genetics 1986 Blackburn EH, Karrer KM -
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.
Cell 1985 Greider CW, Blackburn EH -
The internally located telomeric sequences in the germ-line chromosomes of Tetrahymena are at the ends of transposon-like elements.
Cell 1985 Cherry JM, Blackburn EH -
Reproducible and variable genomic rearrangements occur in the developing somatic nucleus of the ciliate Tetrahymena thermophila.
Molecular and cellular biology 1985 Howard EA, Blackburn EH -
The nucleotide sequence of the 17S ribosomal RNA gene of Tetrahymena thermophila and the identification of point mutations resulting in resistance to the antibiotics paromomycin and hygromycin.
The Journal of biological chemistry 1985 Spangler EA, Blackburn EH -
A drug-resistant mutation in the ribosomal DNA of Tetrahymena.
Proceedings of the National Academy of Sciences of the United States of America 1985 Bruns PJ, Katzen AL, Martin L, Blackburn EH -
Conserved arrangements of repeated DNA sequences in nontranscribed spacers of ciliate ribosomal RNA genes: evidence for molecular coevolution.
Nucleic acids research 1985 Challoner PB, Amin AA, Pearlman RE, Blackburn EH -
DNA sequences of telomeres maintained in yeast.
Nature 1984 Shampay J, Szostak JW, Blackburn EH -
Telomeres: do the ends justify the means?
Cell 1984 Blackburn EH -
Identification of a telomeric DNA sequence in Trypanosoma brucei.
Cell 1984 Blackburn EH, Challoner PB -
The molecular structure of centromeres and telomeres.
Annual review of biochemistry 1984 Blackburn EH -
Methylation of ribosomal RNA genes in the macronucleus of Tetrahymena thermophila.
Nucleic acids research 1983 Blackburn EH, Pan WC, Johnson CC -
DNA termini in ciliate macronuclei.
Cold Spring Harbor symposia on quantitative biology 1983 Blackburn EH, Budarf ML, Challoner PB, Cherry JM, Howard EA, Katzen AL, Pan WC, Ryan T -
Cloning yeast telomeres on linear plasmid vectors.
Cell 1982 Szostak JW, Blackburn EH -
Allele-specific, selective amplification of a ribosomal RNA gene in Tetrahymena thermophila.
Cell 1982 Pan WC, Orias E, Flacks M, Blackburn EH -
Tandemly repeated C-C-C-C-A-A hexanucleotide of Tetrahymena rDNA is present elsewhere in the genome and may be related to the alteration of the somatic genome.
The Journal of cell biology 1981 Yao MC, Blackburn E, Gall J -
Sequence-specific fragmentation of macronuclear DNA in a holotrichous ciliate.
Cell 1981 Katzen AL, Cann GM, Blackburn EH -
Non-nucleosomal packaging of a tandemly repeated DNA sequence at termini of extrachromosomal DNA coding for rRNA in Tetrahymena.
Proceedings of the National Academy of Sciences of the United States of America 1981 Blackburn EH, Chiou SS -
Single extrachromosomal ribosomal RNA gene copies are synthesized during amplification of the rDNA in Tetrahymena.
Cell 1981 Pan WC, Blackburn EH -
Amplification of the rRNA genes in Tetrahymena.
Cold Spring Harbor symposia on quantitative biology 1979 Yao MC, Blackburn E, Gall JG -
A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena.
Journal of molecular biology 1978 Blackburn EH, Gall JG -
Gene F of bacteriophage phiX174. Correlation of nucleotide sequences from the DNA and amino acid sequences from the gene product.
Journal of molecular biology 1976 Air GM, Blackburn EH, Coulson AR, Galibert F, Sanger F, Sedat JW, Ziff EB -
Transcription and sequence analysis of a fragment of bacteriophage phiX174 DNA.
Journal of molecular biology 1976 Blackburn EH -
The nucleotide and amino acid sequences of the N (5') terminal region of gene G of bacteriophage phiphiX 174.
Journal of molecular biology 1975 Air GM, Blackburn EH, Sanger F, Coulson AR -
Transcription by Escherichia coli RNA polymerase of a single-stranded fragment by bacteriophage phiX174 DNA 48 residues in length.
Journal of molecular biology 1975 Blackburn EH