Edward Hsiao, MD, PhD
Professor
Medicine
School of Medicine

MD: MD, PhD, Johns Hopkins Medical School, 2001 Residency: Johns Hopkins Hospital, Baltimore, MD, Internal Medicine, 2001-2004 Fellowship: UCSF, Division of Diabetes, Endocrinology and Metabolism, 2004-2007 Board Certifications: Internal Medicine, 2004; Endocrinology and Metabolism, 2006

ACADEMIC INTERESTS My research is driven by a desire to understand how major hormonal and regulatory pathways determine the specification, differentiation, and morphogenesis of mesenchymal tissues such as bone, cartilage, muscle, and fat. Mis-regulation of these pathways leads to significant medical diseases, including the inappropriate formation of mineralized tissues in atherosclerosis, heterotopic ossification, and cancer.

My research focuses on understanding how these regulatory signals control normal and pathologic tissue formation as a way to identifying new therapeutic avenues for treating human diseases. Our laboratory takes a comprehensive approach to understanding hormone signaling in human diseases using synthetic biology approaches, mouse models, and human stem cell models.

By combining multiple approaches with state-of-the art methods, our laboratory is working to develop a broader understanding of the biology underlying skeletal development, devise novel therapeutic approaches for treating human skeletal disorders and bone injuries, and examine how hormone signals affect important tissues such as fat, muscle, bone, cartilage, and blood vessels.

CLINICAL INTERESTS: General Endocrinology with an interest in inherited skeletal diseases, including fibrous dysplasia of the bone (FD), McCune-Albright syndrome (MAS), and fibrodysplasia ossificans progressiva (FOP).

Appointments: 415-353-2350 Availability: General Endocrinology, 3rd Tuesday PM of each month

Laboratory website: https://hsiaolab.ucsf.edu

• Overall survival with [177Lu]Lu-PSMA-617 versus cabazitaxel in metastatic castration-resistant prostate cancer (TheraP): secondary outcomes of a randomised, open-label, phase 2 trial.
  The Lancet. Oncology 2023 Hofman MS, Emmett L, Sandhu S, Iravani A, Buteau JP, Joshua AM, Goh JC, Pattison DA, Tan TH, Kirkwood ID, Ng S, Francis RJ, Gedye C, Rutherford NK, Weickhardt A, Scott AM, Lee ST, Kwan EM, Azad AA, …
• Study methodology and insights from the palovarotene clinical development program in fibrodysplasia ossificans progressiva.
  BMC medical research methodology 2023 Pignolo RJ, Al Mukaddam M, Baujat G, Brown MA, De Cunto C, Hsiao EC, Keen R, Le Quan Sang KH, Grogan DR, Marino R, Strahs AR, Kaplan FS
• Frontal bone loss following coronal brow lift: A mimicker of head variant linear morphea.
  JAAD case reports 2023 Kazmi M, Zhang WR, Hsiao E, Gross A, Grouse K, Link TM, Tetzlaff M, Theodosopoulos P, Haemel A
• Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages.
  Nature communications 2023 Groeger M, Matsuo K, Heidary Arash E, Pereira A, Le Guillou D, Pino C, Telles-Silva KA, Maher JJ, Hsiao EC, Willenbring H
• EML4::ALK fusions in complex lymphatic malformations.
  Pediatric blood & cancer 2023 Apsel Winger B, Devine WP, Hsiao EC, Zapala M, Van Ziffle J, Gupta N, Frieden IJ, Shimano KA
• A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy.
  Calcified tissue international 2023 Niu I, Hsiao EC, Wustrack R, Wysolmerski JJ, Dann P, Masharani U
• Improving care pathways for people living with rare bone diseases (RBDs): outcomes from the first RBD Summit.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2023 Chandran M, Alves I, Carpenter T, Davis M, Hsiao EC, Petryk A, Semler JO, Sleiman M
• CO32 Heterotopic Ossification in Palovarotene-Treated and Untreated Individuals with Fibrodysplasia Ossificans Progressiva: Matched and Weighted Analyses.
  Value in Health 2023 M. Al Mukaddam, G. Baujat, A.M. Cheung, C. De Cunto, E.C. Hsiao, R. Keen, J. Marden, J. Signorovitch, E. Boing, R. Marino, A. Strahs, R.J. Pignolo
• Most Fractures Treated Nonoperatively in Individuals With Fibrodysplasia Ossificans Progressiva Heal With a Paucity of Flareups, Heterotopic Ossification, and Loss of Mobility.
  Clinical orthopaedics and related research 2023 Lindborg CM, Al Mukaddam M, Baujat G, Cho TJ, De Cunto CL, Delai PLR, Eekhoff EMW, Haga N, Hsiao EC, Morhart R, de Ruiter R, Scott C, Seemann P, Szczepanek M, Tabarkiewicz J, Pignolo RJ, Kaplan FS
• Human iPSC-Derived Proinflammatory Macrophages cause Insulin Resistance in an Isogenic White Adipose Tissue Microphysiological System.
  Small (Weinheim an der Bergstrasse, Germany) 2023 Qi L, Matsuo K, Pereira A, Lee YT, Zhong F, He Y, Zushin PH, Gröger M, Sharma A, Willenbring H, Hsiao EC, Stahl A
• A follow-up report on the published paper Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva.
  Orphanet journal of rare diseases 2023 Wallace H, Lee RH, Hsiao EC
• Reduction of New Heterotopic Ossification (HO) in the Open-Label, Phase 3 MOVE Trial of Palovarotene for Fibrodysplasia Ossificans Progressiva (FOP).
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Pignolo RJ, Hsiao EC, Al Mukaddam M, Baujat G, Berglund SK, Brown MA, Cheung AM, De Cunto C, Delai P, Haga N, Kannu P, Keen R, Le Quan Sang KH, Mancilla EE, Marino R, Strahs A, Kaplan FS
• The effects of palovarotene in patients with fibrodysplasia ossificans progressiva: a plain language summary.
  Future Rare Diseases 2023 Robert J Pignolo, Edward C Hsiao, Mona Al Mukaddam, Geneviève Baujat, Staffan K Berglund, Matthew A Brown, Angela M Cheung, Carmen De Cunto, Patricia Delai, Nobuhiko Haga, Peter Kannu, Richard Keen, …
• Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole-Exome Sequencing in a Patient with Delayed-Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1R206H -Specific Human Cellular and Zebrafish Models.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Wentworth KL, Lalonde RL, Groppe JC, Brewer N, Moody T, Hansberry S, Taylor KE, Shore EM, Kaplan FS, Pignolo RJ, Yelick PC, Hsiao EC
• PSAT208 A Case of Hypercalcemia From PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy.
  Journal of the Endocrine Society 2022 Isabella Niu, Edward Hsiao, Rosanna Wustrack, John Wysolmerski, Pamela Dann, Umesh Masharani
• Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery.
  Nature communications 2022 Yang YS, Kim JM, Xie J, Chaugule S, Lin C, Ma H, Hsiao E, Hong J, Chun H, Shore EM, Kaplan FS, Gao G, Shim JH
• The natural history of fibrodysplasia ossificans progressiva: A prospective, global 36-month study.
  Genetics in medicine : official journal of the American College of Medical Genetics 2022 Pignolo RJ, Baujat G, Brown MA, De Cunto C, Hsiao EC, Keen R, Al Mukaddam M, Le Quan Sang KH, Wilson A, Marino R, Strahs A, Kaplan FS
• Identification of Risk Factors in the Development of Heterotopic Ossification After Primary Total Hip Arthroplasty.
  The Journal of clinical endocrinology and metabolism 2022 Singh S, Morshed S, Motamedi D, Kidane J, Paul A, Hsiao EC, Wentworth KL
• Palovarotene for Fibrodysplasia Ossificans Progressiva (FOP): Results of a Randomized, Placebo-Controlled, Double-Blind Phase 2 Trial.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Pignolo RJ, Baujat G, Hsiao EC, Keen R, Wilson A, Packman J, Strahs AL, Grogan DR, Kaplan FS
• Gene Therapy for Fibrodysplasia Ossificans Progressiva: Feasibility and Obstacles.
  Human gene therapy 2022 Eekhoff EMW, de Ruiter RD, Smilde BJ, Schoenmaker T, de Vries TJ, Netelenbos C, Hsiao EC, Scott C, Haga N, Grunwald Z, De Cunto CL, di Rocco M, Delai PLR, Diecidue RJ, Madhuri V, Cho TJ, Morhart R, …
• ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.
  Pain 2022 Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC
• Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva.
  Orphanet journal of rare diseases 2022 Kou S, Kile S, Kambampati SS, Brady EC, Wallace H, De Sousa CM, Cheung K, Dickey L, Wentworth KL, Hsiao EC
• Corrigendum to "ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages" [Bone. 153 2021 Dec; 116129. doi:10.1016/j.bone.2021.116129. Epub 2021 Jul 24. PMID: 34311122].
  Bone 2022 Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC
• The Clinical Significance of Small Vessel Vasculitis on Temporal Artery Biopsies.
  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2022 Quigley J, Sammel AM, Laurent R, Brewer J, Hsiao E, Schembri G, Fraser CL
• POSC373 Use of Aids, Assistive Devices and Adaptations by Individuals with Fibrodysplasia Ossificans Progressiva (FOP): 36-Month Results from a Global Natural History Study.
  Value in Health 2022 M Al Mukaddam, G Baujat, A Houchard, EC Hsiao, R Keen, R Marino, RJ Pignolo, FS Kaplan
• A single center evaluation of applicant experiences in virtual interviews across eight internal medicine subspecialty fellowship programs.
  Medical education online 2021 Huppert LA, Hsu G, Elnachef N, Flint L, Frank JA, Gensler LS, Hsiao EC, Khanna RR, Qasim A, Schwartz BS, Widera E, Zapata C, Babik JM
• Fibrodysplasia Ossificans Progressiva: What Have We Achieved and Where Are We Now? Follow-up to the 2015 Lorentz Workshop.
  Frontiers in endocrinology 2021 de Ruiter RD, Smilde BJ, Pals G, Bravenboer N, Knaus P, Schoenmaker T, Botman E, Sánchez-Duffhues G, Pacifici M, Pignolo RJ, Shore EM, van Egmond M, Van Oosterwyck H, Kaplan FS, Hsiao EC, Yu PB, …
• Modeling the ACVR1R206H mutation in human skeletal muscle stem cells.
  eLife 2021 Barruet E, Garcia SM, Wu J, Morales BM, Tamaki S, Moody T, Pomerantz JH, Hsiao EC
• Social and Clinical Impact of COVID-19 on Patients with Fibrodysplasia Ossificans Progressiva.
  Research square 2021 Kou S, Kile S, Kambampati SS, Brady EC, Wallace H, De Sousa CM, Cheung K, Dickey L, Wentworth KL, Hsiao E
• Prevalence of fibrodysplasia ossificans progressiva (FOP) in the United States: estimate from three treatment centers and a patient organization.
  Orphanet journal of rare diseases 2021 Pignolo RJ, Hsiao EC, Baujat G, Lapidus D, Sherman A, Kaplan FS
• Whole-body Computed Tomography Versus Dual Energy X‑ray Absorptiometry for Assessing Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva.
  Calcified tissue international 2021 Warner SE, Kaplan FS, Pignolo RJ, Smith SE, Hsiao EC, De Cunto C, Di Rocco M, Harnett K, Grogan D, Genant HK
• ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages.
  Bone 2021 Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC
• Re-defining the role of surgery in the management of patients with oligometastatic stage IV melanoma in the era of effective systemic therapies.
  European journal of cancer (Oxford, England : 1990) 2021 Ch'ng S, Uyulmaz S, Carlino MS, Pennington TE, Shannon KF, Rtshiladze M, Stretch JR, Nieweg OE, Varey AHR, Hsiao E, Kapoor R, Pires da Silva I, Lo SN, Spillane AJ, Scolyer RA, Long GV, Hong AM, Saw …
• Off-on-off-on use of imatinib in three children with fibrodysplasia ossificans progressiva.
  Bone 2021 Kaplan FS, Teachey DT, Andolina JR, Siegel DM, Mancilla EE, Hsiao EC, Al Mukaddam M, Rocke DM, Pignolo RJ
• Global Wnt Inhibition With a Porcupine Inhibitor Decreases Established Trabecular Bone in a Mouse Model of Fibrous Dysplasia.
  Journal of the Endocrine Society 2021 Hsuan Lung, Tania Moody, Kelly Wentworth, Misun Kang, Sunita Ho, Edward Hsiao
• [177Lu]Lu-PSMA-617 versus cabazitaxel in patients with metastatic castration-resistant prostate cancer (TheraP): a randomised, open-label, phase 2 trial.
  Lancet (London, England) 2021 Hofman MS, Emmett L, Sandhu S, Iravani A, Joshua AM, Goh JC, Pattison DA, Tan TH, Kirkwood ID, Ng S, Francis RJ, Gedye C, Rutherford NK, Weickhardt A, Scott AM, Lee ST, Kwan EM, Azad AA, Ramdave S, …
• Cardiopulmonary and Neurologic Dysfunctions in Fibrodysplasia Ossificans Progressiva.
  Biomedicines 2021 Khan F, Yu X, Hsiao EC
• A Global Natural History Study of Fibrodysplasia Ossificans Progressiva (FOP): 12-Month Outcomes.
  Osteologie/Osteology 2021 M Al Mukaddam, C Stockklausner, RJ Pignolo, G Baujat, MA Brown, C De Cunto, M Di Rocco, EC Hsiao, R Keen, K-H Le Quan Sang, A Strahs, R Marino, FS Kaplan
• Longitudinal and Flare-Up-Specific Biomarkers in Fibrodysplasia Ossificans Progressiva (FOP): Data from a Global Natural History Study.
  Osteologie/Osteology 2021 RJ Pignolo, JO Semler, M Al Mukaddam, G Baujat, C De Cunto, EC Hsiao, R Keen, K Harnett, R Marino, FS Kaplan
• Medications Used by Individuals with Fibrodysplasia Ossificans Progressiva (FOP): Data from a Global Natural History Study.
  Osteologie/Osteology 2021 R Keen, C Stockklausner, M Al Mukaddam, G Baujat, C De Cunto, EC Hsiao, RJ Pignolo, K Harnett, R Marino, FS Kaplan
• Use of Assistive Devices and Adaptations by Individuals with Fibrodysplasia Ossificans Progressiva (FOP): Data from a Global Natural History Study.
  Osteologie/Osteology 2021 EC Hsiao, JO Semler, M Al Mukaddam, G Baujat, C De Cunto, R Keen, RJ Pignolo, K Harnett, R Marino, FS Kaplan
• Virtual Interviews at Graduate Medical Education Training Programs: Determining Evidence-Based Best Practices.
  Academic medicine : journal of the Association of American Medical Colleges 2020 Huppert LA, Hsiao EC, Cho KC, Marquez C, Chaudhry RI, Frank J, Goglin SE, Hsu G, Kathpalia P, Khanna R, Kompala T, Rao MN, Bower BA, Trafas V, Santhosh L, Schwartz BS, Babik JM
• A natural history study of fibrodysplasia ossificans progressiva (FOP): 12-month outcome results.
  Bone Reports 2020 Robert J. Pignolo, Geneviève Baujat, Matthew A. Brown, Carmen De Cunto, Maja Di Rocco, Edward C. Hsiao, Richard Keen, Mona Al Mukaddam, Kim Hanh Le Quan Sang, Andrew Strahs, Rose Marino, Frederick S. …
• Measuring outcomes in ultra-rare bone diseases: Methodology of the palovarotene fibrodysplasia ossificans progressiva clinical development programme.
  Bone Reports 2020 Robert J. Pignolo, Geneviève Baujat, Matthew A. Brown, Carmen De Cunto, Maja Di Rocco, Edward C. Hsiao, Richard Keen, Mona Al Mukaddam, Andrew Strahs, Donna R. Grogan, Rose Marino, Frederick S. Kaplan
• A global natural history study of Fibrodysplasia Ossificans Progressiva (FOP): 12-month outcomes.
  Endocrine Abstracts 2020 Mona Al Mukaddam, Robert J. Pignolo, Geneviève Baujat, Matthew A Brown, Cunto Carmen De, Rocco Maja Di, Edward C. Hsiao, Richard Keen, Quan Sang Kim-Hanh Le, Andrew Strahs, Rose Marino, Frederick S …
• Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva.
  Orphanet journal of rare diseases 2020 Kou S, De Cunto C, Baujat G, Wentworth KL, Grogan DR, Brown MA, Di Rocco M, Keen R, Al Mukaddam M, le Quan Sang KH, Masharani U, Kaplan FS, Pignolo RJ, Hsiao EC
• MON-348 Surgical Management of Bilateral Hip Fracture in a Patient with Fibrodysplasia Ossificans Progressiva Treated with Palovarotene.
  Journal of the Endocrine Society 2020 Sukhmani Singh, Joseph Kidane, Kelly Lee Wentworth, Daria Motamedi, Saam Morshed, Edward Chiaming Hsiao
• MON-710 ACVR1 Activation in Primary and iPS-Derived Human Skeletal Muscle Stem Cells Impairs Myogenic Transcriptional Signature and Function.
  Journal of the Endocrine Society 2020 Emilie Barruet, Steven Garcia, Stanley Tamaki, Blanca M Morales, Jake Wu, Tania Moody, Jason H Pomerantz, Edward Chiaming Hsiao
• OR29-05 A Natural History Study of Fibrodysplasia Ossificans Progressiva (FOP): 12-Month Outcomes.
  Journal of the Endocrine Society 2020 Mona Al Mukaddam, Robert J Pignolo, Geneviève Baujat, Matthew A Brown, Carmen De Cunto, Maja Di Rocco, Edward C Hsiao, Richard W Keen, Kim-Hanh Le Quan Sang, Andrew Strahs, Rose Marino, Frederick S …
• SUN-344 Patients with Fibrodysplasia Ossificans Progressiva Have an Increased Prevalence of Cardiac Conduction Abnormalities.
  Journal of the Endocrine Society 2020 Samuel Kou, Carmen DeCunto, Geneviève Baujat, Kelly Lee Wentworth, Donna Grogan, Matthew A Brown, Maja D Rocco, Richard Keen, Mona Al Mukaddam, Frederick S Kaplan, Robert J Pignolo, Edward Chiaming …
• SUN-368 Wnt Inhibition Decreases Trabecular Bone in a Mouse Model of Fibrous Dysplasia.
  Journal of the Endocrine Society 2020 Hsuan Lung, Kelly Wentworth, Tania Moody, Misun Kang, Sunita Ho, Edward Hsiao
• Surgical management of bilateral hip fractures in a patient with fibrodysplasia ossificans progressiva treated with the RAR-γ agonist palovarotene: a case report.
  BMC musculoskeletal disorders 2020 Singh S, Kidane J, Wentworth KL, Motamedi D, Morshed S, Schober AE, Hsiao EC
• Self-reported baseline phenotypes from the International Fibrodysplasia Ossificans Progressiva (FOP) Association Global Registry.
  Bone 2020 Pignolo RJ, Cheung K, Kile S, Fitzpatrick MA, De Cunto C, Al Mukaddam M, Hsiao EC, Baujat G, Delai P, Eekhoff EMW, Di Rocco M, Grunwald Z, Haga N, Keen R, Levi B, Morhart R, Scott C, Sherman A, Zhang …
• Advances in Models of Fibrous Dysplasia/McCune-Albright Syndrome.
  Frontiers in endocrinology 2020 Lung H, Hsiao EC, Wentworth KL
• Inflammation in Fibrodysplasia Ossificans Progressiva and Other Forms of Heterotopic Ossification.
  Current osteoporosis reports 2019 Matsuo K, Chavez RD, Barruet E, Hsiao EC
• Palovarotene inhibits the development of new heterotopic ossification in fibrodysplasia ossificans progressiva (FOP).
  Bone Abstracts 2019 Frederick Kaplan, Edward C Hsiao, Genevieve Baujat, Richard Keen, Cunto Carmen De, Rocco Maja Di, Matthew A Brown, Mukaddam Mona M Al, Donna R Grogan, Robert J Pignolo
• Correction to: Natural history of fibrodysplasia ossificans progressiva: cross-sectional analysis of annotated baseline phenotypes.
  Orphanet journal of rare diseases 2019 Pignolo RJ, Baujat G, Brown MA, De Cunto C, Di Rocco M, Hsiao EC, Keen R, Al Mukaddam M, Sang KLQ, Wilson A, White B, Grogan DR, Kaplan FS
• Natural history of fibrodysplasia ossificans progressiva: cross-sectional analysis of annotated baseline phenotypes.
  Orphanet journal of rare diseases 2019 Pignolo RJ, Baujat G, Brown MA, De Cunto C, Di Rocco M, Hsiao EC, Keen R, Al Mukaddam M, Sang KLQ, Wilson A, White B, Grogan DR, Kaplan FS
• Effect of donor variation on osteogenesis and vasculogenesis in hydrogel cocultures.
  Journal of tissue engineering and regenerative medicine 2019 Pennings I, van Dijk LA, van Huuksloot J, Fledderus JO, Schepers K, Braat AK, Hsiao EC, Barruet E, Morales BM, Verhaar MC, Rosenberg AJWP, Gawlitta D
• Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva.
  British journal of clinical pharmacology 2019 Wentworth KL, Masharani U, Hsiao EC
• NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification.
  JCI insight 2018 Barruet E, Morales BM, Cain CJ, Ton AN, Wentworth KL, Chan TV, Moody TA, Haks MC, Ottenhoff TH, Hellman J, Nakamura MC, Hsiao EC
• Special considerations for clinical trials in fibrodysplasia ossificans progressiva (FOP).
  British journal of clinical pharmacology 2018 Hsiao EC, Di Rocco M, Cali A, Zasloff M, Al Mukaddam M, Pignolo RJ, Grunwald Z, Netelenbos C, Keen R, Baujat G, Brown MA, Cho TJ, De Cunto C, Delai P, Haga N, Morhart R, Scott C, Zhang K, Diecidue RJ,…
• Fibrodysplasia ossificans progressiva: a current review of imaging findings.
  Skeletal radiology 2018 Bauer AH, Bonham J, Gutierrez L, Hsiao EC, Motamedi D
• Utilizing 18F-fluoroethyltyrosine (FET) positron emission tomography (PET) to define suspected nonenhancing tumor for radiation therapy planning of glioblastoma.
  Practical radiation oncology 2018 Hayes AR, Jayamanne D, Hsiao E, Schembri GP, Bailey DL, Roach PJ, Khasraw M, Newey A, Wheeler HR, Back M
• Clinical-pathological correlations in three patients with fibrodysplasia ossificans progressiva.
  Bone 2017 Wentworth KL, Bigay K, Chan TV, Ho JP, Morales BM, Connor J, Brooks E, Shahriar Salamat M, Sanchez HC, Wool G, Pignolo RJ, Kaplan FS, Hsiao EC
• Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice.
  Endocrinology 2017 Ho L, Wang L, Roth TM, Pan Y, Verdin EM, Hsiao EC, Nissenson RA
• The FOP Connection Registry: Design of an international patient-sponsored registry for Fibrodysplasia Ossificans Progressiva.
  Bone 2017 Mantick N, Bachman E, Baujat G, Brown M, Collins O, De Cunto C, Delai P, Eekhoff M, Zum Felde R, Grogan DR, Haga N, Hsiao E, Kantanie S, Kaplan F, Keen R, Milosevic J, Morhart R, Pignolo R, Qian X, di…
• Early clinical observations on the use of imatinib mesylate in FOP: A report of seven cases.
  Bone 2017 Kaplan FS, Andolina JR, Adamson PC, Teachey DT, Finklestein JZ, Ebb DH, Whitehead B, Jacobs B, Siegel DM, Keen R, Hsiao E, Pignolo RJ
• Application of human induced pluripotent stem cells to model fibrodysplasia ossificans progressiva.
  Bone 2017 Barruet E, Hsiao EC
• Fibrodysplasia ossificans progressiva: baseline characteristics of 101 subjects participating in a global, longitudinal, natural history study.
  Bone Abstracts 2017 Frederick S Kaplan, Edward C Hsiao, Genevieve Baujat, Matthew A Brown, Cunto Carmen De, Rocco Maja Di, Richard Keen, Makkadam Mona Al, Donna R Grogan, Robert J Pignolo
• International physician survey on management of FOP: a modified Delphi study.
  Orphanet journal of rare diseases 2017 Di Rocco M, Baujat G, Bertamino M, Brown M, De Cunto CL, Delai PLR, Eekhoff EMW, Haga N, Hsiao E, Keen R, Morhart R, Pignolo RJ, Kaplan FS
• Fluorescent tagged episomals for stoichiometric induced pluripotent stem cell reprogramming.
  Stem cell research & therapy 2017 Schmitt CE, Morales BM, Schmitz EMH, Hawkins JS, Lizama CO, Zape JP, Hsiao EC, Zovein AC
• Dual Somatostatin Receptor/FDG PET/CT Imaging in Metastatic Neuroendocrine Tumours: Proposal for a Novel Grading Scheme with Prognostic Significance.
  Theranostics 2017 Chan DL, Pavlakis N, Schembri GP, Bernard EJ, Hsiao E, Hayes A, Barnes T, Diakos C, Khasraw M, Samra J, Eslick E, Roach PJ, Engel A, Clarke SJ, Bailey DL
• EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells.
  Stem cell reports 2017 Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush JO
• The Rare Bone Disease Working Group: report from the 2016 American Society for Bone and Mineral Research Annual Meeting.
  Bone 2017 Drake MT, Collins MT, Hsiao EC
• BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Hayashi Y, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, Yamanaka S
• Gs/Gi Regulation of Bone Cell Differentiation: Review and Insights from Engineered Receptors.
  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2016 Hsiao EC, Millard SM, Nissenson RA
• The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling.
  Stem cell research & therapy 2016 Barruet E, Morales BM, Lwin W, White MP, Theodoris CV, Kim H, Urrutia A, Wong SA, Srivastava D, Hsiao EC
• A Novel T55A Variant of Gs α Associated with Impaired cAMP Production, Bone Fragility, and Osteolysis.
  Case reports in endocrinology 2016 Wentworth K, Hsing A, Urrutia A, Zhu Y, Horvai AE, Bastepe M, Hsiao EC
• Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization.
  Bone reports 2016 Cain CJ, Gaborit N, Lwin W, Barruet E, Ho S, Bonnard C, Hamamy H, Shboul M, Reversade B, Kayserili H, Bruneau BG, Hsiao EC
• Increased Gs Signaling in Osteoblasts Reduces Bone Marrow and Whole-Body Adiposity in Male Mice.
  Endocrinology 2016 Cain CJ, Valencia JT, Ho S, Jordan K, Mattingly A, Morales BM, Hsiao EC
• Using Human Induced Pluripotent Stem Cells to Model Skeletal Diseases.
  Methods in molecular biology (Clifton, N.J.) 2016 Barruet E, Hsiao EC
• A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting.
  Calcified tissue international 2015 Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC
• Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations.
  The Journal of clinical endocrinology and metabolism 2015 Shah AD, Hsiao EC, O'Donnell B, Salmeen K, Nussbaum R, Krebs M, Baumgartner-Parzer S, Kaufmann M, Jones G, Bikle DD, Wang Y, Mathew AS, Shoback D, Block-Kurbisch I
• Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015 Wang L, Hsiao EC, Lieu S, Scott M, O'Carroll D, Urrutia A, Conklin BR, Colnot C, Nissenson RA
• Chronic recurrent multifocal osteomyelitis with an atypical presentation in an adult man.
  Skeletal radiology 2015 Hong CW, Hsiao EC, Horvai AE, Link TM
• Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts.
  Experimental cell research 2015 Wattanachanya L, Wang L, Millard SM, Lu WD, O'Carroll D, Hsiao EC, Conklin BR, Nissenson RA
• Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.
  Nature neuroscience 2015 Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L
• Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia.
  PloS one 2014 Akil O, Hall-Glenn F, Chang J, Li A, Chang W, Lustig LR, Alliston T, Hsiao EC
• Panostotic expansile bone disease with massive jaw tumor formation and a novel mutation in the signal peptide of RANK.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014 Schafer AL, Mumm S, El-Sayed I, McAlister WH, Horvai AE, Tom AM, Hsiao EC, Schaefer FV, Collins MT, Anderson MS, Whyte MP, Shoback DM
• Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells.
  Nature 2014 Bershteyn M, Hayashi Y, Desachy G, Hsiao EC, Sami S, Tsang KM, Weiss LA, Kriegstein AR, Yamanaka S, Wynshaw-Boris A
• Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.
  Orphanet journal of rare diseases 2013 Matsumoto Y, Hayashi Y, Schlieve CR, Ikeya M, Kim H, Nguyen TD, Sami S, Baba S, Barruet E, Nasu A, Asaka I, Otsuka T, Yamanaka S, Conklin BR, Toguchida J, Hsiao EC
• Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche.
  Cell stem cell 2013 Schepers K, Pietras EM, Reynaud D, Flach J, Binnewies M, Garg T, Wagers AJ, Hsiao EC, Passegué E
• AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophy.
  PloS one 2013 Spindler MJ, Burmeister BT, Huang Y, Hsiao EC, Salomonis N, Scott MJ, Srivastava D, Carnegie GK, Conklin BR
• Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice.
  Blood 2012 Schepers K, Hsiao EC, Garg T, Scott MJ, Passegué E
• Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor.
  Calcified tissue international 2011 Kazakia GJ, Speer D, Shanbhag S, Majumdar S, Conklin BR, Nissenson RA, Hsiao EC
• Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice.
  Stem cell research & therapy 2011 Hsiao EC, Nguyen TD, Ng JK, Scott MJ, Chang WC, Zahed H, Conklin BR
• Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance.
  Circulation research 2010 van Laake LW, Qian L, Cheng P, Huang Y, Hsiao EC, Conklin BR, Srivastava D
• Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010 Hsiao EC, Boudignon BM, Halloran BP, Nissenson RA, Conklin BR
• Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation.
  Molecular endocrinology (Baltimore, Md.) 2010 Hsiao EC, Millard SM, Louie A, Huang Y, Conklin BR, Nissenson RA
• Engineering GPCR signaling pathways with RASSLs.
  Nature methods 2008 Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL
• Marking embryonic stem cells with a 2A self-cleaving peptide: a NKX2-5 emerald GFP BAC reporter.
  PloS one 2008 Hsiao EC, Yoshinaga Y, Nguyen TD, Musone SL, Kim JE, Swinton P, Espineda I, Manalac C, deJong PJ, Conklin BR
• MicroRNA regulation of cell lineages in mouse and human embryonic stem cells.
  Cell stem cell 2008 Ivey KN, Muth A, Arnold J, King FW, Yeh RF, Fish JE, Hsiao EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D
• Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor.
  PloS one 2007 Chang WC, Ng JK, Nguyen T, Pellissier L, Claeysen S, Hsiao EC, Conklin BR
• Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D
• A Series of RASSLs Activated by a Single Agonist.
  The FASEB Journal 2006 Peter Chang, Edward Hsiao, Alex C Zambon, Bruce R Conklin
• Growth differentiation factor-15: induction in liver injury through p53 and tumor necrosis factor-independent mechanisms.
  The Journal of surgical research 2005 Zimmers TA, Jin X, Hsiao EC, Perez EA, Pierce RH, Chavin KD, Koniaris LG
• An unusual development.
  The American journal of medicine 2005 Hsiao E, Charles R, Magid C, Nivatpumin P, Wiener CM
• Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury.
  Shock (Augusta, Ga.) 2005 Zimmers TA, Jin X, Hsiao EC, McGrath SA, Esquela AF, Koniaris LG
• Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling.
  The Journal of clinical endocrinology and metabolism 2005 Nakakura EK, Sriuranpong VR, Kunnimalaiyaan M, Hsiao EC, Schuebel KE, Borges MW, Jin N, Collins BJ, Nelkin BD, Chen H, Ball DW
• Diagnostic I-123 scintigraphy to assess potential breast uptake of I-131 before radioiodine therapy in a postpartum woman with thyroid cancer.
  Clinical nuclear medicine 2004 Hsiao E, Huynh T, Mansberg R, Bautovich G, Roach P
• Cases from the Osler medical service at Johns Hopkins University.
  The American journal of medicine 2004 Maruthur NM, Hsiao EC, Lee J, Nivatpumin P
• Transient absence of hepatic uptake on gallium-67 scintigraphy following fludarabine therapy.
  Clinical nuclear medicine 2004 Huynh T, Mansberg R, Hsiao E, Coyle L, Roach P
• Pericarditis associated with cryptococcal meningitis on Ga-67 scintigraphy.
  Clinical nuclear medicine 2004 Hsiao E, Mansberg R, Huynh T, Roach P
• Cytokine-responsive gene-2/IFN-inducible protein-10 expression in multiple models of liver and bile duct injury suggests a role in tissue regeneration.
  Journal of immunology (Baltimore, Md. : 1950) 2001 Koniaris LG, Zimmers-Koniaris T, Hsiao EC, Chavin K, Sitzmann JV, Farber JM
• Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury.
  Molecular and cellular biology 2000 Hsiao EC, Koniaris LG, Zimmers-Koniaris T, Sebald SM, Huynh TV, Lee SJ
• Structural and functional conservation of the Drosophila doublesex splicing enhancer repeat elements.
  RNA (New York, N.Y.) 1996 Hertel KJ, Lynch KW, Hsiao EC, Liu EH, Maniatis T