Elias Botvinick, MD
Professor
Medicine
School of Medicine

A Professor in Residence, Co-Director of the Adult Cardiology Non-Invasive Laboratory, and Director of the Cardiac Stress Testing Laboratory at the University of California, San Francisco. Dr. Botvinick received his medical degree from New York University School of Medicine in 1967, and completed a residency in Medicine at Bellevue Hospital in New York, followed by a fellowship in Nuclear Medicine from UCSF in 1976.

Dr. Botvinick’s primary research interest has been scintigraphic methods. His research involves recent applications of the scintigraphic imaging agent indicates its ability to map the regional density of sympathetic nerves and support the hypothesis that an altered balance in the relationship of perfusion and innervation can increase vulnerability to life threatening arrhythmias. Overall, Dr. Botvinick’s research has been a collaborative effort to develop non-invasive graphic and imaging methods for the identification and evaluation of cardiac anatomy and pathophysiology, and apply them to the diagnosis, risk stratification and monitoring of clinical disease.

Dr. Botvinick has written 178 articles, 46 book chapters, 301 abstracts, with 8 significant publications.

Expertise: Nuclear Medicine and Cardiology

Specialty: Nuclear cardiology, scintigraphy, cardiovascular diseases

Professional Interests: Nuclear medicine, nuclear cardiology, PET/CT, MRI, CT, cardiac cardiology, echo cardiology, nuclear magnetic resonance, cardiovascular imaging, stress testing, heart, myocardial perfusion, scintigraphy, coronary, synchrony, synchronization

Education and Training:

• Medical School: New York University School of Medicine, New York
• Internship: Bellevue Hospital, New York - Medicine
• Internship: United States Army, Hospital, Fort Riley
• Residency: Bellevue Hospital, New York - Medicine
• Fellowship: University of California, San Francisco - Nuclear Medicine
• New York State Medical License
• Controlled Substance Registration Certificate
• California State Medical
• Internal Medicine Boards
• Nuclear Medicine Boards
• Cardiovascular Boards
• Certified, Basic Cardiac Life Support
• Certified, Advanced Cardiac Life Support

• Utility of Equilibrium Radionuclide Angiogram-Derived Measures of Dyssynchrony to Predict Outcomes in Heart Failure Patients Undergoing Cardiac Resynchronization Therapy.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2016 Badhwar N, James J, Hoffmayer KS, O'Connell JW, Green D, De Marco T, Botvinick EH
• Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99mTc-tetrofosmin: Method and validation.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2015 Shrestha U, Sciammarella M, Alhassen F, Yeghiazarians Y, Ellin J, Verdin E, Boyle A, Seo Y, Botvinick EH, Gullberg GT
• Image reconstruction in higher dimensions: myocardial perfusion imaging of tracer dynamics with cardiac motion due to deformation and respiration.
  Physics in medicine and biology 2015 Shrestha UM, Seo Y, Botvinick EH, Gullberg GT
• Comparison of radionuclide angiographic synchrony analysis to echocardiography and magnetic resonance imaging for the diagnosis of arrhythmogenic right ventricular cardiomyopathy.
  Heart rhythm 2015 Johnson CJ, Roberts JD, James JH, Hoffmayer KS, Badhwar N, Ku IA, Zhao S, Naeger DM, Rao RK, O'Connell JW, De Marco T, Botvinick EH, Scheinman MM
• Erratum to: Isolated right ventricular cardiac sarcoidosis demonstrated by (18)FDG positron emission tomography.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2015 Pampaloni MH, Nazer B, Botvinick E
• Quantitative Signature of Coronary Steal in a Patient with Occluded Coronary Arteries Supported by Collateral Circulation Using Dynamic SPECT.
  IEEE Nuclear Science Symposium conference record. Nuclear Science Symposium 2014 Shrestha U, Botvinick EH, Yeghiazarians Y, Seo Y, Gullberg GT
• Isolated right ventricular cardiac sarcoidosis demonstrated by ¹⁸FDG positron emission tomography.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2014 Hernandez Pampaloni M, Nazer B, Nazar B, Botvinick E
• Imaging synchrony.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2009 Botvinick EH, O'Connell JW, Badhwar N
• The variable functional effects of the pacing site in normal and scarred ventricles.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2009 del Romeral LM, Stillson C, Lesh M, Botvinick E
• The relationship of myocardial contraction and electrical excitation--the correlation between scintigraphic phase image analysis and electrophysiologic mapping.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2009 del Romeral LM, Stillson C, Lesh M, Dae M, Botvinick E
• A pilot study of changes in (18)F-FDG uptake, calcification and global metabolic activity of the aorta with aging.
  Hellenic journal of nuclear medicine 2009 Bural GG, Torigian DA, Botvinick E, Houseni M, Basu S, Chen W, Alavi A
• Current methods of pharmacologic stress testing and the potential advantages of new agents.
  Journal of nuclear medicine technology 2009 Botvinick EH
• Localization of ventricular tachycardia exit site and subsequent contraction sequence and functional effects with bedside radionuclide angiography.
  JACC. Cardiovascular imaging 2008 Botvinick E, Davis J, Dae M, O'Connell J, Schechtmann N, Abbott J, Morady F, Lanzer P, Iskikian J, Scheinman M
• Age-related decrease in cardiopulmonary adrenergic neuronal function in children as assessed by I-123 metaiodobenzylguanidine imaging.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2008 Chen W, Botvinick EH, Alavi A, Zhang Y, Yang S, Perini R, Zhuang H
• Myocardial perfusion and function: single photon emission computed tomography.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2007 Hansen CL, Goldstein RA, Akinboboye OO, Berman DS, Botvinick EH, Churchwell KB, Cooke CD, Corbett JR, Cullom SJ, Dahlberg ST, Druz RS, Ficaro EP, Galt JR, Garg RK, Germano G, Heller GV, Henzlova MJ, …
• The aging of the heart and blood vessels: a consideration of anatomy and physiology in the era of computed tomography, magnetic resonance imaging, and positron emission tomographic imaging methods with special consideration of atherogenesis.
  Seminars in nuclear medicine 2007 Botvinick EH, Perini R, Bural G, Chen W, Chryssikos T, Houseni M, Hernandez-Pampaloni M, Torigian DA, Alavi A
• Equilibrium radionuclide angiocardiography.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2006 Corbett JR, Akinboboye OO, Bacharach SL, Borer JS, Botvinick EH, DePuey EG, Ficaro EP, Hansen CL, Henzlova MJ, Van Kriekinge S, Quality Assurance Committee of the American Society of Nuclear …
• A novel approach to multipinhole SPECT for myocardial perfusion imaging.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006 Funk T, Kirch DL, Koss JE, Botvinick E, Hasegawa BH
• A unique method by which to quantitate synchrony with equilibrium radionuclide angiography.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2005 O'Connell JW, Schreck C, Moles M, Badwar N, DeMarco T, Olgin J, Lee B, Tseng Z, Kumar U, Botvinick EH
• Clinical value of attenuation correction in stress-only Tc-99m sestamibi SPECT imaging.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2004 Heller GV, Bateman TM, Johnson LL, Cullom SJ, Case JA, Galt JR, Garcia EV, Haddock K, Moutray KL, Poston C, Botvinick EH, Fish MB, Follansbee WP, Hayes S, Iskandrian AE, Mahmarian JJ, Vandecker W
• Increased right ventricular activity: artifact of camera head misalignment.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2003 Pham KH, Botvinick EH
• Scintigraphic blood pool and phase image analysis: the optimal tool for the evaluation of resynchronization therapy.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2003 Botvinick EH
• Unique contraction pattern in patients after coronary bypass graft surgery by gated SPECT myocardial perfusion imaging.
  Clinical nuclear medicine 2003 Yun JH, Block M, Botvinick EH
• Current practice. The role of noninvasive testing and affect of VANQWISH/FRISC II trials on managing acute coronary syndrome patients.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2001 Allman KC, Godoy I, Olea E, Lekakis J, Zafir N, Metcalfe M, Prigent F, Botvinick EH, Hendrix GH
• Intrinsic dual-energy processing of myocardial perfusion images.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2000 Brown JK, Tang HR, Hattner RS, Bocher M, Ratzlaff NW, Kadkade PP, Hasegawa BH, Botvinick EH
• Long-term estrogen replacement therapy is associated with improved exercise capacity in postmenopausal women without known coronary artery disease.
  American heart journal 2000 Redberg RF, Nishino M, McElhinney DB, Dae MW, Botvinick EH
• Ventricular contraction abnormalities in dilated cardiomyopathy: effect of biventricular pacing to correct interventricular dyssynchrony.
  Journal of the American College of Cardiology 2000 Kerwin WF, Botvinick EH, O'Connell JW, Merrick SH, DeMarco T, Chatterjee K, Scheibly K, Saxon LA
• An unusual presentation of non-Hodgkin's lymphoma: a case report.
  Clinical nuclear medicine 2000 Challa S, Botvinick EH, Neymark E, Price D, Hawkins RA
• Impact of a home-based walking and resistance training program on quality of life in patients with heart failure.
  The American journal of cardiology 2000 Oka RK, De Marco T, Haskell WL, Botvinick E, Dae MW, Bolen K, Chatterjee K
• Effects of the repeated administration of adenosine and heparin on myocardial perfusion in patients with chronic stable angina pectoris.
  The American journal of cardiology 2000 Barron HV, Sciammarella MG, Lenihan K, Michaels AD, Botvinick EH
• Is there any advantage to the acquisition of 24-hour thallium images, in the presence of persistent perfusion defects at 4 h after reinjection?
  European journal of nuclear medicine 1998 Bobba K, Botvinick EH, Sciammarella MG, Starsken NF, Zhu YY, Lapidus A, Dae MW
• Potential added value of three-dimensional reconstruction and display of single photon emission computed tomographic gated blood pool images.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1998 Botvinick EH, O'Connell JW, Kadkade PP, Glickman SL, Dae MW, Cohen TJ, Abbott J, Krishnan R
• Nonperfusion applications in nuclear cardiology: report of a task force of the American Society of Nuclear Cardiology.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1998 DePuey EG, Port S, Wackers FJ, Rozanski A, Botvinick EH, Dae MW, Tamaki N
• Fast acquisition of myocardial SPECT images with Tc-99m sestamibi for the diagnosis of coronary artery disease.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1997 Segall GM, Stepp C, Kadkade PP, Dae MW, Botvinick EH
• Strategies for extraction of quantitative data from volumetric dynamic cardiac positron emission tomography data.
  Cardiology 1997 Huesman RH, Klein GJ, Reutter BW, Coxson PG, Botvinick EH, Budinger TF
• Comparison of adenosine to dipyridamole in degree of coronary hyperemic response in heart transplant recipients.
  The American journal of cardiology 1996 Chou TM, Sudhir K, Amidon TM, Klinski CS, DeMarco T, Chatterjee K, Botvinick EH
• Diagnostic utility of tomographic myocardial perfusion imaging with technetium 99m furifosmin (Q12) compared with thallium 201: results of a phase III multicenter trial.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1996 Hendel RC, Verani MS, Miller DD, Wackers FJ, McMahon M, Cerqueira MD, Botvinick EH, Kvols L, Gerson MC
• Cardiac activation mapping by MRI.
  Magma (New York, N.Y.) 1996 Knollmann FD, Mäurer J, Kücherer H, Böck JC, O'Connell JW, Botvinick E, Eichstädt HW, Felix R
• Stress imaging. Current clinical options for the diagnosis, localization, and evaluation of coronary artery disease.
  The Medical clinics of North America 1995 Botvinick EH
• Acute and chronic effects of transient myocardial ischemia on sympathetic nerve activity, density, and norepinephrine content.
  Cardiovascular research 1995 Dae MW, O'Connell JW, Botvinick EH, Chin MC
• Adenosine-induced coronary vasodilation during transesophageal Doppler echocardiography. Rapid and safe measurement of coronary flow reserve ratio can predict significant left anterior descending coronary stenosis.
  Circulation 1995 Redberg RF, Sobol Y, Chou TM, Malloy M, Kumar S, Botvinick E, Kane J
• Variability of normal coronary anatomy: implications for the interpretation of thallium-SPECT myocardial perfusion images in single-vessel disease.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995 Segall GM, Atwood JE, Botvinick EH, Dae MW, Lucas JR
• Segmental analysis of resting echocardiographic function and stress scintigraphic perfusion: implications for myocardial viability.
  American heart journal 1995 Foster E, O'Kelly B, LaPidus A, Sandler D, Tucker K, Dae M, Schiller NB, Botvinick EH
• A consideration of current clinical options for stress imaging in the diagnosis and evaluation of coronary artery disease.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1994 Botvinick EH
• Effects of long-term right ventricular apical pacing on left ventricular perfusion, innervation, function and histology.
  Journal of the American College of Cardiology 1994 Lee MA, Dae MW, Langberg JJ, Griffin JC, Chin MC, Finkbeiner WE, O'Connell JW, Botvinick E, Scheinman MM, Rosenqvist M
• Does myocardial perfusion scintigraphy demonstrate clinical usefulness in patients with markedly positive exercise tests? An assessment of the method in a high-risk subset.
  American heart journal 1994 Krishnan R, Lu J, Dae MW, Botvinick EH
• Assessment of perfused left ventricular mass in normal, ischemic, and reperfused myocardium by means of single-photon emission computed tomography of technetium-99m isonitrile.
  American heart journal 1993 Wolfe CL, O'Connell JW, Sievers RE, Cobb C, Dae MW, Botvinick E
• Effects of canine myocardial infarction on sympathetic efferent neuronal function: scintigraphic and electrophysiologic correlates.
  American heart journal 1993 Newman D, Munoz L, Chin M, Franz M, Herre J, Scheinman MM, Botvinick E, Dae M
• Hypertrophic cardiomyopathy in the young: another form of ischemic cardiomyopathy?
  Journal of the American College of Cardiology 1993 Botvinick EH, Dae MW, Krishnan R, Ewing S
• Myocardial perfusion scintigraphy in left bundle branch block: a perspective on the issue from image analysis in a clinical context.
  American heart journal 1993 Krishnan R, Lu J, Zhu YY, Dae MW, Botvinick EH
• Myocardial viability: evidence provided by the analysis of left ventricular systolic function.
  Coronary artery disease 1993 Lucas JR, Botvinick EH, Dae MW
• The proper tool for the job.
  Journal of the American College of Cardiology 1993 Botvinick EH
• Basal interventricular septal thallium-201 defects: real or artifact?
  Clinical nuclear medicine 1993 Starksen NF, O'Connell W, Dae MW, Botvinick EH
• A quantitative assessment of patient motion and its effect on myocardial perfusion SPECT images.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1993 Botvinick EH, Zhu YY, O'Connell WJ, Dae MW
• Diagnostic and prognostic value of ambulatory electrocardiographic monitoring.
  American heart journal 1992 Munoz del Romeral L, Dae MW, Ports TA, Botvinick EH
• Scintigraphic assessment of MIBG uptake in globally denervated human and canine hearts--implications for clinical studies.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992 Dae MW, De Marco T, Botvinick EH, O'Connell JW, Hattner RS, Huberty JP, Yuen-Green MS
• Usefulness of adenosine in augmenting ventricular preexcitation for noninvasive localization of accessory pathways.
  The American journal of cardiology 1992 Cohen TJ, Tucker KJ, Abbott JA, Botvinick EH, Foster E, Schiller NB, O'Connell JW, Scheinman MM
• The applications of adenosine in noninvasive cardiac imaging.
  Herz 1992 Tucker KJ, Cohen TJ, Botvinick EH, Schiller NB
• Advances in myocardial scintigraphy in coronary heart disease.
  American journal of cardiac imaging 1992 Botvinick EH
• Two-dimensional echocardiographic phase analysis. Its potential for noninvasive localization of accessory pathways in patients with Wolff-Parkinson-White syndrome.
  Circulation 1992 Kuecherer HF, Abbott JA, Botvinick EH, Scheinman ED, O'Connell JW, Scheinman MM, Foster E, Schiller NB
• Comparison of the findings on preoperative dipyridamole perfusion scintigraphy and intraoperative transesophageal echocardiography: implications regarding the identification of myocardium at ischemic risk.
  Journal of the American College of Cardiology 1991 Watters TA, Botvinick EH, Dae MW, Cahalan M, Urbanowicz J, Benefiel DJ, Schiller NB, Goldstone G, Reilly L, Stoney RJ
• Dipyridamole perfusion scintigraphy.
  Seminars in nuclear medicine 1991 Botvinick EH, Dae MW
• Phase image triangulation of accessory pathways in patients undergoing catheter ablation of posteroseptal pathways.
  Pacing and clinical electrophysiology : PACE 1991 Oeff M, Scheinman MM, Abbott JA, Botvinick EH, Griffin JC, Herre JM, Dae MW
• Scintigraphic assessment of sympathetic innervation after transmural versus nontransmural myocardial infarction.
  Journal of the American College of Cardiology 1991 Dae MW, Herre JM, O'Connell JW, Botvinick EH, Newman D, Munoz L
• Relative importance of activation sequence compared to atrioventricular synchrony in left ventricular function.
  The American journal of cardiology 1991 Rosenqvist M, Isaaz K, Botvinick EH, Dae MW, Cockrell J, Abbott JA, Schiller NB, Griffin JC
• Dipyridamole perfusion scintigraphy: the experience with its application in one hundred seventy patients with known or suspected unstable angina.
  American heart journal 1991 Zhu YY, Chung WS, Botvinick EH, Dae MW, Lim AD, Ports TA, Danforth JW, Wolfe CL, Goldschlager N, Chatterjee K
• The promise of technetium-99m-based perfusion imaging agents.
  Circulation 1990 Botvinick EH
• Benefits of physiologic atrioventricular synchronization for pacing with an exercise rate response.
  The American journal of cardiology 1990 Landzberg JS, Franklin JO, Mahawar SK, Himelman RB, Botvinick EH, Schiller NB, Springer MJ, Griffin JC
• Imaging of the heart using metaiodobenzylguanidine.
  Journal of thoracic imaging 1990 Dae MW, Botvinick EH
• Comparison of transesophageal echocardiographic and scintigraphic estimates of left ventricular end-diastolic volume index and ejection fraction in patients following coronary artery bypass grafting.
  Anesthesiology 1990 Urbanowicz JH, Shaaban MJ, Cohen NH, Cahalan MK, Botvinick EH, Chatterjee K, Schiller NB, Dae MW, Matthay MA
• "Hot spot" imaging agents for acute myocardial infarction.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990 Botvinick EH
• Epicardial and endocardial localized 31P magnetic resonance spectroscopy: evidence for metabolic heterogeneity during regional ischemia.
  Magnetic resonance in medicine 1990 Gober JR, Schaefer S, Camacho SA, DeGroot M, Obregon R, Botvinick EH, Weiner M, Massie B
• Late reversibility: a viability issue.
  Journal of the American College of Cardiology 1990 Botvinick EH
• Oblique reformatting of multislice magnetic resonance images for improved visualization of coronary arteries.
  Journal of digital imaging 1990 Hylton NM, Chung WS, Botvinick EH, Schiller NB, Sheldon P, Kaufman L
• Blood pool scintigraphy.
  Cardiology clinics 1989 Botvinick EH, Dae MW, O'Connell JW
• Noninvasive assessment of cardiomyopathy in normotensive diabetic patients between 20 and 50 years old.
  The American journal of medicine 1989 Bouchard A, Sanz N, Botvinick EH, Phillips N, Heilbron D, Byrd BF, Karam JH, Schiller NB
• Response of myocardial metabolites to graded regional ischemia: 31P NMR spectroscopy of porcine myocardium in vivo.
  Circulation research 1989 Schaefer S, Camacho SA, Gober J, Obregon RG, DeGroot MA, Botvinick EH, Massie B, Weiner MW
• Value of color Doppler estimation of regurgitant volume in patients with chronic aortic insufficiency.
  American heart journal 1989 Bouchard A, Yock P, Schiller NB, Blumlein S, Botvinick EH, Greenberg B, Cheitlin M, Massie BM
• ECG left anterior fascicular block reveals diverse patterns on scintigraphic phase analysis.
  American heart journal 1989 Dae M, Wen YM, Botvinick EH, Scheinman M
• The scintigraphic characteristics of ventricular pre-excitation through Mahaim fibers with the use of phase analysis.
  Journal of the American College of Cardiology 1989 Schechtmann N, Botvinick EH, Dae M, Scheinman MM, O'Connell JW, Davis J, Winston S, Schwartz A, Abbott J
• Scintigraphic assessment of regional cardiac adrenergic innervation.
  Circulation 1989 Dae MW, O'Connell JW, Botvinick EH, Ahearn T, Yee E, Huberty JP, Mori H, Chin MC, Hattner RS, Herre JM
• Nuclear magnetic resonance imaging-guided phosphorus-31 spectroscopy of the human heart.
  Journal of the American College of Cardiology 1988 Schaefer S, Gober J, Valenza M, Karczmar GS, Matson GB, Camacho SA, Botvinick EH, Massie B, Weiner MW
• The clinical and pathophysiologic implications of pain, ST abnormalities, and scintigraphic changes induced during dipyridamole infusion: their relationships to the peripheral hemodynamic response.
  American heart journal 1988 Zhu YY, Lee W, Botvinick E, Dae M, Chatterjee K, Danforth J, Ports T
• Breast attenuation artifacts in Tl-201 scintigraphy.
  Radiology 1988 Botvinick EH
• In vivo alterations of high-energy phosphates and intracellular pH during reversible ischemia in pigs: a 31P magnetic resonance spectroscopy study.
  American heart journal 1988 Camacho SA, Lanzer P, Toy BJ, Gober J, Valenza M, Botvinick EH, Weiner MW
• Gallium lung scintigraphy in amiodarone pulmonary toxicity.
  Chest 1988 Zhu YY, Botvinick E, Dae M, Golden J, Hattner R, Scheinman M
• Dipyridamole myocardial perfusion scintigraphy.
  The Western journal of medicine 1988 Botvinick EH, Dae M
• Estimation of the functional and anatomic extent of myocardial infarction using magnetic resonance imaging.
  American heart journal 1988 White RD, Holt WW, Cheitlin MD, Cassidy MM, Ports TA, Lim AD, Botvinick EH, Higgins CB
• Analysis of thallium-201 "washout" from parametric color coded images.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1988 Botvinick EH, O'Connell WJ, Dae MW, Hattner RS, Schechtmann NM
• Improvement in myocardial performance without a decrease in high-energy phosphate metabolites after isoproterenol in Syrian cardiomyopathic hamsters.
  Circulation 1988 Camacho SA, Wikman-Coffelt J, Wu ST, Watters TA, Botvinick EH, Sievers R, James TL, Jasmin G, Parmley WW
• Substrate regulation of the nucleotide pool during regional ischaemia and reperfusion in an isolated rat heart preparation: a phosphorus-31 magnetic resonance spectroscopy analysis.
  Cardiovascular research 1988 Camacho SA, Parmley WW, James TL, Abe H, Wu ST, Botvinick EH, Watters TA, Schiller N, Sievers R, Wikman-Coffelt J
• Chemomechanics of altered perfusion pressure in rat hearts.
  Basic research in cardiology 1988 Watters TA, Botvinick E, Parmley WW, Wu S, Wikman-Coffelt J
• Quantitation of intracardiac shunts by cine-CT.
  Journal of computer assisted tomography 1988 Garrett JS, Jaschke W, Aherne T, Botvinick EH, Higgins CB, Lipton MJ
• Segmental evaluation of left ventricular wall motion after myocardial infarction: magnetic resonance imaging versus echocardiography.
  American heart journal 1988 White RD, Cassidy MM, Cheitlin MD, Emilson B, Ports TA, Lim AD, Botvinick EH, Schiller NB, Higgins CB
• Factors influencing myocardial response to metabolic acidosis in isolated rat hearts.
  The American journal of physiology 1987 Watters TA, Wendland MF, Parmley WW, James TL, Botvinick EH, Wu ST, Sievers R, Wikman-Coffelt J
• Augmented preexcitation assessed by scintigraphic phase analysis during atrial pacing.
  American heart journal 1987 Botvinick E, Schechtmann N, Dae M, Scheinman M, Davis J, Herre J, Iskikian T, Abbott J
• Effects of altered coronary perfusion pressure on function and metabolism of normal and cardiomyopathic hamster hearts.
  Journal of molecular and cellular cardiology 1987 Bouchard A, Watters TA, Wu S, Parmley WW, Stone RD, Botvinick E, Sievers R, Jasmin G, Wikman-Coffelt J
• Hemodynamic and clinical evaluation of piroximone, a new inotrope-vasodilator agent, in severe congestive heart failure.
  Journal of the American College of Cardiology 1987 Axelrod RJ, De Marco T, Dae M, Botvinick EH, Chatterjee K
• Advances in noninvasive cardiovascular imaging: implications for the anesthesiologist.
  Anesthesiology 1987 Cahalan MK, Litt L, Botvinick EH, Schiller NB
• Left ventricular dimensions and mechanics in distance runners.
  American heart journal 1986 Mickelson JK, Byrd BF, Bouchard A, Botvinick EH, Schiller NB
• Quantitation of regional myocardial function by cine computed tomography: pharmacologic changes in wall thickness.
  Journal of the American College of Cardiology 1986 Lanzer P, Garrett J, Lipton MJ, Gould R, Sievers R, O'Connell W, Botvinick E, Higgins CB
• Quantitation of mitral regurgitation by Doppler echocardiography.
  Circulation 1986 Blumlein S, Bouchard A, Schiller NB, Dae M, Byrd BF, Ports T, Botvinick EH
• Cine-computed tomography of Ebstein anomaly.
  Journal of computer assisted tomography 1986 Garrett JS, Schiller NB, Botvinick EH, Higgins CB, Lipton MJ
• Poor correlation between pulmonary arterial wedge pressure and left ventricular end-diastolic volume after coronary artery bypass graft surgery.
  Anesthesiology 1986 Hansen RM, Viquerat CE, Matthay MA, Wiener-Kronish JP, DeMarco T, Bahtia S, Marks JD, Botvinick EH, Chatterjee K
• Differentiation of reversible and irreversible myocardial injury by MR imaging with and without gadolinium-DTPA.
  Radiology 1986 McNamara MT, Tscholakoff D, Revel D, Soulen R, Schechtmann N, Botvinick E, Higgins CB
• Noninvasive quantitation of the left heart by echocardiography and scintigraphy.
  Cardiovascular clinics 1986 Schiller NB, Botvinick EH
• Effects of intravenous administration of a new nonionic dimeric contrast medium on the coronary circulation. Comparison with monomeric ionic and nonionic media.
  Investigative radiology 1985 Lanzer P, Dean PB, Lipton MJ, Sievers R, Botvinick E, Higgins CB
• Measurement of cardiac output by cine computed tomography.
  The American journal of cardiology 1985 Garrett JS, Lanzer P, Jaschke W, Botvinick E, Sievers R, Higgins CB, Lipton MJ
• Interaction of "supplementary" scintigraphic indicators of ischemia and stress electrocardiography in the diagnosis of multivessel coronary disease.
  Journal of the American College of Cardiology 1985 Canhasi B, Dae M, Botvinick E, Lanzer P, Schechtmann N, Faulkner D, O'Connell W, Schiller N
• The effects of coronary angioplasty and reperfusion on distribution of myocardial flow.
  Circulation 1985 Wahr DW, Ports TA, Botvinick EH, Dae M, Schechtmann N, Huberty J, Hattner RS, O'Connell JW, Turley K
• Undrained bloody pericardial effusion in the early postoperative period after coronary bypass surgery: a prospective blood pool study.
  American heart journal 1985 Viquerat CE, Hansen RM, Botvinick EH, Dae MW, Wiener-Kronish JP, Matthay MA
• [Imaging of the heart using nuclear magnetic resonance tomography. I: Tomography].
  Zeitschrift fur Kardiologie 1985 Lanzer PA, Botvinick EH, Higgins CB
• The etiology and implications of dense cavitary "photopenia" on myocardial perfusion scintigraphy.
  Investigative radiology 1985 Dae M, Canhasi B, Botvinick E, Olvera S, Schechtmann N, Engelstad B, Hattner R, Schiller N, O'Connell W, Faulkner D
• ECG-synchronized cardiac MR imaging: method and evaluation.
  Radiology 1985 Lanzer P, Barta C, Botvinick EH, Wiesendanger HU, Modin G, Higgins CB
• Magnetic resonance imaging of the heart: a review of the experience in 172 subjects.
  Radiology 1985 Higgins CB, Byrd BF, McNamara MT, Lanzer P, Lipton MJ, Botvinick E, Schiller NB, Crooks LE, Kaufman L
• Normal cardiac dimensions by magnetic resonance imaging.
  The American journal of cardiology 1985 Byrd BF, Schiller NB, Botvinick EH, Higgins CB
• Magnetic resonance imaging in hypertrophic cardiomyopathy.
  The American journal of cardiology 1985 Higgins CB, Byrd BF, Stark D, McNamara M, Lanzer P, Lipton MJ, Schiller NB, Botvinick E, Chatterjee K
• Detection and characterization of acute myocardial infarction in man with use of gated magnetic resonance.
  Circulation 1985 McNamara MT, Higgins CB, Schechtmann N, Botvinick E, Lipton MJ, Chatterjee K, Amparo EG
• [Diagnosis of left bundle branch block with the phase analysis of radionuclide images].
  Zhonghua xin xue guan bing za zhi 1985 Wen YM, Botvinick EH
• Assessment of left intraventricular block by scintigraphic analysis.
  Chinese medical journal 1985 Wen YM, Botvinick EH, Sheinman MM
• Assessment of cardiac anatomy using nuclear magnetic resonance imaging.
  Journal of the American College of Cardiology 1985 Higgins CB, Lanzer P, Stark D, Botvinick E, Schiller NB, Lipton MJ, Crooks LE, Kaufman L
• Cardiosynchronous MRI intensity changes of the great vessels and pulmonary circulation. A preliminary report.
  Annales de radiologie 1985 Lallemand D, Wesbey GE, Gooding CA, Ehman R, Brasch RC, Ortendahl D, McNamara MT, Lanzer P, Botvinick E, Crooks E
• Magnetic resonance (MR) imaging of aorta and pulmonary circulation. Initial experience with ECG-gating.
  Annales de radiologie 1985 Lallemand D, Gooding CA, Wesbey GE, Brasch RC, Botvinick E, Lanzer P, McNamara MT
• Magnetic resonance imaging strategies for heart studies.
  Radiology 1984 Crooks LE, Barker B, Chang H, Feinberg D, Hoenninger JC, Watts JC, Arakawa M, Kaufman L, Sheldon PE, Botvinick E
• Mechanisms of improved left ventricular function following intravenous MDL 17,043 in patients with severe chronic heart failure.
  American heart journal 1984 Kereiakes DJ, Viquerat C, Lanzer P, Botvinick EH, Spangenberg R, Buckingham M, Parmley WW, Chatterjee K
• Phase image characterization of localized and generalized left ventricular contraction abnormalities.
  Journal of the American College of Cardiology 1984 Frais M, Botvinick E, Shosa D, O'Connell W, Pacheco Alvarez J, Dae M, Hattner R, Faulkner D
• The scintigraphic identification of "severe myocardial ischemia".
  Giornale italiano di cardiologia 1984 Botvinick EH
• Value of noninvasive assessment of patients with atypical chest pain and suspected coronary spasm using ergonovine infusion and thallium-201 scintigraphy.
  The American journal of cardiology 1984 DiCarlo LA, Botvinick EH, Canhasi BS, Schwartz AS, Chatterjee K
• Catheter-induced His bundle ablation in a patient with reentrant tachycardia associated with a nodoventricular tract.
  Journal of the American College of Cardiology 1984 Bhandari A, Morady F, Shen EN, Schwartz AB, Botvinick E, Scheinman MM
• Right ventricular myocardial infarction with ventricular septal rupture.
  American heart journal 1984 Kereiakes DJ, Ports TA, Botvinick EH, Schiller NB, Turley K, Chatterjee K
• Improved regional ventricular function after successful surgical revascularization.
  Journal of the American College of Cardiology 1984 Brundage BH, Massie BM, Botvinick EH
• Imaging by nuclear magnetic resonance in patients with chronic ischemic heart disease.
  Circulation 1984 Higgins CB, Lanzer P, Stark D, Botvinick E, Schiller NB, Crooks L, Kaufman L, Lipton MJ
• Phase image evaluation of patients with ventricular pre-excitation syndromes.
  Journal of the American College of Cardiology 1984 Botvinick E, Frais M, O'Connell W, Faulkner D, Scheinman M, Morady F, Sung R, Shosa D, Dae M
• Characterization of conduction and concentration abnormalities by scintigraphic phase analysis.
  International journal of cardiology 1984 Dae MW, Botvinick EH
• Cardiac imaging using gated magnetic resonance.
  Radiology 1984 Lanzer P, Botvinick EH, Schiller NB, Crooks LE, Arakawa M, Kaufman L, Davis PL, Herfkens R, Lipton MJ, Higgins CB
• Imaging and characterization of acute myocardial infarction in vivo by gated nuclear magnetic resonance.
  Circulation 1984 Wesbey G, Higgins CB, Lanzer P, Botvinick E, Lipton MJ
• The functional implications of scintigraphic measures of myocardial ischemia and infarction.
  American heart journal 1983 Misbach GA, Botvinick EH, Tyberg JV, Parmley WW, Dunn RF, Frais M
• Diagnostic test use in different practice settings. A controlled comparison.
  Archives of internal medicine 1983 Hlatky MA, Lee KL, Botvinick EH, Brundage BH
• Evaluation of the post-coronary artery bypass patient by myocardial perfusion scintigraphy and computed tomography.
  AJR. American journal of roentgenology 1983 Engelstad BL, Wagner S, Herfkens R, Botvinick E, Brundage B, Lipton M
• Cardiovascular imaging with nuclear magnetic resonance.
  Cardiology clinics 1983 Higgins CB, Botvinick EH, Lanzer P, Herfkens R, Lipton MJ, Crooks LE, Kaufman L
• Volume loading improves low cardiac output in experimental right ventricular infarction.
  Journal of the American College of Cardiology 1983 Goldstein JA, Vlahakes GJ, Verrier ED, Schiller NB, Botvinick E, Tyberg JV, Parmley WW, Chatterjee K
• Nuclear magnetic resonance imaging of the cardiovascular system: normal and pathologic findings.
  Radiology 1983 Herfkens RJ, Higgins CB, Hricak H, Lipton MJ, Crooks LE, Lanzer P, Botvinick E, Brundage B, Sheldon PE, Kaufman L
• Late prognostic value of scintigraphic parameters of acute myocardial infarction size in complicated myocardial infarction without heart failure.
  The American journal of cardiology 1983 Botvinick EH, Perez-Gonzalez JF, Dunn R, Ports T, Chatterjee K, Parmley W
• Variability in coronary hemodynamics in response to ergonovine in patients with normal coronary arteries and atypical chest pain.
  Journal of the American College of Cardiology 1983 Schwartz AB, Donmichael TA, Botvinick EH, Ishimori T, Parmley WW, Chatterjee K
• Electrophysiologic mechanism of exercise-induced sustained ventricular tachycardia.
  The American journal of cardiology 1983 Sung RJ, Shen EN, Morady F, Scheinman MM, Hess D, Botvinick EH
• What is the reliability and the utility of scintigraphic methods for the assessment of ventricular function?
  Cardiovascular clinics 1983 Botvinick EH, Glazer HB, Shosa DW
• The independent value of exercise thallium scintigraphy to physicians.
  Circulation 1982 Hlatky M, Botvinick E, Brundage B
• The late prognostic value of acute scintigraphic measurement of myocardial infarction size.
  Circulation 1982 Perez-Gonzalez J, Botvinick EH, Dunn R, Rahimtoola S, Ports T, Chatterjee K, Parmley WW
• An accurate means of detecting and characterizing abnormal patterns of ventricular activation by phase image analysis.
  The American journal of cardiology 1982 Botvinick EH, Frais MA, Shosa DW, O'Connell JW, Pacheco-Alvarez JA, Scheinman M, Hattner RS, Morady F, Faulkner DB
• Phase image characterization of ventricular contraction in left and right bundle branch block.
  The American journal of cardiology 1982 Frais MA, Botvinick EH, Shosa DW, O'Connell WJ, Scheinman MM, Hattner RS, Morady F
• Diagnostic accuracy of cardiologists compared with probability calculations using Bayes' rule.
  The American journal of cardiology 1982 Hlatky M, Botvinick E, Brundage B
• Hemodynamic benefit of atrial pacing in right ventricular myocardial infarction.
  Annals of internal medicine 1982 Topol EJ, Goldschlager N, Ports TA, Dicarlo LA, Schiller NB, Botvinick EH, Chatterjee K
• The significance of nitroglycerin-induced changes in ventricular function after acute myocardial infarction.
  The American journal of cardiology 1982 Dunn RF, Botvinick EH, Benge W, Chatterjee K, Parmley WW
• Are regions of ischaemia detected on stress perfusion scintigraphy predictive of sites of subsequent myocardial infarction?
  British heart journal 1982 Frais M, Botvinick E, Shosa D, O'Connell W
• The phase image: its relationship to patterns of contraction and conduction.
  Circulation 1982 Botvinick E, Dunn R, Frais M, O'Connell W, Shosa D, Herfkens R, Scheinman M
• Detecting and localizing peripheral arterial disease: assessment of 201Tl scintigraphy.
  AJR. American journal of roentgenology 1981 Seder JS, Botvinick EH, Rahimtoola SH, Goldstone J, Price DC
• The inconsistent pattern of thallium defects: a clue to the false positive perfusion scintigram.
  The American journal of cardiology 1981 Dunn RF, Wolff L, Wagner S, Botvinick EH
• Contrast enhancement of thallium-201 myocardial scintigrams: improved sensitivity with diminished specificity in coronary disease detection.
  American heart journal 1981 Massie B, Botvinick E, Arnold S, Shames D, Brundage B, Hanlon JT, Sheldon K
• The complementary roles of M-mode echocardiography and scintigraphy in the evaluation of adults with suspected left-to-right shunts. Additional observations on the role of two-dimensional echocardiography.
  Circulation 1980 Botvinick EH, Schiller NB
• Evaluation of left ventricular performance by gated radionuclide angiography.
  Clinical nuclear medicine 1980 Greenberg BH, Drew D, Botvinick EH, Werner JA, Klausner SC, Shames DM, Parmley WW
• A consideration of factors affecting the diagnostic accuracy of thallium-201 myocarial perfusion scintigraphy in detecting coronary artery disease.
  Seminars in nuclear medicine 1980 Botvinick EH, Dunn RF, Hattner RS, Massie BM
• Myocardial perfusion scintigraphy.
  Archives of internal medicine 1980 Botvinick EH
• Correlation of thallium-201 scintigrams with coronary anatomy: factors affecting region by region sensitivity.
  The American journal of cardiology 1979 Massie BM, Botvinick EH, Brundage BH
• Left ventricular volume from paired biplane two-dimensional echocardiography.
  Circulation 1979 Schiller NB, Acquatella H, Ports TA, Drew D, Goerke J, Ringertz H, Silverman NH, Brundage B, Botvinick EH, Boswell R, Carlsson E, Parmley WW
• The noninvasive identification of left main and three-vessel coronary artery disease by myocardial stress perfusion scintigraphy and treadmill exercise electrocardiography.
  Circulation 1979 Dash H, Massie BM, Botvinick EH, Brundage BH
• Myocardial scintigraphy with technetium-99m stannous pyrophosphate: an insensitive test for nontransmural myocardial infarction.
  The American journal of cardiology 1979 Massie BM, Botvinick EH, Werner JA, Chatterjee K, Parmley WW
• Relationship of regional myocardial perfusion to segmental wall motion: a physiologic basis for understanding the presence and reversibility of asynergy.
  Circulation 1978 Massie BM, Botvinick EH, Brundage BH, Greenberg B, Shames D, Gelberg H
• Gallium-67 uptake in silent myocardial infarction: a case report.
  Radiology 1978 Schor RA, Massie BM, Botvinick EH, Shames DM
• The specificity of pyrophosphate myocardial scintigrams in patients with prior myocardial infarction: concise communication.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1978 Botvinick EH, Shames DM, Sharpe DN, Klausner SC, Werner JA, Chatterjee K, Parmley WW
• Beneficial effects of hydralazine in severe mitral regurgitation.
  Circulation 1978 Greenberg BH, Massie BM, Brundage BH, Botvinick EH, Parmley WW, Chatterjee K
• Thallium-201 myocardial perfusion scintigraphy to evaluate patients after coronary bypass surgery.
  The American journal of cardiology 1978 Greenberg BH, Hart R, Botvinick EH, Werner JA, Brundage BH, Shames DM, Chatterjee K, Parmley WW
• The noninvasive diagnosis of right ventricular infarction.
  Circulation 1978 Sharpe DN, Botvinick EH, Shames DM, Schiller NB, Massie BM, Chatterjee K, Parmley WW
• The clinical estimation of acute myocardial infarct size with 99mTechnetium pyrophosphate scintigraphy.
  Circulation 1978 Sharpe DN, Botvinick EH, Shames DM, Norman A, Chatterjee K, Parmley WW
• Myocardial perfusion scintigraphy in patients with mitral valve prolapse: Its advantage over stress electrocardiography in diagnosing associated coronary artery disease and its implications for the etiology of chest pain.
  Circulation 1978 Massie B, Botvinick EH, Shames D, Taradash M, Werner J, Schiller N
• Myocardial scintigraphy in coronary artery disease.
  Cleveland Clinic quarterly 1978 Botvinick EH, Shames D, Parmley WW
• Thallium-20 1 myocardial perfusion scintigraphy for the clinical clarification of normal, abnormal and equivocal electrocardiographic stress tests.
  The American journal of cardiology 1978 Botvinick EH, Taradash MR, Shames DM, Parmley WW
• Right ventricular compression as a sign of cardiac tamponade: an analysis of echocardiographic ventricular dimensions and their clinical implications.
  Circulation 1977 Schiller NB, Botvinick EH
• The application of radionuclide infarct scintigraphy to diagnose perioperative myocardial infarction following revascularization.
  Circulation 1977 Klausner SC, Botvinick EH, Shames D, Ullyot DJ, Fishman NH, Roe BB, Ebert PA, Chatterjee K, Parmley WW
• Myocardial stress perfusion scintigraphy with rubidium-81 versus stress electrocardiography.
  The American journal of cardiology 1977 Botvinick EH, Shames DM, Gershengorn KM, Carlsson E, Ratshin RA, Parmley WW
• The hemodynamics of coronary arterial stenosis.
  Cardiovascular clinics 1977 Tyberg JV, Massie BM, Botvinick EH, Parmley W
• The specificity of the diffuse pattern of cardiac uptake in myocardial infarction imaging with technetium-99m stannous pyrophosphate.
  Circulation 1977 Prasquier R, Taradash MR, Botvinick EH, Shames DM, Parmley WW
• Noninvasive diagnosis of a false left ventricular aneurysm with radioisotope gated cardiac blood pool imaging. Differentiation from true aneurysm.
  The American journal of cardiology 1976 Botvinick EH, Shames D, Hutchinson JC, Roe BB, Fitzpatrick M
• Myocardial infarction in closed-chest dogs: a simplified method for production.
  Journal of applied physiology 1975 Lappin HA, Botvinick EH, Parmley WW, Tyberg JV
• Noninvasive quantitation of myocardial infarction with technetium 99m pyrophosphate.
  Circulation 1975 Botvinick EH, Shames D, Lappin H, Tyberg JV, Townsend R, Parmley WW
• Echocardiographic demonstration of early mitral valve closure in severe aortic insufficiency. Its clinical implications.
  Circulation 1975 Botvinick EH, Schiller NB, Wickramasekaran R, Klausner SC, Gertz E