Dylan Chan, MD, PhD
Professor
Otolaryngology
School of Medicine
Dylan K. Chan, MD, PhD, is an Associate Professor in Residence and he is the Director of the Children’s Communication Center (CCC) in the Department of Otolaryngology – Head and Neck Surgery (ONHS) at the University of California, San Francisco.
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He received his PhD in Sensory Neuroscience from the Rockefeller University in New York, and he obtained his medical degree from Weill Medical College of Cornell University, New York. Dr. Chan completed his ONHS residency from Stanford University School of Medicine, California, followed by a Pediatric Otolaryngology fellowship at the Seattle Children’s Hospital, Washington.
In 2014, Dr. Chan established the UCSF Children’s Communication Center, which is devoted to delivering multidisciplinary care for families of deaf and hard of hearing children, performing community outreach and education, and conducting clinical and translational research projects. By addressing existing shortfalls in care delivery and developing novel treatments, he hopes to significantly impact hearing health in children. His laboratory is interested in investigating the pathophysiology and genetics of hearing loss associated with mutations in Connexin 26, the most commonly affected gene in congenital hearing loss, and the development of gene therapy for hearing restoration.
Dr. Chan is a scientific reviewer for various scientific journals, frequent invited speaker at local and national conferences, and has published over 15 articles
Specialty: Cochlear Implant Surgery and Pediatric Otolaryngology
Expertise: Pediatric hearing loss, cochlear implantation, chronic ear surgery, and ear canal reconstruction; obstructive sleep apnea and sleep endoscopy; velopharyngeal insufficiency
Professional Interests: Multidisciplinary management, diagnostic testing, genetics, and treatment of deaf and hard of hearing children; health disparities in treatment and outcomes of pediatric hearing loss; pathophysiology and genetics of Connexin-26-associated hearing loss; pediatric communication disorders.
Education and Training:
- PhD: The Rockefeller University, New York, NY – Sensory Neuroscience
- Medical School: Weill Medical College of Cornell University, New York, NY
- Residency: Stanford University School of Medicine, CA – Otolaryngology-Head and Neck Surgery
- Fellowship: Seattle Children’s Hospital, WA – Pediatric Otolaryngology
Awards and Honors:
- 2014 ANS/AAO-HNSF - Herbert Silverstein Award
- 2014 American Hearing Research Foundation Research Grant
- 2015 American Society for Pediatric Otolaryngology Career Development Award
Grants and Projects
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Publications (79)
Top publication keywords:
DeafnessCochlear ImplantsHearing TestsHearing Loss, Noise-InducedHearingHearing LossLanguage Development DisordersCochlear ImplantationCochleaHearing Loss, SensorineuralSleep Apnea, ObstructiveSpeech PerceptionLanguage DevelopmentConnexinsHearing Aids
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Differences in Hearing Devices and Speech Therapy Utilization Between Children With Permanent Unilateral Versus Bilateral Hearing Loss.
Ear and hearing 2024 Brodie KD, Florentine MM, Taketa E, Ho M, Chan DK -
Geographic, Sociodemographic, and Clinical Factors Associated With Parental Self-Efficacy in Pediatric Patients With Hearing Loss.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2024 Khalsa IK, Florentine MM, Liao EN, Stephans J, Chan DK -
Synaptic ribbon dynamics after noise exposure in the hearing cochlea.
Communications biology 2024 Ismail Mohamad N, Santra P, Park Y, Matthews IR, Taketa E, Chan DK -
Probing versus primary nasal endoscopy for the treatment of congenital dacryocystoceles.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 2024 Ahmad TR, Lindquist KJ, Oatts JT, de Alba Campomanes AG, Kersten RC, Chan DK, Indaram M -
Congenital Cytomegalovirus Testing Outcomes From the ValEAR Trial.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2024 Orb QT, Pesch M, Allen CM, Wilkes A, Ahmad I, Alfonso K, Antonio SM, Mithal LB, Brinkmeier JV, Carvalho D, Chan D, Cheng AG, Chi D, Cohen M, Discolo CM, Duran C, Germiller J, Gibson L, Grunstein E, …
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TMTC4 is a hair cell-specific human deafness gene.
JCI insight 2023 Li J, Choi BY, Eltawil Y, Ismail Mohamad N, Park Y, Matthews IR, Han JH, Kim BJ, Sherr EH, Chan DK -
TAD evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function.
Nature communications 2023 Okhovat M, VanCampen J, Nevonen KA, Harshman L, Li W, Layman CE, Ward S, Herrera J, Wells J, Sheng RR, Mao Y, Ndjamen B, Lima AC, Vigh-Conrad KA, Stendahl AM, Yang R, Fedorov L, Matthews IR, Easow SA,… -
Hearing Impairment and School Engagement Outcomes in US Children.
JAMA otolaryngology-- head & neck surgery 2023 Khalsa IK, Chan DK -
Risk Factors Associated with Delays in Hearing Loss Identification in Pediatric Patients.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2023 Lindeborg MM, Khalsa IK, Liao EN, Stephans JR, Chan DK -
Modulating the Unfolded Protein Response with ISRIB Mitigates Cisplatin Ototoxicity.
bioRxiv : the preprint server for biology 2023 Li J, Rouse SL, Matthews IR, Sherr EH, Chan DK -
Sociodemographic Disparities and Hearing-Related Quality of Life in Children With Hearing Loss.
JAMA network open 2023 Warren BR, Khalsa IK, Stephans J, Chan DK -
Sociodemographic Disparities in Educational Services in Children who are Deaf or Hard of Hearing.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2023 Stephens EM, Eltawil Y, Khalsa IK, Manjarrez L, Stephans J, Chan DK -
Disparities in Newborn Hearing Screening Outcomes in the United States From 2007 to 2017.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2023 Gutierrez KL, Koyamatsu R, Lahiff M, Jutte DP, Chan DK -
International Pediatric Otolaryngology Group (IPOG) consensus on scoring of pediatric Drug Induced Sleep Endoscopy (DISE).
International journal of pediatric otorhinolaryngology 2023 Parikh SR, Boudewyns A, Friedman NR, Schwartz SR, Baldassari CM, Benedek P, Carr MM, Chan DK, Chan KC, Cheng AT, Couloigner V, Diala OR, DeRowe A, El-Hakim H, Fayoux P, Hsu WC, Ishman S, Kirkham EM, … -
Understanding Barriers to Timely Diagnosis and Intervention Among Immigrant Children With Hearing Loss.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2023 Jaradeh K, Liao EN, Chehab LZ, Tebb KP, Florentine MM, Bellfort-Salinas S, Chan DK -
TAD Evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function.
bioRxiv : the preprint server for biology 2023 Okhovat M, VanCampen J, Lima AC, Nevonen KA, Layman CE, Ward S, Herrera J, Stendahl AM, Yang R, Harshman L, Li W, Sheng RR, Mao Y, Fedorov L, Ndjamen B, Vigh-Conrad KA, Matthews IR, Easow SA, Chan DK,… -
Impact of Sociodemographic Disparities on Language Outcomes After Cochlear Implantation in a Diverse Pediatric Cohort.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2023 Liao EN, Yaramala N, Coulthurst S, Merrill K, Ho M, Kramer K, Chan DK -
Factors associated with congenital cytomegalovirus infection detected by dried blood spot testing in children with hearing loss.
International journal of pediatric otorhinolaryngology 2023 Liao EN, Stephans J, Taketa E, Mohamad NI, Kaur Khalsa I, Naugle K, Chan DK -
Predictors of successful natural sleep MRI for sensorineural hearing loss in infants.
International journal of pediatric otorhinolaryngology 2022 Liao EN, Li Y, Fung A, Lawless L, Czechowicz J, Ho M, Luu K, Meyer L, Mohamad NI, Nadaraja GS, Taketa E, Virbalas J, Weinstein JE, Tsai T, Chan DK -
Hearing Loss Screening, Diagnosis, and Treatment for Refugees and Asylees in an Urban Clinic, 2014-2017.
OTO open 2022 Jaradeh K, Liao E, Dieterich C, Truong S, Anand P, Chan DK, Raphael E -
The Early-Childhood Hearing Screening Program in a Low-Income Setting-Reply.
JAMA otolaryngology-- head & neck surgery 2022 Brodie KD, David AP, Chan DK -
Impact of Genetic Testing on Hearing Interventions.
The Laryngoscope 2022 Brodie KD, Liao EN, Florentine MM, Chan DK -
Prevention and management of hearing loss in patients receiving ototoxic medications.
Bulletin of the World Health Organization 2022 Lindeborg MM, Jung DH, Chan DK, Mitnick CD -
Outcomes of Gene Panel Testing for Sensorineural Hearing Loss in a Diverse Patient Cohort.
JAMA network open 2022 Liao EN, Taketa E, Mohamad NI, Chan DK -
Congenital aural atresia and first branchial cleft anomalies: Cholesteatoma and surgical management.
Laryngoscope investigative otolaryngology 2022 Liao EN, Chan DK -
Outcomes of an Early Childhood Hearing Screening Program in a Low-Income Setting.
JAMA otolaryngology-- head & neck surgery 2022 Brodie KD, David AP, Kriss H, Chan DK -
Disparities in Speech and Language Delay Among Children With Aural Atresia.
Ear and hearing 2022 Florentine MM, Le Clec'h S, Upton SM, Scarpelli C, Carr JP, Chan DK -
Early surgical and audiologic outcomes of active, transcutaneous, osseointegrated bone-conduction hearing device (Osia 2® system) placement.
International journal of pediatric otorhinolaryngology 2022 Florentine MM, Virbalas J, Chan DK -
Racial and ethnic disparities in diagnostic efficacy of comprehensive genetic testing for sensorineural hearing loss.
Human genetics 2021 Florentine MM, Rouse SL, Stephans J, Conrad D, Czechowicz J, Matthews IR, Meyer AK, Nadaraja GS, Parikh R, Virbalas J, Weinstein JE, Chan DK -
Access Challenge Index: A Novel Disparity Measure Predictive of Language Outcomes in Children Who Are Deaf/Hard of Hearing.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2021 Florentine MM, Strohl MP, Benvenuti CS, Eiseman M, Ho M, Meyer AK, Scarpelli C, Chan DK -
Racial and ethnic disparities in genetic testing for hearing loss: a systematic review and synthesis.
Human genetics 2021 Rouse SL, Florentine MM, Taketa E, Chan DK -
Tracking Home Language Production and Environment in Children Who Are Deaf or Hard of Hearing.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2021 Sola AM, Brodie KD, Stephans J, Scarpelli C, Chan DK -
Prevalence of SARS-CoV-2 Infection in Children Without Symptoms of Coronavirus Disease 2019.
JAMA pediatrics 2021 Sola AM, David AP, Rosbe KW, Baba A, Ramirez-Avila L, Chan DK -
Validation of a Hearing-Related Quality-of-Life Questionnaire for Parents and Deaf or Hard-of-Hearing Infants and Toddlers.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2020 Sola AM, Vukkadala N, Giridhar S, Stephans J, Allen IE, Chan DK -
Endoscope-assisted open rhinoplasty approach for removal of nasal dermoid with intracranial extension.
Otolaryngology Case Reports 2020 Abel P. David, Adrian E. House, Dylan K. Chan -
Genetic Testing Leading to Early Identification of Childhood Ocular Manifestations of Usher Syndrome.
The Laryngoscope 2020 Brodie KD, Moore AT, Slavotinek AM, Meyer AK, Nadaraja GS, Conrad DE, Weinstein JE, Chan DK -
Integrated stress response inhibition provides sex-dependent protection against noise-induced cochlear synaptopathy.
Scientific reports 2020 Rouse SL, Matthews IR, Li J, Sherr EH, Chan DK -
Management of Congenital Cytomegalovirus-Related Hearing Loss.
Current Otorhinolaryngology Reports 2020 Abel P. David, Dylan K. Chan -
Cryoprobe retrieval of an airway foreign body: A case report and literature review.
International journal of pediatric otorhinolaryngology 2019 David AP, Xu MJ, Rosbe KW, Meyer AK, Gesthalter YB, Chan DK -
Awake bedside nasal endoscopy for primary management of neonatal dacryocystoceles with intranasal cysts.
International journal of pediatric otorhinolaryngology 2019 Zhao NW, Chan DK -
Seeking equilibrium: The experiences of parents of infants and toddlers who are deaf/hard-of-hearing.
Journal of pediatric rehabilitation medicine 2019 Vukkadala N, Giridhar SBP, Okumura MJ, Chan DK -
Implications of dried blood spot testing for congenital CMV on management of children with hearing loss: A preliminary report.
International journal of pediatric otorhinolaryngology 2018 Lee ER, Chan DK -
Use of otoacoustic emissions to improve outcomes and reduce disparities in a community preschool hearing screening program.
PloS one 2018 Cedars E, Kriss H, Lazar AA, Chan C, Chan DK -
Deletion of Tmtc4 activates the unfolded protein response and causes postnatal hearing loss.
The Journal of clinical investigation 2018 Li J, Akil O, Rouse SL, McLaughlin CW, Matthews IR, Lustig LR, Chan DK, Sherr EH -
Unilateral Hearing Loss in Youth: Development of Candidate Items for a Condition-Specific Validated Instrument.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2018 Purcell PL, Edwards TC, Wisneski M, Chan DK, Ou H, Horn DL, Skirko JR, Sie KCY -
Linguistic and behavioral performance of bilingual children with hearing loss.
International journal of pediatric otorhinolaryngology 2018 Vukkadala N, Perez D, Cabala S, Kapur C, Chan DK -
Case 45: Masses in the Oral Cavity.
2018 Peter J. Koltai, Wen-Chun Jimmy Lan, Dylan K. Chan, Stephen R. Hoff -
Endoscopic percutaneous suture lateralization for neonatal bilateral vocal fold immobility.
International journal of pediatric otorhinolaryngology 2018 Montague GL, Bly RA, Nadaraja GS, Conrad DE, Parikh SR, Chan DK -
Diagnosis and Treatment of Congenital Sensorineural Hearing Loss.
Current otorhinolaryngology reports 2017 Chari DA, Chan DK -
Impact of Primary Language and Insurance on Pediatric Hearing Health Care in a Multidisciplinary Clinic.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2017 Su BM, Park JS, Chan DK -
Prevalence of Hearing Loss in US Children and Adolescents: Findings From NHANES 1988-2010.
JAMA otolaryngology-- head & neck surgery 2017 Su BM, Chan DK -
Tongue surgeries for pediatric obstructive sleep apnea: a systematic review and meta-analysis.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2017 Camacho M, Noller MW, Zaghi S, Reckley LK, Fernandez-Salvador C, Ho E, Dunn B, Chan D -
Characteristics of Extremely Low Gestational Age Newborns Undergoing Tracheotomy: A Secondary Analysis of the Trial of Late Surfactant Randomized Clinical Trial.
JAMA otolaryngology-- head & neck surgery 2017 Wai KC, Keller RL, Lusk LA, Ballard RA, Chan DK, Trial of Late Surfactant (TOLSURF) Study Group -
Response to Letter to the Editor.
International journal of pediatric otorhinolaryngology 2016 Cedars E, Chan D, Meyer A, Rosbe K -
Clinically small tonsils are typically not obstructive in children during drug-induced sleep endoscopy.
The Laryngoscope 2016 Miller C, Purcell PL, Dahl JP, Johnson K, Horn DL, Chen ML, Chan DK, Parikh SR -
Sound-Induced Intracellular Ca2+ Dynamics in the Adult Hearing Cochlea.
PloS one 2016 Chan DK, Rouse SL -
Conversion of traditional osseointegrated bone-anchored hearing aids to the Baha® attract in four pediatric patients.
International journal of pediatric otorhinolaryngology 2016 Cedars E, Chan D, Lao A, Hardies L, Meyer A, Rosbe K -
Sinonasal Quality of Life in Children With Cystic Fibrosis.
JAMA otolaryngology-- head & neck surgery 2016 Chan DK, McNamara S, Park JS, Vajda J, Gibson RL, Parikh SR -
Occult central venous stenosis leading to airway obstruction after subtotal parathyroidectomy.
Ear, nose, & throat journal 2016 Meiklejohn DA, Chan DK, Lalakea ML -
The current state of pediatric drug-induced sleep endoscopy.
The Laryngoscope 2016 Friedman NR, Parikh SR, Ishman SL, Ruiz AG, El-Hakim H, Ulualp SO, Wootten CT, Koltai PJ, Chan DK -
Airway Obstruction during Drug-Induced Sleep Endoscopy Correlates with Apnea-Hypopnea Index and Oxygen Nadir in Children.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2016 Dahl JP, Miller C, Purcell PL, Zopf DA, Johnson K, Horn DL, Chen ML, Chan DK, Parikh SR -
Supraglottoplasty for laryngomalacia with obstructive sleep apnea: A systematic review and meta-analysis.
The Laryngoscope 2015 Camacho M, Dunn B, Torre C, Sasaki J, Gonzales R, Liu SY, Chan DK, Certal V, Cable BB -
Airway response to sirolimus therapy for the treatment of complex pediatric lymphatic malformations.
International journal of pediatric otorhinolaryngology 2015 Alemi AS, Rosbe KW, Chan DK, Meyer AK -
Progressive Hearing Loss and Head Trauma in Enlarged Vestibular Aqueduct: A Systematic Review and Meta-analysis.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2015 Alemi AS, Chan DK -
Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane.
Journal of Visualized Experiments 2015 Omar Akil, Stephanie L. Rouse, Dylan K. Chan, Lawrence R. Lustig -
Surgical method for virally mediated gene delivery to the mouse inner ear through the round window membrane.
Journal of visualized experiments : JoVE 2015 Akil O, Rouse SL, Chan DK, Lustig LR -
A new scoring system for upper airway pediatric sleep endoscopy.
JAMA otolaryngology-- head & neck surgery 2014 Chan DK, Liming BJ, Horn DL, Parikh SR -
Perioperative ketorolac increases post-tonsillectomy hemorrhage in adults but not children.
The Laryngoscope 2014 Chan DK, Parikh SR -
Upper aerodigestive magnetic foreign bodies in children.
The Laryngoscope 2014 Brown JC, Baik FM, Ou HC, Otjen JP, Parish HG, Chan DK -
GJB2-associated hearing loss: systematic review of worldwide prevalence, genotype, and auditory phenotype.
The Laryngoscope 2013 Chan DK, Chang KW -
Effect of obesity and medical comorbidities on outcomes after adjunct surgery for obstructive sleep apnea in cases of adenotonsillectomy failure.
Archives of otolaryngology--head & neck surgery 2012 Chan DK, Jan TA, Koltai PJ -
Supraglottoplasty for occult laryngomalacia to improve obstructive sleep apnea syndrome.
Archives of otolaryngology--head & neck surgery 2012 Chan DK, Truong MT, Koltai PJ -
Masses in the Oral Cavity.
NeoReviews 2011 Peter J. Koltai, Wen-Chun Jimmy Lan, Dylan K. Chan, Stephen R. Hoff -
Diagnostic yield in the workup of congenital sensorineural hearing loss is dependent on patient ethnicity.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2011 Chan DK, Schrijver I, Chang KW -
Connexin-26-associated deafness: phenotypic variability and progression of hearing loss.
Genetics in medicine : official journal of the American College of Medical Genetics 2010 Chan DK, Schrijver I, Chang KW -
Protection against cisplatin-induced ototoxicity by adeno-associated virus-mediated delivery of the X-linked inhibitor of apoptosis protein is not dependent on caspase inhibition.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2007 Chan DK, Lieberman DM, Musatov S, Goldfein JA, Selesnick SH, Kaplitt MG -
Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear.
Proceedings of the National Academy of Sciences of the United States of America 2006 Asai Y, Chan DK, Starr CJ, Kappler JA, Kollmar R, Hudspeth AJ -
AAV-mediated delivery of the caspase inhibitor XIAP protects against cisplatin ototoxicity.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2006 Cooper LB, Chan DK, Roediger FC, Shaffer BR, Fraser JF, Musatov S, Selesnick SH, Kaplitt MG -
Ca2+ current-driven nonlinear amplification by the mammalian cochlea in vitro.
Nature neuroscience 2005 Chan DK, Hudspeth AJ