Edmond Linossi, PhD
Associate Specialist
Cardiovascular Research Inst
School of Medicine

Publications (21)

Top publication keywords:
Signal TransductionCytokinesJanus Kinase 1Protein Conformation, alpha-HelicalTyrosineHepatocyte Growth FactorProtein BindingProtein Interaction Domains and MotifsShc Signaling Adaptor ProteinsProtein DomainsSuppressor of Cytokine Signaling Proteinssrc Homology DomainsProtein Conformation, beta-StrandProto-Oncogene Proteins c-metProteasome Endopeptidase Complex

• Author Correction: CIS is a potent checkpoint in NK cell-mediated tumor immunity.
  Nature immunology 2024 Delconte RB, Kolesnik TB, Dagley LF, Rautela J, Shi W, Putz EM, Stannard K, Zhang JG, Teh C, Firth M, Ushiki T, Andoniou CE, Degli-Esposti MA, Sharp PP, Sanvitale CE, Infusini G, Liau NPD, Linossi EM,…
• Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.
  Nature communications 2023 Linossi EM, Li K, Veggiani G, Tan C, Dehkhoda F, Hockings C, Calleja DJ, Keating N, Feltham R, Brooks AJ, Li SS, Sidhu SS, Babon JJ, Kershaw NJ, Nicholson SE
• Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.
  bioRxiv : the preprint server for biology 2023 Estevam GO, Linossi EM, Macdonald CB, Espinoza CA, Michaud JM, Coyote-Maestas W, Collisson EA, Jura N, Fraser JS
• Trapping Tribbles: Nanobody-assisted structure of the TRIB2 pseudokinase.
  Structure (London, England : 1993) 2022 Santana FR, Linossi EM, Jura N
• Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.
  Nature communications 2021 Linossi EM, Li K, Veggiani G, Tan C, Dehkhoda F, Hockings C, Calleja DJ, Keating N, Feltham R, Brooks AJ, Li SS, Sidhu SS, Babon JJ, Kershaw NJ, Nicholson SE

Show all (16 more) Hide

• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  Research square 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  bioRxiv : the preprint server for biology 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• State of the structure address on MET receptor activation by HGF.
  Biochemical Society transactions 2021 Linossi EM, Estevam GO, Oshima M, Fraser JS, Collisson EA, Jura N
• A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics.
  Scientific reports 2021 Knox J, Joly N, Linossi EM, Carmona-Negrón JA, Jura N, Pintard L, Zuercher W, Roy PJ
• Understanding SOCS protein specificity.
  Growth factors (Chur, Switzerland) 2018 Linossi EM, Calleja DJ, Nicholson SE
• Identification of a second binding site on the TRIM25 B30.2 domain.
  The Biochemical journal 2018 D'Cruz AA, Kershaw NJ, Hayman TJ, Linossi EM, Chiang JJ, Wang MK, Dagley LF, Kolesnik TB, Zhang JG, Masters SL, Griffin MDW, Gack MU, Murphy JM, Nicola NA, Babon JJ, Nicholson SE
• Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.
  eLife 2017 Kedzierski L, Tate MD, Hsu AC, Kolesnik TB, Linossi EM, Dagley L, Dong Z, Freeman S, Infusini G, Starkey MR, Bird NL, Chatfield SM, Babon JJ, Huntington N, Belz G, Webb A, Wark PA, Nicola NA, Xu J, …
• Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7.
  Cerebral cortex (New York, N.Y. : 1991) 2017 Lawrenson ID, Krebs DL, Linossi EM, Zhang JG, McLennan TJ, Collin C, McRae HM, Kolesnik TB, Koh K, Britto JM, Kueh AJ, Sheikh BN, El-Saafin F, Nicola NA, Tan SS, Babon JJ, Nicholson SE, Alexander WS, …
• CIS is a potent checkpoint in NK cell-mediated tumor immunity.
  Nature immunology 2016 Delconte RB, Kolesnik TB, Dagley LF, Rautela J, Shi W, Putz EM, Stannard K, Zhang JG, Teh C, Firth M, Ushiki T, Andoniou CE, Degli-Esposti MA, Sharp PP, Sanvitale CE, Infusini G, Liau NP, Linossi EM, …
• Structure and Functional Characterization of the Conserved JAK Interaction Region in the Intrinsically Disordered N-Terminus of SOCS5.
  Biochemistry 2015 Chandrashekaran IR, Mohanty B, Linossi EM, Dagley LF, Leung EW, Murphy JM, Babon JJ, Nicholson SE, Norton RS
• Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins.
  Immunological reviews 2015 Linossi EM, Nicholson SE
• Key role of suppressor of cytokine signaling 3 in regulating gp130 cytokine-induced signaling and limiting chondrocyte responses during murine inflammatory arthritis.
  Arthritis & rheumatology (Hoboken, N.J.) 2014 Liu X, Croker BA, Campbell IK, Gauci SJ, Alexander WS, Tonkin BA, Walsh NC, Linossi EM, Nicholson SE, Lawlor KE, Wicks IP
• Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
  PLoS pathogens 2014 Kedzierski L, Linossi EM, Kolesnik TB, Day EB, Bird NL, Kile BT, Belz GT, Metcalf D, Nicola NA, Kedzierska K, Nicholson SE
• Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.
  PloS one 2013 Linossi EM, Chandrashekaran IR, Kolesnik TB, Murphy JM, Webb AI, Willson TA, Kedzierski L, Bullock AN, Babon JJ, Norton RS, Nicola NA, Nicholson SE
• Suppression of cytokine signaling: the SOCS perspective.
  Cytokine & growth factor reviews 2013 Linossi EM, Babon JJ, Hilton DJ, Nicholson SE
• The SOCS box-adapting proteins for ubiquitination and proteasomal degradation.
  IUBMB life 2012 Linossi EM, Nicholson SE